1998

Foreign peptides expressed in engineered chimeric self molecules.: Biotechnol Genet Eng Rev. 1998;15:159-98. Unique Identifier : AIDSLINE MED/98234691; Casares S; Bot A; Brumeanu TD; Bona CA; Department of Microbiology, Mount Sinai School of Medicine, New York,; NY 10029, USA.
How the MHC selects Th1/Th2 immunity.: Immunol Today. 1998 Apr;19(4):157-63. Unique Identifier : AIDSLINE MED/98237948; Murray JS; Dept of Microbiology, University of Kansas, Lawrence 66045, USA.; While the effects of cytokines on T helper 1 (Th1)/Th2 differentiation are well documented, it is less clear why a dichotomy of effector cytokine production would initiate from antigen-specific lymphocytes. Nevertheless, in defined experimental systems, the interaction between T-cell receptor TCR), peptide and major h
HIV hyperimmune globulin or intravenous immune globulin inhibits response to an HIV vaccine.: Biotechnol Appl Biochem. 1998 Apr;27 ( Pt 2):89-95. Unique Identifier : AIDSLINE MED/98231061; Jelonek MT; Maskrey JL; Cummins LM; Arora Y; Steimer KS; White-Scharf M; Keller MA; Department of Pediatrics, UCLA School of Medicine, Harbor-UCLA Medical; Center, Torrance 90509, USA.; The murine model was developed to assess the effects of maternally transferred HIV hyperimmune globulin or human intravenous immune globulin on the immunization of the offspring at 18-21 days of age with rgp 120SF2-complete Freund s adjuvant. Either HIV hyperimmune globulin or intravenous immune globulin was administe
The athlete: an immunocompromised host.: Adv Pediatr Infect Dis. 1997;13:79-99. Unique Identifier : AIDSLINE MED/98205952; Hughes WT; Department of Infectious Diseases, St. Jude Children's Research; Hospital, Memphis, Tennessee, USA.
Three-dimensional structure of HIV-1 Rev protein filaments.: J Struct Biol. 1998 Jan;121(1):41-52. Unique Identifier : AIDSLINE MED/98234702; Watts NR; Misra M; Wingfield PT; Stahl SJ; Cheng N; Trus BL; Steven AC; Williams RW; Laboratory of Structural Biology Research, National Institute of; Arthritis and Musculoskeletal and Skin Diseases, National Institutes; of Health, Bethesda, Maryland 20892, USA.; The HIV-1 Rev protein facilitates the export of incompletely spliced and unspliced viral mRNAs from the nucleus. Rev polymerizes into two types of filaments in vitro. In the presence of RNA, Rev forms poorly ordered structures, while in the absence of RNA it polymerizes into regular hollow filaments. We have determine
Relapse prevention as an interventive model for HIV risk reduction in gay and bisexual men.: AIDS Educ Prev. 1998 Feb;10(1):1-18. Unique Identifier : AIDSLINE MED/98165993; Roffman RA; Stephen RS; Curtin L; Gordon JR; Craver JN; Stern M; Beadnell B; Downey L; School of Social Work, University of Washington, Seattle 98105-6299,; USA.; Despite considerable self-initiated HIV risk reduction among men who have sex with men, little is known about how to design interventions that will effectively assist individuals from this population in maintaining safer sex behaviors over time. The present study evaluated the effectiveness of a 17-session group couns
Effectiveness of an HIV risk reduction counseling intervention for out-of-treatment drug users.: AIDS Educ Prev. 1998 Feb;10(1):19-33. Unique Identifier : AIDSLINE MED/98165994; Kotranski L; Semaan S; Collier K; Lauby J; Halbert J; Feighan K; Division of Research and Evaluation, Philadelphia Health Management; Corporation, PA 19102-5085, USA.; This study examined and compared the effectiveness of two counseling interventions designed to reduce the HIV drug and sexual risk behaviors of 684 out-of-treatment drug users recruited from South Philadelphia, PA. All study participants received a standard intervention and one half were randomly assigned to also rece
Factors related to condom use among four groups of female sex workers in Bali, Indonesia.: AIDS Educ Prev. 1998 Feb;10(1):34-45. Unique Identifier : AIDSLINE MED/98165995; Ford K; Wirawan DN; Fajans P; Department of Epidemiology, School of Public Health, University of; Michigan, Ann Harbor 48109-2029, USA. kford@sph.umich.edu; This article tests a behavioral model of condom use for four groups of female commercial sex workers. Data were drawn from a study of 614 female sex workers conducted in Bali, Indonesia . AIDS knowledge, risk behaviors, and factors related to condom use varied substantially among
Cultural feasibility studies in preparation for clinical trials to reduce maternal-infant HIV transmission in Haiti.: AIDS Educ Prev. 1998 Feb;10(1):46-62. Unique Identifier : AIDSLINE MED/98165996; Coreil J; Losikoff P; Pincu R; Mayard G; Ruff AJ; Hausler HP; Desormeau J; Davis H; Boulos R; Halsey NA; College of Public Health, University of South Florida, Tampa 33612,; USA.; A cultural feasibility study is defined as one that investigates scientific as well as ethical, behavioral, and social issues in the design of clinical trials. The value of such a broadly defined assessment is illustrated through the presentation of two case studies conducted to prepare for clinical trials to reduce m
Sources of information for HIV prevention program managers: a national survey.: AIDS Educ Prev. 1998 Feb;10(1):63-74. Unique Identifier : AIDSLINE MED/98165997; Goldstein E; Wrubel J; Faigeles B; DeCarlo P; Center for AIDS Prevention Studies (CAPS), San Francisco, CA 94105,; USA.; This study s objective was to find out if HIV prevention program planners seek out science in designing interventions, and if not, where they turn for prevention information. Researchers conducted a survey of 284 program managers of AIDS prevention programs across the United States . Rey
Assessing the construct validity of the AIDS Attitude Scale.: AIDS Educ Prev. 1998 Feb;10(1):75-89. Unique Identifier : AIDSLINE MED/98165998; Bruce KE; Reid BC; Department of Psychology, University of North Carolina at Wilmington; 28403, USA. bruce@uncwil.edu; To assess the construct validity of the AIDS Attitude Scale (AAS) Shrum, Turner, & Bruce, 1989), we administered it and related attitude scales to introductory psychology students (n = 279) and gay/lesbian support group members (n = 38). A subset of the students (n = 105) participated in a concurrent validity study
Reproductive decisions of women at risk for acquiring HIV infection.: AIDS Educ Prev. 1998 Feb;10(1):90-7. Unique Identifier : AIDSLINE MED/98165999; Ahluwalia IB; DeVellis RF; Thomas JC; Department of Health Behavior and Health Education, University of; North Carolina at Chapel Hill, USA.; Approximately 1 to 1.5 million people in the United States are infected with HIV. The incidence of HIV is increasing among women and children. Little information exists regarding the determinants of reproductive decisions of women at risk of HIV infection. This study investigated the c
Th2-like cytokine activity in dermatitis herpetiformis.: Br J Dermatol. 1998 Feb;138(2):242-7. Unique Identifier : AIDSLINE MED/98265578; Caproni M; Feliciani C; Fuligni A; Salvatore E; Atani L; Bianchi B; Pour SM; Proietto G; Toto P; Coscione G; Amerio P; Fabbri P; Department of Dermatology, University of Florence, Italy.; Dermatitis herpetiformis (DH) is a chronic subepidermal blistering disease, in which a perivascular cellular infiltrate, composed mainly of CD4+ T lymphocytes together with a varying number of neutrophils and eosinophils, is thought to be important in the pathogenesis of blister formation. The aim of this study was to
An indolent penile herpetic ulcer in a patient with previously undiagnosed human immunodeficiency virus infection.: Br J Dermatol. 1998 Feb;138(2):334-6. Unique Identifier : AIDSLINE MED/98265596; Tayal SC; Pattman RS; Mclelland J; Sviland L; Snow MH; Department of Genito-Urinary Medicine, Newcastle General Hospital,; Newcastle Upon Tyne, U.K.; We report a case of an atypical penile herpetic ulcer in a man with previously undiagnosed human immunodeficiency virus (HIV) infection. Swabs of the lesion were negative for herpes simplex virus (HSV) by culture and electron microscopy. However, histopathology of biopsy material showed characteristic herpetic multinu
Streptococcal impetigo induces Th1-preponderant activation of T lymphocytes with subsequent anergy to superantigenic exotoxins in patients with atopic dermatitis [letter]: Br J Dermatol. 1998 Feb;138(2):357-8. Unique Identifier : AIDSLINE MED/98265602; Tokura Y; Ishii-Ginoza M; Seo N; Ito T; Sakurai M; Furukawa F; Takigawa M
Unusual skin ulceration in an HIV-positive patient who had cutaneous syphilis and neurosyphilis [letter]: Br J Dermatol. 1998 Feb;138(2):366-7. Unique Identifier : AIDSLINE MED/98265610; Ajithkumar K
Increased presence of Epstein-Barr virus DNA in ocular fluid samples from HIV negative immunocompromised patients with uveitis.: Br J Ophthalmol. 1998 Mar;82(3):245-51. Unique Identifier : AIDSLINE MED/98265330; Ongkosuwito JV; Van der Lelij A; Bruinenberg M; Wienesen-van Doorn M; Feron EJ; Hoyng CB; de Keizer RJ; Klok AM; Kijlstra A; Department of Ophthalmology, Academic Medical Centre, University of; Amsterdam, Netherlands.; AIMS: To investigate whether routine testing for Epstein-Barr virus (EBV) is necessary in the examination of a patient with uveitis. METHODS: Intraocular EBV DNA was determined in 183 ocular fluid samples taken from patients with AIDS and uveitis, HIV negative immunocompromised uveitis, acute retinal necrosis, toxopla
Sustained release intravitreal ganciclovir implant as salvage treatment in AIDS related cytomegalovirus retinitis [letter]: Br J Ophthalmol. 1998 Mar;82(3):333. Unique Identifier : AIDSLINE MED/98265353; Kamal A; King A; Sylvestri G; Dhillon B
Photo-cross-linking studies suggest a model for the architecture of an active human immunodeficiency virus type 1 integrase-DNA complex.: Biochemistry. 1998 May 12;37(19):6667-78. Unique Identifier : AIDSLINE MED/98244844; Heuer TS; Brown PO; Department of Biochemistry, Program in Cancer Biology, Stanford; University Medical Center, California 94305-5428, USA.; The virally encoded integrase protein carries out retroviral integration, which requires specific interactions with the two ends of the viral DNA, and also with host DNA that is the target of integration. We attached a photo-cross-linking agent to specific viral and target DNA sites to identify regions of the integras
[The usefulness of abdominal echography in the diagnosis of extrapulmonary tuberculosis in patients with HIV infection]: Enferm Infecc Microbiol Clin. 1998 Feb;16(2):61-5. Unique Identifier : AIDSLINE MED/98247508; Dominguez-Castellano A; Yanez P; Muniain MA; Balonga B; Rios MJ; Rodriguez-Bano J; Bueno C; Perez-Cano R; Servicio de Medicina Interna, Hospital Universitario Virgen; Macarena-San Lazaro, Sevilla. adomin@cica.es; BACKGROUND: The aim of the present study was to analyze the diagnostic profitability of echography as an indicator of extrapulmonary tuberculosis in patients with HIV infection. PATIENTS AND METHODS: HIV positive patients presenting fever of long duration were prospectively studied with an active search for specific e
Inhibition of human immunodeficiency virus type 1 replication by nuclear chimeric anti-HIV ribozymes in a human T lymphoblastoid cell line.: Hum Gene Ther. 1998 Mar 20;9(5):621-8. Unique Identifier : AIDSLINE MED/98211332; Michienzi A; Conti L; Varano B; Prislei S; Gessani S; Bozzoni I; Istituto Pasteur, Fondazione Cenci-Bolognetti, Department of Genetics; and Molecular Biology, University La Sapienza, Rome, Italy.; Human immunodeficiency virus (HIV) infection represents one of the most challenging systems for gene therapy. Thanks to the extended knowledge of the molecular biology of the HIV life cycle, many different strategies have been developed including transdominant modifications of HIV proteins, RNA decoys, antisense RNA,
Eight-year observation and comparative study of specific pathogen-free cats experimentally infected with feline immunodeficiency virus (FIV) subtypes A and B: terminal acquired immunodeficiency syndrome in a cat infected with FIV petaluma strain.: J Vet Med Sci. 1998 Mar;60(3):315-21. Unique Identifier : AIDSLINE MED/98221550; Kohmoto M; Uetsuka K; Ikeda Y; Inoshima Y; Shimojima M; Sato E; Inada G; Toyosaki T; Miyazawa T; Doi K; Mikami T; Department of Veterinary Microbiology, Graduate School of Agriculture; and Life Sciences, University of Tokyo.; Three specific pathogen-free cats experimentally infected with feline immunodeficiency virus (FIV) strains Petaluma, TM1 and TM2, respectively were observed for over 8 years. Without showing any significant clinical signs of immunodeficiency syndrome AIDS) for 8 years and 4 months of asymptomatic phase, the Petaluma-i
Rapid and progressive CD4+ decline in a monkey infected with an SIV+HIV-1 chimeric virus.: J Vet Med Sci. 1998 Mar;60(3):361-3. Unique Identifier : AIDSLINE MED/98221558; Nagamachi D; Igarashi T; Shimada T; Kuwata T; Ui M; Ami Y; Enose Y; Ido E; Fukumoto M; Hayami M; Department of Pathology and Tumor Biology, Graduate School of; Medicine, Kyoto, Japan.; We previously constructed a simian immunodeficiency virus+human immunodeficiency virus type 1 (HIV-1) chimeric virus, NM-3rN to generate a pathogenic HIV-1 in macaque monkeys. During the in vivo passage of this virus in several monkeys, a viral strain, R43-56 was obtained which acquired a better replication ability in
Immunoregulatory activity in adult rat testicular interstitial fluid: relationship with intratesticular CD8+ lymphocytes following treatment with ethane dimethane sulfonate and testosterone implants.: Biol Reprod. 1998 Apr;58(4):935-42. Unique Identifier : AIDSLINE MED/98206800; Hedger MP; Wang J; Lan HY; Atkins RC; Wreford NG; Institute of Reproduction and Development, Monash University, Clayton,; Victoria, Australia. mark.hedger@med.monash.edu.au; Regulation of T-cell traffic and function in the adult rat testis was assessed following treatment with the specific Leydig cell cytoxin, ethane dimethane sulfonate (EDS), and s.c. testosterone implants to prevent Leydig cell recovery. The distribution of T-cell subsets in the testis was determined immunohistochemical
Characterization of lymphocytes in the adult rat testis by flow cytometry: effects of activin and transforming growth factor beta on lymphocyte subsets in vitro.: Biol Reprod. 1998 Apr;58(4):943-51. Unique Identifier : AIDSLINE MED/98206801; Tompkins AB; Hutchinson P; de Kretser DM; Hedger MP; Institute of Reproduction and Development, Monash University, Clayton,; Victoria, Australia.; The rat testis is considered to be an immunologically privileged site because of its reduced capacity to support antigen-specific immune responses. To understand this phenomenon, it is essential to characterize both the lymphocyte subpopulations normally present in the testis and their regulation by testicular cytokin
Accidental transmission of HCV and treatment with interferon.: J Gastroenterol Hepatol. 1998 Mar;13(3):238-43. Unique Identifier : AIDSLINE MED/98230159; Takagi H; Uehara M; Kakizaki S; Takahashi H; Takezawa J; Kabeya K; Satoh K; Kojima A; Saito S; Matsumoto T; Hashimoto Y; Abe T; Yamada T; Konaka K; Shimoda R; Takayama H; Takehara K; Nagamine T; Mori M; The First Department of Internal Medicine, Gunma University School of; Medicine, Maebashi, Japan. htakagi@sb.gunma-u.ac.jp; Accidental transmission of contagious pathogens, especially hepatitis C virus (HCV), by needlestick or other means as an occupational hazard for medical staff is of concern. We retrospectively analysed cases of work-related accidental injury with pathogens such as hepatitis B virus (HBV), HCV, syphilis and human immun
[Prevention of hepatitis B--analysis of cost-effectiveness after liver transplantation]: Langenbecks Arch Chir Suppl Kongressbd. 1997;114:1048-50. Unique Identifier : AIDSLINE MED/98235417; Golling M; Arnold JC; Rudek B; Theilmann L; Herfarth C; Otto G; Chirurgische und Medizinische Universitatsklinik Heidelberg.; HBV recurrence, despite immunoprophylaxis which occurred in 67% of our patients, remains the main problem following liver transplantation for HBV infection. Pretransplant viral replication (HBV-DNA) and probably viral mutation may account to some degree for the failures involved in hyperimmunoglobulin prophylaxis. In
Educational preparation of nurses to meet the needs of human immunodeficiency virus (HIV) infected patients.: Br J Theatre Nurs. 1998 Apr;8(1):21-7. Unique Identifier : AIDSLINE MED/98254751; Vials JM; School of Nursing and Midwifery, University of Wolverhampton.
Isoform-specific O-glycosylation by murine UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T3, in vivo.: Glycobiology. 1998 Apr;8(4):367-71. Unique Identifier : AIDSLINE MED/98165749; Nehrke K; Hagen FK; Tabak LA; Department of Dental Research, School of Dentistry, University of; Rochester, Rochester, NY 14648, USA.; Multiple isoforms of UDP-GalNAc:polypeptide N-acetylgalactosaminyl- transferase (ppGaNTase) have been cloned and expressed from a variety of organisms. In general, these isoforms display different patterns of tissue-specific expression, but exhibit overlapping substrate specificities, in vitro . A peptide substrate, d
The effect of pair formation and variable infectivity on the spread of an infection without recovery.: Math Biosci. 1998 Feb;148(1):83-113. Unique Identifier : AIDSLINE MED/98260117; Kretzschmar M; Dietz K; Institut fur Medizinische Biometrie, Universitat Tubingen, Germany.; mirjam.kretzschmar@rivm.nl; For the spread of an infection without recovery we compare the properties of a model in which contacts are assumed to be instantaneous and every contact is with a new partner to a model with an explicit description of partnership formation and duration. We investigate the dynamic behaviour at the beginning of the epid
Recurrent central diabetes insipidus secondary to cryptococcal meningitis.: J Assoc Acad Minor Phys. 1998;9(1):22-4. Unique Identifier : AIDSLINE MED/98246763; Woredekal Y; Department of Medicine, Brooklyn Veterans Administration Medical; Center, New York, USA.; Meningitis is often associated with hyponatremia due to inappropriate secretion of antidiuretic hormone, and diabetes insipidus is associated with bacterial meningitis. This article describes a patient with acquired immunodeficiency syndrome who experienced recurrent episodes of central diabetes insipidus in associati
Oral hairy leukoplakia with ultrastructural evidence of Merkel-like cells in human tongue epithelium.: Bull Group Int Rech Sci Stomatol Odontol. 1998 Jan-Mar;40(1):24-37. Unique Identifier : AIDSLINE MED/98228858; Cobb M; MacNeill R; Tobin J; Department of Periodontics, School of Dentistry, University of; Missouri-Kansas City, USA. CobbC@smtpgate.umkc.edu; The purpose of this investigation was to examine cells in the stratum basale and subjacent lamina propria of oral hairy leukoplakia (OHL) specimens for previously unreported morphological changes. Tongue biopsy specimens were obtained from ten HIV-positive and five healthy male patients and examined by light (LM) and
An efficient and cost-effective isotope labeling protocol for proteins expressed in Escherichia coli.: J Biomol NMR. 1998 Jan;11(1):97-102. Unique Identifier : AIDSLINE MED/98227443; Cai M; Huang Y; Sakaguchi K; Clore GM; Gronenborn AM; Craigie R; Laboratory of Chemical Physics, National Institute of Diabetes and; Digestive and Kidney Diseases, National Institutes of Health,; Bethesda, MD 20892-0520, USA.; A cost-effective protocol for uniform 15N and/or 13C isotope labeling of bacterially expressed proteins is presented. Unlike most standard protocols, cells are initially grown in a medium containing nutrients at natural abundance and isotopically labeled nutrients are only supplied at the later stages of growth and du
Pregnant women should routinely be offered HIV tests [news]: BMJ. 1998 May 2;316(7141):1333. Unique Identifier : AIDSLINE MED/98273459; Mayor S
Screening for human T cell leukaemia/lymphoma virus among blood donors in Sweden: cost effectiveness analysis.: BMJ. 1998 May 9;316(7142):1417-22. Unique Identifier : AIDSLINE MED/98239599; Tynell E; Andersson S; Lithander E; Arneborn M; Blomberg J; Hansson HB; Krook A; Nomberg M; Ramstedt K; Shanwell A; Bjorkman A; Division of Infectious Diseases, Karolinska Institutet, Danderyd; University Hospital, Danderyd, Sweden. elsa.tynell@inf.ds.sll.se; OBJECTIVE: To analyse the cost effectiveness of a national programme to screen blood donors for infection with the human T cell leukaemia/lymphoma virus. DESIGN: Three models for calculating the costs and benefits of screening were developed. The first model analysed the cost of continuously testing all donations; the
The epidemiology of cancer of the small bowel.: Cancer Epidemiol Biomarkers Prev. 1998 Mar;7(3):243-51. Unique Identifier : AIDSLINE MED/98180738; Neugut AI; Jacobson JS; Suh S; Mukherjee R; Arber N; Department of Medicine, College of Physicians and Surgeons, Columbia; University, New York, New York 10032, USA.; Despite its anatomical location between two regions of high cancer risk, the small bowel rarely develops a malignant tumor. However, in recent years, small bowel cancer incidence rates have begun to rise. The purpose of this review is to explore the descriptive and analytic epidemiology of small bowel cancer for those
Categorical funding to seamless systems of care: the challenge for community-based primary care providers.: J Case Manag. 1997 Fall;6(3):96-103. Unique Identifier : AIDSLINE MED/98235052; Ulmer C; Lewis-Idema D; Falik M; Raggio TP; Stoessel P; Coughlin T; Butterworth D; Tillman J; MDS Associates, Wheaton, MD 20902, USA.; Integrating categorical funding to design seamless systems of care for individual patients is a challenge faced by many local community-based providers. Providers may choose to develop separate site-specific categorical programs for patients with human immunodeficiency virus (HIV) [e.g., specialized treatment site o
Rabies infection and specific effect of vaccination in mice selected for high and low immunobiological parameters.: Braz J Med Biol Res. 1997 Nov;30(11):1309-13. Unique Identifier : AIDSLINE MED/98193407; Queiroz-da-Silva LH; De-Franco M; Sant'Anna OA; Departamento de Apoio, Curso de Medicina Veterinaria, Universidade; Estadual Paulista, Aracatuba, SP, Brasil.; Innate and acquired resistance to rabies infection was investigated in mice genetically selected for high (H) or low (L) antibody responsiveness from selections I, III and IV and in mice selected for maximal (AIRmax) or minimal (AIRmin) acute inflammatory reaction. These mouse lines were infected intramuscularly with
Serological level of ICAM and ELAM adhesion molecules in allergic vascularitis.: Rom J Intern Med. 1997 Jan-Dec;35(1-4):83-8. Unique Identifier : AIDSLINE MED/98223750; Alecu M; Coman G; Galatescu E; Dermatovenereology Center, Scarlat Longhin Clinical Hospital for; Dermatology, Bucharest, Romania.; A 24-patient lot with hypersensitivity vasculitis was investigated for serological determinations of ICAM and ELAM adhesion molecules. Determinations were made in attack and in remission. Over two thirds of the cases presented elevated serological levels of ICAM and ELAM in attack, with twofold higher values than norm
AIDS and HIV infection worldwide.: Commun Dis Rep CDR Wkly. 1997 May 23;7(21):189-90. Unique Identifier : AIDSLINE MED/98166358
AIDS and HIV infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1998 Feb 27;8(9):84. Unique Identifier : AIDSLINE MED/98185084
Socioeconomic influences on the transmission of human immunodeficiency virus infection: the hidden risk.: Arch Fam Med. 1998 May-Jun;7(3):214-7. Unique Identifier : AIDSLINE MED/98255892; Fournier AM; Carmichael C; Department of Family Medicine and Community Health, University of; Miami School of Medicine, Miami Beach, Fla 33101, USA.; Worldwide, and in pockets of poverty in the United States , there is growing evidence that poverty is a major contributor to the spread of human immunodeficiency virus infection. Specific socioeconomic forces contributing to the spread of the infection include the status of women, prost
Longitudinal models for AIDS marker data.: Stat Methods Med Res. 1998 Mar;7(1):13-27. Unique Identifier : AIDSLINE MED/98194458; Boscardin WJ; Taylor JM; Law N; Department of Biostatistics, UCLA 90095-1772, USA.; Over the past decade, researchers have put a great amount of effort into developing suitable models for the analysis of longitudinal CD4 data and other markers of AIDS progression. These models must be general enough to allow for different patterns of change in the marker data. In this paper, we review the existing li
Increasing efficiency from censored survival data by using random effects to model longitudinal covariates.: Stat Methods Med Res. 1998 Mar;7(1):28-48. Unique Identifier : AIDSLINE MED/98194459; Hogan JW; Laird NM; Center for Statistical Sciences, Brown University, Providence, RI; 02912, USA. jhogan@stat.brown.edu; When estimating a survival time distribution, the loss of information due to right censoring results in a loss of efficiency in the estimator. In many circumstances, however, repeated measurements on a longitudinal process which is associated with survival time are made throughout the observation time, and these measu
Malignant melanoma in an HIV-infected man: a case report and literature review.: Cancer Invest. 1998;16(4):217-24. Unique Identifier : AIDSLINE MED/98250917; Aboulafia DM; Section of Hematology/Oncology, Virginia Mason Medical Center,; Seattle, Washington, USA.; Although it is not proven by causative association, several studies indicate that patients with acquired immune deficiency syndrome (AIDS) have a high risk for developing cutaneous malignancies, especially lymphoma and Kaposi s sarcoma. Other malignant cutaneous lesions seen in this patient population include basal-ce
Skin and soft tissue infections in critical care.: Crit Care Clin. 1998 Apr;14(2):251-62. Unique Identifier : AIDSLINE MED/98222629; Hill MK; Sanders CV; Department of Medicine, Louisiana State University School of Medicine,; New Orleans, USA.; Clinicians in the critical care setting see extensive, severe, and often necrotizing infection, as well as atypical or unusual infection that can be misdiagnosed, resulting in delays in treatment. Greater numbers of immunocompromised patients are at risk for both types of infection. A thorough understanding of various
Genetic effects on HIV disease progression [letter]: Nat Med. 1998 May;4(5):536. Unique Identifier : AIDSLINE MED/98244606; Ioannidis JP; O'Brien TR; Rosenberg PS; Contopoulos-Ioannidis DG; Goedert JJ
Are Japanese researchers exploiting Thai HIV patients? [news]: Nat Med. 1998 May;4(5):540. Unique Identifier : AIDSLINE MED/98244610; Saegusa A
Funding for Gallo Institute under threat [news]: Nat Med. 1998 May;4(5):541. Unique Identifier : AIDSLINE MED/98244612; Ault A
Chemokines and HIV-1 second receptors: the therapeutic connection.: Nat Med. 1998 May;4(5):563-8. Unique Identifier : AIDSLINE MED/98244628; Cairns JS; D'Souza MP; Targeted Intervention Branch, Division of AIDS, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.
B cells inhibit induction of T cell-dependent tumor immunity.: Nat Med. 1998 May;4(5):627-30. Unique Identifier : AIDSLINE MED/98244640; Qin Z; Richter G; Schuler T; Ibe S; Cao X; Blankenstein T; Max-Delbruck-Center for Molecular Medicine, Berlin, FRG.; Cytotoxic T lymphocyte (CTL) mediated tumor immunity against major histocompatibility antigen (MHC) class I-positive but class II-negative tumors often requires help from CD4+ T cells. These CD4 cells are activated by MHC class II-positive cells that present tumor derived antigens. Considering that different antigen p
Sharps injuries in dental practice.: Prim Dent Care. 1998 Jan;5(1):33-9. Unique Identifier : AIDSLINE MED/98187014; Robinson P; United Medical and Dental Schools of Guy's and St. Thomas's, London.; Sharps injuries are common in dental practice and may allow transmission of blood-borne viruses. The transmission rates of hepatitis B (HBV) to non-vaccinated recipients, hepatitis C (HCV) and human immunodeficiency virus (HIV) after a needlestick injury are 6-30%, 2.7-10% and 0.1-0.3% respectively. Five strategies to
Remune response [letter]: Nat Biotechnol. 1998 Apr;16(4):314. Unique Identifier : AIDSLINE MED/98216555; Trauger R
Binding kinetics and bioassay of RRE mRNA fragments to a peptide containing the recognition domain of HIV-1 Rev.: Biomed Pept Proteins Nucleic Acids. 1996-97;2(3):85-8. Unique Identifier : AIDSLINE MED/98236257; West ML; Ramsdale TE; Centre for Drug Design and Development, University of Queensland, St.; Lucia, Australia.; Surface plasmon resonance techniques have been used to examine the kinetics of binding for two RNA fragments to an RNA binding domain of HIV-1 REv. RBE3 RNA elicited an apparent dissociation constant (KD) of 121 nM while RREIIB41-79 RNA exhibited an apparent dissociation constant (KD) of 2.5 nM. The dissociation rates
Communicable diseases surveillance.: Commun Dis Intell. 1998 Apr 16;22(4):61-7. Unique Identifier : AIDSLINE MED/98244097
Open-label phase I study of combination therapy with zidovudine and interferon-beta in patients with AIDS-related Kaposi's sarcoma: AIDS Clinical Trials Group Protocol 057.: Cytokines Cell Mol Ther. 1998 Mar;4(1):17-23. Unique Identifier : AIDSLINE MED/98217966; Miles S; Levine A; Feldstein M; Carden J; Cabriallas S; Marcus S; Mitsuyasu R; Gill P; Division of Hematology-Oncology, UCLA Clinical AIDS Research and; Education Center, UCLA School of Medicine, USA.; smiles@medl.medsch.ucla.edu; The aim of this study was to identify a safe and tolerable dose of recombinant interferon-beta (IFN-beta) used in conjunction with a fixed dose of zidovudine in patients with early-stage, good-prognosis AIDS-related Kaposi s sarcoma. We conducted a phase I, dose-escalation controlled trial of 22.5, 45 of 90 million un
Irradiated IL-2 gene-modified plasmacytoma vaccines are more efficient than live vaccines.: Int J Oncol. 1998 May;12(5):1195-8. Unique Identifier : AIDSLINE MED/98207192; Simova J; Bubenik J; Jandlova T; Indrova M; Institute of Molecular Genetics, Academy of Sciences of the Czech; Republic, Flemingovo nam. 2, 166 37 Prague 6, Czech Republic.; The effect of irradiation on the therapeutic efficacy of IL-2 gene-modified plasmacytoma cells used as a vaccine in the immunotherapy of parental murine plasmacytoma X63-Ag8.653 was examined. Local administration of the IL-2-secreting plasmacytoma irradiated with a dos
It's more than literacy: the assimilation effect of the translation model.: Ethn Health. 1997 Nov;2(4):323-8. Unique Identifier : AIDSLINE MED/98187443; Saini F; Rowling L; Northern Sydney Area Health Service, Royal North Shore Hospital, St; Leonards, Australia.; Availability and access to correct information is a pre-requisite for people to be able to make informed decisions about their health. This paper will examine the effect of the sole reliance on translation in producing health promotion materials for people from Non English Speaking Background (NESB). In
How drug resistance emerges as a result of poor compliance during short course chemotherapy for tuberculosis.: Int J Tuberc Lung Dis. 1998 Jan;2(1):10-5. Unique Identifier : AIDSLINE MED/98220574; Mitchison DA; Department of Medical Microbiology, St. George's Hospital Medical; School, London, UK. dmitchis@sghms.ac.uk; OBJECTIVE: To explore mechanisms by which drug resistance might arise as a result of poor compliance during short course chemotherapy. DESIGN: Four theoretical mechanisms are first described. RESULTS: Examples of the way the mechanisms probably operate are taken from: 1) a study of once-weekly chemotherapy with strept
The use of restriction fragment length polymorphism (RFLP) analysis for epidemiological studies of tuberculosis in developing countries.: Int J Tuberc Lung Dis. 1998 Jan;2(1):16-26. Unique Identifier : AIDSLINE MED/98220575; Cohn DL; O'Brien RJ; Research and Surveillance Unit, Global Tuberculosis Programme, World; Health Organization, Geneva, Switzerland.; DNA fingerprinting, of which restriction fragment length polymorphism (RFLP) typing is the most common method used, has permitted novel investigations of the epidemiology and pathogenesis of tuberculosis. The use of IS6110, an insertion sequence which is present in Mycobacterium tuberculosis, is generally considered t
The International Tuberculosis Surveillance Research Unit (TSRU): the first 30 years.: Int J Tuberc Lung Dis. 1998 Jan;2(1):5-9. Unique Identifier : AIDSLINE MED/98220573; Rouillon A; International Union Against Tuberculosis and Lung Disease, Paris,; France. IUATLDParis@compuserve.com
[Methods and perspectives of AIDS prevention among teachers of secondary schools in the village of Namur]: Sante Publique. 1997 Dec;9(4):475-82. Unique Identifier : AIDSLINE MED/98245546; Meremans P; Sace C; Brasseur P; Deccache A; Universite Catholique de Louvain-en-Woluwe, Belgique.; In 1994, ASBL Namur-Entraide-Sida has been involved in a survey through questionnaires for teachers of the whole high schools in Namur ( Belgium ). Its purpose was to better notice what sort of viewpoints and modalities in preventing youngs from aids were developed or not during the
Sulfoquinovosyldiacylglycerol, KM043, a new potent inhibitor of eukaryotic DNA polymerases and HIV-reverse transcriptase type 1 from a marine red alga, Gigartina tenella.: Chem Pharm Bull (Tokyo). 1998 Apr;46(4):684-6. Unique Identifier : AIDSLINE MED/98240207; Ohta K; Mizushina Y; Hirata N; Takemura M; Sugawara F; Matsukage A; Yoshida S; Sakaguchi K; Department of Applied Biological Science, Faculty of Science and; Technology, Science University of Tokyo, Japan.; A new sulfolipid, KM043, which belongs to the 6-sulfo-alpha-D-quinovopyranosyl-(1-->3 )-1 ,2 -diacylglycerol SQDG) class of compounds, has been isolated from a marine red alga, Gigartina tenella, as a potent inhibitor of eukaryotic DNA polymerases and HIV-reverse transcriptase type 1. Its structure was determined on t
Syntheses of HIV-protease inhibitors having a peptide moiety which binds to GP120.: Chem Pharm Bull (Tokyo). 1998 Apr;46(4):697-703. Unique Identifier : AIDSLINE MED/98240208; Asagarasu A; Uchiyama T; Achiwa K; School of Pharmaceutical Sciences, University of Shizuoka, Japan.; Some HIV-protease inhibitor derivatives having an N-carbomethoxycarbonyl-prolyl-phenylalanine benzyl ester (CPF) moiety as a binding site to gp120 were designed and synthesized. Almost all the compounds bearing CPF on the phenoxyacetyl group showed protease-inhibitory activity. Compounds 25a and 25b, which have the CP
Practical synthesis of (2s,3s)-3-amino-2-hydroxy-4-phenylbutyric acid, a key component of HIV protease inhibitors.: Chem Pharm Bull (Tokyo). 1998 Apr;46(4):733-5. Unique Identifier : AIDSLINE MED/98240215; Shibata N; Itoh E; Terashima S; Sagami Chemical Research Center, Sagamihara, Kanagawa, Japan.
Brain HIV burden and length of survival after AIDS diagnosis.: Clin Neuropathol. 1998 Mar-Apr;17(2):95-9. Unique Identifier : AIDSLINE MED/98222115; Soontornniyomkij V; Nieto-Rodriguez JA; Martinez AJ; Kingsley LA; Achim CL; Wiley CA; Department of Pathology (Division of Neuropathology), University of; Pittsburgh, Pennsylvania 15213, USA.; Patients with AIDS in the late stages of disease can develop dementia . Previous studies have suggested HIV encephalitis is the pathological substrate of HIV-associated dementia. We hypothesized that patients who survive longer after the initial diagnosis of AIDS would have a higher
Effects of methylprednisolone and cyclophosphamide pulse therapy on renal infiltrating cells in patients with crescentic glomerulonephritis.: Chin Med J (Engl). 1997 Mar;110(3):206-9. Unique Identifier : AIDSLINE MED/98256698; Tang Z; Zhou H; Yao X; Hu W; Leishi L; Jinling Hospital, School of Medicine, Nanjing University, China.; OBJECTIVE: To investigate the effects of pulse methylprednisolone MP) and monthly intravenous cyclophosphamide (CTX) therapy (MP + CTX) on renal infiltrating cells in patients with rapid progressive glomerular nephritis (RPGN). METHODS: Twelve patients with RPGN (> 50% crescents) were given MP + CTX therapy and receiv
Vaccination with monoclonal anti-idiotypic antibody on immunocompetent mice bearing human ovarian carcinoma.: Chin Med J (Engl). 1997 Apr;110(4):259-63. Unique Identifier : AIDSLINE MED/98256580; Qian H; Wang J; Feng J; Gynecologic Oncology Center, People's Hospital, Beijing Medical; University, China.; OBJECTIVE: To observe the effects of anti-idiotypic monoclonal antibody 6B11 against ovarian carcinoma SKOV3 on immunocompetent mice BCF1 both in vivo and in vitro, so as to investigate the possibility of using it as a tumor vaccine. METHODS: After immunization with 6B11 and normal mice (NM) IgG respectively on 2 grou
Emerging pathogens: the Hong Kong experience.: Chin Med J (Engl). 1997 Jul;110(7):560-6. Unique Identifier : AIDSLINE MED/98256572; Siau H; Yuen KY; Peiris JS; Wong SS; Ho PL; Cao L; Yam WC; Shortridge KF; Chau PY; Im SW; Ng MH; Department of Microbiology, University of Hong Kong, Queen Mary; Hospital Compound.
[Effect of bone xenograft transplantation on total T lymphocyte and its subset counts in mouse blood and spleen]: Chung Hua Wai Ko Tsa Chih. 1996 Aug;34(8):453-6. Unique Identifier : AIDSLINE MED/98256543; Sang H; Hu Y; Xia H; Institute of Orthopaedics, Xijing Hospital, Fourth Military Medical; University, Xi'an.; Fresh calf cancellous bone xenograft (FX), antigen free cancellous bone carrier (BC) and reconstituted bone xenograft RBX) were inplanted in the thigh muscle pouches of Balb/c mice. Histological examinations were done at 7, 14 and 28 days postoperation, and indirect immunofluorescence was used to determine the positiv
Perianal manifestations of human immunodeficiency virus infection: experience with 260 patients.: Dis Colon Rectum. 1998 May;41(5):606-11; discussion 611-2. Unique Identifier : AIDSLINE MED/98254076; Barrett WL; Callahan TD; Orkin BA; Department of Surgery, The George Washington University, Washington,; DC, USA.; PURPOSE: Individuals infected with the human immunodeficiency virus often have disorders affecting the anorectum. These disorders may be complex and difficult to treat. We reported our early experience with 40 human immunodeficiency virus-positive patients with perianal disorders in 1990. We now present our series of
Cytomegalovirus enteritis: a highly lethal condition requiring early detection and intervention.: Dis Colon Rectum. 1998 May;41(5):619-23. Unique Identifier : AIDSLINE MED/98254078; Page MJ; Dreese JC; Poritz LS; Koltun WA; Department of Surgery, Milton S. Hershey Medical Center, Pennsylvania; State University College of Medicine, Hershey 17033-0850, USA.; Cytomegalovirus infection causing symptomatic enteritis is most usually associated with immunosuppressed transplant patients or patients positive for human immunodeficiency virus. Most reports studying this illness are small and do not clearly define the risk factors or mortality rates. METHODS: The present study retr
Affinity capillary electrophoresis investigation of an epitope on human immunodeficiency virus recognized by a monoclonal antibody.: Electrophoresis. 1998 Mar;19(3):415-9. Unique Identifier : AIDSLINE MED/98211519; Qian XH; Tomer KB; Laboratory of Structural Biology, National Institute of Environmental; Health Sciences, Research Triangle Park, NC 27709, USA.; Affinity capillary electrophoresis (ACE) has been used to investigate the epitope on the human immunodeficiency virus (HIV) core protein p24 recognized by the monoclonal antibody (mAb) 13-102-100. The affinity of a series of peptides with N- and C-terminal truncations of the epitope sequence determined by mass spectro
The Ick protein tyrosine kinase is not involved in antibody-mediated CD4 (CDR3-loop) signal transduction that inhibits HIV-1 transcription.: Eur J Immunol. 1998 May;28(5):1445-57. Unique Identifier : AIDSLINE MED/98264612; Coudronniere N; Corbeil J; Robert-Hebmann V; Mesnard JM; Devaux C; CRBM/CNRS UPR 1086-Laboratoire Infections retrovirales et; signalisation cellulaire, Montpellier, France.; Monoclonal antibodies (mAb) that bind to the immunoglobulin CDR3-like region in the D1 domain of the CD4 molecule can inhibit the HIV-1 life cycle in CD4-positive T cells and lymphoblastoid cell lines at the stage of transcription. This antiviral effect requires the integrity of the cytoplasmic tail of CD4 which is kn
Surface expression of TRAIL/Apo-2 ligand in activated mouse T and B cells.: Eur J Immunol. 1998 May;28(5):1492-8. Unique Identifier : AIDSLINE MED/98264616; Mariani SM; Krammer PH; Division of Immunogenetics, German Cancer Research Center, Heidelberg.; Like other members of the TNF family, TRAIL/Apo-2 ligand induces apoptosis in sensitive target cells in a caspase-dependent fashion. We recently found that TRAIL may be constitutively expressed on the surface of mouse and human tumor cells of T and B origin. To define the pattern of TRAIL expression in normal immune c
Enforced expression of human bcl-2 in CD4+ T cells enhances human herpesvirus 7 replication and induction of cytopathic effects.: Eur J Immunol. 1998 May;28(5):1587-96. Unique Identifier : AIDSLINE MED/98264627; Secchiero P; Bertolaso L; Gibellini D; Ricci D; Bemis K; Capitani S; Gallo RC; Zauli G; Institute of Human Anatomy, University of Ferrara, Italy.; The cytopathic effects (CPE) resulting from the infection of CD4+ T cells by human herpes-virus 7 (HHV-7) comprises two major mechanisms: generation of large polyploid cells, which eventually undergo necrotic lysis, and apoptosis, predominantly occurring in small mononucleated cells. To dissect the relative contributi
Somatic hypermutation of the T cell receptor V beta gene in microdissected splenic white pulps from HIV-1-positive patients.: Eur J Immunol. 1998 May;28(5):1604-10. Unique Identifier : AIDSLINE MED/98264629; Cheynier R; Henrichwark S; Wain-Hobson S; Unite de Retrovirologie Moleculaire, Institut Pasteur, Paris, France.; Somatic mutation of rearranged immunoglobulin V genes occurs in germinal centers (GC), resulting in affinity maturation of the immune response. Rearranged T cell receptor (TCR) genes were thought to be excluded from this process despite similarities in their gene structure. Somatic mutations were found among TCR V alp
ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains.: Eur J Immunol. 1998 May;28(5):1689-700. Unique Identifier : AIDSLINE MED/98264639; Samson M; Edinger AL; Stordeur P; Rucker J; Verhasselt V; Sharron M; Govaerts C; Mollereau C; Vassart G; Doms RW; Parmentier M; IRIBHN, Universite libre de Bruxelles, Belgium.; Leukocyte chemoattractants act through a rapidly growing subfamily of G protein-coupled receptors. We report the cloning of a novel human gene encoding an orphan receptor (ChemR23) related to the C3a, C5a and formyl Met-Leu-Phe receptors, and more distantly to the subfamilies of chemokine receptors. ChemR23 transcript
Demonstration of identical expanded clones within both CD8+CD28+ and CD8+CD28- T cell subsets in HIV type 1-infected individuals.: Eur J Immunol. 1998 May;28(5):1738-42. Unique Identifier : AIDSLINE MED/98264644; Mugnaini EN; Spurkland A; Egeland T; Sannes M; Brinchmann JE; Institute of Transplantation Immunology, Rikshospitalet National; Hospital, Oslo, Norway.; In HIV-1-infected individuals, the CD8+CD28- T cell subset is considerably expanded and is frequently the largest subset of T cells found in peripheral blood. It has been assumed, but not proven, that CD8+CD28- T cells derive from CD8+CD28+ T cells in vivo. To further study the ontogeny of CD8+CD28- T cells, we have p
Depletion of EBV-infected cells in donor marrow by counterflow elutriation.: Exp Hematol. 1998 May;26(5):395-9. Unique Identifier : AIDSLINE MED/98250537; Gross TG; Hinrichs SH; Davis JR; Mitchell D; Bishop MR; Wagner JE; Department of Pathology/Microbiology, UNMC/Eppley Cancer Center,; University of Nebraska Medical Center, Omaha 68198, USA.; Epstein-Barr virus (EBV)-associated posttransplantation lymphoproliferative disease (PTLD) is a well-recognized complication of T cell-depleted (TCD) allogeneic bone marrow transplantation (BMT). Certain methods of TCD, such as counterflow elutriation (CE), have not been associated with an increased incidence of PTLD.
Encephalitozoon intestinalis: humoral responses in interferon-gamma receptor knockout mice infected with a microsporidium pathogenic in AIDS patients.: Exp Parasitol. 1998 May;89(1):113-21. Unique Identifier : AIDSLINE MED/98264659; El Fakhry Y; Achbarou A; Desportes-Livage I; Mazier D; INSERM U313, Immunobiologie Cellulaire et Moleculaire des Infections; Parasitaires, CHU Pitie-Salpetriere, Paris, France.; IFN-gamma receptor knockout mice and wild-type mice were infected per os with Encephalitozoon intestinalis. Both groups developed an infection that was chronic in the mutant mice whereas it was only transient in wild-type mice. The infection of mutant mice was characterized by the continual shedding of spores in feces
Genomic organization and promoter characterization of human CXCR4 gene.: FEBS Lett. 1998 Apr 17;426(2):271-8. Unique Identifier : AIDSLINE MED/98258970; Caruz A; Samsom M; Alonso JM; Alcami J; Baleux F; Virelizier JL; Parmentier M; Arenzana-Seisdedos F; Unite d'Immunologie Virale, Institut Pasteur, Paris, France.; CXCR4 is the receptor for the CXC chemokine SDF1 that has essential functions on embryo organogenesis, immunological functions and T lymphocyte trafficking. Recently, CXCR4 has drawn unexpected attention as it was recently identified as a co-factor required for entry of lymphotropic HIV isolates in CD4+ T lymphocytes.
Likelihood models for detecting positively selected amino acid sites and applications to the HIV-1 envelope gene.: Genetics. 1998 Mar;148(3):929-36. Unique Identifier : AIDSLINE MED/98198821; Nielsen R; Yang Z; Department of Integrative Biology, University of California, Berkeley; 94720-3140, USA. rasmus@mws4.biol.berkeley.edu; Several codon-based models for the evolution of protein-coding DNA sequences are developed that account for varying selection intensity among amino acid sites. The neutral model assumes two categories of sites at which amino acid replacements are either neutral or deleterious. The positive-selection model assumes
[New herpesviruses HHV 6, 7 and 8 and their clinical significance]: Fortschr Med. 1998 Feb 20;116(5):37-9. Unique Identifier : AIDSLINE MED/98213917; Menz M; Eggers HJ; Universitat zu Koln, Institut fur Virologie, Koln.
Transitions in insurance and employment among people with HIV infection.: Inquiry. 1998 Spring;35(1):36-48. Unique Identifier : AIDSLINE MED/98259304; Fleishman JA; Center for Cost and Financing Studies, Agency for Health Care Policy; and Research, Rockville, MD 20852, USA.; This article examines the extent to which people with HIV infection change their insurance and employment status over time and investigates the correlates of such changes. Data come from the AIDS Cost and Services Utilization Survey, which followed 1,949 HIV-infected adults over an 18-month period that began March 1,
Human papillomavirus and human immunodeficiency virus infections: relation with cervical dysplasia-neoplasia in African women.: Int J Cancer. 1998 May 18;76(4):480-6. Unique Identifier : AIDSLINE MED/98250003; La Ruche G; You B; Mensah-Ado I; Bergeron C; Montcho C; Ramon R; Toure-Coulibaly K; Welffens-Ekra C; Dabis F; Orth G; Programme National de Lutte contre le SIDA, Abidjan, Cote d'Ivoire.; Our study assessed the factors associated with cervical squamous intra-epithelial lesions (SILs) and invasive cervical cancer, with special attention to human immunodeficiency virus (HIV) and human papillomavirus (HPV) infections. Women from 3 outpatient gynecology clinics of Abidjan,
Sulfated glycoglycerolipid from archaebacterium inhibits eukaryotic DNA polymerase alpha, beta and retroviral reverse transcriptase and affects methyl methanesulfonate cytotoxicity.: Int J Cancer. 1998 May 18;76(4):512-8. Unique Identifier : AIDSLINE MED/98250009; Ogawa A; Murate T; Izuta S; Takemura M; Furuta K; Kobayashi J; Kamikawa T; Nimura Y; Yoshida S; First Department of Surgery, Nagoya University School of Medicine,; Japan.; A sulfated glycoglycerolipid, 1-O-(6 -sulfo-alpha-D-glucopyranosyl)-2,3-di-O-phytanyl- sn-glycerol (KN-208), a derivative of the polar lipid isolated from an archaebacterium, strongly inhibited DNA polymerase (pol) alpha and pol beta in vitro among 5 eukaryotic DNA polymerases alpha, beta, gamma, delta, and epsilon).
Thymic anti-tumor effectors in mice cured of lymphoma by cyclophosphamide plus TNF-alpha therapy: phenotypic and functional characterization up to 20 months after initial tumor inoculation.: Int J Cancer. 1998 May 18;76(4):579-86. Unique Identifier : AIDSLINE MED/98250019; Ehrke MJ; Verstovsek S; Pocchiari SK; Krawczyk CM; Ujhazy P; Zaleskis G; Maccubbin DL; Meer JM; Mihich E; Department of Experimental Therapeutics, Grace Cancer Drug Center,; Roswell Park Cancer Institute, Buffalo, NY 14263, USA.; Ehrke@SC3101.Med.Buffalo.edu; As reported previously, cyclophosphamide plus tumor necrosis factor-alpha treatment of C57BL/6 mice bearing advanced EL4 lymphoma induced approx. 60% long-term (i.e., >60 days) survivors. These mice developed protective immunity, as evidenced by 1) rejection (100% survival) of EL4 tumor re-implanted on day 60 (day 0 =
Potent antitumor activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine in choriocarcinoma-bearing rats.: Int J Cancer. 1998 May 18;76(4):595-600. Unique Identifier : AIDSLINE MED/98250021; Hatse S; Naesens L; Degreve B; Segers C; Vandeputte M; Waer M; De Clercq E; Balzarini J; Rega Institute for Medical Research, Katholieke Universiteit, Leuven,; Belgium.; The acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine (PMEA) is a potent and selective antiretroviral agent which is currently evaluated in its oral prodrug form, bis(POM)PMEA (adefovir dipivoxil), in phase II and III clinical trials in human hepatitis B virus HBV)- and human immunodeficiency virus (H
Psychological distress in HIV-1 disease in relationship to hypocholesterolemia.: Int J Psychiatry Med. 1997;27(2):159-71. Unique Identifier : AIDSLINE MED/98226842; Shor-Posner G; Baldewicz T; Feaster D; Blaney NT; Miguez-Burbano M; Szapocznik J; Goodkin K; Eisdorfer C; Baum MK; Department of Psychiatry and Behavioral Sciences, University of Miami; School of Medicine, FL 33101, USA.; OBJECTIVE: Altered levels of serum cholesterol, which are prevalent in early HIV-1 infection, have been associated with disturbances in mood state and behavior. The objective of this study was to evaluate the relationship of serum cholesterol status and psychological distress in HIV-1 seropositive and seronegative men
[Costs of accidental punctures in hospital health personnel]: Gac Sanit. 1998 Jan-Feb;12(1):29-38. Unique Identifier : AIDSLINE MED/98247528; Solano Bernad VM; Rubio Cebrian S; Hernandez Navarrete MJ; Peral Casado A; Sierra Moros MJ; Castan Cameo S; Arribas Llorente JL; Servicio de Medicina Preventiva, Hospital Miguel Servet, Zaragoza.; OBJECTIVES: The aim of this study was to calculate the average cost of each hepatitis B, C and HIV follow-up carried out in the health personnel that have suffered an exposure to blood and body fluids and to estimate the cost for each of the different types of sources as well as to identify the items that account for
IMS supports name-specific HIV reports.: Iowa Med. 1998 Mar-Apr;88(2):12. Unique Identifier : AIDSLINE MED/98210384
CDC reports first-ever decline in AIDS diagnoses--treatment and prevention advances spur new trend [news]: J Ark Med Soc. 1998 Feb;94(9):388-9. Unique Identifier : AIDSLINE MED/98211139
HIV seropositivity in a burn center's population.: J Burn Care Rehabil. 1998 Mar-Apr;19(2):138-41. Unique Identifier : AIDSLINE MED/98215604; Mele JA 3rd; Linder SA; Calabria R; Ikeda CJ; Division of Plastic and Reconstructive Surgery, Saint Francis Memorial; Hospital, San Francisco, CA 94109, USA.; HIV infection in a patient with burn injuries complicates the care of both the patient and the treating burn team. In the patient, HIV slows wound healing and increases the complications seen with burns. For the treating team, HIV is a hazard that infects the large volume of bodily fluids to which the burn team is pot
In situ polymerase chain reaction amplification of HIV-1 DNA in brain tissue.: J Virol Methods. 1998 Feb;70(2):119-27. Unique Identifier : AIDSLINE MED/98220877; Strappe PM; Wang TH; McKenzie CA; Lowrie S; Simmonds P; Bell JE; Department of Pathology, University of Edinburgh, Western General; Hospital, UK.; A direct in situ polymerase chain reaction (IS-PCR) assay is described for the detection of HIV-1 proviral DNA in formalin fixed paraffin embedded brain tissue. Biotin-16-dUTP is incorporated during the PCR process and microwave pretreatment of tissue sections ensures that no non-specific incorporation into damaged or
Evaluation of 14 commercial HIV-1/HIV-2 antibody assays using serum panels of different geographical origin and clinical stage including a unique seroconversion panel.: J Virol Methods. 1998 Feb;70(2):139-51. Unique Identifier : AIDSLINE MED/98220879; Thorstensson R; Andersson S; Lindback S; Dias F; Mhalu F; Gaines H; Biberfeld G; Swedish Institute for Infectious Disease Control and Karolinska; Institute, Stockholm. rigmor.thorstensson@smi.ki.se; The performance of 14 commercially available HIV-1/2 antibody assays were compared using well-characterized serum panels containing in total 1500 1800 sera. The panels included consecutive HIV-negative blood donor sera from Sweden , unselected blood donor and patient sera from
Diagnosis of human immunodeficiency virus infection by a polymerase chain reaction assay evaluated in patients harbouring strains of diverse geographical origin.: J Virol Methods. 1998 Feb;70(2):153-66. Unique Identifier : AIDSLINE MED/98220880; Van Laethem K; Beuselinck K; Van Dooren S; De Clercq E; Desmyter J; Vandamme AM; Department of Microbiology and Immunology, Rega Institute for Medical; Research and University Hospitals, Katholieke Universiteit Leuven,; Belgium.; Since the development of the highly sensitive polymerase chain reaction, PCR has been increasingly used for the diagnosis of viral infections, including the detection of human immunodeficiency virus (HIV), the causative agent of AIDS. In our laboratory a diagnostic PCR is carried out on proviral HIV-1 DNA using a stan
Development of a syncytia inhibition assay for the detection of antibodies to bovine leukemia virus in naturally infected cattle; comparison with Western blot and agar gel immunodiffusion.: J Virol Methods. 1998 Feb;70(2):177-82. Unique Identifier : AIDSLINE MED/98220882; Johnson M; Rommel F; Mone J; Department of Biology, Millersville University, PA 17551, USA.; A syncytia inhibition assay (SIA) for the detection of antibodies to bovine leukemia virus is described. This test involves specific antibody-mediated inhibition of BLV-induced cytopathic effects in an indicator cell line. A total of 300 sera were screened commercially by agar gel immunodiffusion (AGID) and were then
Effects of chronic growth hormone treatment on energy intake and resting energy metabolism in patients with human immunodeficiency virus-associated wasting--a clinical research center study.: J Clin Endocrinol Metab. 1998 May;83(5):1542-7. Unique Identifier : AIDSLINE MED/98251563; Mulligan K; Tai VW; Schambelan M; Division of Endocrinology, San Francisco General Hospital, California; 94110, USA.; In previous studies, treatment with recombinant human GH (rhGH) produced sustained increases in weight and lean body mass (LBM) and decreases in fat mass in patients with human immunodeficiency virus (HIV)-associated wasting. To evaluate the effects of chronic rhGH treatment on components of energy balance, we recruit
Chronic cryptosporidiosis in patients with AIDS: stable remission and possible eradication after long-term, low dose azithromycin.: J Clin Pathol. 1998 Feb;51(2):138-42. Unique Identifier : AIDSLINE MED/98265398; Dionisio D; Orsi A; Sterrantino G; Meli M; Di Lollo S; Ibba Manneschi L; Trotta M; Pozzi M; Sani L; Leoncini F; Infectious Diseases Unit, Careggi Hospital, Florence, Italy.; AIMS: To investigate the effectiveness of long term, low dose azithromycin treatment for chronic cryptosporidiosis in patients with AIDS. METHODS: Azithromycin was administered as initial daily treatment to 13 patients with AIDS: 6 patients received 500 mg for 30 to 40 days (mean 35); 3 patients received 1000 mg for 2
Differentiation between actinic reticuloid and cutaneous T cell lymphoma by T cell receptor gamma gene rearrangement analysis and immunophenotyping.: J Clin Pathol. 1998 Feb;51(2):154-8. Unique Identifier : AIDSLINE MED/98265401; Bakels V; van Oostveen JW; Preesman AH; Meijer CJ; Willemze R; Department of Dermatology, Free University Hospital, Amsterdam,; Netherlands.; AIMS: Differentiation between actinic reticuloid and cutaneous T cell lymphoma can be extremely difficult. Demonstration of clonal T cell receptor (TCR) gene rearrangements has been suggested as a potential diagnostic criterion, but the results obtained thus far have been conflicting. This study investigated whether T
Follicular mucinosis as a presenting sign of acute myeloblastic leukemia.: J Am Acad Dermatol. 1998 May;38(5 Pt 2):803-5. Unique Identifier : AIDSLINE MED/98252487; Sumner WT; Grichnik JM; Shea CR; Moore JO; Miller WS; Burton CS; Department of Medicine, Duke University Medical Center, Durham, NC; 27710, USA.; Follicular mucinosis is often associated with mycosis fungoides and has been rarely observed to occur with other neoplastic and inflammatory conditions. We describe a 60-year-old patient with follicular mucinosis who later developed acute myelogenous leukemia. This is the first reported case of follicular mucinosis as
Degos disease in a patient with acquired immunodeficiency syndrome.: J Am Acad Dermatol. 1998 May;38(5 Pt 2):852-6. Unique Identifier : AIDSLINE MED/98252499; Requena L; Farina C; Barat A; Department of Dermatology, Fundacion Jimenez Diaz, Universidad; Autonoma, Madrid, Spain.; Malignant atrophic papulosis is a rare disorder characterized by pathognomonic cutaneous lesions that consist of infarctive thrombosis. Visceral involvement often occurs; the gastrointestinal tract and the central nervous system are most frequently involved. Malignant atrophic papulosis has not been previously describ
Evaluation of an HIV/AIDS continuing education program.: J Contin Educ Nurs. 1998 Mar-Apr;29(2):85-93. Unique Identifier : AIDSLINE MED/98243583; Sowell R; Seals G; Wilson B; Robinson C; Department of Administrative and Clinical Nursing, University of South; Carolina, Columbia, USA.; An HIV/AIDS education model was implemented for rural nurses as a demonstration project in Georgia. The overall goal of the project was to increase the quality of and access to HIV/AIDS-specific services in rural communities. Public health and community nurses were the focus of this effort due to their current roles i
HIV-associated eosinophilic pustular folliculitis: successful treatment of a Japanese patient with UVB phototherapy.: J Dermatol. 1998 Mar;25(3):178-84. Unique Identifier : AIDSLINE MED/98236594; Misago N; Narisawa Y; Matsubara S; Hayashi S; Department of Internal Medicine, Saga Medical School, Japan.; We report the successful treatment with ultraviolet B phototherapy of a patient with HIV-associated eosinophilic pustular folliculitis. We were able to observe the clinical and therapeutic course for about one year and three months. This 35-year-old homosexual Japanese man presented with disseminated, discrete, follic
Neutrophil eccrine hidradenitis in a patient with AIDS.: J Dermatol. 1998 Mar;25(3):199-200. Unique Identifier : AIDSLINE MED/98236598; Krischer J; Rutschmann O; Roten SV; Harms M; Saurat JH; Pechere M; Clinic of Dermatology, University Hospital Geneva, Switzerland.; Neutrophilic eccrine hidradenitis (NEH), first described as a rare, transient, and benign complication of various chemotherapy regimens for acute leukemia, has also been observed in other conditions, including three HIV-positive patients and even in otherwise healthy individuals (1-3). A similar histological pattern w
AIDS discourse: a critical reading of mainstream press surveillance of marginal identity.: J Homosex. 1998;35(1):75-93. Unique Identifier : AIDSLINE MED/98185606; Myrick R; Department of Communication, Auburn University, AL 36849-5211, USA.; This article examines the discursive strategies used by two major daily newspapers from the South from 1981 to 1994 as they construct the story of AIDS and represent gay identity and desire to the general public. The research employs a cultural studies approach to communication to analyze power relationships at work
"Semi-straight sort of sex": class and gay community attachment explored within a framework of older homosexually active men.: J Homosex. 1998;35(2):65-83. Unique Identifier : AIDSLINE MED/98185610; Chapple MJ; Kippax S; Smith G; School of Behavioural Sciences, Macquarie University, Sydney NSW,; Australia.; Gay Community Attachment has proved a significant predictor of successful behavior change among gay-identifying men in response to HIV/AIDS. Related work at Macquarie University, Sydney, Australia , indicated that attachment to gay community is not a simple issue; rather, complex
Mycobacterium terrae: a potential surrogate for Mycobacterium tuberculosis in a standard disinfectant test.: J Hosp Infect. 1998 Mar;38(3):183-92. Unique Identifier : AIDSLINE MED/98222253; Griffiths PA; Babb JR; Fraise AP; Hospital Infection Research Laboratory, City Hospital NHS Trust,; Birmingham, UK.; The susceptibility of Mycobacterium tuberculosis and Mycobacterium avium-intracellulare to the disinfections used for spillage and heat sensitive instruments has received much attention in recent years. The use of clinical isolates of M. tuberculosis and M. avium-intracellulare as test organisms is considered unsuitab
Immunologic abnormalities exhibited in IL-7 transgenic mice with dermatitis.: J Invest Dermatol. 1998 May;110(5):740-5. Unique Identifier : AIDSLINE MED/98239141; Uehira M; Matsuda H; Nakamura A; Nishimoto H; Shionogi Institute for Medical Science, Osaka, Japan.; Interleukin (IL)-7 transgenic mice, which we established previously, developed severe dermatitis characterized by massive infiltration of gammadelta T cells in the dermal lesion. To fully understand the pathology of this intriguing skin disease, we examined several immunologic features of dermis infiltrating lymphocyt
Mutations in the cytomegalovirus UL97 gene associated with ganciclovir-resistant retinitis.: J Infect Dis. 1998 May;177(5):1176-81. Unique Identifier : AIDSLINE MED/98253832; Liu W; Kuppermann BD; Martin DF; Wolitz RA; Margolis TP; F. I. Proctor Foundation and the Department of Ophthalmology,; University of California at San Francisco, 94143-0944, USA.; Vitreous from patients with cytomegalovirus ( CMV ) retinitis was studied in order to identify mutations in the CMV UL97 gene associated with clinical resistance to ganciclovir. Point mutations known to confer resistance (V460,
Lack of reactivation of cytomegalovirus (CMV) retinitis after stopping CMV maintenance therapy in AIDS patients with sustained elevations in CD4 T cells in response to highly active antiretroviral therapy.: J Infect Dis. 1998 May;177(5):1182-7. Unique Identifier : AIDSLINE MED/98253833; Macdonald JC; Torriani FJ; Morse LS; Karavellas MP; Reed JB; Freeman WR; Department of Ophthalmology, University of California, San Diego,; School of Medicine, USA.; The suppression of human immunodeficiency virus (HIV) replication and elevation in CD4 cells observed with protease inhibitor combination regimens known as HAART (highly active antiretroviral therapy) may allow AIDS patients to undergo an immune recovery that allows them to suppress the progression of
Altered drug sensitivity, fitness, and evolution of human immunodeficiency virus type 1 with pol gene mutations conferring multi-dideoxynucleoside resistance.: J Infect Dis. 1998 May;177(5):1207-13. Unique Identifier : AIDSLINE MED/98253837; Maeda Y; Venzon DJ; Mitsuya H; Experimental Retrovirology Section, Medicine Branch, National Cancer; Institute, National Institutes of Health, Bethesda, Maryland 20892,; USA.; Investigations were done to determine whether the replication kinetics of human immunodeficiency virus (HIV)-1 were altered when the virus acquired a set or subsets of five mutations (A62V, V75I, F77L, F116Y, and Q151M) in the pol gene conferring resistance to multiple dideoxynucleosides. In the absence of drugs, the
Distinct determinants of human immunodeficiency virus type 1 RNA and DNA loads in vaginal and cervical secretions.: J Infect Dis. 1998 May;177(5):1214-20. Unique Identifier : AIDSLINE MED/98253838; Iversen AK; Larsen AR; Jensen T; Fugger L; Balslev U; Wahl S; Gerstoft J; Mullins JI; Skinhoj P; Department of Infectious Diseases, Rigshospitalet, National University; Hospital, Copenhagen, Denmark. aifrhm@inet.uni-c.dk; The relationship between human immunodeficiency virus type 1 HIV-1) viral RNA and proviral DNA load in vagina and cervix and that found in the plasma and peripheral blood mononuclear cells PBMC) was investigated in 28 HIV-1-infected women. Of the patients, 64% had > or = 1 HIV-1 RNA-positive genital sample, while 71%
Measurement of human immunodeficiency virus type 1 plasma virus load based on reverse transcriptase (RT) activity: evidence of variabilities in levels of virion-associated RT.: J Infect Dis. 1998 May;177(5):1221-9. Unique Identifier : AIDSLINE MED/98253839; Garcia Lerma JG; Yamamoto S; Gomez-Cano M; Soriano V; Green TA; Busch MP; Folks TM; Heneine W; HIV/Retrovirus Diseases Branch, Division of AIDS, STD, and TB; Laboratory Research, Centers for Disease Control and Prevention,; Atlanta, Georgia 30333, USA.; Virus load based on levels of functional reverse transcriptase RT) was measured in plasma from 50 human immunodeficiency virus HIV) type 1-infected persons, in 87 samples from 10 HIV-1 seroconversion panels, and in 100 uninfected persons by use of Amp-RT, an ultrasensitive RT assay. Of the 50 clinical samples, 38 (76%
Immune responses to human immunodeficiency virus (HIV) type 1 induced by canarypox expressing HIV-1MN gp120, HIV-1SF2 recombinant gp120, or both vaccines in seronegative adults. NIAID AIDS Vaccine Evaluation Group.: J Infect Dis. 1998 May;177(5):1230-46. Unique Identifier : AIDSLINE MED/98253840; Clements-Mann ML; Weinhold K; Matthews TJ; Graham BS; Gorse GJ; Keefer MC; McElrath MJ; Hsieh RH; Mestecky J; Zolla-Pazner S; Mascola J; Schwartz D; Siliciano R; Corey L; Wright PF; Belshe R; Dolin R; Jackson S; Xu S; Fast P; Walker MC; Stablein D; Excler JL; Tartaglia J; Paoletti E; et al; Johns Hopkins University School of Public Health, Baltimore, Maryland,; USA. mclement@jhsph.edu; A safety and immunogenicity trial was conducted in vaccinia-immune and vaccinia-naive human immunodeficiency virus HIV)-uninfected adults who were randomized to receive 10(6) or 10(7) TCID50 of canarypox (ALVAC) vector expressing HIV-1MN gp160 or 10(5.5) TCID50 of ALVAC-rabies virus glycoprotein control at 0 and 1 or
Passive immunization of newborn rhesus macaques prevents oral simian immunodeficiency virus infection.: J Infect Dis. 1998 May;177(5):1247-59. Unique Identifier : AIDSLINE MED/98253841; Van Rompay KK; Berardi CJ; Dillard-Telm S; Tarara RP; Canfield DR; Valverde CR; Montefiori DC; Cole KS; Montelaro RC; Miller CJ; Marthas ML; California Regional Primate Research Center, Department of Pathology,; Microbiology, and Immunology, School of Veterinary Medicine,; University of California, Davis 95616-8542, USA.; To determine if passively acquired antiviral antibodies modulate virus transmission and disease progression in human pediatric AIDS, the potential of pre- and postexposure passive immunization with hyperimmune serum to prevent oral simian immunodeficiency virus (SIV) infection or disease progression in newborn rhesus
The in vitro induction of human immunodeficiency virus (HIV) replication in purified protein derivative-positive HIV-infected persons by recall antigen response to Mycobacterium tuberculosis is the result of a balance of the effects of endogenous interleukin-2 and proinflammatory and antiinflammatory cytokines.: J Infect Dis. 1998 May;177(5):1332-8. Unique Identifier : AIDSLINE MED/98253853; Goletti D; Weissman D; Jackson RW; Collins F; Kinter A; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, Maryland; 20892-2520, USA.; Coinfection with Mycobacterium tuberculosis and human immunodeficiency virus (HIV) is a serious problem, particularly in developing countries. Recently, M. tuberculosis and purified protein derivative (PPD) were demonstrated to induce HIV replication in CD8 T cell-depleted peripheral blood mononuclear cells from HIV-p
A cloned antigen (recombinant K39) of Leishmania chagasi diagnostic for visceral leishmaniasis in human immunodeficiency virus type 1 patients and a prognostic indicator for monitoring patients undergoing drug therapy.: J Infect Dis. 1998 May;177(5):1339-44. Unique Identifier : AIDSLINE MED/98253854; Houghton RL; Petrescu M; Benson DR; Skeiky YA; Scalone A; Badaro R; Reed SG; Gradoni L; Corixa Corp., Seattle, Washington 98104, USA. houghton@corixa.com; Serologic assays using crude antigens for the diagnosis of visceral leishmaniasis in human immunodeficiency virus type 1 HIV)-seropositive patients have been shown to lack sensitivity and specificity, particularly in AIDS patients. Antibodies to a cloned antigen, recombinant (r) K39, of Leishmania chagasi are specific
Naive human T cells develop into Th1 or Th0 effectors and exhibit cytotoxicity early after stimulation with Leishmania-infected macrophages.: J Infect Dis. 1998 May;177(5):1345-51. Unique Identifier : AIDSLINE MED/98253855; Russo DM; Chakrabarti P; Burns JM Jr; Department of Microbiology, Meharry Medical College, Nashville,; Tennessee 37208, USA.; Studies of human disease suggest that naturally acquired immunity is the predominant outcome of Leishmania infection. Normally protective immune mechanisms activated during asymptomatic or self-healing infections may be minimal in patients who develop disease. To explore early immune responses, an in vitro model of hu
Albendazole for treatment and prophylaxis of microsporidiosis due to Encephalitozoon intestinalis in patients with AIDS: a randomized double-blind controlled trial.: J Infect Dis. 1998 May;177(5):1373-7. Unique Identifier : AIDSLINE MED/98253859; Molina JM; Chastang C; Goguel J; Michiels JF; Sarfati C; Desportes-Livage I; Horton J; Derouin F; Modai J; Division of Infectious Diseases, Hopital Saint-Louis, Paris, France.; molina@chu-stlouis.fr; A double-blind placebo-controlled trial was conducted to assess the efficacy and safety of albendazole (400 mg twice daily for 3 weeks) for the treatment of Encephalitozoon intestinalis infection in patients with AIDS. Clearance of microsporidia from the intestinal tract was obtained in 4 of 4 patients in the albendaz
Identification of more than one mutation in the hepatitis B virus polymerase gene arising during prolonged lamivudine treatment.: J Infect Dis. 1998 May;177(5):1382-5. Unique Identifier : AIDSLINE MED/98253861; Niesters HG; Honkoop P; Haagsma EB; de Man RA; Schalm SW; Osterhaus AD; Department of Gastroenterology, University Hospital Rotterdam, The; Netherlands. niesters@viro.fgg.eur.nl; Lamivudine has been shown to be a potent and nontoxic inhibitor of hepatitis B virus (HBV) replication in chronically infected patients. During prolonged treatment, drug resistance may develop, related to a mutation of Met to Val or Ile in the YM552DD
Effect on normal vaginal flora of three intravaginal microbicidal agents potentially active against human immunodeficiency virus type 1.: J Infect Dis. 1998 May;177(5):1386-90. Unique Identifier : AIDSLINE MED/98253862; Rosenstein IJ; Stafford MK; Kitchen VS; Ward H; Weber JN; Taylor-Robinson D; Department of Genitourinary Medicine and Communicable Diseases; Jefferiss Research Trust Laboratories), Imperial College School of; Medicine at St. Mary's, London, United Kingdom. ijr30@ic.ac.uk; The effect on normal vaginal flora of three intravaginal microbicides potentially active against human immunodeficiency virus type 1 was examined. Volunteers received dextrin sulfate D2S), nonoxynol-9 (N-9), or docusate sodium in separate placebo-controlled studies. High vaginal swabs were obtained for bacterial cultu
A new look at T cells.: J Exp Med. 1998 May 4;187(9):1367-71. Unique Identifier : AIDSLINE MED/98234418; McMichael AJ; O'Callaghan CA; Institute of Molecular Medicine, Nuffield Department of Medicine, John; Radcliffe Hospital, Oxford OX3 9DS, United Kingdom.; andrew.mcmichael@ndm.ox.ac.uk
Analysis of Gag-specific cytotoxic T lymphocytes in simian immunodeficiency virus-infected rhesus monkeys by cell staining with a tetrameric major histocompatibility complex class I-peptide complex.: J Exp Med. 1998 May 4;187(9):1373-81. Unique Identifier : AIDSLINE MED/98234419; Kuroda MJ; Schmitz JE; Barouch DH; Craiu A; Allen TM; Sette A; Watkins DI; Forman MA; Letvin NL; Harvard Medical School, Division of Viral Pathogenesis, Department of; Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; 02215, USA.; A tetrameric recombinant major histocompatibility complex (MHC) class I-peptide complex was used as a staining reagent in flow cytometric analyses to quantitate and define the phenotype of Gag-specific cytotoxic T lymphocytes (CTLs) in the peripheral blood of simian immunodeficiency virus macaque (SIVmac)-infected rhe
Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes.: J Exp Med. 1998 May 4;187(9):1383-93. Unique Identifier : AIDSLINE MED/98234420; Gallimore A; Glithero A; Godkin A; Tissot AC; Pluckthun A; Elliott T; Hengartner H; Zinkernagel R; Institute of Experimental Immunology, CH-8091, Zurich, Switzerland.; awen.gallimore@ndm.ox.ac.uk; This study describes the construction of soluble major histocompatibility complexes consisting of the mouse class I molecule, H-2Db, chemically biotinylated beta2 microglobulin and a peptide epitope derived from the glycoprotein (GP; amino acids 33-41) of lymphocytic choriomeningitis virus (LCMV). Tetrameric class I c
Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus In vivo.: J Exp Med. 1998 May 4;187(9):1395-402. Unique Identifier : AIDSLINE MED/98234421; Callan MF; Tan L; Annels N; Ogg GS; Wilson JD; O'Callaghan CA; Steven N; McMichael AJ; Rickinson AB; Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3; 9DS, United Kingdom.; Primary infection with virus can stimulate a vigorous cytotoxic T cell response. The magnitude of the antigen-specific component versus the bystander component of a primary T cell response remains controversial. In this study, we have used tetrameric major histocompatibility complex-peptide complexes to directly visua
A role for Fas in negative selection of thymocytes in vivo.: J Exp Med. 1998 May 4;187(9):1427-38. Unique Identifier : AIDSLINE MED/98234424; Kishimoto H; Surh CD; Sprent J; Department of Immunology, IMM4, The Scripps Research Institute, 10550; North Torrey Pines Road, La Jolla, California 92037, USA.; To seek information on the role of Fas in negative selection, we examined subsets of thymocytes from normal neonatal mice versus Fas-deficient lpr/lpr mice injected with graded doses of antigen. In normal mice, injection of 1-100 microg of staphylococcal enterotoxin B (SEB) induced clonal elimination of SEB-reactive V
Disturbed CD4+ T cell homeostasis and in vitro HIV-1 susceptibility in transgenic mice expressing T cell line-tropic HIV-1 receptors.: J Exp Med. 1998 May 4;187(9):1439-49. Unique Identifier : AIDSLINE MED/98234425; Sawada S; Gowrishankar K; Kitamura R; Suzuki M; Suzuki G; Tahara S; Koito A; PRESTO, Japan Science and Technology Corporation, and Tsukuba Life; Science Center, The Institute of Physical and Chemical Research; (RIKEN), Tsukuba, Ibaraki 305, Japan. sawada@rtcmain.rtc.riken.go.jp; T cell line-tropic (T-tropic) HIV type 1 strains enter cells by interacting with the cell-surface molecules CD4 and CXCR4. We have generated transgenic mice predominantly expressing human CD4 and CXCR4 on their CD4-positive T lymphocytes (CD4+ T cells). Their primary thymocytes are susceptible to T-tropic but not to m
Overexpression of Ki-67 and cyclins A and B1 in JC virus-infected cells of progressive multifocal leukoencephalopathy.: J Neuropathol Exp Neurol. 1998 Mar;57(3):226-30. Unique Identifier : AIDSLINE MED/98260841; Ariza A; Mate JL; Isamat M; Calatrava A; Fernandez-Vasalo A; Navas-Palacios JJ; Department of Pathology, Hospital Germans Trias i Pujol, Autonomous; University of Barcelona, Spain.; Both SV40 and JC virus (JCV) appropriate the host cell replicative machinery to attend to their own reproductive needs. SV40 large T antigen is able to induce the expression of cyclins A, B1, and E (but not of cylin D1) in transfected diploid cells. Whether JCV infection influences cyclin expression in a similar fashi
Cancer in human immunodeficiency virus-infected children: a case series from the Children's Cancer Group and the National Cancer Institute.: J Clin Oncol. 1998 May;16(5):1729-35. Unique Identifier : AIDSLINE MED/98246297; Granovsky MO; Mueller BU; Nicholson HS; Rosenberg PS; Rabkin CS; Division of Cancer Epidemiology and Genetics, National Cancer; Institute, Bethesda, MD, USA. granovsm@epndce.nci.nih.gov; PURPOSE: To describe the spectrum of malignancies in human immunodeficiency virus (HIV)-infected children and the clinical outcome of patients with these tumors. METHODS: We retrospectively surveyed the Children s Cancer Group (CCG) and the National Cancer Institute (NCI) for cases of cancer that occurred between July
Prospective randomized trial of two dose levels of interferon alfa with zidovudine for the treatment of Kaposi's sarcoma associated with human immunodeficiency virus infection: a Canadian HIV Clinical Trials Network study.: J Clin Oncol. 1998 May;16(5):1736-42. Unique Identifier : AIDSLINE MED/98246298; Shepherd FA; Beaulieu R; Gelmon K; Thuot CA; Sawka C; Read S; Singer J; Department of Medicine of the Toronto Hospital, Canada.; fshepherd@torhosp.toronto.on.ca; PURPOSE: Interferon alfa alone has shown antitumor activity against Kaposi s sarcoma (KS), and phase I and II clinical trials showed that interferon and zidovudine could be administered safely to patients with human immunodeficiency virus HIV)-associated KS. These observations led to our trial of zidovudine with two d
World Health Organization. Guidelines for counselling people about Human Immunodeficiency Virus [letter]: J Palliat Care. 1998 Spring;14(1):55. Unique Identifier : AIDSLINE MED/98236629; Bayes R
Striving for balance: palliative care patients' experiences of making everyday choices.: J Palliat Care. 1998 Spring;14(1):7-17. Unique Identifier : AIDSLINE MED/98236621; Bottorff JL; Steele R; Davies B; Garossino C; Porterfield P; Shaw M; School of Nursing, University of British Columbia, Vancouver, Canada.; A fundamental principle of palliative care is the provision of patient-centred care, an approach explicitly based on the patient s perspective. Although much attention has been given to determining patients preferences for involvement in medical decisions, choices related to personal and nursing care routines have be
T-cells and HLA-class II expression in the large intestine of infants in the early postnatal period.: J Pediatr Gastroenterol Nutr. 1998 Apr;26(4):422-8. Unique Identifier : AIDSLINE MED/98211867; Ormala T; Rintala R; Savilahti E; Department of Pediatrics, Kuopio University Hospital, Finland.; BACKGROUND: There is only limited knowledge of the development of the immune responses of the gut in very young infants after exposure to bacterial and food antigens at birth. METHODS: In this study, 49 large intestinal biopsy specimens, which were judged to have normal morphology, were taken from 49 young infants. El
Nutrition and the client with AIDS.: J Pract Nurs. 1998 Mar;48(1):16-25; quiz 26-8. Unique Identifier : AIDSLINE MED/98235059; Davidhizar R; Dunn C; The nutritional problems that go along with HIV infection and AIDS are significant and in fact contribute to death. Nutrition not only affects overall health but one s ability to respond to therapies and quality of life. Malnutrition and wasting syndrome result from compromised nutritional status. Early detection an
Membrane-induced alterations in HIV-1 Gag and matrix protein-protein interactions.: J Mol Biol. 1998 Mar 27;277(2):161-9. Unique Identifier : AIDSLINE MED/98181018; Scarlata S; Ehrlich LS; Carter CA; Department of Physiology and Biophysics, S.U.N.Y. Stony Brook, NY; 11794, USA.; The matrix (MA) domain of human immunodeficiency virus type 1 HIV-1) contains sequences that direct association with the nucleus at early times in the virus replication cycle and with the plasma membrane at late times in the cycle. Localization to these sites is critical for functions related to the establishment of t
Role of the human homolog of the yeast transcription factor SPT5 in HIV-1 Tat-activation.: J Mol Biol. 1998 Mar 27;277(2):179-97. Unique Identifier : AIDSLINE MED/98181020; Wu-Baer F; Lane WS; Gaynor RB; Department of Internal Medicine, University of Texas Southwestern; Medical Center, Dallas, TX 75235-8594, USA.; The transactivator protein Tat stimulates transcriptional elongation from the HIV-1 LTR. One mechanism by which Tat increases HIV-1 transcription is by interacting with RNA polymerase II and TFIIH to increase phosphorylation of the polymerase C-terminal domain. Recent studies indicate that specific elongation factors
CIS elements and trans-acting factors required for minus strand DNA transfer during reverse transcription of the genomic RNA of murine leukemia virus.: J Mol Biol. 1998 Mar 27;277(2):225-35. Unique Identifier : AIDSLINE MED/98181023; Allain B; Rascle JB; de Rocquigny H; Roques B; Darlix JL; Ecole Normale Superieure de Lyon, 46 allee d'Italie, Lyon, 69364,; France.; During reverse transcription of the retroviral genomic RNA, two obligatory DNA strand transfers take place to synthesize the complete proviral DNA with two LTRs. We have previously shown that using an in vitro system made up of two viral RNAs mimicking the 5 and 3 regions of the retroviral genome, both nucleocapsid
Endogenous reverse transcriptase assays reveal synergy between combinations of the M184V and other drug resistance-conferring mutations in interactions with nucleoside analog triphosphates.: J Mol Biol. 1998 Mar 27;277(2):237-47. Unique Identifier : AIDSLINE MED/98181024; Quan Y; Gu Z; Li X; Liang C; Parniak MA; Wainberg MA; McGill University AIDS Centre, Jewish General Hospital, Montreal,; Quebec, Canada.; Resistance of HIV-1 reverse transcriptase (RT) to nucleoside analogs (e.g. AZT , ddC and 3TC ) is conferred by variou
Evolutionary rate and genetic heterogeneity of human T-cell lymphotropic virus type II (HTLV-II) using isolates from European injecting drug users.: J Mol Evol. 1998 May;46(5):602-11. Unique Identifier : AIDSLINE MED/98213688; Salemi M; Vandamme AM; Gradozzi C; Van Laethem K; Cattaneo E; Taylor G; Casoli C; Goubau P; Desmyter J; Bertazzoni U; Rega Institute for Medical Research and University Hospitals,; Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000; Leuven, Belgium. marco.salemi@uz.kuleuven.ac.be; Seven new Italian and two new British HTLV-II isolates were obtained from injecting drug users and the entire long terminal repeat (LTR) region was sequenced. Restriction analysis showed that all the Italian isolates are of the IIb subtype, whereas the British isolates are of the IIa subtype. To understand whether the
Abstinence and safer sex HIV risk-reduction interventions for African American adolescents: a randomized controlled trial [see comments]: JAMA. 1998 May 20;279(19):1529-36. Unique Identifier : AIDSLINE MED/98266933; Jemmott JB 3rd; Jemmott LS; Fong GT; Department of Psychology, Princeton University, NJ 08544-1010, USA.; jemmott@princeton.edu; CONTEXT: African American adolescents are at high risk of contracting sexually transmitted infection with human immunodeficiency virus (HIV), but which behavioral interventions to reduce risk are most effective and who should conduct them is not known. OBJECTIVE: To evaluate the effects of abstinence and safer-sex HIV
Comparison of molecular changes in lung cancers in HIV-positive and HIV-indeterminate subjects.: JAMA. 1998 May 20;279(19):1554-9. Unique Identifier : AIDSLINE MED/98266937; Wistuba II; Behrens C; Milchgrub S; Virmani AK; Jagirdar J; Thomas B; Ioachim HL; Litzky LA; Brambilla EM; Minna JD; Gazdar AF; Hamon Center for Therapeutic Oncology Research, University of Texas; Southwestern Medical Center, Dallas 75235-8593, USA.; CONTEXT: Human immunodeficiency virus (HIV) infection has been associated with an increasing incidence of malignancy, and HIV-infected persons have an increased incidence of primary lung carcinoma compared with the general population. OBJECTIVE: To investigate the molecular changes present in HIV-associated lung tumor
Preventing sexually transmitted infections among adolescents: a clash of ideology and science [editorial; comment]: JAMA. 1998 May 20;279(19):1574-5. Unique Identifier : AIDSLINE MED/98266941; DiClemente RJ
[Hairy leukoplakia in immunodeficiency not due to HIV (letter; comment)]: Med Clin (Barc). 1998 Feb 28;110(7):279. Unique Identifier : AIDSLINE MED/98224056; Aneiros Cachaza J; Fernandez Feijoo MV; Carvia Ponsaille R
The Swedish HIV epidemics seen in the rear view: small "nuclear groups" are responsible for the transmission in the country]: Lakartidningen. 1998 Apr 8;95(15):1628-9. Unique Identifier : AIDSLINE MED/98261833; Giesecke J
[A HIV epidemics threatens Asia]: Lakartidningen. 1998 Apr 8;95(15):1682-3. Unique Identifier : AIDSLINE MED/98261849; Christenson B; Lundbergh P; Smittskyddsenheten, Karolinska sjukhuset, Stockholm.
[HIV in Africa is transmitted with varying intensity]: Lakartidningen. 1998 Apr 8;95(15):1684. Unique Identifier : AIDSLINE MED/98261850; Christenson B; Lundbergh P; Smittskyddsenheten, Karolinska sjukhuset, Stockholm.
Undefined CD4 lymphocytopenia without clinical complications. A report of two cases.: Panminerva Med. 1998 Mar;40(1):69-71. Unique Identifier : AIDSLINE MED/98234844; Cascio G; Massobrio AM; Cascio B; Anania A; Department of Internal Medicine, University of Turin, Italy.; A form of idiopathic CD4 lymphocytopenia (ICL) has been recently described. Its diagnostic criteria have been defined by the Centers for Disease Control (CDC), Atlanta. Associations of ICL with hepatitis C infection have been reported, while some ICL patients have presented abnormalities partly similar to those observ
Imported tropical diseases in subjects with HIV infection.: Panminerva Med. 1998 Mar;40(1):72-4. Unique Identifier : AIDSLINE MED/98234845; Manfredi R; Mastroianni A; Coronado OV; Chiodo F; Department of Clinical and Experimental Medicine, University of; Bologna, Italy.; The authors report a case of Plasmodium falciparum malaria and a case of lymphatic filariasis caused by Brugia malayi, imported by HIV-infected patients during trips in endemic countries. The clinical and laboratory picture, as well as treatment response of imported malaria and filariasis did not differ significantly
Inhibition of polyadenylation by stable RNA secondary structure.: Nucleic Acids Res. 1998 Apr 15;26(8):1870-6. Unique Identifier : AIDSLINE MED/98186825; Klasens BI; Das AT; Berkhout B; Department of Human Retrovirology, Academic Medical Center, University; of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, PO Box 22700, 1100; DE Amsterdam, The Netherlands.; The presence of a polyadenylation signal in the repeat (R) region of the HIV-1 genome, which is located at both the 5 and 3 ends of the viral transcripts, requires differential regulation of polyadenylation. The HIV-1 poly(A) site can fold in a stable stem-loop structure that is well-conserved among different human
Mismatched nucleotides may facilitate expansion of trinucleotide repeats in genetic diseases.: Nucleic Acids Res. 1998 Apr 15;26(8):1980-4. Unique Identifier : AIDSLINE MED/98186839; Nakayabu M; Miwa S; Suzuki M; Izuta S; Sobue G; Yoshida S; Department of Neurology and Laboratory of Cancer Cell Biology,; Institute of Disease Mechanism and Control, Nagoya University School; of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.; We have studied the contribution of mismatch sequences to the trinucleotide repeat expansion that causes hereditary diseases. Using an oligonucleotide duplex, (CAG)5/(CTG)5, as a template-primer, DNA synthesis was carried out using either Escherichia coli DNA polymerase I (Klenow fragment) or human immunodeficiency vi
NMR evidence for a base triple in the HIV-2 TAR C-G.C+ mutant-argininamide complex.: Nucleic Acids Res. 1998 Apr 15;26(8):1991-5. Unique Identifier : AIDSLINE MED/98186841; Brodsky AS; Erlacher HA; Williamson JR; MIT Department of Chemistry, Building 56-546, Cambridge, MA 02139,; USA.; Formation of a specific complex between the HIV Tat protein and the small RNA element TAR is critical for activation of viral transcription. A model complex for this interaction composed of HIV-2 TAR and the amide derivative of arginine has been developed to study how Tat and TAR interact specifically. We have previou
The association between cryptococcal variety and immunocompetent and immunocompromised hosts.: Pharmacotherapy. 1998 Mar-Apr;18(2):255-64. Unique Identifier : AIDSLINE MED/98204705; Peachey PR; Gubbins PO; Martin RE; Arkansas Poison Control/Drug Information Center, Little Rock, USA.; The varieties of Cryptococcus neoformans serotypes are neoformans and gattii. Data suggest an association between cryptococcal variety and host immune status. In addition, the two varieties differ in their epidemiology and pathogenicity. Furthermore, symptoms, outcome, and response of cryptococcosis to antifungal ther
Age-related macular degeneration. Can we stem this worldwide public health crisis?: Postgrad Med. 1998 May;103(5):153-6, 161-4. Unique Identifier : AIDSLINE MED/98253217; Starr CE; Guyer DR; Yannuzzi LA; Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston,; USA.; Age-related macular degeneration, the leading cause of legal blindness in people over age 60 worldwide, represents a public health crisis that deserves the attention and understanding of all physicians. The dry form of the disease is more common than the wet, but the wet form causes the most severe vision loss. Other
Outpatient management of HIV-infected adults. The varied challenges for primary care.: Postgrad Med. 1998 May;103(5):219-28. Unique Identifier : AIDSLINE MED/98253221; Myers RA Jr; Inpatient HIV Service, Maricopa Medical Center, Phoenix, AZ 85010,; USA. ramyers95@aol.com; Care of persons infected with HIV presents many challenges to primary care physicians. In addition to keeping current on the rapidly advancing medical aspects of the disease, physicians also must be prepared to recognize the complex psychosocial issues that confront their patients. In this article, Dr Myers reviews es
Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor.: Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):4831-6. Unique Identifier : AIDSLINE MED/98226727; Lubkowski J; Yang F; Alexandratos J; Wlodawer A; Zhao H; Burke TR Jr; Neamati N; Pommier Y; Merkel G; Skalka AM; Macromolecular Structure Laboratory, Advanced BioScience; Laboratories-Basic Research Program, National Cancer; Institute-Frederick Cancer Research and Development Center, Frederick,; MD 21702, USA.; The x-ray structures of an inhibitor complex of the catalytic core domain of avian sarcoma virus integrase (ASV IN) were solved at 1.9- to 2.0-A resolution at two pH values, with and without Mn2+ cations. This inhibitor (Y-3), originally identified in a screen for inhibitors of the catalytic activity of HIV type 1 int
CD40 ligand (CD154) stimulation of macrophages to produce HIV-1-suppressive beta-chemokines.: Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5205-10. Unique Identifier : AIDSLINE MED/98226793; Kornbluth RS; Kee K; Richman DD; Department of Medicine, University of California, San Diego, and; Department of Veterans Affairs Medical Center, La Jolla, CA 92093,; USA. rkornbluth@ucsd.edu; beta-chemokines play an important role in the development of immunologic reactions. Macrophages are major beta-chemokine-producing cells during T-cell directed, delayed-type hypersensitivity reactions in tissues, and have been reported to be important producers of beta-chemokines in the lymph nodes of HIV-1-infected i
Generation of CD8 suppressor factor and beta chemokines, induced by xenogeneic immunization, in the prevention of simian immunodeficiency virus infection in macaques.: Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5223-8. Unique Identifier : AIDSLINE MED/98226796; Wang Y; Tao L; Mitchell E; Bogers WM; Doyle C; Bravery CA; Bergmeier LA; Kelly CG; Heeney JL; Lehner T; Department of Immunology, United Medical and Dental Schools of Guy's; and St. Thomas' Hospitals, London SE1 9RT, United Kingdom.; Previous xenogeneic immunization experiments in rhesus macaques with simian immunodeficiency virus (SIV) grown in human CD4(+) T cells consistently elicited protection from challenge with live SIV. However, the mechanism of protection has not been established. We present evidence that xenogeneic immunization induced s
The CCR5 receptor acts as an alloantigen in CCR5Delta32 homozygous individuals: identification of chemokineand HIV-1-blocking human antibodies.: Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5241-5. Unique Identifier : AIDSLINE MED/98226799; Ditzel HJ; Rosenkilde MM; Garred P; Wang M; Koefoed K; Pedersen C; Burton DR; Schwartz TW; Department of Clinical Immunology, Copenhagen University Hospital,; Rigshospitalet, DK-2200 Copenhagen, Denmark. hditzel@scripps.edu; The chemokine receptor CCR5 is the major coreceptor for infection by macrophage-tropic R5 HIV-1. A 32-bp deletion in the gene coding for CCR5 (CCR5Delta32) occurs with a frequency of 10% in the Caucasian population and results in a receptor protein that is truncated and not expressed at the cell surface. CCR5Delta32 h
HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator.: Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5281-6. Unique Identifier : AIDSLINE MED/98226806; Felzien LK; Woffendin C; Hottiger MO; Subbramanian RA; Cohen EA; Nabel GJ; Departments of Internal Medicine and Biological Chemistry, Howard; Hughes Medical Institute, University of Michigan Medical Center, Ann; Arbor, MI 48109-0650, USA.; The accessory protein, Vpr, is a virion-associated protein that is required for HIV-1 replication in macrophages and regulates viral gene expression in T cells. Vpr causes arrest of cell cycle progression at G2/M, presumably through its effect on cyclin B1.Cdc2 activity. Here, we show that the ability of Vpr to activa
[The importance of HIV in the Spanish woman (editorial)]: Rev Clin Esp. 1998 Feb;198(2):55-6. Unique Identifier : AIDSLINE MED/98219627; Palacios S; Cifuentes I
[Primary adrenal failure and AIDS: report of 11 cases and review of the literature]: Rev Clin Esp. 1998 Feb;198(2):74-9. Unique Identifier : AIDSLINE MED/98219631; Baraia-Etxaburu Artetxe J; Astigarraga Aguirre B; Elorza Olabegova R; Teira Cobo R; Yoldi Arrieta A; Cisterna Cancer R; Bustamante Murga V; Santamaria Jauregui JM; Seccione de Enfermedades Infecciosas, Hospital de Basurto, Bilbao.; OBJECTIVE: To know the prevalence of adrenal insufficiency (AI) in our patients with acquired immunodeficiency syndrome (AIDS) and to compare the clinical manifestations with those reported in previous series in the literature. PATIENTS AND METHODS: Retrospective study with review of clinical records of patients with
[Acute pancreatitis and infection with the human immunodeficiency virus]: Rev Clin Esp. 1998 Mar;198(3):133-9. Unique Identifier : AIDSLINE MED/98247581; Sanchez Munoz LA; Ferrero Beneitez OL; Perez Boillos MJ; Munoz Sanchez J; Teira Cobo R; Baraia-Etxaburu J; Zubero Sulibarria Z; Santamaria Jauregui JM; Seccion de Enfermedades Infecciosas, Hospital de Basurto, Bilbao,; Vizcaya.; BACKGROUND: Retrospective study of the etiology and evolution of 40 episodes of acute pancreatitis in 28 patients infected with the human immunodeficiency virus (HIV). RESULTS: AIDS criteria were met by 89.3% of patients. The likely etiology was an opportunist infection in 32.5% of episodes, drug use in 22.5%, and bil
[Increase in transaminases in HIV infection. Toxic liver cell damage with trimethoprim/sulfamethoxazole administration in HIV infection]: Schweiz Rundsch Med Prax. 1998 Mar 4;87(10):361-2. Unique Identifier : AIDSLINE MED/98207455; Junghanss BG; Departement fur Innere Medizin, Kantonsspital Basel.
Improved humoral and cellular immune responses against the gp120 V3 loop of HIV-1 following genetic immunization with a chimeric DNA vaccine encoding the V3 inserted into the hepatitis B surface antigen.: Scand J Immunol. 1998 Apr;47(4):289-95. Unique Identifier : AIDSLINE MED/98260936; Fomsgaard A; Nielsen HV; Bryder K; Nielsen C; Machuca R; Bruun L; Hansen J; Buus S; Department of Virology, Statens Serum Institut, Copenhagen, Denmark.; The gp120-derived V3 loop of HIV-1 is involved in co-receptor interaction, it guides cell tropism, and contains an epitope for antibody neutralization. Thus, HIV-1 V3 is an attractive vaccine candidate. The V3 of the MN strain (MN V3) contains both B- and T-cell epitopes, including a known mouse H-2d-restricted cytoto
Blockade of B7-2, not B7-1, inhibits purified protein derivative-primed T-lymphocyte responses but fails to influence the proportion of Th1 versus Th2 subsets.: Scand J Immunol. 1998 Apr;47(4):355-62. Unique Identifier : AIDSLINE MED/98260944; Shortt J; Hart DN; Watson JD; Baird MA; Department of Pathology, Dunedin School of Medicine, New Zealand.; The ability to select for a cell-mediated response rather than antibody production following infection with intracellular mycobacteria, would be an advantage in preventing the occurrence of disease. Recent work suggests that the two members of the B7 family of costimulatory molecules, B7-1 and B7-2, may differentially
Genetic evaluation of suspected cases of transient HIV-1 infection of infants.: Science. 1998 May 15;280(5366):1073-7. Unique Identifier : AIDSLINE MED/98248614; Frenkel LM; Mullins JI; Learn GH; Manns-Arcuino L; Herring BL; Kalish ML; Steketee RW; Thea DM; Nichols JE; Liu SL; Harmache A; He X; Muthui D; Madan A; Hood L; Haase AT; Zupancic M; Staskus K; Wolinsky S; Krogstad P; Zhao J; Chen I; Koup R; Ho D; Roberts NJ Jr; et al; Department of Pediatrics, University of Rochester, Rochester, NY; 14642, USA. lfrenkel@u.washington.edu; Detection of human immunodeficiency virus-type 1 (HIV-1) on only one or a few occasions in infants born to infected mothers has been interpreted to indicate that infection may be transient rather than persistent. Forty-two cases of suspected transient HIV-1 viremia among 1562 perinatally exposed seroreverting infants
Autoantibodies and common viral illnesses.: Semin Arthritis Rheum. 1998 Apr;27(5):263-71. Unique Identifier : AIDSLINE MED/98232423; Hansen KE; Arnason J; Bridges AJ; University of Wisconsin Hospital and Clinics, Madison 53792, USA.; OBJECTIVES: To review the literature about common autoantibodies produced in association with viral infection. METHODS: Medline review of the medical literature published in English. RESULTS: Common viral infections are often associated with low-titer, polyspecific autoantibodies. However, high-titer antinuclear antib
Toxoplasmosis.: Semin Roentgenol. 1998 Jan;33(1):81-5. Unique Identifier : AIDSLINE MED/98177334; Dunn IJ; Palmer PE; Department of Radiology, University of British Columbia, Vancouver,; Canada.
Telephone support groups for HIV-positive mothers whose children have died of AIDS.: Soc Work. 1998 May;43(3):279-85. Unique Identifier : AIDSLINE MED/98260238; Wiener LS; Pediatric HIV Psychosocial Support Program, National Cancer Institute,; National Institutes of Health, Bethesda, MD, USA.; wienerl@pbmac.nci.nih.gov
The high-risk sexual practices of crack-smoking sex workers recruited from the streets of three American cities. The Multicenter Crack Cocaine and HIV Infection Study Team.: Sex Transm Dis. 1998 Apr;25(4):187-93. Unique Identifier : AIDSLINE MED/98225908; Jones DL; Irwin KL; Inciardi J; Bowser B; Schilling R; Word C; Evans P; Faruque S; McCoy HV; Edlin BR; Department of Sociology, Emory University, Atlanta, Georgia.; BACKGROUND AND OBJECTIVES: Small ethnographic and clinic-based studies indicate that crack-smoking sex workers are at high risk for human immunodeficiency virus (HIV) and sexually transmitted diseases (STD). STUDY GOALS: To examine the prevalence of risky sexual behaviors and HIV and STD in a large sample of street-re
The value of workplace versus income in determining HIV status and other STDs among a sample of Spanish sex workers.: Sex Transm Dis. 1998 Apr;25(4):194-5. Unique Identifier : AIDSLINE MED/98225909; Estebanez P; Grant JC; London School of Hygiene & Tropical Medicine.
Clinico-epidemiologic features of granuloma inguinale in the era of acquired immune deficiency syndrome.: Sex Transm Dis. 1998 Apr;25(4):196-200. Unique Identifier : AIDSLINE MED/98225910; Jamkhedkar PP; Hira SK; Shroff HJ; Lanjewar DN; Department of Skin/STD, Sir J. J. Hospital, Mumbai, India.; BACKGROUND AND OBJECTIVES: Granuloma Inguinale (GI) is an endemic sexually transmitted disease (STD) in India . With increasing prevalence of human immunodeficiency virus (HIV) among patients with STD at a clinic in Mumbai, a study was conducted to determine clinico-epidemiologic fea
The acceptability of oral fluid testing for HIV antibodies. A pilot study in gay bars in a predominantly rural state.: Sex Transm Dis. 1998 Apr;25(4):211-5. Unique Identifier : AIDSLINE MED/98225912; Sy FS; Rhodes SD; Choi ST; Drociuk D; Laurent AA; Naccash RM; Kettinger LD; University of South Carolina School of Public Health, Columbia 29208,; USA.; BACKGROUND: One barrier for individuals desiring human immunodeficiency virus (HIV) antibody testing has been the lack of alternatives to blood HIV testing. Oral fluid HIV testing provides another testing option. OBJECTIVES: To evaluate the acceptability of oral fluid testing for HIV antibodies in a gay bar outreach s
Heterosexual intercourse in a French prison [letter]: Sex Transm Dis. 1998 Apr;25(4):217. Unique Identifier : AIDSLINE MED/98225913; Rotily M; Gore S; Weilandt C
[Kaposi sarcoma-associated Herpesvirus infection of dendritic cells in bone marrow in patients with myelomatosis]: Ugeskr Laeger. 1998 Apr 6;160(15):2264-5. Unique Identifier : AIDSLINE MED/98261899; Abildgaard N; Nielsen JL; Arhus Universitetshospital, Arhus Amtssygehus, medicinsk haematologisk; afdeling B.
[Providing patients with their diagnostic test results. A vignette study in general practice]: Ugeskr Laeger. 1998 Apr 20;160(17):2543-5. Unique Identifier : AIDSLINE MED/98261911; Nexoe J; Falk-Petersen HE; Klit S; Larsen NJ; Winthereik M; Odense Universitet, Specialeuddannelsen i Almen Medicin.; The communication of results of HIV tests and chest-X-rays because of persistent coughing are of particular interest because potential life-threatening disease may be disclosed. For HIV tests it is recommended that the result is communicated to the patient in the doctor s office face to face. In this questionnaire stu
[Role of Danish general practitioners in the prevention of AIDS]: Ugeskr Laeger. 1998 Apr 20;160(17):2546-50. Unique Identifier : AIDSLINE MED/98261912; Sandbaek A; Kragstrup J; Odense Universitet, Fagomr~adet og Forskningsenheden for Almen; Medicin.; The study describes Danish general practitioners perception of their own role and their actual behaviour in the prevention of HIV/AIDS. Data collection was carried out by questionnaire and prospective registration of consultations dealing with HIV/AIDS during a two-week period. The results showed that most of the GPs
The cells observed inside capsules of larvae in the course of experimental trichinellosis in mice.: Wiad Parazytol. 1997;43(3):251-6. Unique Identifier : AIDSLINE MED/98218372; Karmanska K; Houszka M; Widyma A; Stefaniak E; W. Stefanski Institute of Parasitology, Polish Academy of Science,; Wroclaw, Poland.; In the course of trichinellosis in mice the numerous cells inside larval capsules were observed. Beginning on 14 day post infection dpi) they were seen in about 7% of infected muscles fibers but at 21 dpi the percentage of capsules with the cells amounted to 77. In the next stage of infection the number of capsules co
Identification of potential CD8+ T-cell epitopes of the 19 kDa and AhpC proteins from Mycobacterium tuberculosis. No evidence for CD8+ T-cell priming against the identified peptides after DNA-vaccination of mice.: Vaccine. 1998 Apr;16(7):692-7. Unique Identifier : AIDSLINE MED/98223781; Erb KJ; Kirman J; Woodfield L; Wilson T; Collins DM; Watson JD; LeGros G; Malaghan Institute of Medical Research, Wellington, New Zealand.; Mycobacterium tuberculosis is one of the major killers among infectious agents. It is of great importance to develop an efficient vaccine against M. tuberculosis since the only available vaccine, M. bovis-BCG, has a low efficacy. Furthermore, the emergence of multi-drug-resistant M. tuberculosis strains makes it diffi
Apoptosis in asymptomatic HIV-1 seropositives immunized with HIV-1 env glycoprotein (gp160): effects of administration of Zidovudine in vivo and interleukin-2 in vitro.: Vaccine. 1998 Apr;16(7):715-21. Unique Identifier : AIDSLINE MED/98223784; Pierdominici M; Mollicone B; Ricci G; Oliva A; D'Offizi G; Giovannetti A; Aiuti F; Pandolfi F; University of Rome La Sapienza, Italy. pandolfi@axrma.uniroma1.it; In this paper we report the effects of VaxSyn (Protein Sciences Corp.) immunization on spontaneous apoptosis occurring in vitro after culture of PBMC in medium alone in 30 HIV-seropositive patients enrolled in a double-blind clinical trial that included three groups: treatment with VaxSyn,
Whole-killed gp120-depleted HIV-1 antigen in a murine model for prophylactic vaccination.: Vaccine. 1998 Apr;16(7):727-31. Unique Identifier : AIDSLINE MED/98223786; Lanza P; Moss RB; Giermakowska W; Hancock RB; Richieri SP; Theofa G; Jensen FC; Salk PL; Carlo DJ; Immune Response Corporation, Carlsbad, CA 92008, USA.; In this study, the effects were examined of dose and adjuvant of whole-killed gp120-depleted HIV-1 antigen on antibody and cytokine responses in a murine model. Immunization with increasing doses of inactivated HIV-1 antigen in Incomplete Freund s Adjuvant (IFA) resulted in increased production of IL-4 and IgG1 antibo
Early neuropsychological impairment in HIV-seropositive intravenous drug users: evidence from the Italian Multicentre Neuropsychological HIV Study.: Acta Psychiatr Scand. 1998 Feb;97(2):132-8. Unique Identifier : AIDSLINE MED/98177086; Starace F; Baldassarre C; Biancolilli V; Fea M; Serpelloni G; Bartoli L; Maj M; Department of Psychiatry, University of Naples, Italy.; The aim of the Italian Multicentre Neuropsychological HIV Study is to assess the prevalence and natural history of cognitive deficit in intravenous drug users (i.v.DUs) during the asymptomatic phase of HIV infection. The study is currently being conducted in four centres (Napoli, Benevento, Verona and Pavia) whose cat
Individualized strategies in the era of combination antiretroviral therapy.: J Am Board Fam Pract. 1998 Mar-Apr;11(2):158-64. Unique Identifier : AIDSLINE MED/98203836; Goldschmidt RH; Balano KB; Legg JJ; Dong BJ; Family Practice Residency Program, San Francisco General Hospital, CA; 94110, USA.
Put to sleep.: J Am Board Fam Pract. 1998 Mar-Apr;11(2):165. Unique Identifier : AIDSLINE MED/98203837; Magill MK; Department of Family and Preventive Medicine, University of Utah; School of Medicine, Salt Lake City 84132, USA.
Coronary arteriosclerosis after T-cell-mediated injury in transplanted mouse hearts: role of interferon-gamma.: Am J Pathol. 1998 May;152(5):1187-97. Unique Identifier : AIDSLINE MED/98248302; Nagano H; Libby P; Taylor MK; Hasegawa S; Stinn JL; Becker G; Tilney NL; Mitchell RN; Department of Surgery, Brigham and Women's Hospital, Harvard Medical; School, Boston, Massachusetts 02115, USA.; This study evaluated the contribution of acute parenchymal rejection and interferon (IFN)-gamma to the development of graft arterial disease (GAD) in totally allogeneic murine cardiac transplants. BALB/c (H-2d) hearts were transplanted into wild-type C57BL/6 (B6, H-2b) or B6 IFN-gamma-deficient (GKO) recipient mice. A
Interleukin-12 promotes activation of effector cells that induce a severe destructive granulomatous form of murine experimental autoimmune thyroiditis.: Am J Pathol. 1998 May;152(5):1347-58. Unique Identifier : AIDSLINE MED/98248317; Braley-Mullen H; Sharp GC; Tang H; Chen K; Kyriakos M; Bickel JT; Department of Internal Medicine, University of Missouri-Columbia; School of Medicine, 65212, USA. helen_mullen@muccmail.missouri.edu; Granulomatous inflammatory lesions are a major histopathological feature of a wide spectrum of human infectious and autoimmune diseases. Experimental autoimmune thyroiditis (EAT) with granulomatous histopathological features can be induced by mouse thyroglobulin (MTg)-sensitized spleen cells activated in vitro with MT
IGF-I alters lymphocyte survival and regeneration in thymus and spleen after dexamethasone treatment.: Am J Physiol. 1998 Apr;274(4 Pt 2):R912-20. Unique Identifier : AIDSLINE MED/98236865; Hinton PS; Peterson CA; Dahly EM; Ney DM; Department of Nutritional Sciences, University of Wisconsin-Madison; 53706, USA.; Insulin-like growth factor I (IGF-I) is a growth factor for the immune system, increasing lymphocyte number and function via greater lymphocyte generation and/or survival. We investigated the effects of IGF-I on lymphocyte survival and regeneration in the thymus and spleen after dexamethasone (Dex) treatment in rats m
Cross-national comparisons of sexual behavior surveys--methodological difficulties and lessons for prevention [editorial]: Am J Public Health. 1998 May;88(5):730-1. Unique Identifier : AIDSLINE MED/98246825; Spira A; Bajos N; Giami A; Michaels S
Modification of the clinical course of intestinal microsporidiosis in acquired immunodeficiency syndrome patients by immune status and anti-human immunodeficiency virus therapy.: Am J Trop Med Hyg. 1998 May;58(5):555-8. Unique Identifier : AIDSLINE MED/98258387; Conteas CN; Berlin OG; Speck CE; Pandhumas SS; Lariviere MJ; Fu C; Division of Gastroenterology, Southern California Permanente Medical; Group, Los Angeles 90027, USA.; The clinical course of 37 Enterocytozoon bieneusi-infected acquired immunodeficiency syndrome patients with diarrhea was studied. Parasite clearance was seen in 15 patients (40.5%). Clearance of E. bieneusi resulted in a 25-100% reduction in episodes of diarrhea, suggesting that microsporidia are true pathogens. Univa
Examination of the prevalence and seasonal variation of intestinal microsporidiosis in the stools of persons with chronic diarrhea and human immunodeficiency virus infection.: Am J Trop Med Hyg. 1998 May;58(5):559-61. Unique Identifier : AIDSLINE MED/98258388; Conteas CN; Berlin OG; Lariviere MJ; Pandhumas SS; Speck CE; Porschen R; Nakaya T; Division of Gastroenterology, Southern California Permanente Medical; Group, Los Angeles 90027, USA.; The epidemiology of human microsporidiosis is poorly understood and environmental factors affecting transmission of the organism have not been fully elucidated. Temporal variation in the prevalence of microsporidia in the stool of patients with human immunodeficiency v
Evaluation of the protective efficacy of a recombinant dengue envelope B domain fusion protein against dengue 2 virus infection in mice.: Am J Trop Med Hyg. 1998 May;58(5):655-62. Unique Identifier : AIDSLINE MED/98258404; Simmons M; Nelson WM; Wu SJ; Hayes CG; Naval Medical Research Institute, Bethesda, Maryland 20889-5607, USA.; A recombinant protein containing part of the dengue (DEN) 2 envelope protein was evaluated as a subunit immunogen for vaccination against DEN virus infection. A gene fragment encoding amino acids 298-400 (B domain) of the DEN-2 virus envelope was expressed as a fusion protein with the maltose binding protein MBP) of E
Cytotoxic T cells in basal cell carcinomas of skin.: Am J Dermatopathol. 1998 Apr;20(2):143-6. Unique Identifier : AIDSLINE MED/98216860; Deng JS; Falo LD Jr; Kim B; Abell E; Department of Dermatology, University of Pittsburgh School of; Medicine, Department of Veterans Affairs Medical Center, Pennsylvania; 15240, USA.; Previous studies have suggested the importance of CD8+ cytotoxic T-cells of hosts against neoplasms. Earlier studies and our previous investigation showed that a majority of tumor infiltrating T-cells in human basal cell carcinomas (BCCs) belonged to CD4+ T-cells. CD8+ cells were also present in the peritumor areas of
Cutaneous malakoplakia in a patient with acquired immunodeficiency syndrome (AIDS).: Am J Dermatopathol. 1998 Apr;20(2):185-8. Unique Identifier : AIDSLINE MED/98216868; Barnard M; Chalvardjian A; Department of Pathology, St. Michael's Hospital and University of; Toronto, Ontario, Canada.; Malakoplakia is an uncommon granulomatous lesion that afflicts predominantly immunocompromised individuals but is extremely rare in acquired immunodeficiency syndrome (AIDS). We report a case of cutaneous malakoplakia in an AIDS patient that presented as a banal right axillary abscess which resolved after excision and
Septic shock from Mycobacterium tuberculosis after therapy for Pneumocystis carinii.: Arch Intern Med. 1998 May 11;158(9):1033-5. Unique Identifier : AIDSLINE MED/98247851; Clark TM; Burman WJ; Cohn DL; Mehler PS; Department of Medicine, University of Colorado Health Sciences Center,; Denver, USA.; Septic shock resulting from Mycobacterium tuberculosis (TB) occurs only rarely, even among patients infected with human immunodeficiency virus. We report a case of fulminant TB sepsis in the setting of human immunodeficiency virus infection. This case illustrates the hazards of corticosteroid use as a part of empirica
Risk of animal contact in immunocompromised hosts [letter]: Arch Intern Med. 1998 May 11;158(9):1036. Unique Identifier : AIDSLINE MED/98247852; Koch CA; Robyn JA
Guidelines for the treatment of cytomegalovirus diseases in patients with AIDS in the era of potent antiretroviral therapy: recommendations of an international panel. International AIDS Society-USA.: Arch Intern Med. 1998 May 11;158(9):957-69. Unique Identifier : AIDSLINE MED/98247843; Whitley RJ; Jacobson MA; Friedberg DN; Holland GN; Jabs DA; Dieterich DT; Hardy WD; Polis MA; Deutsch TA; Feinberg J; Spector SA; Walmsley S; Drew WL; Powderly WG; Griffiths PD; Benson CA; Kessler HA; University of Alabama at Birmingham School of Medicine, 35233, USA.; Rwhitley@peds.uab.edu; OBJECTIVE: To provide recommendations for the treatment of acquired immunodeficiency syndrome-related cytomegalovirus ( CMV ) end-organ diseases, including retinitis, colitis, pneumonitis, and neurologic diseases. PARTICIPANTS:
Treatment of depressive symptoms in human immunodeficiency virus-positive patients.: Arch Gen Psychiatry. 1998 May;55(5):452-7. Unique Identifier : AIDSLINE MED/98255487; Markowitz JC; Kocsis JH; Fishman B; Spielman LA; Jacobsberg LB; Frances AJ; Klerman GL; Perry SW; Cornell University Medical College, New York, NY 10021, USA.; jcmarko@mail.med.cornell.edu; BACKGROUND: This randomized clinical trial compared 16-week interventions with interpersonal psychotherapy, cognitive behavioral therapy, supportive psychotherapy, and supportive psychotherapy with imipramine for human immunodeficiency virus HIV)-positive patients with depressive symptoms. METHODS: Subjects (N = 101;
Morphine modulates NF kappa B activation in macrophages.: Biochem Biophys Res Commun. 1998 Apr 17;245(2):392-6. Unique Identifier : AIDSLINE MED/98238647; Roy S; Cain KJ; Chapin RB; Charboneau RG; Barke RA; Department of Pharmacology, Veterans Administration Medical Center,; Minneapolis, Minnesota 55417. royxx002@gold.tc.umn.edu; Chronic use of morphine affects the immune system and predisposes an individual to opportunistic infections. Macrophages play an important role in conferring a first line of defense against invading pathogens. Understanding the mechanisms by which morphine affects the functioning of macrophages would have significant
Decreased production of interleukin-12 and other Th1-type cytokines in patients with recent-onset systemic lupus erythematosus.: Arthritis Rheum. 1998 May;41(5):838-44. Unique Identifier : AIDSLINE MED/98248149; Horwitz DA; Gray JD; Behrendsen SC; Kubin M; Rengaraju M; Ohtsuka K; Trinchieri G; University of Southern California School of Medicine, Los Angeles; 90033, USA.; OBJECTIVE: To determine the profile of Th1-type and Th2-type cytokines produced by mononuclear cells from patients with recent-onset systemic lupus erythematosus (SLE), prior to the initiation of treatment with corticosteroids. METHODS: Using sensitive radioimmunoassays, interleukin-4 (IL-4), IL-10, IL-12 p40, tumor n
Prevalence of the diffuse infiltrative lymphocytosis syndrome among human immunodeficiency virus type 1-positive outpatients.: Arthritis Rheum. 1998 May;41(5):863-8. Unique Identifier : AIDSLINE MED/98248152; Williams FM; Cohen PR; Jumshyd J; Reveille JD; University of Texas Health Science Center at Houston, 77225, USA.; OBJECTIVE: To ascertain the prevalence of the diffuse infiltrative lymphocytosis syndrome (DILS) in human immunodeficiency virus type 1 (HIV-1)-positive outpatients. METHODS: The presence of sicca symptoms and visible salivary gland enlargement was determined by interview and physical examination, and the clinical sta
A clinically relevant HIV-1 subunit vaccine protects rhesus macaques from in vivo passaged simian-human immunodeficiency virus infection.: AIDS. 1998 Mar 26;12(5):F15-22. Unique Identifier : AIDSLINE MED/98202437; Mooij P; van der Kolk M; Bogers WM; ten Haaft PJ; Van Der Meide P; Almond N; Stott J; Deschamps M; Labbe D; Momin P; Voss G; Von Hoegen P; Bruck C; Heeney JL; Department of Virology, Biomedical Primate Research Center, Rijswijk,; The Netherlands.; OBJECTIVES: To investigate whether immunization with recombinant HIV-1 envelope protein derived from a clinical isolate could protect macaques from infection with an in vivo passaged chimeric simian-human immunodeficiency virus (SHIV). DESIGN AND METHODS: A total of 16 animals were studied from which three groups of f
The effects of lamivudine treatment on HIV-1 disease progression are highly correlated with plasma HIV-1 RNA and CD4 cell count.: AIDS. 1998 Mar 26;12(5):F23-8. Unique Identifier : AIDSLINE MED/98202438; Montaner JS; DeMasi R; Hill AM; University of British Columbia, St Paul's Hospital, Vancouver, Canada.; OBJECTIVE: To determine the value of plasma HIV-1 RNA and CD4 cell count as predictors of the clinical benefit of antiretroviral treatment. DESIGN AND SETTING: The CAESAR ( Canada , Australia , Europe, South Afr
Decreasing incidence of HIV and sexually transmitted diseases in young Thai men: evidence for success of the HIV/AIDS control and prevention program.: AIDS. 1998 Mar 26;12(5):F29-36. Unique Identifier : AIDSLINE MED/98202439; Celentano DD; Nelson KE; Lyles CM; Beyrer C; Eiumtrakul S; Go VF; Kuntolbutra S; Khamboonruang C; Department of Epidemiology, Johns Hopkins University School of Hygiene; and Public Health, Baltimore, Maryland 21205, USA.; OBJECTIVE: To determine whether HIV and sexually transmitted disease (STD) incidence rates among young men in northern Thailand have declined since the establishment of the 100% Condom Program , and to prospectively document changes in the association between behavioral risk fac
The duration of viral suppression during protease inhibitor therapy for HIV-1 infection is predicted by plasma HIV-1 RNA at the nadir.: AIDS. 1998 Mar 26;12(5):F9-14. Unique Identifier : AIDSLINE MED/98202436; Kempf DJ; Rode RA; Xu Y; Sun E; Heath-Chiozzi ME; Valdes J; Japour AJ; Danner S; Boucher C; Molla A; Leonard JM; Department of Infectious Diseases Research, Abbott Laboratories,; Abbott Park, Illinois 60064-3500, USA.; OBJECTIVE: To determine markers that are associated with the durability of virologic response to therapy with HIV protease inhibitors in HIV-infected individuals. DESIGN: This study encompassed two retrospective analyses of the duration of virologic response to prot
Resistance and cross-resistance with saquinavir and other HIV protease inhibitors: theory and practice [editorial]: AIDS. 1998 Mar 26;12(5):453-60. Unique Identifier : AIDSLINE MED/98202444; Roberts NA; Craig JC; Sheldon J; Roche Discovery, Welwyn Garden City, Hertfordshire, UK.
The frequency of resistant mutant virus before antiviral therapy.: AIDS. 1998 Mar 26;12(5):461-5. Unique Identifier : AIDSLINE MED/98202445; Ribeiro RM; Bonhoeffer S; Nowak MA; Department of Zoology, University of Oxford, UK.; OBJECTIVE: To calculate the expected prevalence of resistant HIV mutants before antiviral therapy. DESIGN: HIV replication generates virus mutants. The prevalence of these mutants is determined by mutation and selection/fitness. Some mutations will confer drug resistance and it is crucial for the success of antiviral
Infection of primary dermal microvascular endothelial cells by Kaposi's sarcoma-associated herpesvirus.: AIDS. 1998 Mar 26;12(5):467-72. Unique Identifier : AIDSLINE MED/98202446; Panyutich EA; Said JW; Miles SA; University of California Los Angeles Care Center, 90095-1793, USA.; OBJECTIVE: To develop an in vitro model for infection of primary human cells with Kaposi s sarcoma (KS) herpesvirus (KSHV). DESIGN: The recent identification of a herpesvirus associated with KS, its successful isolation in vitro, and its complete DNA sequencing facilitates experiments on the pathogenesis of AIDS-relat
Phase II controlled trial of post-exposure immunization with recombinant gp160 versus antiretroviral therapy in asymptomatic HIV-1-infected adults. VaxSyn Protocol Team.: AIDS. 1998 Mar 26;12(5):473-80. Unique Identifier : AIDSLINE MED/98202447; Pontesilli O; Guerra EC; Ammassari A; Tomino C; Carlesimo M; Antinori A; Tamburrini E; Prozzo A; Seeber AC; Vella S; Ortona L; Aiuti F; Department of Clinical Medicine, University of Rome La Sapienza,; Italy.; OBJECTIVE: To alter the natural course of HIV-1 infection by inducing or potentiating immune responses to HIV-1 envelope glycoprotein. DESIGN: Multicentre, double-blind, three-arm, placebo-controlled study. SETTING: Outpatients attending clinics in two University Hospitals. PATIENTS: Ninety-nine asymptomatic HIV-1-inf
Role of transforming growth factor-beta1 in the suppressed allostimulatory function of AIDS patients.: AIDS. 1998 Mar 26;12(5):481-7. Unique Identifier : AIDSLINE MED/98202448; Brooks SP; Bernstein ZP; Schneider SL; Gollnick SO; Tomasi TB; Department of Molecular Immunology, Roswell Park Cancer Institute,; Buffalo, New York 14263, USA.; BACKGROUND: The T-cell stimulatory function of accessory cells isolated from peripheral blood lymphocytes of AIDS patients has been reported to be suppressed. These patients also have elevated levels of the immunosuppressive factor transforming growth factor TGF)-beta1 in their serum and plasma. OBJECTIVE: To explore
Pilot study of zidovudine-lamivudine combination therapy in vertically HIV-infected antiretroviral-naive children.: AIDS. 1998 Mar 26;12(5):489-94. Unique Identifier : AIDSLINE MED/98202449; Horneff G; Adams O; Wahn V; Department of Paediatrics, Institute of Medical Microbiology and; Virology, Heinrich Heine University, Dusseldorf, Germany.; OBJECTIVE: To examine tolerance and efficacy of a zidovudine plus lamivudine combination in HIV-infected children without previous exposure to antiretroviral drugs. METHODS: Thirteen vertically infected children (aged 4 months to 10 years) were treated with zidovudine (approximately 100 mg/m2 three times daily) and la
High incidence of anal high-grade squamous intra-epithelial lesions among HIV-positive and HIV-negative homosexual and bisexual men.: AIDS. 1998 Mar 26;12(5):495-503. Unique Identifier : AIDSLINE MED/98202450; Palefsky JM; Holly EA; Ralston ML; Jay N; Berry JM; Darragh TM; Department of Laboratory Medicine, University of California San; Francisco, 94143, USA.; OBJECTIVE: The incidence of anal cancer among homosexual men exceeds that of cervical cancer in women, and HIV-positive homosexual men may be at even higher risk than HIV-negative men. Cervical cancer is preceded by high-grade squamous intra-epithelial lesions (HSIL) and anal HSIL may similarly be the precursor to ana
The Cote d'Ivoire national HIV counseling and testing program for tuberculosis patients: implementation and analysis of epidemiologic data.: AIDS. 1998 Mar 26;12(5):505-12. Unique Identifier : AIDSLINE MED/98202451; Abouya L; Coulibaly IM; Wiktor SZ; Coulibaly D; N'kragbo M; N'gbo A; Zahui H; Toure K; Jacquemin K; San-Koffi M; Ackah A; Sassan-Morokro M; Maurice C; Whitaker JP; De Cock KM; Greenberg AE; Projet RETRO-CI, Abidjan, Cote d'Ivoire.; OBJECTIVES: To describe the implementation of a free, voluntary and confidential HIV counseling and testing program for patients with newly diagnosed tuberculosis at the eight large outpatient tuberculosis centers in Cote d Ivoire , and to present epidemiologic findings on part
Breastfeeding, genetic, obstetric and other risk factors associated with mother-to-child transmission of HIV-1 in Sao Paulo State, Brazil. Sao Paulo Collaborative Study for Vertical Transmission of HIV-1.: AIDS. 1998 Mar 26;12(5):513-20. Unique Identifier : AIDSLINE MED/98202452; Tess BH; Rodrigues LC; Newell ML; Dunn DT; Lago TD; London School of Hygiene and Tropical Medicine, UK.; OBJECTIVES: To evaluate the effect of maternal, obstetric, neonatal and post-natal factors on the risk of vertical transmission of HIV-1. DESIGN: Multicentre retrospective cohort study. SETTING: Obstetric and paediatric clinics in four cities in Sao Paulo State, Brazil . MAIN OUTCOM
A molecular epidemiologic survey of HIV in Uganda. HIV Variant Working Group.: AIDS. 1998 Mar 26;12(5):521-7. Unique Identifier : AIDSLINE MED/98202453; Rayfield MA; Downing RG; Baggs J; Hu DJ; Pieniazek D; Luo CC; Biryahwaho B; Otten RA; Sempala SD; Dondero TJ; HIV/Retrovirus Diseases Branch, Division of AIDS, STD and TB; Laboratory Research, National Center for Infectious Diseases, Centers; for Disease Control and Prevention, Atlanta, Georgia 30333, USA.; OBJECTIVE: Previous data, based on a small sampling of convenience, reported subtypes A, B, C, D, and G in Uganda , but neither the extent nor the proportion of these subtypes could be evaluated. To establish correctly the prevalence and distribution of HIV-1 subtypes, we analysed v
The impact of new antiretroviral regimes on HIV-associated hospital admissions and deaths [letter]: AIDS. 1998 Mar 26;12(5):529-30. Unique Identifier : AIDSLINE MED/98202454; Domingo P; Guardiola JM; Ris J; Nolla J
High prevalence of hepatitis G virus RNA and antibody to probable viral envelope protein but not both in AIDS patients' plasma [letter]: AIDS. 1998 Mar 26;12(5):530-1. Unique Identifier : AIDSLINE MED/98202455; Woolley I; Valdez H; Walker C; Landay A; Zdunek D; Hess G; Lederman MM
Fatal acute haemolysis in an AIDS patient treated with indinavir [letter]: AIDS. 1998 Mar 26;12(5):531-3. Unique Identifier : AIDSLINE MED/98202456; Prazuck T; Semaille C; Roques S
New treatments for progressive multifocal leukoencephalopathy in HIV-1-infected patients [letter]: AIDS. 1998 Mar 26;12(5):533-5. Unique Identifier : AIDSLINE MED/98202457; Sadler M; Chinn R; Healy J; Fisher M; Nelson MR; Gazzard BG
Longitudinal comparison of HIV-1 RNA burden in plasma and cerebrospinal fluid in two patients starting triple combination antiretroviral therapy [letter]: AIDS. 1998 Mar 26;12(5):535-7. Unique Identifier : AIDSLINE MED/98202458; Iftimovici E; Rabian C; Burgard M; Peytavin G; Rouzioux C; Viard JP
Therapeutic concentrations of indinavir in cerebrospinal fluid of HIV-1-infected patients [letter]: AIDS. 1998 Mar 26;12(5):537. Unique Identifier : AIDSLINE MED/98202459; Brinkman K; Kroon F; Hugen PW; Burger DM
Resolution of azole-resistant oropharyngeal candidiasis after initiation of potent combination antiretroviral therapy [letter]: AIDS. 1998 Mar 26;12(5):538. Unique Identifier : AIDSLINE MED/98202460; Valdez H; Gripshover BM; Salata RA; Lederman MM
Seroprevalence of human herpesvirus-8 in healthy subjects and patients with AIDS-associated and classical Kaposi's sarcoma in France [letter]: AIDS. 1998 Mar 26;12(5):539-40. Unique Identifier : AIDSLINE MED/98202461; Marcelin AG; Dupin N; Bossi P; Calvez V
The first Zambian population-based HIV survey: saliva-based testing is accurate and acceptable [letter]: AIDS. 1998 Mar 26;12(5):540-1. Unique Identifier : AIDSLINE MED/98202462; Fylkesnes K; Kasumba K
High seroprevalence of human herpesvirus-8 in pregnant women and prostitutes from Cameroon [letter]: AIDS. 1998 Mar 26;12(5):541-3. Unique Identifier : AIDSLINE MED/98202463; Bestetti G; Renon G; Mauclere P; Ruffie A; Mbopi Keou FX; Eme D; Parravicini C; Corbellino M; de The G; Gessain A
Indinavir-associated lipodystrophy.: AIDS. 1998 Apr 16;12(6):F37-9. Unique Identifier : AIDSLINE MED/98242894; Viraben R; Aquilina C; Service de Dermatologie, Toulouse, France.; BACKGROUND: Lipodystrophies are rare cutaneous disorders characterized by the symmetrical loss of subcutaneous fat from the body surface. The cause of lipodystrophy is not known, but a possible genetic predisposition is likely and either overt diabetes mellitus or insulin resistance are often associated. DESIGN AND ME
Systematic review of hormonal contraception and risk of HIV transmission: when to resist meta-analysis [editorial]: AIDS. 1998 Apr 16;12(6):545-53. Unique Identifier : AIDSLINE MED/98242895; Stephenson JM; Department of Sexually Transmitted Diseases, University College London; Medical School, UK.
Serological detection of attenuated HIV-1 variants with nef gene deletions.: AIDS. 1998 Apr 16;12(6):555-61. Unique Identifier : AIDSLINE MED/98242896; Greenway AL; Mills J; Rhodes D; Deacon NJ; McPhee DA; AIDS Cellular Biology Unit, National Centre in HIV Virology Research,; Macfarlane Burnet Centre for Medical Research, Fairfield, Victoria,; Australia.; OBJECTIVE: To investigate whether members of a transfusion-linked cohort (the Sydney Bloodbank Cohort) infected with a nef-deleted strain of HIV-1 could be differentiated from individuals infected with wild-type strains of HIV-1 by characterizing the Nef antibody response of cohort members. DESIGN: Retrospective and p
Early modification of host cell gene expression induced by HIV-1.: AIDS. 1998 Apr 16;12(6):563-70. Unique Identifier : AIDSLINE MED/98242897; Scheuring UJ; Corbeil J; Mosier DE; Theofilopoulos AN; Department of Immunology, Scripps Research Institute, La Jolla,; California 92037, USA.; OBJECTIVE: Characterization of the effects of infection with HIV-1 on cellular gene expression. DESIGN AND METHODS: Differential RNA display was applied to compare uninfected and HIV-1LAI-infected CEM cells 24 h post-inoculation. Differential bands were selected, cloned and several clones per band were sequenced. RNas
Cross-clade recognition of p55 by cytotoxic T lymphocytes in HIV-1 infection.: AIDS. 1998 Apr 16;12(6):571-9. Unique Identifier : AIDSLINE MED/98242898; McAdam S; Kaleebu P; Krausa P; Goulder P; French N; Collin B; Blanchard T; Whitworth J; McMichael A; Gotch F; Molecular Immunology Group, Institute of Molecular Medicine, John; Radcliffe Hospital, Oxford, UK.; OBJECTIVES: To evaluate cross-clade recognition of p55 antigen by cytotoxic T lymphocytes (CTL) in persons infected with diverse clades of HIV-1; to facilitate the development of a CTL-inducing vaccine to prevent transmission of multiple clades of HIV-1. DESIGN: Experiments were designed to evaluate whether persons in
Measurement of viral sequences in cerebrospinal fluid of AIDS patients with cerebral white-matter lesions using polymerase chain reaction.: AIDS. 1998 Apr 16;12(6):581-90. Unique Identifier : AIDSLINE MED/98242899; Monno L; Di Stefano M; Zimatore GB; Andreula CF; Appice A; Perulli LM; Fiore JR; Pastore G; Angarano G; Clinic of Infectious Diseases, University of Bari, Italy.; OBJECTIVES: To optimize the use of polymerase chain reaction PCR) on cerebrospinal fluid (CSF) for the evaluation of central nervous system (CNS) white-matter lesions that along with clinical findings and magnetic resonance imaging (MRI) can allow a definite diagnosis to be made; also to evaluate treatment with zidovu
Early manifestations (pre-AIDS) of HIV-1 infection in Uganda.: AIDS. 1998 Apr 16;12(6):591-6. Unique Identifier : AIDSLINE MED/98242900; Morgan D; Ross A; Mayanja B; Malamba S; Whitworth J; Medical Research Council Programme on AIDS, Uganda Virus Research; Institute, Entebbe.; OBJECTIVES: To describe the early manifestations of HIV-1 infection before the development of AIDS, in a rural Ugandan population. METHODS: Three monthly follow-up of HIV-1-infected and uninfected participants in an HIV-1 natural history cohort from the start of the cohort in 1990 to the end of 1996. RESULTS: A total
Effect of combination antiretroviral therapy upon rectal mucosal HIV RNA burden and mononuclear cell apoptosis.: AIDS. 1998 Apr 16;12(6):597-604. Unique Identifier : AIDSLINE MED/98242901; Kotler DP; Shimada T; Snow G; Winson G; Chen W; Zhao M; Inada Y; Clayton F; Department of Medicine, St Luke's-Roosevelt Hospital Center, Columbia; College of Physicians and Surgeons, New York, New York 10025, USA.; BACKGROUND: Pathogen-negative diarrhea is common in HIV infection and has been associated with clinical symptoms, histopathology, HIV expression, CD4+ lymphocyte depletion, cytokine mRNA expression, and apoptosis of lamina propria mononuclear cells. OBJECTIVES AND METHODS: To examine the short-term (7-day) effects of
Cytomegalovirus polymerase chain reaction viraemia in patients receiving ganciclovir maintenance therapy for retinitis.: AIDS. 1998 Apr 16;12(6):605-11. Unique Identifier : AIDSLINE MED/98242902; Bowen EF; Emery VC; Wilson P; Johnson MA; Davey CC; Sabin CA; Farmer D; Griffiths PD; Department of Virology, Royal Free Hospital and School of Medicine,; London, UK.; OBJECTIVES: To determine whether recurrence of polymerase chain reaction (PCR) viraemia during maintenance ganciclovir for cytomegalovirus ( CMV ) retinitis correlates with (i) CMV disease at a new anatomical site, (ii) progres
Increasing survival in AIDS patients with cytomegalovirus retinitis treated with combination antiretroviral therapy including HIV protease inhibitors.: AIDS. 1998 Apr 16;12(6):613-8. Unique Identifier : AIDSLINE MED/98242903; Walsh JC; Jones CD; Barnes EA; Gazzard BG; Mitchell SM; St Stephen's Centre, Chelsea and Westminster Hospital, London, UK.; OBJECTIVE: To assess the effect of combination antiretroviral therapy including HIV protease inhibitors on the survival of patients with cytomegalovirus retinitis (CMVR). DESIGN AND PARTICIPANTS: A longitudinal study of patients
The antiviral effect of ritonavir and saquinavir in combination amongst HIV-infected adults: results from a community-based study.: AIDS. 1998 Apr 16;12(6):619-24. Unique Identifier : AIDSLINE MED/98242904; Rhone SA; Hogg RS; Yip B; Sherlock C; Conway B; Schechter MT; O'Shaughnessy MV; Montaner JS; British Columbia Centre for Excellence in HIV/AIDS, St Paul's; Hospital, Vancouver, Canada.; OBJECTIVE: To characterize the antiviral effect and predictors of response to ritonavir and saquinavir-based antiretroviral combination therapy . DESIGN: Intent-to-treat analysis with suppression of pla
Maximum impact of HIV prevention measures targeted at injecting drug users [see comments]: AIDS. 1998 Apr 16;12(6):625-33. Unique Identifier : AIDSLINE MED/98242905; van Ameijden EJ; Coutinho RA; Municipal Health Service, Division of Public Health and Environment,; Amsterdam, The Netherlands.; OBJECTIVE: To examine whether the decrease in HIV incidence and injecting risk behaviours is ongoing in Amsterdam, and to study the determinants of injecting risk behaviours. DESIGN: Prospective open cohort study (1986-1997) amongst injecting drug users (IDU). METHODS: HIV incidence was studied using Poisson regressio
HIV-1 strains specific for Dutch injecting drug users in heterosexually infected individuals in The Netherlands.: AIDS. 1998 Apr 16;12(6):635-41. Unique Identifier : AIDSLINE MED/98242906; Lukashov VV; Op de Coul EL; Coutinho RA; Goudsmit J; Department of Human Retrovirology, Academic Medical Centre, University; of Amsterdam, The Netherlands.; OBJECTIVE: To study the molecular epidemiology of HIV-1 subtype B amongst heterosexually infected individuals in The Netherlands . DESIGN: The study population comprised 54 individuals infected by subtype B viruses through heterosexual contacts. Serum samples were collected bet
Effect of HIV-1 infection on pregnancy outcome in women in Kigali, Rwanda, 1992-1994. Pregnancy and HIV Study Group.: AIDS. 1998 Apr 16;12(6):643-50. Unique Identifier : AIDSLINE MED/98242907; Leroy V; Ladner J; Nyiraziraje M; De Clercq A; Bazubagira A; Van de Perre P; Karita E; Dabis F; INSERM U330, Universite Victor Segalen Bordeaux 2, France.; OBJECTIVE: To study the effect of HIV-1 infection on pregnancy outcome in women provided with antenatal services including malaria and sexually transmitted disease (STD) treatment in Kigali, Rwanda . SUBJECTS AND METHODS: Pregnant women attending the antenatal clinic ward of the Cen
Pre-AIDS mortality in HIV-infected individuals in England, Wales and Northern Ireland, 1982-1996.: AIDS. 1998 Apr 16;12(6):651-8. Unique Identifier : AIDSLINE MED/98242908; Laurichesse HA; Mortimer J; Evans BG; Farrington CP; Public Health Laboratory Service AIDS and Sexually Transmitted; Diseases Centre, Communicable Disease Surveillance Centre, London, UK.; OBJECTIVE: To assess pre-AIDS mortality in HIV-infected patients in England, Wales and Northern Ireland during the period 1982-1996. DESIGN: Surveillance data on pre-AIDS and AIDS deaths reported to the PHLS-AIDS Centre were analyse
The AIDS incubation period in the UK estimated from a national register of HIV seroconverters. UK Register of HIV Seroconverters Steering Committee.: AIDS. 1998 Apr 16;12(6):659-67. Unique Identifier : AIDSLINE MED/98242909; OBJECTIVES: To monitor changes in the distribution of time intervals from HIV seroconversion to the onset of AIDS and to death and to describe factors associated with the length of these intervals, through a national register of persons with estimated dates of HIV seroconversion. DESIGN AND METHODS: Clinicians caring
Understanding the long-term course of HIV epidemics [editorial; comment]: AIDS. 1998 Apr 16;12(6):669-70. Unique Identifier : AIDSLINE MED/98242910; Des Jarlais DC
Subtype-specific polymerase chain reaction for the identification of HIV-1 genetic subtypes circulating in Africa [letter]: AIDS. 1998 Apr 16;12(6):671-3. Unique Identifier : AIDSLINE MED/98242911; Peeters M; Liegeois F; Bibollet-Ruche F; Patrel D; Vidal N; Esu-Wiliams E; Mboup S; Mpoudi Ngole E; Koumare B; Nzila N; Perret JL; Delaporte E
Quantitative techniques and HIV-1 load in plasma and semen [letter]: AIDS. 1998 Apr 16;12(6):673. Unique Identifier : AIDSLINE MED/98242912; Liuzzi G; Bagnarelli P; Chirianni A; Clementi M; Piazza M
Enhanced detection of human herpesvirus-8 and cytomegalovirus in semen of HIV-seropositive asymptomatic heterosexual men living in Central Africa [letter]: AIDS. 1998 Apr 16;12(6):674-6. Unique Identifier : AIDSLINE MED/98242913; Belec L; Tevi-Benissan C; Mohamed AS; Carbonel N; Matta M; Gresenguet G
Remitting infratentorial leukoencephalopathy in a patient with HIV infection [letter]: AIDS. 1998 Apr 16;12(6):676-8. Unique Identifier : AIDSLINE MED/98242914; Monaco S; Morbin M; Rizzuto N; Di Perri G; Freddi N; Francavilla E
Lack of efficacy of cidofovir in treating AIDS-related cytomegalovirus retinitis after long-term treatment with ganciclovir [letter]: AIDS. 1998 Apr 16;12(6):678-9. Unique Identifier : AIDSLINE MED/98242915; Schurmann D; Bergmann F; Grobusch MP; Behnsch M; Liekfeld A
Discontinuation of Mycobacterium avium complex prophylaxis in patients with a rise in CD4 cell count following highly active antiretroviral therapy [letter]: AIDS. 1998 Apr 16;12(6):680. Unique Identifier : AIDSLINE MED/98242916; Gill J; Moyle G; Nelson M
On the issue of cross-resistance between protease inhibitors [letter]: AIDS. 1998 Apr 16;12(6):680-1. Unique Identifier : AIDSLINE MED/98242917; Birch C
Gynecomastia during indinavir antiretroviral therapy in HIV infection [letter]: AIDS. 1998 Apr 16;12(6):681-2. Unique Identifier : AIDSLINE MED/98242918; Toma E; Therrien R
Steroids as possible inhibitors of HIV-1 protease [letter]: AIDS. 1998 Apr 16;12(6):682-5. Unique Identifier : AIDSLINE MED/98242919; Schramm HJ; Quere L; Buttner J; Wenger T; Dick A; Schramm W
Adherence to the antiretroviral treatment in asymptomatic HIV-infected patients [letter]: AIDS. 1998 Apr 16;12(6):685-6. Unique Identifier : AIDSLINE MED/98242920; Lopez-Suarez A; Fernandez-Gutierrez del Alam; Perez-Guzman E; Giron-Gonzalez JA
Study links failure of anti-HIV drug to patients [news]: Dent Today. 1996 Oct;15(10):33. Unique Identifier : AIDSLINE MED/98229256
Drug shows potency against HIV [news]: Dent Today. 1996 May;15(5):22, 26. Unique Identifier : AIDSLINE MED/98229285
HIV incidence and prevalence beginning to decline [news]: Dent Today. 1996 Jul;15(7):36. Unique Identifier : AIDSLINE MED/98229196
Researchers develop AIDS-destroying viruses [news]: Dent Today. 1997 Oct;16(10):30. Unique Identifier : AIDSLINE MED/98221422
Clinton sets goal for AIDS vaccine [news]: Dent Today. 1997 Oct;16(10):34-5. Unique Identifier : AIDSLINE MED/98221423
Doctors plan to inject themselves with live AIDS vaccine [news]: Dent Today. 1997 Nov;16(11):27, 29. Unique Identifier : AIDSLINE MED/98221499; Marino D
Proposed bill would treat HIV as infectious disease [news]: Dent Today. 1997 Dec;16(12):36. Unique Identifier : AIDSLINE MED/98221348
AIDS deaths decline in the US for first time [news]: Dent Today. 1997 Apr;16(4):34-5. Unique Identifier : AIDSLINE MED/98221482
Eliminating opportunistic infection is essential for AIDS patients [news]: Dent Today. 1998 Jan;17(1):38-9. Unique Identifier : AIDSLINE MED/98221359
Death rates for AIDS decrease throughout the country [news]: Dent Today. 1998 Mar;17(3):38. Unique Identifier : AIDSLINE MED/98253181
An academic centre for gene therapy research with clinical grade manufacturing capability.: Ann Med. 1997 Dec;29(6):579-83. Unique Identifier : AIDSLINE MED/98221020; Islam KB; Blomberg P; Wikstrom K; Smith CI; Center for Gene Therapy Research, Huddinge University Hospital,; Karolinska Institute, Sweden. Khalid.Islam@kfcmail.hs.sll.se; Huddinge University Hospital is a major teaching hospital affiliated with the Karolinska Institute in Southern Stockholm. For the past few years several groups have been working there in different areas of gene therapy relating to cancer, genetic and infectious diseases. However, a facility to produce clinical grade m
Chlamydia pneumoniae and its role in chronic obstructive pulmonary disease.: Ann Med. 1998 Feb;30(1):27-37. Unique Identifier : AIDSLINE MED/98215374; von Hertzen LC; The Finnish Lung Health Association, Helsinki.; The diverging of T-helper (Th) cells into predominantly Th1 and Th2 subsets on the basis of their cytokine profiles has decisively improved our understanding of the pathogenesis of many chronic infectious diseases. Recent data suggest that the presence of interferon-gamma and the subsequent suppression of interleukin-
Retroviral gene transfer in chondrogenic limb bud micromass cultures.: Biotechniques. 1998 Apr;24(4):660-6. Unique Identifier : AIDSLINE MED/98225728; Stott NS; Lee YS; Chuong CM; Department of Pathology, University Southern California, Los Angeles; 90033, USA.; We report development of a model of retroviral gene transduction in high-density limb bud cell micromass culture. The replication competent avian retrovirus RCAS BP (A) carrying the human placental alkaline phosphatase gene (RCAS AP) was used as a marker for retroviral infection and spread. The final protocol balances
Phylogenetic analysis of HIV type 2 strains from Portugal [letter]: AIDS Res Hum Retroviruses. 1998 Apr 10;14(6):471-3. Unique Identifier : AIDSLINE MED/98226200; Heredia A; Vallejo A; Soriano V; Silva A; Mansinho K; Fevereiro S; Mas A; Gutierrez M; Epstein JS; Hewlett IK
Neutralizing antibody and perinatal transmission of human immunodeficiency virus type 1. New York City Perinatal HIV Transmission Collaborative Study Group.: AIDS Res Hum Retroviruses. 1998 Apr 10;14(6):475-81. Unique Identifier : AIDSLINE MED/98226201; Hengel RL; Kennedy MS; Steketee RW; Thea DM; Abrams EJ; Lambert G; McDougal JS; Department of Medicine, Emory University, Atlanta, Georgia 30303, USA.; The major immunologic determinants for perinatal transmission of human immunodeficiency virus type 1 (HIV-1) remain largely unknown. The presence of maternal neutralizing antibodies has been proposed as an explanation for why the majority of infants born to untreated HIV-1-infected women do not become infected. Using
Active immunization of patients with HIV infection: a study of the effect of VaxSyn, a recombinant HIV envelope subunit vaccine, on progression of immunodeficiency.: AIDS Res Hum Retroviruses. 1998 Apr 10;14(6):483-90. Unique Identifier : AIDSLINE MED/98226202; Tsoukas CM; Raboud J; Bernard NF; Montaner JS; Gill MJ; Rachlis A; Fong IW; Schlech W; Djurdjev O; Freedman J; Thomas R; Lafreniere R; Wainberg MA; Cassol S; O'Shaughnessy M; Todd J; Volvovitz F; Smith GE; Immunodeficiency Treatment Centre, McGill AIDS Centre, Montreal; General Hospital, Quebec, Canada.; Infection with the human immunodeficiency virus (HIV) leads to a progressive immunodeficiency characterized by decreasing levels of CD4+ T lymphocytes. VaxSyn, a vaccine based on the recombinant envelope glycoprotein subunit (rgp160) of HIV-1IIIB, was used to immunize HIV-infected patients to determine whether its adm
Anti-F(ab')2 antibody in HIV type 1 infection: relationship to hypergammaglobulinemia and to antibody specific to the V3 loop region of glycoprotein 120.: AIDS Res Hum Retroviruses. 1998 Apr 10;14(6):491-8. Unique Identifier : AIDSLINE MED/98226203; Morrison SA; Pearson SL; Steigbigel RT; Division of Hematology, Health Sciences Center, SUNY at Stony Brook,; New York 11794-8151, USA. smorriso@mail.som.sunysb.edu; As HIV infection and autoimmune disease share certain similarities, it has been suggested that HIV may disrupt control of humoral immunity by the antiidiotype network, and that this may be evident as increased IgG antibody to F(ab )2. When anti-F(ab )2 was quantified by ELISA in sera of randomly chosen HIV-infected ve
Ciprofloxacin inhibits activation of latent human immunodeficiency virus type 1 in chronically infected promonocytic U1 cells.: AIDS Res Hum Retroviruses. 1998 Apr 10;14(6):499-504. Unique Identifier : AIDSLINE MED/98226204; Gollapudi S; Kim CH; Roshanravan B; Gupta S; Department of Medicine, University of California, Irvine 92697, USA.; SVGollap@uci.edu; The effect of ciprofloxacin, a quinolone antibiotic widely used to treat opportunistic bacterial infections in AIDS patients, was examined in the context of reactivation of latent HIV-1 in chronically infected promonocytic U1 cells. Ciprofloxacin inhibited, in a dose-dependent manner, HIV-1 expression in U1 cells acti
Low CD83, but normal MHC class II and costimulatory molecule expression, on spleen dendritic cells from HIV+ patients.: AIDS Res Hum Retroviruses. 1998 Apr 10;14(6):505-13. Unique Identifier : AIDSLINE MED/98226205; McIlroy D; Autran B; Clauvel JP; Oksenhendler E; Debre P; Hosmalin A; Laboratoire d'Immunologie Cellulaire et Tissulaire, URA CNRS 625,; Hopital de la Pitie-Salpetriere, Paris, France.; Dendritic cells (DCs), which are the most potent antigen-presenting cells for T lymphocytes, are targets for HIV in vitro and in vivo. Antigen presentation by DCs has been suggested to be impaired during HIV infection; however, the extent to which DCs from HIV+ individuals are altered, particularly in lymphoid organs
Multiply spliced env and nef transcripts of simian immunodeficiency virus from West African green monkey SIVagm-sab).: AIDS Res Hum Retroviruses. 1998 Apr 10;14(6):515-9. Unique Identifier : AIDSLINE MED/98226206; Bibollet-Ruche F; Cuny G; Pourrut X; Brengues C; Galat-Luong A; Galat G; Delaporte E; Laboratoire Retrovirus, ORSTOM, Montpellier, France.; bibollet@infobiogen.fr; We have characterized the spliced transcripts of nef and envelope genes of SIVagm from African green monkey of the sabaeus subspecies. Most of the transcripts we have studied, representing the most abundant mRNA species in our assay, have undergone a specific splicing event that removes a part of the trans-activation
Herpesvirus saimiri transformation of HIV type 1 suppressive CD8+ lymphocytes from an HIV type 1-infected asymptomatic individual.: AIDS Res Hum Retroviruses. 1998 Apr 10;14(6):521-31. Unique Identifier : AIDSLINE MED/98226207; Lacey SF; Weinhold KJ; Chen CH; McDanal C; Oei C; Greenberg ML; Department of Surgery, Duke University Medical Center, Durham, North; Carolina 27710, USA.; CD8+ T lymphocytes from HIV+ individuals can potently suppress HIV-1 replication in a noncytolytic manner. This suppression appears to be multifactorial and the molecules contributing have not been fully elucidated. As an approach to this question we used herpesvirus saimiri (HVS) to transform CD8+ T lymphocytes from
Geographic and demographic differences in the frequency of human cytomegalovirus gB genotypes 1-4 in immunocompromised patients.: AIDS Res Hum Retroviruses. 1998 Apr 10;14(6):533-6. Unique Identifier : AIDSLINE MED/98226208; Zipeto D; Hong C; Gerna G; Zavattoni M; Katzenstein D; Merigan TC; Rasmussen L; Center for AIDS Research and Division of Infectious Disease, Stanford; University School of Medicine, California 94305, USA.; To test the hypothesis that human cytomegalovirus ( CMV ) gB genotype may differ with geographic origin or patient demographics, CMV DNA was amplified for gB typing from immunocompromised patients in
Identification and molecular characterization of human T lymphotropic virus type II infections in intravenous drug abusers in the former South Vietnam.: AIDS Res Hum Retroviruses. 1998 Apr 10;14(6):537-40. Unique Identifier : AIDSLINE MED/98226209; Fukushima Y; Lewis MJ; Monken C; Komuro K; Kusagawa S; Sato H; Takebe Y; Yamazaki S; Nguyen TH; Hoang A; Hoang TL; Honda M; Hall WW; Department of Medical Microbiology, University College Dublin,; Ireland.; Previous serological studies have demonstrated that some 60% of intravenous drug abusers (IVDAs) in urban areas of the former South Vietnam are infected with HTLV-II. In the present report we have attempted to characterize the viruses using restriction fragment length polymorphism
Grapefruit juice enhances the bioavailability of the HIV protease inhibitor saquinavir in man.: Br J Clin Pharmacol. 1998 Apr;45(4):355-9. Unique Identifier : AIDSLINE MED/98237293; Kupferschmidt HH; Fattinger KE; Ha HR; Follath F; Krahenbuhl S; Division of Clinical Pharmacology & Toxicology, University Hospital,; Zurich, Switzerland.; AIMS: Saquinavir is a potent HIV protease inhibitor whose effectiveness is limited in vivo by its low bioavailability. Since saquinavir is metabolized by CYP3A4, the effect of grapefruit juice, an inhibitor of CYP3A4, was investigated on its bioavailability. METHODS: After an overnight fast, eight healthy volunteers w
ONS position on the care of individuals with HIV infection announced [news]: Oncology (Huntingt). 1998 Apr;12(4):482. Unique Identifier : AIDSLINE MED/98236433
Contrasting phenotypes of liver-infiltrating leucocytes isolated from MCMV-infected BALB/c and C57BL/6 mice.: Int J Exp Pathol. 1998 Feb;79(1):33-46. Unique Identifier : AIDSLINE MED/98276487; Olver SD; Price P; Department of Microbiology, University of Western Australia, Nedlands,; Australia.; We characterized liver-infiltrating leucocytes (LIL) from BALB/c and C57BL/6 mice 0-56 days after murine cytomegalovirus (MCMV) infection. Inflammation clears from C57BL/6 mice 4-5 weeks post infection (pi), but persists for several months in BALB/c mice. The LIL obtained were 60-8
CD8hi+CD57+ T lymphocytes are enriched in antigen-specific T cells capable of down-modulating cytotoxic activity.: Int Immunol. 1998 Mar;10(3):311-23. Unique Identifier : AIDSLINE MED/98236156; Mollet L; Sadat-Sowti B; Duntze J; Leblond V; Bergeron F; Calvez V; Katlama C; Debre P; Autran B; Laboratoire d'Immunologie Cellulaire et Tissulaire, CNRS-URA 625, CHU; Pitie-Salpetriere, Paris, France.; Major expansions of CD8hi+CD57+ T lymphocytes frequently occur during human immunodeficiency virus (HIV) infection and after transplantation. To investigate mechanisms of such cell expansion, we compared the activation and functional status of CD8hi+CD57+ and CD57-peripheral blood lymphocytes (PBL) from normal, bone m
Detection of herpesvirus-like sequences in Kaposi's sarcoma from heart transplant recipients.: J Heart Lung Transplant. 1998 Mar;17(3):288-93. Unique Identifier : AIDSLINE MED/98223069; Briz M; Alonso-Pulpon L; Crespo-Leiro MG; Exposito C; Almagro M; Busto MJ; Fernandez MN; Department of Hematology, Clinica Puerta de Hierro (Madrid), Spain.; BACKGROUND: Herpesvirus-like DNA sequences have been found in lesions from patients with Kaposi s sarcoma in its several forms, suggesting that this tumor may be caused by a new herpesvirus, referred to as Kaposi s sarcoma-associated herpesvirus or human herpesvirus 8. METHODS: We analyzed DNA from skin and lung lesio
HIV-1 vaccine candidate evaluation in non-human primates.: Crit Rev Oncog. 1997;8(2-3):273-91. Unique Identifier : AIDSLINE MED/98230222; Lu Y; Institute for International Vaccine Development, Inc., Cambridge, MA; 02138, USA.; The development of an HIV-1 vaccine in the last 13 years from an industrial point of view has focused on evaluating potential vaccine candidates in non-human primates. This review discusses the HIV-1 vaccine candidates that have been tested in chimpanzees or monkeys and includes those based on recombinant gp120, recom
[Evaluation of the quality of life in artificial nutrition]: Nutr Hosp. 1998 Jan-Feb;13(1):1-7. Unique Identifier : AIDSLINE MED/98239829; Zarazaga Monzon A; Culebras JM; Gomez Candela C; Cos AI; Servicio de Cirugia, Hospital Universitario La Paz, Madrid.; azarazaga@sinix.net; If we define quality of life as being the social, physiological, mental intellectual, and general well being of people, we realize that there is no known health care system that is able to guarantee that well being in all its possible aspects. When we as clinicians assess the positive effects of a treatment applied to
AIDS-associated atypical Pneumocystis carinii pneumonia revisited.: Clin Infect Dis. 1998 Apr;26(4):1005-6. Unique Identifier : AIDSLINE MED/98225686; Groll AH; Keul HG; Brodt R; Schneider M; Department of Pathology, Johann Wolfgang Goethe-University Hospital,; Frankfurt/Main, Germany.
Military tuberculosis with paradoxical expansion of intracranial tuberculomas complicating human immunodeficiency virus infection in a patient receiving highly active antiretroviral therapy.: Clin Infect Dis. 1998 Apr;26(4):1008-9. Unique Identifier : AIDSLINE MED/98225689; Crump JA; Tyrer MJ; Lloyd-Owen SJ; Han LY; Lipman MC; Johnson MA; Department of HIV and Thoracic Medicine, Royal Free Hospital, London,; United Kingdom.
Acute respiratory failure associated with the human immunodeficiency virus (HIV) protease inhibitor indinavir in an HIV-infected patient.: Clin Infect Dis. 1998 Apr;26(4):1012-3. Unique Identifier : AIDSLINE MED/98225692; Dieleman JP; in 't Veld B; Borleffs JC; Schreij G; University Hospital Dijkzigt, Rotterdam, The Netherlands.
Furazolidone-induced mood disorder during the treatment of refractory giardiasis in a patient with AIDS.: Clin Infect Dis. 1998 Apr;26(4):1015. Unique Identifier : AIDSLINE MED/98225694; Elliott AM; Klaus BD; North DS; Martin HP; Denver Department of Veterans Affairs Medical Center, Colorado, USA.
Effect of prophylaxis on the clinical manifestations of AIDS-related opportunistic infections.: Clin Infect Dis. 1998 Apr;26(4):806-10. Unique Identifier : AIDSLINE MED/98225643; Sepkowitz KA; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New; York, New York 10021, USA.; Administration of targeted prophylaxis for AIDS-related opportunistic infections has contributed significantly to the recent decrease in mortality among patients with AIDS in the United States . Most reported prophylaxis trials have focused on determining (a) the percentage of cases pre
Behavioral and demographic risk factors for transmission of human immunodeficiency virus type 1 in heterosexual couples: report from the Heterosexual HIV Transmission Study.: Clin Infect Dis. 1998 Apr;26(4):855-64. Unique Identifier : AIDSLINE MED/98225651; Skurnick JH; Kennedy CA; Perez G; Abrams J; Vermund SH; Denny T; Wright T; Quinones MA; Louria DB; Department of Preventive Medicine, University of Medicine and; Dentistry of New Jersey-New Jersey Medical School, Newark 07103, USA.; We compared 224 heterosexual couples who were discordant for human immunodeficiency virus (HIV) type 1 infection (one partner HIV infected) with 78 HIV-concordant couples (both partners HIV infected) to identify demographic and behavioral risk factors for HIV transmission. Among the 229 couples whose male partner was
Clinical evaluation and microbiology of oropharyngeal infection due to fluconazole-resistant Candida in human immunodeficiency virus-infected patients.: Clin Infect Dis. 1998 Apr;26(4):960-3. Unique Identifier : AIDSLINE MED/98225670; Revankar SG; Dib OP; Kirkpatrick WR; McAtee RK; Fothergill AW; Rinaldi MG; Redding SW; Patterson TF; University of Texas Health Science Center at San Antonio 78284-7881,; USA.; Signs and symptoms of oropharyngeal candidiasis (OPC) were correlated with microbiology and clinical response to fluconazole in a cohort of patients with advanced human immunodeficiency virus (HIV) infection and recurrent OPC. Sixty-four HIV-infected patients with a median CD4 cell count of
Pyogenic bacterial pneumonia in human immunodeficiency virus-infected inpatients: a clinical, radiological, microbiological, and epidemiological study.: Clin Infect Dis. 1998 Apr;26(4):964-71. Unique Identifier : AIDSLINE MED/98225671; Baril L; Astagneau P; Nguyen J; Similowski T; Mengual X; Beigelman C; Caumes E; Katlama C; Bricaire F; Department of Infectious Diseases and Public Health, Pitie-Salpetriere; Hospital, Paris, France.; We prospectively studied features of pyogenic bacterial pneumonia in 263 consecutive human immunodeficiency virus-infected inpatients over a 6-month study period. Risk factors for bacterial pneumonia were examined by a case-control study that included 33 cases who presented with at least one episode of bacterial pneum
Gingivomandibular infection due to Mycobacterium kansasii in a patient with AIDS.: Clin Infect Dis. 1998 Apr;26(4):993-4. Unique Identifier : AIDSLINE MED/98225676; Courrier B; Mauprivez C; Coignard S; Sudaka-Bahadoran A; Kuffer R; Karmochkine M; Raguin G; Faculte de Chirurgie-Dentaire, Hopital Hotel-Dieu, Paris, France.
Adenovirus cholecystitis in a patient with AIDS.: Clin Infect Dis. 1998 Apr;26(4):997-9. Unique Identifier : AIDSLINE MED/98225680; Hedderwick SA; Greenson JK; McGaughy VR; Clark NM; Division of Infectious Diseases, University of Michigan Medical; School, Ann Arbor, USA.
Effect of intracolonic benzalkonium chloride on trinitrobenzene sulphonic acid-induced colitis in the rat.: Aliment Pharmacol Ther. 1998 Mar;12(3):219-28. Unique Identifier : AIDSLINE MED/98230181; Miampamba M; Parr EJ; McCafferty DM; Wallace JL; Sharkey KA; Department of Physiology and Biophysics, University of Calgary,; Alberta, Canada.; BACKGROUND: We investigated the effects of benzalkonium chloride BAC) on trinitrobenzene sulphonic acid (TNBS)-induced colitis in rats. METHODS: TNBS was administered intrarectally before and/or after BAC treatment. In the first study, the effects of treatment with BAC 6, 12 or 24 h after TNBS were examined. In the se
Vertical transmission of viral infections.: Curr Opin Obstet Gynecol. 1998 Apr;10(2):123-8. Unique Identifier : AIDSLINE MED/98212671; Mandelbrot L; Hopital Cochin, Service de Gynecologie Obstetrique I, Paris, France.; laurent.mandelbrot@cch.ap.hop.paris.fr; A variety of congenital viral infections are responsible for a large proportion of the mortality and morbidity in infancy and childhood. Vertical transmission may occur during primary maternal infection or during chronic or recurrent infection, with different implications for counselling and testing in pregnancy. Stra
Recent advances, prospects and problems in designing new strategies for oligonucleotide and gene delivery in therapy.: In Vivo. 1998 Jan-Feb;12(1):59-67. Unique Identifier : AIDSLINE MED/98236339; Romano G; Claudio PP; Kaiser HE; Giordano A; Kimmel Cancer Institute, Jefferson Medical College, Thomas Jefferson; University, Philadelphia, PA 19107, USA.; The field of gene therapy has been in rapid expansion since the first submissions of gene therapy trials in the early 1990s which provided encouraging results. Since then, many gene therapy protocols have been approved for phase I clinical trials for the treatment of inherited genetic diseases and cancer. The possibil
[Changes in knowledge of HIV/AIDS and attitudes for PWA in Tokyo: 1992-1995]: Nippon Koshu Eisei Zasshi. 1997 Dec;44(12):952-65. Unique Identifier : AIDSLINE MED/98213999; Inagaki T; Division of General Affairs, Bureau of Public Health, Tokyo; Metropolitan Government.; In order to assess changes in knowledge of HIV/AIDS and attitude for People With HIV/AIDS (PWA), interview surveys (Dec. 1992, Jan. 1994, Jan. 1995) were carried out annually on random samples of the general public in Tokyo, age between 15-69 years. In total, 4,270 individuals were sampled, with an average response ra
Fumaric acid esters suppress peripheral CD4- and CD8-positive lymphocytes in psoriasis.: Dermatology. 1998;196(2):223-30. Unique Identifier : AIDSLINE MED/98229834; Hoxtermann S; Nuchel C; Altmeyer P; Department of Dermatology, Ruhr-University, Bochum, Germany.; stefan.m.hoextermann@rz.ruhr-uni-bochum.de; BACKGROUND: For severe forms of psoriasis vulgaris, the antipsoriatic fumaric acid esters (FAE) therapy has recently gained increasing acceptance and importance. Until today, there is little knowledge about the mode of action of FAE. However, some evidence exists indicating immunosuppressive effects. OBJECTIVE: The ai
Surveillance of blood transfusion safety: contribution of the hemovigilance strategy in France.: Transfus Med Rev. 1998 Apr;12(2):109-27. Unique Identifier : AIDSLINE MED/98227200; Morel P; Herve P; Etablissement de Transfusion Sanguine de Franche-Comte, Besancon,; France.
Risperidone for the treatment of delusional disorder due to HIV disease [letter]: J Neuropsychiatry Clin Neurosci. 1998 Winter;10(1):111. Unique Identifier : AIDSLINE MED/98208692; Maha A; Goetz K
Lymphocytes from lymph nodes at different distances from human melanoma vary in their capacity to inhibit/enhance tumor cell growth in vitro.: Melanoma Res. 1997 Aug;7 Suppl 2:S59-65. Unique Identifier : AIDSLINE MED/98237529; Farzad Z; McBride WH; Ogbechi H; Asnong-Holthoff C; Morton DL; Cochran AJ; Department of Surgery, University of California, Los Angeles 90095,; USA.; Eighty-six lymph nodes at measured distances from a primary tumor were removed from 68 patients with malignant melanoma. The ability of lymph-node lymphocytes (LNL) from these nodes to modulate proliferation of a melanoma cell line (UCLA-SO-M14) in vitro was tested. LNL from the majority of lymph nodes (66%) inhibited
AIDS. The untold story.: Revolution. 1997 Winter;7(4):58-62. Unique Identifier : AIDSLINE MED/98277921; Monteith SK
Pulsed dye laser treatment of molluscum contagiosum in a patient with acquired immunodeficiency syndrome.: Dermatol Surg. 1998 May;24(5):533-5. Unique Identifier : AIDSLINE MED/98260369; Nehal KS; Sarnoff DS; Gotkin RH; Friedman-Kien A; Ronald O. Perelman Department of Dermatology, New York University; Medical Center, New York, USA.; BACKGROUND: Molluscum contagiosum is usually a self-limited benign viral disease in children and young adults. In patients with acquired immunodeficiency syndrome (AIDS), however, the infection is often widespread, disfiguring, and recalcitrant to conventional therapy. OBJECTIVE: A treatment modality for widespread, r
Neuropathological syndromes in the course of full blown acquired immune deficiency syndrome (AIDS) in adults in Poland 1987-1995).: Folia Neuropathol. 1997;35(3):133-43. Unique Identifier : AIDSLINE MED/98258211; Mossakowski MJ; Zelman IB; Department of Neuropathology, Polish Academy of Sciences, Warszawa.; Morphological analysis of the brains from 100 cases of full blown AIDS patients observed in the course of 1987-1995 years was performed. The material comprised 96 males, 3 females and 1 infant, 11 months old. Early material consisted almost exclusively of homo- and bisexuals, while in the last years heterosexual drug
The white matter changes in microencephalic HIV infected infants. A preliminary report.: Folia Neuropathol. 1997;35(3):145-8. Unique Identifier : AIDSLINE MED/98258212; Dambska M; Kozlowski PB; Brudkowska J; Rao C; Anzil AP; Laure-Kamionowska M; Department of Developmental Neuropathology Medical Research Centre,; Polish Academy of Sciences, Warszawa, Poland.; The brains of six infants 14-34 months of age and with microencephaly (brain weight deficit 20-55.5%) were chosen from a group of cases vertically infected with HIV. The center of our investigations was focused on the white matter changes of which two types were observed in the examined brains. Within the periventricu
The rise of asthma and atopy [editorial]: QJM. 1998 Mar;91(3):169-70. Unique Identifier : AIDSLINE MED/98267427; Hopkin JM
Management of intracerebral lesions in patients with HIV: a retrospective study with discussion of diagnostic problems.: QJM. 1998 Mar;91(3):205-17. Unique Identifier : AIDSLINE MED/98267432; Sadler M; Brink NS; Gazzard BG; Chelsea and Westminster Hospital, London, UK.; A total of 95 patients who presented in 1994 and 1995 with focal brain lesions at a London HIV centre were studied retrospectively. Patients were allocated to definite or presumed diagnostic categories of toxoplasma encephalitis (TE), primary CNS lymphoma (PCNSL) or progressive
Axillary lymph node dissection for breast cancer: a decision analysis of T1 lesions.: Ann Surg Oncol. 1998 Mar;5(2):131-9. Unique Identifier : AIDSLINE MED/98186496; Velanovich V; Department of Surgery, Henry Ford Hospital, Detroit, Michigan; 48202-2689, USA.; BACKGROUND: The value of routine axillary dissection for patients with breast cancer is still being debated. The argument centers around whether the information gained by knowing the lymph node status, which aids in making the decision about adjuvant chemotherapy, justifies the morbidity. This study quantitatively ana
Prevalence of CD8+ T-cell expansions in relation to age in healthy individuals.: J Gerontol A Biol Sci Med Sci. 1998 May;53(3):B196-203. Unique Identifier : AIDSLINE MED/98259332; Ricalton NS; Roberton C; Norris JM; Rewers M; Hamman RF; Kotzin BL; Department of Medicine, National Jewish Medical and Research Center,; Denver, Colorado, USA.; Clonal CD8+ T-cell expansions have been identified in the peripheral blood of healthy adults and occasionally in children. These expansions are often large, yet their etiology is unknown. This study evaluated the relationship between age and the prevalence of these expansions in a healthy population (n = 147) aged 9 m
Principles of current adult HIV pharmacotherapy.: Ann Allergy Asthma Immunol. 1998 May;80(5):363-7; quiz 367-8. Unique Identifier : AIDSLINE MED/98270766; Landor M; Albert Einstein College of Medicine.; OBJECTIVE: To provide a concise review of the current approach to the clinical use of the available drugs for HIV infection. DATA SOURCES: Recent state of the art publications and key reference articles. CONCLUSIONS: Prognostic and monitoring parameters for HIV infection have been established based on new insights i
Hypereosinophilia and markedly elevated immunoglobulin E in a 3-year-old child [clinical conference]: Ann Allergy Asthma Immunol. 1998 May;80(5):371-6. Unique Identifier : AIDSLINE MED/98270767; Thakur BK; Murali MR; New D; Smith TH; Volkman D; Division of Allergy and Immunology, State University of New York,; Stony Brook, USA.
Probenecid hypersensitivity in AIDS: a case report.: Ann Allergy Asthma Immunol. 1998 May;80(5):416-8. Unique Identifier : AIDSLINE MED/98270776; Myers KW; Katial RK; Engler RJ; Department of Allergy and Immunology, Walter Reed Army Medical Center,; Washington, DC 20307, USA.; BACKGROUND: Cidofovir plus probenecid is a new therapeutic alternative for refractory cytomegalovirus and acyclovir-resistant herpes infections in AIDS patients. Probenecid is used in conjunction with the antiherpetic medication (cidofovir) in order to reduce the incidence of nephr
Peripheral blood manifestations of T(H)2 lymphocyte activation in stable atopic asthma and during exercise-induced bronchospasm.: Ann Allergy Asthma Immunol. 1998 May;80(5):424-32. Unique Identifier : AIDSLINE MED/98270778; Hallstrand TS; Ault KA; Bates PW; Mitchell J; Schoene RB; Maine Medical Center, Portland, USA.; BACKGROUND: Recently, TH2 lymphocyte activation has been shown to play a key role in initiating and propagating the inflammatory response in asthmatic airways. This is manifest through increased numbers of activated CD25-(IL-2R)-bearing T-helper cells and can be seen through the IL-5 driven recruitment of eosinophil
Phosphorylation and cytotoxicity of therapeutic nucleoside analogues: a comparison of alpha and gamma herpesvirus thymidine kinase suicide genes.: Cancer Gene Ther. 1998 Mar-Apr;5(2):83-91. Unique Identifier : AIDSLINE MED/98230225; Cazaux C; Tiraby M; Loubiere L; Haren L; Klatzmann D; Tiraby G; Laboratoire de Microbiologie et de Genetique, Universite Paul; Sabatier, Toulouse, France.; Thymidine kinase (TK) genes from three alpha-herpesviruses (i.e., human herpes simplex type 1, varicella-zoster virus, equid herpesvirus 4) and two y-herpesviruses (i.e., Epstein-Barr virus and Saimiri herpesvirus 2) were cloned in expression vectors based on zeocin resistance by complementation of a TK-defective Esch
HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr.: Mol Med. 1998 Mar;4(3):138-43. Unique Identifier : AIDSLINE MED/98224069; Bukrinsky MI; Haffar OK; Picower Institute for Medical Research, Manhasset, NY 11030, USA.; mbukrinsky@picower.edu
[Clinical characteristics of the peripheral form of epidemic neuropathy in the province of Cienfuegos]: Rev Neurol. 1997 Dec;25(148):1852-8. Unique Identifier : AIDSLINE MED/98188439; Cabrera-Gomez JA; Collazo H; Garcia-Francisco L; Lopez-Hernandez O; Rodriguez-Roque MO; Gomez A; Echazabal N; Barrios A; Solano R; Cruz L; Acuna V; Sanchez V; Casanova M; Cabrera-Nunez JA; Vega-Robles J; Departamento de Neurologia, hospitales Clinico-Quirurgico Dr. Gustavo; Aldereguia Lima.; INTRODUCTION: From October 1992 to September 1993 clinical observations of the civil population of Cienfuegos revealed the presence of epidemic neuropathy (EN) reaching about 2,000 patients. The clinical manifestations were not uniform. Although numerous studies have been carried out in our country, none have establis
Oral effects of AIDS [news]: MSDA J. 1995 Summer;38(2):79. Unique Identifier : AIDSLINE MED/98231380
Evaluation of a one-day AIDS continuing education course.: MSDA J. 1996 Spring;39(1):31-6. Unique Identifier : AIDSLINE MED/98231392; Cohen LA; Grace EG; DePaola LG; Baltimore College of Dental Surgery, Dental School, University of; Maryland, Baltimore 21201, USA.; The effectiveness of a one-day acquired immune deficiency syndrome (AIDS) continuing education course for dentists and hygienists was evaluated using pretest, posttest, and six-month follow-up questionnaires. There was a general, though not statistically significant, increase in the percentage of respondents who repor
The Dentists' Well-Being Committee of Maryland.: MSDA J. 1996 Summer;39(2):65-8. Unique Identifier : AIDSLINE MED/98231395; White R; Jones OJ; Employee Assistance Program, University of Maryland Medical System,; Baltimore 21201, USA.; The Maryland Dentist s Well-Being Committee was formed in 1980 as a standing committee of the Maryland State Dental Association. The committee has assisted many dentists over the years with problems such as stress, alcoholism, drug dependence, psychiatric disorders, medical problems, HIV (human immunodeficiency virus)
Developing support programs for dentists with infectious disease.: MSDA J. 1996 Summer;39(2):95-7. Unique Identifier : AIDSLINE MED/98231404; Abel SN; Crosby LR; Center of HIV-Related Disease, St. Claire Hospital Health Center, New; York, NY 10019, USA.; The American Dental Association (ADA) has developed many resources to address growing concerns regarding HIV (human immunodeficiency virus) issues in dental practice, including continuing education courses, workshops, journal articles, and monographs. In addition, the ADA Council on Dental Practice has established a n
Postliver transplant allograft reinfection with a lamivudine-resistant strain of hepatitis B virus: long-term follow-up.: Can J Gastroenterol. 1998 Mar;12(2):125-9. Unique Identifier : AIDSLINE MED/98219961; Yoshida EM; Ma MM; Davis JE; Fischer KP; Kneteman NM; Erb SR; Tyrrell DL; Bain VG; Department of Medicine, University of British Columbia.; Lamivudine is a nucleoside analogue with efficacy in the suppression of hepatitis B viral (HBV) replication. In a previously reported study, lamivudine was administered to patients with chronic, actively replicating HBV infection who subsequently unde
AIDS in Africa [letter]: CMAJ. 1998 May 5;158(9):1129. Unique Identifier : AIDSLINE MED/98260247; Tectonidis M
A side effect of protease inhibitors [letter]: CMAJ. 1998 May 5;158(9):1129-30. Unique Identifier : AIDSLINE MED/98260248; Teitel J
Trichosanthin inhibits T cell activation by interfering with the recruitment of ZAP-70 to CD3 zeta chain.: Cell Res. 1998 Mar;8(1):33-9. Unique Identifier : AIDSLINE MED/98231534; Hong J; Fu SL; Shen ZY; Lu PH; Chou KY; Shanghai Institute of Immunology, Shanghai Second Medical University,; China.; Plant protein Trichosanthin (Tk) has been shown in our previous experiments to suppress antigenic response of T cells. Here we explored its inhibitory mechanisms on the proliferation of human Jurkat leukemia T cell triggered by anti-CD3 McAb. By examination of tyrosine phosphorylation of cell lysate, we were able to s
Suppression of HIV-1 replication in peripheral blood mononuclear cells by fasudil.: J Med Invest. 1998 Feb;44(3-4):211-4. Unique Identifier : AIDSLINE MED/98260102; Akari H; Yamamoto Y; Hiwada H; Saito Y; Takayanagi N; Koyama AH; Adachi A; Department of Virology, University of Tokushima School of Medicine,; Japan.; Fasudil is a potent inhibitor for various protein kinases such as myosin light chain kinase and protein kinase C. It has been used as a drug for improvement of intracranial vasospasm and following ischaemic diseases. In this report, we demonstrate that fasudil suppressed the replication of human immunodeficiency virus
[Differentiation of cytology of BALF between BOOP and UIP]: Chung Hua Chieh Ho Ho Hu Hsi Tsa Chih. 1996 Oct;19(5):276-8. Unique Identifier : AIDSLINE MED/98259127; Zhong D; Shi H; Department of Respiratory Disease, First Affiliated Hospital, Guangxi; Medical University, Nanning.; OBJECTIVE: BOOP is a disease entity proposed by Epler in 1985, and UIP is considered an important disease to be differentiated from BOOP. The aim of this study was to identify characteristic features in BALF samples of patients with BOOP and UIP. METHODS: Differential cell count and T-cell subpopulation of the BALF ob
Few opportunities found for tuberculosis prevention among the urban poor.: Int J Tuberc Lung Dis. 1998 Feb;2(2):124-9. Unique Identifier : AIDSLINE MED/98220590; Bock NN; McGowan JE Jr; Blumberg HM; Department of Medicine, Emory University School of Medicine and Grady; Memorial Hospital, Atlanta, Georgia 30303, USA.; SETTING: Grady Memorial Hospital, a public hospital in Atlanta, Georgia, a city with high rates of tuberculosis. OBJECTIVE: To identify specific points of contact with the public health system where high risk individuals could receive tuberculin testing and isoniazid preventive therapy. DESIGN: Patient interviews and
Directly observed therapy in an inner city hospital [see comments]: Int J Tuberc Lung Dis. 1998 Feb;2(2):134-9. Unique Identifier : AIDSLINE MED/98220592; Smirnoff M; Goldberg R; Indyk L; Adler JJ; Department of Nursing, The Mount Sinai Medical Center, New York, New; York, USA.; SETTING: A directly observed therapy (DOT) tuberculosis (TB) program in a large urban teaching hospital in the East Harlem section of New York City. OBJECTIVE: In response to an emergent epidemic of TB, the State Department of Health mobilized a coalition of providers outside the public sector to provide DOT and medic
Influence of the human immunodeficiency virus in the incidence of tuberculosis in a cohort of intravenous drug users: effectiveness of anti-tuberculosis chemoprophylaxis.: Int J Tuberc Lung Dis. 1998 Feb;2(2):140-6. Unique Identifier : AIDSLINE MED/98220593; Jansa JM; Serrano J; Cayla JA; Vidal R; Ocana I; Espanol T; Department of Epidemiology, Municipal Institute of Health, Barcelona,; Spain. jjansa@imsb.bcn.es; SETTING: A residential program in Barcelona for drug addicts therapeutic community) admitted between November 1988 and March 1992, and followed until September 1994. OBJECTIVE: To study the incidence of tuberculosis as related to the presence of tuberculosis infection and/or human immunodeficiency virus (HIV) infectio
Detection of anti-lipoarabinomannan antibodies for the diagnosis of active tuberculosis.: Int J Tuberc Lung Dis. 1998 Feb;2(2):160-3. Unique Identifier : AIDSLINE MED/98220596; Del Prete R; Picca V; Mosca A; D'Alagni M; Miragliotta G; Institute of Medical Microbiology, University of Bari, Italy.; SETTING: A serological test that contributes in diagnosing tuberculosis would aid patient management. OBJECTIVE: To evaluate MycoDot, a new commercially available serological test, for the detection of immunoglobulin G antibodies to lipoarabinomannan LAM), a glycolipid common to mycobacteria. DESIGN: Serum samples fro
HIV infection among patients with tuberculosis in KwaZulu/Natal, South Africa [letter]: Int J Tuberc Lung Dis. 1998 Feb;2(2):172. Unique Identifier : AIDSLINE MED/98220599; Colvin M; Karim Abdool SS
Adrenocortical function in active pulmonary tuberculosis [letter]: Int J Tuberc Lung Dis. 1998 Feb;2(2):172-4. Unique Identifier : AIDSLINE MED/98220600; Kelestimur F
Treatment regimens in HIV-infected tuberculosis patients. An official statement of the International Union Against Tuberculosis and Lung Disease. Paris, 16 September 1997.: Int J Tuberc Lung Dis. 1998 Feb;2(2):175-8. Unique Identifier : AIDSLINE MED/98220601
A review of sex differences in the epidemiology of tuberculosis.: Int J Tuberc Lung Dis. 1998 Feb;2(2):96-104. Unique Identifier : AIDSLINE MED/98220586; Holmes CB; Hausler H; Nunn P; Tuberculosis Research and Surveillance Unit, Global Tuberculosis; Programme, World Health Organization, Geneva, Switzerland.; Globally, the prevalence of infection with Mycobacterium tuberculosis is similar in males and females until adolescence, after which it is higher in males. In industrialized countries in the middle of this century (1930s to 1950s), females aged 15 to 34 years had higher tuberculosis notification rates than males of th
Fluoroquinolones: a new treatment for tuberculosis?: Int J Tuberc Lung Dis. 1998 Apr;2(4):265-71. Unique Identifier : AIDSLINE MED/98220150; Gillespie SH; Kennedy N; Department of Medical Microbiology, Royal Free Hospital School of; Medicine, London, UK. stepheng@rfhsm.ac.uk; The fluoroquinolones have secured an important place in the management of bacterial infection, they are well absorbed orally, are found in respiratory secretions in higher concentrations than in serum and are concentrated inside macrophages. The agents are well tolerated and have an excellent safety record in long-ter
The molecular epidemiology of tuberculosis in Zaragoza, Spain: a retrospective epidemiological study in 1993.: Int J Tuberc Lung Dis. 1998 Apr;2(4):281-7. Unique Identifier : AIDSLINE MED/98220152; Samper S; Iglesias MJ; Rabanaque MJ; Lezcano MA; Vitoria LA; Rubio MC; Gomez-Lus R; Gomez LI; Otal I; Martin C; Department of Microbiology and Preventive Medicine, School of; Medicine, University of Zaragoza, Spain.; SETTING: The incidence of tuberculosis (TB) in Spain is one of the highest in Europe. In Zaragoza region the incidence rate of tuberculosis and the acquired immune deficiency syndrome (AIDS) are close to the national average. OBJECTIVE: To better define the molecular epidemiology of
Nationwide surveillance of drug-resistant tuberculosis in The Netherlands: rates, risk factors and treatment outcome.: Int J Tuberc Lung Dis. 1998 Apr;2(4):288-95. Unique Identifier : AIDSLINE MED/98220153; Lambregts-van Weezenbeek CS; Jansen HM; Nagelkerke NJ; van Klingeren B; Veen J; Royal Netherlands Tuberculosis Association (KNCV), The Hague, The; Netherlands.; SETTING: The Netherlands , 1993 and 1994. OBJECTIVE: To determine 1) rates of drug resistance in relation to nationality and country of birth, 2) risk factors for drug resistance, 3) treatment outcome of drug-resistant cases, and 4) rates of primary and acquired drug resistance
Drug-resistant tuberculosis in human immunodeficiency virus infected persons in Italy. The Italian Drug-Resistant Tuberculosis Study Group.: Int J Tuberc Lung Dis. 1998 Apr;2(4):303-11. Unique Identifier : AIDSLINE MED/98220155; Angarano G; Carbonara S; Costa D; Gori A; Institute of Infectious Disease, University of Bari, Italy.; OBJECTIVE: To describe the prevalence and epidemiological-clinical characteristics of tuberculosis (TB) resistance to first-line drugs in Italian human immunodeficiency virus (HIV)-infected subjects. DESIGN: Prospective, observational multicenter (25 Centers of Infectious Diseases) study. Mycobacterium tuberculosis st
The bacteriology of pulmonary tuberculosis in a population with high human immunodeficiency virus seroprevalence.: Int J Tuberc Lung Dis. 1998 Apr;2(4):312-6. Unique Identifier : AIDSLINE MED/98220156; Karstaedt AS; Jones N; Khoosal M; Crewe-Brown HH; Department of Medicine, Baragwanath Hospital, Johannesburg, South; Africa.; SETTING: A public sector urban university hospital in Soweto, South Africa . OBJECTIVE: To describe the utility of sputum smear microscopy and the prevalence of Mycobacterium tuberculosis resistance to antituberculosis drugs according to human immunodeficiency virus (HIV) serostatu
Lack of direct correlation between CD4 T-lymphocyte counts and induration sizes of the tuberculin skin test in human immunodeficiency virus type 1 seropositive patients.: Int J Tuberc Lung Dis. 1998 Apr;2(4):317-23. Unique Identifier : AIDSLINE MED/98220157; Diagbouga S; Fumoux F; Ledru E; Sanou PT; Barro D; Marchal G; Centre MURAZ, Organisation de Coordination et de Cooperation pour la; lutte contre les Grandes Endemies (OCCGE), Bobo-Dioulasso, Burkina; Faso, France.; SETTING: The study was conducted in Bobo-Dioulasso, Burkina Faso , where Mycobacterium tuberculosis infection and human immunodeficiency virus type 1 (HIV-1) infection are prevalent. OBJECTIVE: To identify proportions of representative (test) populations who are reactive to the tub
Disseminated histoplasmosis presenting with cutaneous lesions in a patient with acquired immunodeficiency syndrome.: J Eur Acad Dermatol Venereol. 1998 Mar;10(2):182-5. Unique Identifier : AIDSLINE MED/98214539; Angius AG; Viviani MA; Muratori S; Cusini M; Brignolo L; Alessi E; Institute of Dermatological Sciences of the University of Milan, IRCCS; Ospedale Maggiore of Milan, Italy.; OBJECTIVE: Presentation of a case of disseminated histoplasmosis, observed in a non-endemic area, in which cutaneous lesions and fever were the dominant clinical signs of the infection. CASE: A 54-year-old homosexual man with acquired immunodeficiency syndrome (AIDS) related Kaposi s sarcoma presented with cutaneous l
AIDS wasting syndrome as an enterometabolic disorder: the gut hypothesis.: Altern Med Rev. 1998 Feb;3(1):40-53. Unique Identifier : AIDSLINE MED/98262759; Kaminski M Jr; Weil S; Bland J; Jan P; FUHS/Chicago Medical School, USA.; There is an interesting relationship between the HIV virus, the health of the gastrointestinal tract, and AIDS wasting syndrome, involving Tumor Necrosis Factor alpha (TNF alpha), specific and non-specific immunity in the gut, gut permeability, and oxidative stress. It is hypothesized that the progression of HIV to fu
Two-tiered health care: the root of ethical problems in recent clinical trials [editorial]: Int J Infect Dis. 1998 Jan-Mar;2(3):123-6. Unique Identifier : AIDSLINE MED/98246588; Brewer TF; Heymann SJ
Intramedullary tuberculoma in a patient with human immunodeficiency virus infection and disseminated multidrug-resistant tuberculosis: case report.: Int J Infect Dis. 1998 Jan-Mar;2(3):164-7. Unique Identifier : AIDSLINE MED/98281371; Borges MA; Carmo MI; Sambo MR; Borges FC; Araujo CM; Campos MJ; Jacinto AM; Mansinho K; Leitao OC; Department of Internal Medicine, Hospital Egas Moniz, Lisbon,; Portugal.
Paracoccidioidomycosis and tuberculosis in AIDS patients: report of two cases in Brazil.: Int J Infect Dis. 1998 Jan-Mar;2(3):168-72. Unique Identifier : AIDSLINE MED/98281372; Nogueira SA; Caiuby MJ; Vasconcelos V; Halpern M; Gouveia C; Thorpe B; Ramparini C; Macieira JM; Lambert JS; Infectious Disease Service, Hospital Universitario Clementino Fraga; Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil.
An AIDS patient with fever and pancytopenia.: Int J Infect Dis. 1998 Jan-Mar;2(3):173-5. Unique Identifier : AIDSLINE MED/98281373; Nord J; Karter D; LaBombardi V; Department of Medicine, Saint Vincent's Hospital and Medical Center,; New York, New York 10011, USA.
Acute cholecystitis in AIDS patients: correlation of Tc-99m hepatobiliary scintigraphy with histopathologic laboratory findings and CD4 counts.: Clin Nucl Med. 1998 Apr;23(4):226-8. Unique Identifier : AIDSLINE MED/98214812; Cacciarelli AG; Naddaf SY; el-Zeftawy HA; Aziz M; Omar WS; Kumar M; Atay S; Abujudeh H; Gillooley J; Abdel-Dayem HM; Department of Medicine, St Vincent's Hospital and Medical Center of; New York, Valhalla 10011, USA.; BACKGROUND: AIDS patients are susceptible to opportunistic gastrointestinal infections including ascending cholangitis and cholecystitis, especially if CD4 count is
Kaposi's sarcoma following long-term immunosuppressive therapy: clinical, histologic, and ultrastructural study.: Cutis. 1998 Mar;61(3):137-41; quiz 152. Unique Identifier : AIDSLINE MED/98199780; Roszkiewicz A; Roszkiewicz J; Lange M; Tukaj C; Department of Pathomorphology, Medical Academy of Gdansk, Poland.; Multifocal Kaposi s sarcoma in a patient with chronic myeloid leukemia treated with busulfan, a cytostatic and suppressive drug, is reviewed. After five years of treatment, during which temporary remissions occurred, the patient experienced a relapse of leukemia and a considerable immune deficiency. This was expressed
Low serum antimycobacterial drug levels in non-HIV-infected tuberculosis patients [see comments]: Chest. 1998 May;113(5):1178-83. Unique Identifier : AIDSLINE MED/98255730; Kimerling ME; Phillips P; Patterson P; Hall M; Robinson CA; Dunlap NE; Division of International Health, School of Public Health, University; of Alabama at Birmingham, 35294-0008, USA.; BACKGROUND: Despite the use of directly observed therapy (DOT) by tuberculosis control programs, patient treatment failure, relapse, and acquired drug resistance remain problematic in a small number. We investigated serum drug levels in non-HIV-infected tuberculosis patients who were receiving DOT by the health depart
Use of adjunctive corticosteroids in severe adult non-HIV Pneumocystis carinii pneumonia.: Chest. 1998 May;113(5):1215-24. Unique Identifier : AIDSLINE MED/98255736; Pareja JG; Garland R; Koziel H; Department of Medicine, Beth Israel Deaconess Medical Center and; Harvard Medical School, Boston, MA 02215, USA.; STUDY OBJECTIVE: To examine the use of adjunctive corticosteroids in cases of severe Pneumocystis carinii pneumonia (PCP) in non-HIV-infected adult patients. DESIGN: Retrospective review of medical records. SETTING: Tertiary care urban teaching hospital. PATIENTS: Review identified 31 consecutive histologically confir
Pulmonary complications of HIV infection: autopsy findings.: Chest. 1998 May;113(5):1225-9. Unique Identifier : AIDSLINE MED/98255737; Afessa B; Green W; Chiao J; Frederick W; Division of Critical Care, University of Florida Health Science; Center, Jacksonville, USA.; STUDY OBJECTIVES: To describe the pulmonary complications in patients with HIV infection, and the changes in the incidence of these complications over a 12-year period. DESIGN: Retrospective review of autopsy records. SETTING: Two university-affiliated medical centers. PATIENTS: We studied autopsy findings from 233 pa
[Appeal to prevent the spread of AIDS (editorial)]: Chung Hua Nei Ko Tsa Chih. 1996 Oct;35(10):651-2. Unique Identifier : AIDSLINE MED/98254658; Zhang J
Detection of HIV-RNA-positive monocytes in peripheral blood of HIV-positive patients by simultaneous flow cytometric analysis of intracellular HIV RNA and cellular immunophenotype.: Cytometry. 1998 Apr 1;31(4):265-74. Unique Identifier : AIDSLINE MED/98211324; Patterson BK; Mosiman VL; Cantarero L; Furtado M; Bhattacharya M; Goolsby C; Department of Obstetrics and Gynecology, Northwestern University; Medical School, Department of Medicine, Chicago, Illinois 60611, USA.; bpatters@nmh.org; Determinations of plasma HIV viral RNA copy numbers help to define the kinetics of HIV-1 infection in vivo and to monitor antiretroviral therapy. However, questions remain regarding the identity of various infected cell types contributing to this free virus pool and to the in vivo lifecycle of HIV during disease progr
Immunopathology of T-lymphocyte subsets in juvenile and rapidly progressive periodontitis.: Egypt Dent J. 1994 Jan;40(1):581-8. Unique Identifier : AIDSLINE MED/98249739; Abdel-Razzak MY; Abo-Azma NE; el-Zefzaf E; Ghoneim SM; Faculty of Dentistry, Tanta University.; The immunopathology of T4 & T8 cell subsets in gingival tissues from 20 patients affected with either juvenile (JP) or rapidly progressive periodontitis (RPP) were studied using immunoperoxidase method for monoclonal antibodies of T4 & T8. Results were compared with gingival samples taken from systemically and
Demonstration of T-cell subsets in oral lichen planus.: Egypt Dent J. 1994 Jan;40(1):633-8. Unique Identifier : AIDSLINE MED/98249747; el-Zefzaf E; Abd-el-Razzak M; Ghoneim S; Abu-Azma N; Oral Medicine, Department Faculty of Dentistry, Tanta University.; The distribution of T cell subsets (T4 & T8) in 10 lesions of oral lichen planus was investigated using an immuno-peroxidase technique. Most of the infiltrating cells consisted of a mixture of T4 (helper/inducer) and T8 (suppressor/cytotoxic) cells, presented in the stroma with varied intensity in their distributio
Identification of lymphocyte subsets in pregnancy gingivitis.: Egypt Dent J. 1994 Jan;40(1):653-6. Unique Identifier : AIDSLINE MED/98249750; Aboul-Dahab OM; el-Sherbiny MM; Abdel-Rahman R; Shoeb M; Faculty of Oral and Dental Medicine, Cairo University.; The percentage of gingival tissue and peripheral T, T Subsets and B lymphocytes were assessed in ten pregnant women during the first, second and third trimesters. Clinically the gingival index GI) was found to be higher during pregnancy than in the control group. The percentage of the T3, T4 and B cells appeared to de
Further studies on the immunopathology of atopic keratoconjunctivitis using flow cytometry.: Exp Eye Res. 1997 Dec;65(6):803-8. Unique Identifier : AIDSLINE MED/98279263; Avunduk AM; Avunduk MC; Dayanir V; Tekelioglu Y; Karadeniz Technical University, School of Medicine, Department of; Ophthalmology, Trabzon, Turkey.; Atopic keratoconjunctivitis (AKC) is an ocular manifestation of systemic hypersensitivity. Although the pathogenesis of AKC is not fully understood, some previous data suggest that a decrease in numbers of suppressor T lymphocyte (Ts) and increase of Th, especially Th2 (the second subgroup of helper T lymphocyte), at
Epidemiological aspects of tuberculosis in the Padua Health District 1985-1996.: Eur J Epidemiol. 1998 Feb;14(2):125-8. Unique Identifier : AIDSLINE MED/98215457; Baldo V; Menegon T; Zannoni F; Angelopoulos A; Majori S; Piron L; Renzulli G; Trivello R; Institute of Hygiene, University of Padua, Italy.; trivello@ux1.unipd.it; The present study was carried out in order to monitor the epidemiology of Mycobacterium tuberculosis disease in the Padua Health District over the period 1985-1996 with a view to the situation in some population subgroups. The average annual rate per 100,000 persons per year was 7.9 with a peak in 1994 (15.6 per 100,0
Validity and reliability in reporting sexual partners and condom use in a Swiss population survey.: Eur J Epidemiol. 1998 Feb;14(2):139-46. Unique Identifier : AIDSLINE MED/98215459; Jeannin A; Konings E; Dubois-Arber F; Landert C; Van Melle G; Institute of Social and Preventive Medicine, University of Lausanne,; Switzerland. Andre.Jeannin@inst.hospvd.ch; OBJECTIVES: To examine the validity and reliability of indicators of sexual behaviour and condom use in annual telephone surveys n=2800) of the general population aged 17 to 45 for the evaluation of AIDS prevention in Switzerland . METHODS: A test-retest study with additional f
Importance of the N-glycan in the V3 loop of HIV-1 envelope protein for CXCR-4- but not CCR-5-dependent fusion.: FEBS Lett. 1998 Apr 24;426(3):367-72. Unique Identifier : AIDSLINE MED/98260895; Nakayama EE; Shioda T; Tatsumi M; Xin X; Yu D; Ohgimoto S; Kato A; Sakai Y; Ohnishi Y; Nagai Y; Department of Viral Infection, Institute of Medical Science,; University of Tokyo, Japan.; The V3 region of HIV-1 envelope protein possesses a single N-linked sugar chain, which is conserved in most HIV-1 strains. We studied its role in the life cycle of HIV-1 strains with different co-receptor usage. Removal of the glycan appeared to cause a marked reduction of CXCR-4- but not CCR-5-dependent virus entry.
Pregnancy outcome in women with beta-thalassemia major and HIV infection.: Eur J Obstet Gynecol Reprod Biol. 1998 Apr;77(2):163-9. Unique Identifier : AIDSLINE MED/98237384; Kumar RM; Khuranna A; Department of Obstetrics and Gynaecology, Faculty of Medicine and; Health Sciences, UAE University, Al Ain, United Arab Emirates.; OBJECTIVES: To conduct a study of maternal and foetal outcome in pregnant transfusion-dependent beta-thalassemia major (beta-TM) women with HIV-1 disease. STUDY DESIGN: The course and outcome of pregnancy was studied prospectively in 123 women with transfusion-dependent beta-thalassemia major, of which 81 were HIV-1 p
[Lactic acidosis and hepatic mitochondrial changes during a treatment with zidovudine]: Gastroenterol Clin Biol. 1997;21(12):979-81. Unique Identifier : AIDSLINE MED/98249143; Charton-Bain MC; Flamant M; Aubertin JM; Belair MF; Gilquin J; Kazatchkine M; Bruneval P; Service d'Anatomie Pathologique, Hopital Broussais, Paris.; Adverse effects of zidovudine, which mainly result in myopathies and hematological disorders, could be due to multitissular mitochondrial toxicity of the drug. During zidovudine treatment, most cases of lactic acidosis have been attributed to mitochondrial myopathy. We report a case of hepatocellular failure with lact
[Efficacy of lamivudine on the replication of hepatitis B virus in a patient with acquired immunodeficiency syndrome (letter)]: Gastroenterol Clin Biol. 1997;21(12):997-8. Unique Identifier : AIDSLINE MED/98249148; Gil H; Vuitton DA; Rozenbaum A; Bresson-Hadni S; Dupond JL
Adequacy of screening cervical cytology among human immunodeficiency virus-seropositive women.: Gynecol Oncol. 1998 May;69(2):109-13. Unique Identifier : AIDSLINE MED/98263210; Spinillo A; Capuzzo E; Tenti P; De Santolo A; Piazzi G; Iasci A; Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo,; Pavia, Italy.; OBJECTIVE: To evaluate the adequacy of cytology in detecting cervical intraepithelial neoplasia (CIN) among human immunodeficiency virus (HIV)-seropositive women compared to controls. METHODS: A cross-sectional study was carried out evaluating 241 HIV-seropositive women and 991 controls (404 HIV seronegative and 587 o
Flow cytometric characterization of human umbilical cord blood lymphocytes: immunophenotypic features.: Haematologica. 1998 Mar;83(3):197-203. Unique Identifier : AIDSLINE MED/98234755; D'Arena G; Musto P; Cascavilla N; Di Giorgio G; Fusilli S; Zendoli F; Carotenuto M; Division of Hematology, IRCCS Casa Sollievo della Sofferenza Hospital,; San Giovanni Rotondo, Italy.; BACKGROUND AND OBJECTIVE: One of the most important potential advantages in the use of human umbilical cord blood (HUCB) for hematopoietic reconstitution after myeloablative therapy seems to be the lower occurrence of acute graft-versus-host-disease (GvHD) in recipients after allogeneic transplantation. Since mature T
Mutational analysis of the CCR5 and CXCR4 genes (HIV-1 co-receptors) in resistance to HIV-1 infection and AIDS development among intravenous drug users.: Hum Genet. 1998 Apr;102(4):483-6. Unique Identifier : AIDSLINE MED/98260876; Alvarez V; Lopez-Larrea C; Coto E; Laboratorio de Genetica Molecular (Instituto Reina Sofia de; Investigaciones Nefrologicas), Hospital Central de Asturias, Oviedo,; Spain.; We analysed a group of Spanish intravenous drug users and controls to determine the role of mutations at the chemokine receptor-5/HIV-1 cofactor (CCR5), previously implicated in resistance to HIV-1 infection, and CXCR4 genes in susceptibility to HIV-1 infection. The complete coding sequence of both genes was amplified
CD8+ T cells inhibit immunoglobulin E synthesis in low responder SJL/J mice.: Immunology. 1998 Feb;93(2):230-7. Unique Identifier : AIDSLINE MED/98279345; Yang M; Cao Y; Mohapatra SS; Department of Immunology, University of Manitoba, Winnipeg, Canada.; In an effort to examine the basis for low IgE responsiveness of SJL/J strain mice, we analysed the profiles of cytokines, such as interleukin-2 ( IL-2 ), IL-4 and interferon-gamma (IFN-gamma), in SJL/J and A.SW/SnJ mice following immunization. Splenocytes of ovalbumin (O
Projection of HIV infection in Calcutta.: Indian J Med Res. 1998 Apr;107:159-72. Unique Identifier : AIDSLINE MED/98267902; Basu A; Basu S; Chakraborty MS; Dewanji A; Ghosh JK; Majumder PP; Indian Statistical Institute, West Bengal, Calcutta.; Starting with the base year of 1991, the HIV infection projection for 1992-99 for the total, as well as various high-risk sub-populations of Calcutta, the first of its kind is provided. These projections are based on statistical methodology developed in this paper. Our methodology for spread of HIV infection takes int
A study on opportunistic enteric parasites in 80 HIV seropositive patients.: Indian J Pathol Microbiol. 1998 Jan;41(1):31-7. Unique Identifier : AIDSLINE MED/98242175; Talib SH; Singh J; Department of Medicine, Government Medical College, Aurangabad,; Maharashtra.; AIDS is characteristically associated with several opportunistic enteric protozoal infestations that cause chronic and at times fatal diarrhoeas. A study is undertaken to isolated opportunistic enteric parasites in 80 HIV seropositive patients. An attempt is made to correlate and signify the presence of coexistent ora
Correlation between plasma levels of cytokines and HIV-1 RNA copy number in HIV-infected patients.: Infection. 1998 Mar-Apr;26(2):100-3. Unique Identifier : AIDSLINE MED/98222163; Hittinger G; Poggi C; Delbeke E; Profizi N; Lafeuillade A; Dept. of Infectious Diseases, Hopital Chalucet, Toulon, France.; The plasma levels of HIV-1 RNA, tumor necrosis factor alpha TNF-alpha), soluble receptors type II of TNF-alpha (sTNF-alpha RII), soluble receptors of interleukin-4 (sR IL-4), interleukin-6 IL-6), soluble receptors of interleukin-6 (sR IL-6), granulocyte macrophage colony stimulating factor (GM-CSF), soluble receptors
Imbalance in cytokine production by whole blood related to presence of cytopathogenic HIV-1 strains in HIV-1-infected patients.: Infection. 1998 Mar-Apr;26(2):109-12. Unique Identifier : AIDSLINE MED/98222165; Benyoucef S; Lion G; Gerard Y; Wattre P; De Groote D; Hober D; Laboratorie de Virologie, Institut Gernez Rieux, CHU, Lille, France.; The possible association between the emergence of cytopathogenic HIV-1 variants and disturbance of the cytokine production in the course of HIV-1 infection was studied in 18 infected patients. The cytopathogenicity of the isolates was studied in a microassay based on the use of HIV-1-infectible Hela-CD4 cells carrying
Prophylaxis of Pneumocystis carinii pneumonia in HIV-infected children one to five years old: a multicenter surveillance study in paediatric hospitals in Germany [letter]: Infection. 1998 Mar-Apr;26(2):135. Unique Identifier : AIDSLINE MED/98222172; Rummelein N; Wintergerst U; Belohradsky BH
Mediterranean leishmaniasis in HIV-infected patients: epidemiological, clinical, and diagnostic features of 22 cases.: Infection. 1998 Mar-Apr;26(2):93-9. Unique Identifier : AIDSLINE MED/98222162; Agostoni C; Dorigoni N; Malfitano A; Caggese L; Marchetti G; Corona S; Gatti S; Scaglia M; Infectious Diseases Research Labs, University-IRCCS San Matteo, Pavia,; Italy.; Twenty-two Italian HIV-infected patients developed leishmaniasis, clinically manifested as visceral (13 cases), cutaneous (2 cases) and disseminated disease (7 cases). Twenty were males and two females (mean age: 32.8 years) with a mean CD4+ cell count of 46.8/microliter at diagnosis; risk factors were intravenous dru
Role of nitric oxide in the regulation of lymphocyte apoptosis and HIV-1 replication.: Int J Immunopharmacol. 1997 Jul;19(7):387-97. Unique Identifier : AIDSLINE MED/98229966; Hermann E; Idziorek T; Kusnierz JP; Mouton Y; Capron A; Bahr GM; Unite INSERM 167, Institut Pasteur de Lille, France.; Nitric oxide (NO) has been implicated in certain immunopathogenetic mechanisms during the course of infection with human immunodeficiency virus (HIV). We have evaluated the levels of NO release and lymphocyte apoptosis in peripheral blood mononuclear cell (PBMC) cultures from HIV-1 infected subjects and healthy contro
Provisional country estimates of prevalent adult human immunodeficiency virus infections as of end 1994: a description of the methods.: Int J Epidemiol. 1998 Feb;27(1):101-7. Unique Identifier : AIDSLINE MED/98223191; Burton AH; Mertens TE; Surveillance, Evaluation, and Forecasting Unit, Global Programme on; AIDS, World Health Organization, Geneva, Switzerland.; BACKGROUND: A country-by-country review of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) data was undertaken by the World Health Organization . This paper describes the methods used to make estimates of HIV prevalence. RESULTS: It is estimated that, global
A review of hepatitis C virus (HCV) vertical transmission: risks of transmission to infants born to mothers with and without HCV viraemia or human immunodeficiency virus infection.: Int J Epidemiol. 1998 Feb;27(1):108-17. Unique Identifier : AIDSLINE MED/98223192; Thomas SL; Newell ML; Peckham CS; Ades AE; Hall AJ; Department of Epidemiology & Biostatistics, Institute of Child Health,; London, UK.; BACKGROUND: Hepatitis C virus (HCV) vertical transmission studies have reported conflicting findings, possibly due to differences in HCV transmission risk factors among maternal populations, or to methodological differences. METHODS: Systematic review of worldwide published and unpublished HCV vertical transmission st
Epidemiology of drug-resistant tuberculosis in New Jersey from 1991 to 1995.: Int J Epidemiol. 1998 Feb;27(1):121-6. Unique Identifier : AIDSLINE MED/98223194; Liu Z; Shilkret KL; Finelli L; New Jersey Department of Health and Senior Services, Division of; Communicable Diseases, Trenton 08625-0369, USA.; BACKGROUND: In a nationwide survey in 1991, the proportion of Mycobacterium tuberculosis isolates resistant to both isoniazid and rifampin (MDR-TB) in New Jersey (6.6%) was ranked second highest in the United States . The objectives of this study were to describe drug-resistant TB trend
Intrafamilial clustering and 4-year follow-up of asymptomatic human T-cell leukaemia virus type I (HTLV-I) infection in Benin West Africa).: Int J Epidemiol. 1998 Feb;27(1):146-52. Unique Identifier : AIDSLINE MED/98223198; Houinato D; Verdier M; Preux PM; Josse R; Letenneur L; Ayed Z; Avode G; Massit B; Boutros-Toni F; Denis F; Zohoun T; Salamon R; Dumas M; Institute of Neuroepidemiology and Tropical Neurology, School of; Medicine, Limoges, France.; BACKGROUND: Few data exist concerning familial human T-cell leukaemia virus type I (HTLV-I) carrier states and transmission in African countries. Two previous surveys performed in Benin in 1989 and 1990 using a three-level cluster sampling method allowed us to identify HTLV-I positi
Cytomegalovirus glycoprotein B genotyping in ocular fluids and blood of AIDS patients with cytomegalovirus retinitis.: Invest Ophthalmol Vis Sci. 1998 Jun;39(7):1183-7. Unique Identifier : AIDSLINE MED/98281388; Peek R; Verbraak F; Bruinenberg M; Van der Lelij A; Van den Horn G; Kijlstra A; Netherlands Ophthalmic Research Institute, Amsterdam.; PURPOSE: To determine the frequency of cytomegalovirus glycoprotein B (gB) genotypes in clinical samples of ocular fluids of patients with acquired immune deficiency syndrome AIDS) who have cytomegalovirus retinitis and to compare these with the cytomegalovirus gB genotype in paire
Distinct patterns of T cell receptor distribution of peripheral blood CD8+ cells during different stages of chronic infection with hepatitis B virus.: Hum Immunol. 1998 Apr;59(4):199-211. Unique Identifier : AIDSLINE MED/98227746; Chen X; Cooksley G; Sing G; Clinical Research Centre, Royal Brisbane Hospital Research Foundation,; Australia.; We compared the Vbeta TCR repertoires of CD8+ peripheral blood lymphocytes between 21 patients with chronic hepatitis B (CHB) and 9 healthy individuals, using RT-PCR analysis. Several differences were seen between CHB patients and controls, including a marked increase in the expression of two to five Vbeta families in
Cytokine profile associated to effector functions of human T cell clones specific for Schistosoma mansoni antigens.: Hum Immunol. 1998 Apr;59(4):219-24. Unique Identifier : AIDSLINE MED/98227748; Silva-Teixeira DN; Contigli C; Goes AM; Departamento de Bioquimica e Imunologia, Inst. Ciencias Biologicas,; Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.; T cell lines and clones specific for Schistosoma mansoni antigens were established to study cellular immunity in human schistosomiasis. Flow cytometric analysis of the clones demonstrated that all of them were of the helper inducer T cell subset (CD3+, CD4+, CD8-), and expressed the alphabeta T cell receptor, besides
Mapping of multiple RNA binding sites of human T-cell lymphotropic virus type I rex protein within 5'- and 3'-Rex response elements.: J Biol Chem. 1998 May 8;273(19):11463-71. Unique Identifier : AIDSLINE MED/98234324; Askjaer P; Kjems J; Department of Molecular and Structural Biology, University of Aarhus,; C. F. Mollers Alle, Building 130, DK-8000 Aarhus C, Denmark.; Interaction between the human T-cell lymphotropic virus type I Rex protein and viral transcripts in the nucleus is essential to the cytoplasmic appearance of unspliced and singly spliced viral RNA. Rex has been shown to mediate its function through direct interaction with a highly ordered secondary structure in the 3
Pre-steady state of reaction of nucleoside diphosphate kinase with anti-HIV nucleotides.: J Biol Chem. 1998 May 8;273(19):11491-7. Unique Identifier : AIDSLINE MED/98234328; Schneider B; Xu YW; Sellam O; Sarfati R; Janin J; Veron M; Deville-Bonne D; Unite de Regulation Enzymatique des Activites Cellulaires, CNRS URA; 1149, France.; The pre-steady-state reaction of Dictyostelium nucleoside diphosphate (NDP) kinase with dideoxynucleotide triphosphates ddNTP) and AZT triphosphate was studied by quenching of protein fluorescence after manual mixing or by stopped flow. The fluorescen
Molecular ordering in HIV-induced apoptosis. Oxidative stress, activation of caspases, and cell survival are regulated by transaldolase.: J Biol Chem. 1998 May 8;273(19):11944-53. Unique Identifier : AIDSLINE MED/98234389; Banki K; Hutter E; Gonchoroff NJ; Perl A; Department of Pathology, State University of New York Health Science; Center, College of Medicine, Syracuse, New York 13210, USA.; Dysregulated apoptosis may underlie the etiology of T cell depletion by human immunodeficiency virus type 1 (HIV-1). We show that HIV-induced apoptosis is preceded by an exponential increase in reactive oxygen intermediates (ROIs) produced in mitochondria. This leads to caspase-3 activation, phosphatidylserine (PS) ex
Evaluation of BACTEC MYCO/F lytic medium for recovery of mycobacteria and fungi from blood.: J Clin Microbiol. 1998 May;36(5):1176-9. Unique Identifier : AIDSLINE MED/98233858; Waite RT; Woods GL; University of Texas Medical Branch, Galveston 77555-0740, USA.; The reliability of MYCO/F Lytic medium in the BACTEC 9240 blood culture system was evaluated by comparing its performance to that of the Isolator system for the recovery of fungi and to that of the ESP II system for the recovery of mycobacteria. Of 717 specimens of blood cultured for fungi, 24 were positive; 12 sample
Ultrastructure, immunofluorescence, western blot, and PCR analysis of eight isolates of Encephalitozoon (Septata) intestinalis established in culture from sputum and urine samples and duodenal aspirates of five patients with AIDS.: J Clin Microbiol. 1998 May;36(5):1201-8. Unique Identifier : AIDSLINE MED/98233864; Croppo GP; Croppo GP; Moura H; Da Silva AJ; Leitch GJ; Moss DM; Wallace S; Slemenda SB; Pieniazek NJ; Visvesvara GS; Division of Parasitic Diseases, Centers for Disease Control and; Prevention, Atlanta, Georgia 30341-3724, USA.; Microsporidia are ancient, intracellular, eukaryotic protozoan parasites that form spores and that lack mitochondria. Currently, as many as eight species included under six genera are known to infect humans, mostly patients with AIDS. Among these, Enterocytozoon bieneusi, the agent of gastrointestinal (GI) disease, is
Three cases of Anaerobiospirillum succiniciproducens bacteremia confirmed by 16S rRNA gene sequencing.: J Clin Microbiol. 1998 May;36(5):1209-13. Unique Identifier : AIDSLINE MED/98233865; Tee W; Korman TM; Waters MJ; Macphee A; Jenney A; Joyce L; Dyall-Smith ML; Victorian Infectious Diseases Reference Laboratory, Western Health; Care Network, Old Fairfield Hospital Campus, Australia.; weet@hna.ffh.vic.gov.au; We describe three cases of Anaerobiospirillum succiniciproducens bacteremia from Australia . We believe one of these cases represents the first report of A. succiniciproducens bacteremia in a human immunodeficiency virus (HIV)-infected individual. The other two patients had an un
Number of days required for recovery of mycobacteria from blood and other samples.: J Clin Microbiol. 1998 May;36(5):1456-7. Unique Identifier : AIDSLINE MED/98233918; Esteban J; Molleja A; Fernandez-Roblas R; Soriano F; Department of Medical Microbiology, Fundacion Jimenez Diaz, Madrid,; Spain. fjdmicro@microb.net; From 1991 to 1996, 541 blood samples were tested for the presence of mycobacteria; 56 were positive (30 patients, 26 human immunodeficiency virus positive). The species found were Mycobacterium avium (41 samples from 18 patients), Mycobacterium tuberculosis (12 samples from 9 patients), and three other species (1 samp
Rapid detection of species of the opportunistic yeast Trichosporon by PCR.: J Clin Microbiol. 1998 May;36(5):1458-60. Unique Identifier : AIDSLINE MED/98233919; Sugita T; Nishikawa A; Shinoda T; Department of Microbiology, Meiji College of Pharmacy, Tokyo, Japan.; Trichosporon species are opportunistic pathogens, associated with a high mortality rate in immunocompromised patients. Oligonucleotide primers were used to amplify a 170-bp fragment of small-subunit ribosomal DNA of all species in the genus Trichosporon by PCR. The primers amplify DNAs of all species in the genus Tric
Blockade of CC chemokine receptor 5 (CCR5)-tropic human immunodeficiency virus-1 replication in human lymphoid tissue by CC chemokines.: J Clin Invest. 1998 May 1;101(9):1876-80. Unique Identifier : AIDSLINE MED/98244996; Margolis LB; Glushakova S; Grivel JC; Murphy PM; Laboratory of Molecular and Cellular Biophysics, National Institute of; Child Health and Human Development, National Institutes of Health,; Bethesda, Maryland 20892, USA.; The CC chemokines MIP-1alpha, MIP-1beta, and RANTES suppress replication of certain HIV-1 strains in cultured PBMC and T cell lines by blocking interaction of gp120 with CC chemokine receptor 5 (CCR5). However, the same chemokines can enhance HIV-1 replication in cultured macrophages. The net effect of chemokines on H
HIV and the dental profession.: J Dent Assoc S Afr. 1997 Dec;52(12):721-6. Unique Identifier : AIDSLINE MED/98250886; Lapidus A; Sandler M; Graduate School of Business Administration, Johannesburg, South; Africa.; In order to assess the response of dentists to the increasing incidence of HIV, a study was conducted to explore their attitudes, knowledge and the additional costs involved in treating HIV positive patients. The response of dentists to the increasing incidence of HIV positive patients is influenced by their fears and
The "hidden patient": older relatives raising children orphaned by AIDS.: J Am Med Womens Assoc. 1998 Spring;53(2):65-71, 76. Unique Identifier : AIDSLINE MED/98258262; Joslin D; Harrison R; Department of Community Health, William Paterson University of New; Jersey, USA.; In the United States today, thousands of grandmothers and other third- and fourth-generation relatives are raising children and adolescents whose primary parent, usually the mothers, has died from acquired immune deficiency syndrome (AIDS) or is too ill to serve as the primary parent.
Sex work and health: a question of safety in the workplace.: J Am Med Womens Assoc. 1998 Spring;53(2):77-82. Unique Identifier : AIDSLINE MED/98258264; Alexander P; Sex work is an occupation or trade involving exchange of sexual services for economic compensation. Although health problems associated with prostitution, such as sexually transmitted diseases and violence, are commonly assumed to be risks of the trade, the illegality and stigma of prostitution have prevented the me
[Maternal and congenital syphilis]: J Gynecol Obstet Biol Reprod (Paris). 1998 Mar;27(2):150-60. Unique Identifier : AIDSLINE MED/98262495; Narducci F; Switala I; Rajabally R; Decocq J; Delahousse G; Pavillon Paul-Gelle, Roubaix.; Testing for syphilis during pregnancy reveals a positive serologic status in 0.02% of cases. However, a 66% rate of stillbirths is noted in women who are infected and who have not benefited from any treatment. Routine screening is at present performed during the early stages of pregnancy but a second serologic test du
Upper extremity infections in patients with the human immunodeficiency virus.: J Hand Surg [Am]. 1998 Mar;23(2):348-52. Unique Identifier : AIDSLINE MED/98215568; Gonzalez MH; Nikoleit J; Weinzweig N; Pulvirenti J; Department of Orthopaedic Surgery, University of Illinois at Chicago,; Cook County Hospital, 60612, USA.; Twenty-eight patients with upper extremity infections and positive for the human immunodeficiency virus (HIV) were identified. The risk factor for HIV infection was intravenous drug injection in 24 patients, homosexual contact in 3, and heterosexual contact in 1. Eight of the patients had the acquired immunodeficiency
The immunological system in hemochromatosis.: J Hepatol. 1998;28 Suppl 1:1-7. Unique Identifier : AIDSLINE MED/98236353; de Sousa M; Porto G; Abel Salazar Institute for the Biomedical Sciences, Oporto, Portugal.
Guidelines for antiretrovirals in pediatric HIV [news]: Infect Control Hosp Epidemiol. 1998 Mar;19(3):216. Unique Identifier : AIDSLINE MED/98211920
Generation, persistence, and modulation of Th0 effector cells: role of autocrine IL-4 and IFN-gamma.: J Immunol. 1998 Jun 1;160(11):5280-7. Unique Identifier : AIDSLINE MED/98266161; Miner KT; Croft M; La Jolla Institute for Allergy and Immunology, Division of; Immunochemistry, San Diego, CA 92121, USA.; Many studies have classified CD4 responses into either Th1-like or Th2-like, based on cytokine secretion profiles, but little significance has been placed on Th0 cells. This has largely resulted from studies that suggested that Th0 populations primarily comprise individual Th1 and Th2 cells. Here, we show that priming
Macrophages induce cellular immunity by activating Th1 cell responses and suppressing Th2 cell responses.: J Immunol. 1998 Jun 1;160(11):5300-8. Unique Identifier : AIDSLINE MED/98266164; Desmedt M; Rottiers P; Dooms H; Fiers W; Grooten J; Department of Molecular Biology, Flanders Interuniversity Institute; for Biotechnology, Ghent, Belgium.; Differentiation of naive CD4+ T cells (Th0) into Th1 or Th2 cells determines whether antigen will raise a cellular or a humoral immune response. The maturation pathway chosen by the Th0 cell is often decisive for the outcome of disease and depends among others on the (co-)stimulatory attributes of the APC and the natu
Topical FK506 suppresses cytokine and costimulatory molecule expression in epidermal and local draining lymph node cells during primary skin immune responses.: J Immunol. 1998 Jun 1;160(11):5331-40. Unique Identifier : AIDSLINE MED/98266168; Homey B; Assmann T; Vohr HW; Ulrich P; Lauerma AI; Ruzicka T; Lehmann P; Schuppe HC; Department of Dermatology, University of Dusseldorf, Germany.; homey@uni-duesseldorf.de; Recently, it has been shown that the immunosuppressive macrolide lactone, FK506, exerts good therapeutic efficacy in inflammatory skin diseases. The aim of this study was to analyze the influence of topical FK506 on molecular (IL-1alpha, IL-1beta, IL-2 , IL-4, IL-12 p35
Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype.: J Immunol. 1998 Jun 1;160(11):5347-54. Unique Identifier : AIDSLINE MED/98266170; Munder M; Eichmann K; Modolell M; Max Planck Institut fur Immunobiologie, Freiburg, Germany.; Activated murine macrophages metabolize L-arginine via two main pathways that are catalyzed by the inducible enzymes nitric oxide synthase (iNOS) and arginase. We have previously shown that CD4+ T cell-derived cytokines regulate a competitive balance in the expression of both enzymes in macrophages; Thl-type cytokines
Rapamycin inhibits the generation of graft-versus-host disease- and graft-versus-leukemia-causing T cells by interfering with the production of Th1 or Th1 cytotoxic cytokines.: J Immunol. 1998 Jun 1;160(11):5355-65. Unique Identifier : AIDSLINE MED/98266171; Blazar BR; Taylor PA; Panoskaltsis-Mortari A; Vallera DA; Department of Pediatrics, University of Minnesota Hospital and Clinic,; Minneapolis 55455, USA.; Rapamycin (RAPA), an inhibitor of cytokine responses, is under investigation in humans for graft-vs-host disease (GVHD) prevention. The mechanisms responsible for GVHD prevention are unknown. We show that RAPA is more effective in inhibiting CD8+ or TCR gammadelta+ than CD4+ T cell-mediated murine GVHD. To determine h
IL-12 promotes drug-induced clearance of Mycobacterium avium infection in mice.: J Immunol. 1998 Jun 1;160(11):5428-35. Unique Identifier : AIDSLINE MED/98266180; Doherty TM; Sher A; Immunobiology Section, Laboratory of Parasitic Diseases, National; Institute of Allergy and Infectious Diseases, Health, Bethesda, MD; 20892, USA.; The intracellular pathogen Mycobacterium avium is a major cause of opportunistic infection in AIDS patients and is difficult to manage using conventional chemotherapeutic approaches. In the current study, we describe a strategy for the treatment of M. avium in T cell-deficient hosts based on the simultaneous administr
IL-5-dependent immunity to microfilariae is independent of IL-4 in a mouse model of onchocerciasis.: J Immunol. 1998 Jun 1;160(11):5436-40. Unique Identifier : AIDSLINE MED/98266181; Hogarth PJ; Taylor MJ; Bianco AE; Division of Molecular Biology and Immunology, Liverpool School of; Tropical Medicine, United Kingdom.; Th2 lymphocyte responses under the control of IL-4 and IL-5 are frequently associated with protective responses to parasitic helminths. Studies on the role of these cytokines in acquired resistance to parasitic nematodes indicate that, in the case of gastrointestinal nematodes, immunity is mediated by IL-4, while immu
Control of Leishmania major infection in mice lacking TNF receptors.: J Immunol. 1998 Jun 1;160(11):5506-13. Unique Identifier : AIDSLINE MED/98266190; Nashleanas M; Kanaly S; Scott P; University of Pennsylvania School of Veterinary Medicine, Philadelphia; 19104, USA.; TNF participates in the induction of nitric oxide (NO) production and macrophage activation, leading to the elimination of intracellular pathogens. We previously found that TNF receptor p55-deficient mice (TNFRp55-/-) control replication of Leishmania major in vivo but fail to resolve their lesions. Here we report tha
Differential requirement for CD4 help in the development of an antigen-specific CD8+ T cell response depending on the route of immunization.: J Immunol. 1998 Jun 1;160(11):5522-9. Unique Identifier : AIDSLINE MED/98266192; Bour H; Horvath C; Lurquin C; Cerottini JC; MacDonald HR; Ludwig Institute for Cancer Research, University of Lausanne,; Epalinges, Switzerland.; Previous studies in our laboratory have shown that DBA/2 mice injected i.p. with syngeneic P815 tumor cells transfected with the HLA-CW3 gene (P815-CW3) showed a dramatic expansion of activated CD8+CD62L- T cells expressing exclusively the Vbeta10 segment. We have used this model to study the regulatory mechanisms inv
Theiler's virus infection of genetically susceptible mice induces central nervous system-infiltrating CTLs with no apparent viral or major myelin antigenic specificity.: J Immunol. 1998 Jun 1;160(11):5661-8. Unique Identifier : AIDSLINE MED/98266209; Lin X; Pease LR; Murray PD; Rodriguez M; Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.; Intracranial infection of susceptible mice with Theiler s virus results in persistent infection and spinal cord demyelination similar to human multiple sclerosis. While central nervous system infiltrating lymphocytes (CNS-ILs) in these mice display no virus-specific CTL activity, the cells were found to be activated k
The effect of deletion of the V3 loop of gp120 on cytotoxic T cell responses and HIV gp120-mediated pathogenesis.: J Immunol. 1998 Jun 1;160(11):5676-83. Unique Identifier : AIDSLINE MED/98266211; Kmieciak D; Wasik TJ; Teppler H; Pientka J; Hsu SH; Takahashi H; Okumura K; Kaneko Y; Kozbor D; Department of Microbiology and Immunology, Thomas Jefferson; University, Philadelphia, PA 19107, USA.; New strategies for improving the efficacy of HIV vaccines are of significant importance. In this study, we analyzed the effect of deletion of the hypervariable V3 loop of gp120 on envelope env)-specific CTL responses in PBMC of HIV-infected individuals. We showed increased CTL activities against conserved epitopes of
[Physiological role and dynamics of cytokines in respiratory infections]: Nippon Naika Gakkai Zasshi. 1998 Feb 10;87(2):217-22. Unique Identifier : AIDSLINE MED/98210480; Ogushi F
Long-term persistence of activated cytotoxic T lymphocytes after viral infection of the central nervous system.: J Exp Med. 1998 May 18;187(10):1575-82. Unique Identifier : AIDSLINE MED/98252863; Hawke S; Stevenson PG; Freeman S; Bangham CR; Nuffield Department of Medicine, University of Oxford, John Radcliffe; Hospital, Headington, Oxford OX3 9DU, United Kingdom.; s.hawke@cxwms.ac.uk; Mice intranasally inoculated with influenza A/X-31 are protected against a subsequent intracerebral challenge with the neurovirulent influenza A/WSN and this heterotypic protection is mediated by CD8(+) cytotoxic T lymphocytes. We have studied the kinetics of this secondary immune response and found that despite the e
HIV-1 selection by epidermal dendritic cells during transmission across human skin.: J Exp Med. 1998 May 18;187(10):1623-31. Unique Identifier : AIDSLINE MED/98252867; Reece JC; Handley AJ; Anstee EJ; Morrison WA; Crowe SM; Cameron PU; Department of Microbiology and Immunology, University of Melbourne,; Parkville, Victoria, Australia 3052.; Macrophage tropic HIV-1 is predominant during the initial viremia after person to person transmission of HIV-1 (Zhu, T., H. Mo, N. Wang, D.S. Nam, Y. Cao, R.A. Koup, and D.D. Ho. 1993. Science. 261:1179-1181.), and this selection may occur during virus entry and carriage to the lymphoid tissue. Human skin explants wer
Characterization of human CD8+ T cells reactive with Mycobacterium tuberculosis-infected antigen-presenting cells.: J Exp Med. 1998 May 18;187(10):1633-40. Unique Identifier : AIDSLINE MED/98252868; Lewinsohn DM; Alderson MR; Briden AL; Riddell SR; Reed SG; Grabstein KH; Division of Pulmonary & Critical Care Medicine, University of; Washington, Seattle, Washington 98104, USA. dml@u.washington.edu; Previous studies in murine models, including those using the beta2 microglobulin knockout mouse, have suggested an important role for CD8+ T cells in host defense to Mycobacterium tuberculosis (Mtb). At present, little is understood about these cells in the human immune response to tuberculosis. This report demonstrat
The effect of class II major histocompatibility complex expression on adherence of Helicobacter pylori and induction of apoptosis in gastric epithelial cells: a mechanism for T helper cell type 1-mediated damage.: J Exp Med. 1998 May 18;187(10):1659-69. Unique Identifier : AIDSLINE MED/98252871; Fan X; Crowe SE; Behar S; Gunasena H; Ye G; Haeberle H; Van Houten N; Gourley WK; Ernst PB; Reyes VE; Department of Pediatrics, University of Texas Medical Branch,; Galveston, Texas 77555, USA.; Helicobacter pylori infection is associated with gastric epithelial damage, including apoptosis, ulceration, and cancer. Although bacterial factors and the host response are believed to contribute to gastric disease, no receptor has been identified that explains how the bacteria attach and signal the host cell to unde
Factors secreted by human T lymphotropic virus type I HTLV-I)-infected cells can enhance or inhibit replication of HIV-1 in HTLV-I-uninfected cells: implications for in vivo coinfection with HTLV-I and HIV-1.: J Exp Med. 1998 May 18;187(10):1689-97. Unique Identifier : AIDSLINE MED/98252874; Moriuchi H; Moriuchi M; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, Maryland; 20892, USA. hmoriuchi@atlas.niaid.nih.gov; It remains controversial whether human T lymphotropic virus type I (HTLV-I) coinfection leads to more rapid progression of human immunodeficiency virus (HIV) disease in dually infected individuals. To investigate whether HTLV-I infection of certain cells can modulate HIV-1 infection of surrounding cells, primary CD4(+
HIV-risk behavior and the public health context of HIV/AIDS among women living with a severe and persistent mental illness.: J Nerv Ment Dis. 1998 May;186(5):276-82. Unique Identifier : AIDSLINE MED/98275391; Weinhardt LS; Carey MP; Carey KB; Department of Psychology, Syracuse University, New York 13244-2340,; USA.; We documented HIV-risk behavior and the public health context of AIDS in women living with a severe and persistent mental illness. Sixty-one women were recruited from outpatient clinics and day-treatment programs at a state psychiatric hospital. They completed a survey that included measures of HIV-related risk behavi
Bioactive kaurane diterpenoids from Annona glabra.: J Nat Prod. 1998 Apr;61(4):437-9. Unique Identifier : AIDSLINE MED/98245376; Chang FR; Yang PY; Lin JY; Lee KH; Wu YC; Graduate Institute of Natural Products, Kaosiung Medical College,; Taiwan, Republic of China.; Phytochemical analysis of the fruits of Annona glabra yielded two new kaurane diterpenoids, annoglabasin A (methyl-16 beta-acetoxy-19-al-ent-kauran-17-oate)(1) and annoglabasin B (16 alpha-hydro-19-acetoxy-ent-kauran-17-oic acid)(2), along with 11 known kaurane derivatives (3-13). The structures of the new compounds w
Factors associated with serum HCV RNA positivity in anti-HCV antibody positive intravenous drug users.: J Clin Epidemiol. 1998 May;51(5):423-7. Unique Identifier : AIDSLINE MED/98281269; Pirisi M; Toniutto P; Fabris C; Lombardelli T; Falleti E; Tisminetzky SG; Baralle F; Bartoli E; Dipartimento di Patologia e Medicina Sperimentale e Clinica,; Universita degli Studi di Udine, Italy.; Serum hepatitis C virus (HCV) RNA, HCV genotypes and liver function tests were evaluated in a series of 189 unselected, consecutive anti-HCV positive intravenous drug users (IVDUs). Serum HCV RNA was detected in 106/189 patients. Abnormal liver function tests were associated with alcohol abuse, but not with the presen
Glomerular pathology: recent advances.: J Pathol. 1998 Feb;184(2):123-9. Unique Identifier : AIDSLINE MED/98265411; Gibson IW; More IA; University Department of Pathology, Western Infirmary, Glasgow, U.K.; The last decade has seen significant advances in the fields of cellular and molecular biology and pathology. These have contributed to our understanding of the mechanisms of glomerular disease and indicate possible novel approaches to therapy. This review discusses recent insights into the pathogenesis of glomerular d
Correlation of T-helper secretory differentiation and types of antigen-presenting cells in squamous intraepithelial lesions of the uterine cervix.: J Pathol. 1998 Mar;184(3):283-90. Unique Identifier : AIDSLINE MED/98276520; al-Saleh W; Giannini SL; Jacobs N; Moutschen M; Doyen J; Boniver J; Delvenne P; Department of Pathology, University Hospital of Liege, CHU Sart; Tilman, Belgium.; This study addressed the notion that the progression of cervical cancer is associated with a T-helper 2 (TH2) immunodeviation by analysing cytokine expression in 60 cervical biopsy specimens, spanning the spectrum from normal cervical tissue to high-grade squamous intraepithelial lesions (SILs). The biopsies were anal
Psychosocial histories, social environment, and HIV risk behaviors of injection and noninjection drug using homeless youths.: J Psychoactive Drugs. 1998 Jan-Feb;30(1):1-10. Unique Identifier : AIDSLINE MED/98224875; Martinez TE; Gleghorn A; Marx R; Clements K; Boman M; Katz MH; San Francisco Department of Public Health-AIDS Office, California; 94102-6033, USA.; Injection drug use is a common risk behavior for HIV infection among homeless, runaway and street youths. However, the psychosocial histories and current social environment of these youths are not well understood. The authors recruited 186 homeless, runaway and street youths using systematic street-based sampling meth
Estimation of the prevalence of injection drug use in greater Boston in 1993.: J Psychoactive Drugs. 1998 Jan-Feb;30(1):21-4. Unique Identifier : AIDSLINE MED/98224877; Wolf RC; Case P; Pagano M; Department of Health Policy and Management, Johns Hopkins University; School of Hygiene and Public Health, Baltimore, Maryland 21205, USA.; This article is a report on different methods of estimation of the number of injection drug users (IDUs) in the Boston standard metropolitan statistical area (SMSA) in 1993. Because the sharing of needles is a means of transmission for HIV, an estimate of the prevalence of injection drug use is essential for acquired
Attitudes toward methadone maintenance: implications for HIV prevention.: J Psychoactive Drugs. 1998 Jan-Feb;30(1):89-97. Unique Identifier : AIDSLINE MED/98224884; Zule WA; Desmond DP; University of Texas Health Science Center at San Antonio, 78284, USA.; Attitudes of opioid users toward methadone maintenance were studied using semi-structured field interviews. One hundred and sixty-one heroin and speedball users in San Antonio, Texas, were interviewed between 1989 and 1992. Users were classified according to whether or not they had ever been on methadone maintenance.
Factors for progression of periodontal diseases.: J Oral Pathol Med. 1998 Mar;27(3):101-5. Unique Identifier : AIDSLINE MED/98223289; Ellis SD; Tucci MA; Serio FG; Johnson RB; Department of Periodontics, School of Dentistry, University of; Mississippi Medical Center, Jackson 39216-4505, USA.; Progression factors for periodontal diseases have been suggested by in vitro study of peripheral blood and gingival cells; however, those factors are not established in vivo. This investigation assessed biopsies of three groups of gingival tissues: those adjacent to a 1) 6 mm gi
Intra-epithelial subpopulations of T lymphocytes and Langerhans cells in oral lichen planus.: J Oral Pathol Med. 1998 Mar;27(3):116-23. Unique Identifier : AIDSLINE MED/98223292; Walton LJ; Macey MG; Thornhill MH; Farthing PM; Department of Oral Pathology, St Bartholomew's and the Royal London; School of Medicine and Dentistry, England.; This study has addressed the question of whether there is selective recruitment and distribution of intra-epithelial leucocytes in lesions of oral lichen planus (OLP). T-lymphocyte subsets were examined in the epithelium and peripheral blood of patients and controls using flow cytometry and double immunofluorescence,
Oral manifestations of HIV infection by gender and transmission category in Mexico City.: J Oral Pathol Med. 1998 Mar;27(3):135-40. Unique Identifier : AIDSLINE MED/98223295; Ramirez-Amador V; Esquivel-Pedraza L; Sierra-Madero J; Ponce-de-Leon S; Ponce-de-Leon S; Universidad Autonoma Metropolitana-Xochimilco, Mexico City, Mexico.; A cross-sectional analysis was conducted in Mexico City from September 1989 to March 1996, to determine the prevalence of HIV-related oral manifestations by gender and route of HIV transmission. The diagnosis of HIV-associated oral lesions was based on preestablished criteria. For the statistical analysis chi-squared
Oral manifestations of HIV infection in 600 South African patients.: J Oral Pathol Med. 1998 Apr;27(4):176-9. Unique Identifier : AIDSLINE MED/98223037; Arendorf TM; Bredekamp B; Cloete CA; Sauer G; Department of Oral Medicine & Periodontology, Faculty of Dentistry,; University of the Western Cape and WHO Oral Health Collaborating; Centre, Cape Town, South Africa.; Oral lesions associated with HIV infection, as classified by the EC-Clearinghouse on Oral Problems related to HIV infection and the WHO Collaborating Centre on Oral manifestations of the immunodeficiency virus, were studied in 600 consecutive HIV-infected patients in Cape Town, South
Lack of serologic association between human herpesvirus-8 infection and multiple myeloma and monoclonal gammopathies of undetermined significance [letter]: J Natl Cancer Inst. 1998 May 20;90(10):781-2. Unique Identifier : AIDSLINE MED/98266686; Santarelli R; Angeloni A; Farina A; Gonnella R; Gentile G; Martino P; Petrucci MT; Mandelli F; Frati L; Faggioni A
Race and the treatment of cytomegalovirus retinitis in a cohort of patients with acquired immunodeficiency syndrome.: J Natl Med Assoc. 1998 Apr;90(4):214-20. Unique Identifier : AIDSLINE MED/98242542; Wutoh AK; Hidalgo J; Bareta J; Rhee W; Beardsley R; Steidl S; Department of Clinical and Administrative Pharmacy, Howard University; College of Pharmacy, Washington, DC 20059, USA.; This historical cohort study assessed the impact of race on critical factors in the diagnosis and drug treatment of cytomegalovirus ( CMV ) retinitis in acquired immunodeficiency syndrome (AIDS) patients over a 7-year period. T
Nephrolithiasis from indinavir, a new human immunodeficiency virus drug.: J Urol. 1998 Jun;159(6):2074; discussion 2074-5. Unique Identifier : AIDSLINE MED/98258470; Lerner LB; Cendron M; Rous SN; Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon,; New Hampshire 03756-0001, USA.
South African health care in black and white [interview by Gabrielle Murphy]: Lancet. 1998 May 9;351(9113):1421-4. Unique Identifier : AIDSLINE MED/98254259; Zuma N
Antiretroviral therapy in countries with low health expenditure [letter]: Lancet. 1998 May 9;351(9113):1433-4. Unique Identifier : AIDSLINE MED/98254269; Arya SC
Massachusetts HIV-1 programme [letter]: Lancet. 1998 May 9;351(9113):1439. Unique Identifier : AIDSLINE MED/98254278; Epstein A
Health nurses: attitudes towards treating AIDS patients.: Med Law. 1997;16(4):729-42. Unique Identifier : AIDSLINE MED/98234794; Tabak N; Ben-Or T; Zur F; Nursing Dept. Faculty of Medicine, Tel-Aviv University, Israel.; Many nurses working in hospitals, especially in the wards, as well as nurses in community clinics have been involved in treating AIDS sufferers. In spite of clear and widespread information available to professionals, strong apprehensions still exist as to the contagious nature of the disease. A survey was carried out
[Levels of immunoglobulin and subpopulations of T lymphocytes and NK cells in men occupationally exposed to microwave radiation in frequencies of 6-12 GHz]: Med Pr. 1998;49(1):45-9. Unique Identifier : AIDSLINE MED/98249499; Dmoch A; Moszczynski P; Oddzialu Wewnetrznego Szpitala Miejskiego w Kielcach.; Immunoglobulin concentrations and T-lymphocyte subsets in workers of TV re-transmission and satellite communication centres were assessed. An increase in IgG and IgA concentrations, an increased count of lymphocytes and T8 lymphocytes, an decreased count of NK cells and a lower value of T-helper/T-suppressor ratio wer
CD45RA and CD45RO isoform expression on intrahepatic T-lymphocytes in chronic hepatitis C.: Microbios. 1997;92(371):73-82. Unique Identifier : AIDSLINE MED/98251515; Fiore G; Galetta V; Piazzolla G; Angarano I; Jirillo E; Schiraldi O; Antonaci S; Department of Internal Medicine, Immunology and Infectious Diseases,; University of Bari Medical School, Italy.; A liver tissue recruitment of antigen-specific cytotoxic cells has been reported in chronic hepatitis C virus (HCV) infection, but whether they really play a role in viral clearance is still a matter of investigation. To further evaluate T-cell involvement in HCV-induced hepatic disease, the authors analysed, in a coh
Construction of the chimeric reverse transcriptase of simian immunodeficiency virus sensitive to nonnucleoside reverse transcriptase inhibitor.: Microbiol Immunol. 1998;42(3):195-202. Unique Identifier : AIDSLINE MED/98230210; Isaka Y; Sato A; Kawauchi S; Suyama A; Miki S; Hayami M; Fujiwara T; Discovery Research Laboratories 1, Shionogi & Co., Ltd., Settsu,; Osaka, Japan.; A number of structurally diverse compounds have been shown to be potent inhibitors of the DNA polymerase activity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). The compounds can be grouped into two broad classes; nucleoside analogs and nonnucleoside RT inhibitors. The nonnucleoside RT inhi
Hospitalization costs associated with homelessness in New York City [see comments]: N Engl J Med. 1998 Jun 11;338(24):1734-40. Unique Identifier : AIDSLINE MED/98272349; Salit SA; Kuhn EM; Hartz AJ; Vu JM; Mosso AL; New York City Health and Hospitals Corporation, New York 10118, USA.; BACKGROUND: Homelessness is believed to be a cause of health problems and high medical costs, but data supporting this association have been difficult to obtain. We compared lengths of stay and reasons for hospital admission among homeless and other low-income persons in New York City to estimate the hospitalization c
Paronychia and pyogenic granuloma of the great toes in patients treated with indinavir [letter]: N Engl J Med. 1998 Jun 11;338(24):1776-7. Unique Identifier : AIDSLINE MED/98272368; Bouscarat F; Bouchard C; Bouhour D
Clinton 'is failing to honour pledge on AIDS vaccine' [news]: Nature. 1998 May 21;393(6682):199. Unique Identifier : AIDSLINE MED/98268756; Macilwain C
Nathanson takes top job at AIDS research office [news]: Nature. 1998 May 21;393(6682):204. Unique Identifier : AIDSLINE MED/98268763
[Alternative measures against AIDS (news)]: Ned Tijdschr Geneeskd. 1997 Jul 19;141(29):1452-3. Unique Identifier : AIDSLINE MED/98281364
[Failing AIDS therapy (news)]: Ned Tijdschr Geneeskd. 1997 Aug 2;141(31):1547. Unique Identifier : AIDSLINE MED/98281365
[Infection with T-lymphotropic virus in Dutch blood donors, 1993-1996]: Ned Tijdschr Geneeskd. 1997 Aug 9;141(32):1571-2. Unique Identifier : AIDSLINE MED/98205335; Zaaijer HL; Lelie PN; van der Poel CL; Academisch Ziekenhuis Vrije Universiteit, afd. Klinische Microbiologie; en Ziekenhuishygiene, Amsterdam.; Infection with human T-lymphotrophic virus (HTLV) type 1 causes a neurological disorder or leukaemia in a minority of infected persons. Since January 1993 the Dutch blood banks screen each donation for presence of HTLV-1 infection. Approximately 4,000,000 donations from 700,000 donors have been tested. The numbers of
Fractionator analysis shows loss of neurons in the lateral geniculate nucleus of macaques infected with neurovirulent simian immunodeficiency virus.: Neuropathol Appl Neurobiol. 1998 Feb;24(1):44-52. Unique Identifier : AIDSLINE MED/98210897; Berman NE; Raymond LA; Warren KA; Raghavan R; Joag SV; Narayan O; Cheney PD; Department of Anatomy and cell Biology, University of Kansas Medical; Center, Kansas City 66160-7400, USA.; Infection of macaques with neurovirulent strains of simian immunodeficiency virus (SIVmac) is an experimental model for the neurological manifestations of AIDS. Loss of neurons has been reported in the cerebral cortex following immunodeficiency viral infection, but thalamic structures which may contribute to electroph
Calcification in the basal ganglia with chronic active Epstein-Barr virus infection.: Neurology. 1998 May;50(5):1485-8. Unique Identifier : AIDSLINE MED/98255455; Morita M; Tsuge I; Matsuoka H; Ito Y; Itosu T; Yamamoto M; Morishima T; Department of Pediatrics, Nagoya University School of Medicine, Japan.; We report three Japanese children with chronic active Epstein-Barr virus (EBV) infection and neurologic findings that included symmetric calcifications in the bilateral basal ganglia. This finding, common in pediatric acquired immunodeficiency syndrome (AIDS), suggests that EBV could be responsible for calcification i
Syndrome of continuous muscle fiber activity in a human immunodeficiency virus-infected patient.: Neurology. 1998 May;50(5):1506-7. Unique Identifier : AIDSLINE MED/98255464; Garea MJ; Aparicio-Blanco M; Espino P; Duenas A; Dominguez LA; Bachiller P; Department of Neurology, Hospital Universitario Rio-Hortega,; Valladolid, Spain.
[The ingestion of foreign bodies for the purpose of self-injury. The conservative treatment of 2 clinical cases]: Minerva Chir. 1997 Dec;52(12):1519-21. Unique Identifier : AIDSLINE MED/98218226; Bergantino A; Divisione di Chirurgia Generale, Ospedale Civile di Borgosesia; Vercelli), Regione Piemonte, Azienda USL 11.; Although not rare, the ingestion of foreign bodies becomes uncommon when it is done with intent to cause self-damage. When used for this purpose, foreign bodies usually take the form of liquid substances, such as caustic agents, detergents, poisons, etc. It is less rare in certain situations like psychiatric and priso
Tissue-type plasminogen activator activity in HIV-associated HUS.: Nephrol Dial Transplant. 1998 Apr;13(4):919-23. Unique Identifier : AIDSLINE MED/98227804; Peraldi MN; Maslo C; Berrou J; Rondeau E; Rozenbaum W; Sraer JD; Service de Nephrologie A, Hopital Tenon, Paris, France.; BACKGROUND: In children, haemolytic uraemic syndrome (HUS) is associated with high plasma plasminogen activator inhibitor type 1 (PAI-1), which may contribute to the persistence of renal glomerular and arteriolar thrombi. HUS has been described in HIV-infected patients, but the pathophysiology of HUS in these patients
Henoch-Schonlein purpura associated with human immunodeficiency virus infection.: Nephrol Dial Transplant. 1998 Apr;13(4):988-90. Unique Identifier : AIDSLINE MED/98227818; Hall TN; Brennan B; Leahy MF; Woodroffe AJ; Renal Unit, Fremantle Hospital, Western Australia, Australia.
A role for granulomatous inflammation in the transmission of infectious disease: schistosomiasis and tuberculosis.: Parasitology. 1997;115 Suppl:S113-25. Unique Identifier : AIDSLINE MED/98233188; Doenhoff MJ; School of Biological Sciences, University of Wales, Bangor, Gwynedd,; UK.; The relationship between cell-mediated granulomatous inflammation and transmission of disease in schistosomiasis and tuberculosis has been explored. In 2 experiments involving Schistosoma mansoni-infected normal and T cell-deprived mice, and infected deprived mice that had been variously reconstituted with immune or n
Enhancing antibodies in HIV infection.: Parasitology. 1997;115 Suppl:S127-40. Unique Identifier : AIDSLINE MED/98233189; Fust G; 3rd Department of Medicine, Semmelweis Medical University, Hungarian; Academy of Science, Budapest, Hungary.; The author has summarized the history of discovery, the mechanism and the clinical significance of antibody-dependent enhancement ADE) of HIV infection. ADE has two major forms: (a) complement-mediated antibody-dependent enhancement (C-ADE) and b) complement-independent Fc receptor-dependent ADE (FcR-ADE). The most im
The relationship between immunological responsiveness controlled by T-helper 2 lymphocytes and infections with parasitic helminths.: Parasitology. 1997;115 Suppl:S33-44. Unique Identifier : AIDSLINE MED/98233180; Pritchard DI; Hewitt C; Moqbel R; Centre for the Mechanisms of Human Toxicity, Leicester, UK.; It should have been difficult until relatively recently for immunologists to ascribe a sound biological reason for the continued possession of the allergic phenotype in human populations. Nevertheless, for the past 20 years or so textbooks of immunology have routinely exhibited fanciful and perhaps exaggerated diagram
Vitamin A and public health: challenges for the next decade.: Proc Nutr Soc. 1998 Feb;57(1):159-65. Unique Identifier : AIDSLINE MED/98233212; Ross DA; Department of Infectious and Tropical Diseases, London School of; Hygiene and Tropic Medicine, UK. dross@tan2.healthnet.org
An intervention for changing high-risk HIV behaviors of African American drug-dependent women.: Res Nurs Health. 1998 Jun;21(3):239-50. Unique Identifier : AIDSLINE MED/98270672; Harris RM; Bausell RB; Scott DE; Hetherington SE; Kavanagh KH; University of Maryland School of Nursing, Baltimore 21201, USA.; The purpose of this study was to test the effectiveness of an AIDS education intervention for methadone-dependent, African American women. The women were randomly assigned to experimental n=107) or control (n=97) group. The experimental group participated in a peer counseling and leadership training program conducted
HIV informal caregiving: emergent conflict and growth.: Res Nurs Health. 1998 Jun;21(3):251-60. Unique Identifier : AIDSLINE MED/98270673; Reynolds NR; Alonzo AA; The Ohio State University, College of Nursing, Columbus 43210, USA.; Findings are reported from a prospective study of 20 persons on the experience of providing informal care to partners or family members with HIV syndrome. In-depth, focused interviews were completed. Data were initially coded using an inductive technique and thematically analyzed. The informal care providers were foun
[Pulmonary artery hypertension in HIV seropositive drug addicts. Apropos of 10 cases]: Rev Mal Respir. 1998 Feb;15(1):97-102. Unique Identifier : AIDSLINE MED/98212885; Petureau F; Escamilla R; Hermant C; Mourlanette P; Berjaud J; Krempf M; Service de Pneumo-Allergologie, CHU de Toulouse, Hopital de Purpan.; Pulmonary hypertension (PH) is a classic complication associated with intravenous drug addiction. Various pathogenic mechanisms may be involved but HIV infection now appears to be the main etiologic factor. We report herein 10 case of PH occurred in HIV+ intravenous drug abusers. Each patient had several pathogenic fa
[The 1998 cover of the Medical Review of Liege: histoplasmosis in an AIDS patient]: Rev Med Liege. 1998 Jan;53(1):2-3. Unique Identifier : AIDSLINE MED/98216001; Pierard GE; Service de Dermatopathologie, Universite de Liege.
Rhodococcus equi pneumonia in patients infected with the human immunodeficiency virus. Report of 2 cases and review of the literature.: Scand J Infect Dis. 1997;29(6):535-41. Unique Identifier : AIDSLINE MED/98233221; Capdevila JA; Bujan S; Gavalda J; Ferrer A; Pahissa A; Servei de Malalties Infeccioses, Hospital General Vall d'Hebron,; Barcelona, Spain.; Rhodococcus equi is a cause of lung infection in immunosuppressed hosts. Since the start of the HIV epidemic, 76 cases of R. equi lung infection (MEDLINE 1985-96) affecting this population have been described. We report 2 additional cases and review the clinical data, radiological findings, treatment and outcome of th
The influence of cytomegalovirus on the natural history of HIV infection: evidence of rapid course of HIV infection in HIV-positive patients infected with cytomegalovirus.: Scand J Infect Dis. 1997;29(6):543-9. Unique Identifier : AIDSLINE MED/98233222; Sinicco A; Raiteri R; Sciandra M; Dassio G; Bechis G; Maiello A; Department of Medical and Surgical Sciences, University of Turin,; Italy.; We studied a cohort of 299 HIV-positive individuals with known date of seroconversion to evaluate the role of Cytomegalovirus CMV ) in the natural history of HIV. The study population consisted of 236 initially CMV-positive patients, 55 CMV-negative subjects and
Mycobacterium fortuitum complex in Sweden during an 11-year period.: Scand J Infect Dis. 1997;29(6):573-7. Unique Identifier : AIDSLINE MED/98233228; Svahn A; Hoffner SE; Petrini B; Kallenius G; Swedish Institute for Infectious Disease Control, Karolinska Institute; and Hospital, Stockholm, Sweden.; Records of patients have been retrospectively examined studied during an 11-y period, from whom Mycobacterium fortuitum or M. chelonae was isolated in Sweden . Respiratory isolates were obtained from 71 patients. Clinical information was accessible in 52, chest X-ray was pathologica
Patterns of mycobacterium avium culture and PCR positivity in immunodeficient HIV-infected patients: progression from localized to systematic disease, German Aids Study Group (GASG/IDKF).: Scand J Infect Dis. 1997;29(6):579-84. Unique Identifier : AIDSLINE MED/98233229; Bogner JR; Rusch-Gerdes S; Mertenskotter T; Loch O; Emminger C; Baumgarten R; Brockmeyer NH; Brockhaus W; Jablonowski H; Stoehr A; Roth A; Albrecht H; Roth K; Tschauder S; Dietrich M; Medizinische Poliklinik, Munchen, Germany.; Our aim was to establish the frequency and the longitudinal pattern of MAC culture positivity in late stage HIV-infected patients. Two other aims were to analyse risk factors for progression from localized to systemic disease and the value of PCR diagnosis using blood specimens. A total of 107 patients were recruited
Pneumocystis carinii colonization in the absence of immunosuppression.: Scand J Infect Dis. 1997;29(6):591-3. Unique Identifier : AIDSLINE MED/98233231; Armbruster C; Hassl A; Kriwanek S; 2nd Medical Department, Pulmologisches Zentrum Vienna, Austria.; A prospective study was undertaken to evaluate the incidence and the course of Pneumocystis carinii colonization in immunocompetent patients with severe pulmonary diseases. A further perspective was to determine the diagnostic values of different detection methods. Bronchoalveolar lavage fluid samples from 77/838 adul
Toxoplasmosis in Danish AIDS patients.: Scand J Infect Dis. 1997;29(6):597-600. Unique Identifier : AIDSLINE MED/98233233; Garly ML; Petersen E; Pedersen C; Lundgren JD; Gerstoft J; Department of Medicine B, Frederiksberg Hospital, Denmark.; Infection with Toxoplasma gondii was studied in 600 patients with AIDS, diagnosed in the eastern part of Denmark from 1980 up to and including 1990. The median age was 38 years, and 223 (44%) had anti-T. gondii IgG antibodies. Of th
False-negative result in a microparticle enzyme immunoassay MEIA) for the detection of antibodies to human immunodeficiency HIV) [letter]: Scand J Infect Dis. 1997;29(6):643-4. Unique Identifier : AIDSLINE MED/98286664; Aguilera A; Cabarcos A; Garcia-Riestra C; Regueiro BJ
Viral safety of recombinant factor IX.: Semin Hematol. 1998 Apr;35(2 Suppl 2):22-7. Unique Identifier : AIDSLINE MED/98224835; Adamson S; Charlebois T; O'Connell B; Foster W; Genetics Institute, Andover, MA 01810, USA.; The viral safety of Chinese hamster ovary (CHO)-cell-based pharmaceuticals is well established. There have been more than 100 million infusions of CHO-derived pharmaceuticals without a single documented case of viral transmission. The recombinant factor IX (rFIX) process builds on this safety record by using a state-o
Hepatitis C antibody prevalence and risk factors of some female sex workers in Thailand.: Southeast Asian J Trop Med Public Health. 1997 Sep;28(3):507-12. Unique Identifier : AIDSLINE MED/98222385; Luksamijarulkul P; Deangbubpha A; Department of Microbiology, Faculty of Public Health, Mahidol; University Bangkok, Thailand.; One high risk group for hepatitis C virus (HCV) infection is female sex workers (FSWs). A study of HCV antibody prevalence and group risk factors was conducted in 200 FSWs in Ratchaburi Province, Thailand , during June to December 1995. FSWs were interviewed and their blood specim
Second report of AIDS related attitudes and sexual practices of the Jakarta Waria (male transvestites) in 1995.: Southeast Asian J Trop Med Public Health. 1997 Sep;28(3):525-9. Unique Identifier : AIDSLINE MED/98222387; Lubis I; Master J; Munif A; Iskandar N; Bambang M; Papilaya A; Roesin R; Manurung S; Graham R; AIDS and STD Prevention Program, Indonesian Public Health Association,; Indonesia.; As the second part of a community based educational campaign to convey the risk of HIV/AIDS to commercial sex workers in Jakarta, from May-July 1995, a total of 253 male transvestites (WARIA) were questioned about their sexual behavior patterns and their knowledge and attitude toward HIV/AIDS. In the previous report,
Pure red cell aplasia due to persistent B19 parvovirus infection in patient infected with human immunodeficiency virus type 1. Recovery with alpha-interferon therapy.: Sangre (Barc). 1998 Feb;43(1):67-9. Unique Identifier : AIDSLINE MED/98238045; Martins A; Costa A; Oliveira MJ; Rodrigues M; Ribeiro AP; Silvestre F; Reis A; Medicine (Medicina 1 and Haematology Services) Department, Hospital; Geral de Santo Antonio, Porto, Portugal.; B19 parvovirus (PV) infection is ordinarily resolved with the production of specific antibodies that neutralize virus infectivity for erythroid host cells. Nevertheless persistent infection with B19 PV and pure red blood cell aplasia have been documented. A 27 year-old male. i.v. drug abuser, HIV+ and HCV was diagnose
[Hearing aids--are they used?]: Tidsskr Nor Laegeforen. 1998 Mar 30;118(9):1347. Unique Identifier : AIDSLINE MED/98261868; Laukli E
[Hearing aids among the elderly--not only in the drawer!]: Tidsskr Nor Laegeforen. 1998 Mar 30;118(9):1414-6. Unique Identifier : AIDSLINE MED/98261882; Breidablik HJ; Kommunelegekontoret i Sula, Langev~ag.; The majority of hearing-aids are offered to elderly patients with presbyacusis. It is commonly assumed in the general population and among health professionals that many hearing-aids are not being used regularly on a daily basis. 83 patients over the age of 70 were visited unannounced and interviewed in their homes. T
Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV.: Trends Genet. 1998 Apr;14(4):144-50. Unique Identifier : AIDSLINE MED/98257018; Moore PS; Chang Y; Department of Pathology, Columbia University College of Physicians and; Surgeons, New York, NY 10032, USA. psm9@columbia.edu; A common feature of many tumor viruses is that they possess genes that produce specific proteins to inhibit major cellular tumor-suppressor pathways. Despite intensive studies, the reasons why these diverse and unrelated viruses have independently evolved oncogenes remains obscure. Kaposi-sarcoma-associated herpesviru
Induction therapy with an immunomodulatory CD2 antibody does not inhibit allograft vasculopathy after rat heart transplantation.: Transplant Proc. 1998 May;30(3):868-70. Unique Identifier : AIDSLINE MED/98257486; Dengler TJ; Szabo G; Amann K; Nottmeyer W; Vahl C; Hagl S; Zimmermann R; Department of Cardiology, University of Heidelberg, Germany.
Cytoimmunology in monitoring: the Munich experience.: Transplant Proc. 1998 May;30(3):873-4. Unique Identifier : AIDSLINE MED/98257488; Hammer C; Reichenspurner R; Meiser B; Reichart B; Institute for Surgical Research, Klinikum Grosshadern; Ludwig-Maximilians University, Munich, Germany.
[AIDS-related non-Hodgkin lymphomas. Clinical picture and prognosis]: Ugeskr Laeger. 1998 Apr 27;160(18):2685-8. Unique Identifier : AIDSLINE MED/98261924; Penkowa M; Hansen PB; H:S Rigshospitalet, epidemiafdeling M.; Patients infected with HIV are at high risk for developing non-Hodgkin s lymphomas (NHL). HIV-associated NHLs seem to be increasing in number. They consist of two major histopathological subtypes originating from B-lymphocytes: Burkitt-like lymphomas and diffuse large cell lymphomas. There seems to be a clear associat
[The spread of HIV in Greenland. Heterosexual epidemic--risk or reality? A 10-year review of HIV transmission and preventive care]: Ugeskr Laeger. 1998 May 4;160(19):2851-5. Unique Identifier : AIDSLINE MED/98261935; Winthereik M; H:S Rigshospitalet, afdeling M.; With the first report of an HIV-positive Inuit in 1985 Greenland was considered a high risk area for a self-sustained heterosexual HIV-epidemic, due to high incidences of sexually transmitted diseases. In 1986 a national HIV-interve
Comparison of four tests to evaluate the reactivity of rabbit sera against envelope or Gag-related proteins of bovine leukemia virus (BLV).: Vet Microbiol. 1998 Feb 15;60(1):13-25. Unique Identifier : AIDSLINE MED/98257988; Domenech A; Llames L; Goyache J; Suarez G; Gomez-Lucia E; Dpto. Patologia Animal I, Facultad de Veterinaria, Universidad; Complutense, Madrid, Spain.; Bovine leukemia virus (BLV) has a long latency period during which animals are inapparently infected, may spread the disease, and are only detected by serological techniques or by the most cumbersome molecular biology techniques. We have compared techniques for detecting either total antibodies (ELISA), anti-p24 and G
The first strand transfer during HIV-1 reverse transcription can occur either intramolecularly or intermolecularly.: Virology. 1998 May 10;244(2):245-51. Unique Identifier : AIDSLINE MED/98263801; van Wamel JL; Berkhout B; Department of Human Retrovirology, Academic Medical Center, University; of Amsterdam, The Netherlands.; Reverse transcription is a complicated process that involves at least two cDNA transfer reactions to produce a full-length copy DNA of the retroviral RNA genome. Because one retrovirus particle contains two identical genomic RNA molecules, the transfers can occur in an intramolecular or intermolecular manner. The mech
The tyrosine-17 residue of Nef in SIVsmmPBj14 is required for acute pathogenesis and contributes to replication in macrophages.: Virology. 1998 May 10;244(2):261-72. Unique Identifier : AIDSLINE MED/98263803; Saucier M; Hodge S; Dewhurst S; Gibson T; Gibson JP; McClure HM; Novembre FJ; Division of Microbiology and Immunology, Yerkes Regional Primate; Research Center, Atlanta, Georgia, USA.; The variant simian immunodeficiency virus termed SIVsmmPBj14 induces a rapidly fatal disease in pig-tailed macaques. The acute pathogenic effects of this virus appear to be associated with at least two in vitro characteristics: the ability to induce lymphocyte proliferation; and the ability to replicate in unstimulate
Establishment of MAIDS-defective virus-infected B cell lines and their characterization.: Virology. 1998 May 10;244(2):283-93. Unique Identifier : AIDSLINE MED/98263805; Klein SJ; Simard C; Jolicoeur P; Laboratory of Molecular Biology, Clinical Research Institute of; Montreal, Quebec, Canada.; Mice inoculated with the murine AIDS (MAIDS)-defective virus develop severe B and T cell dysfunctions. The primary event in the development of this disease is the infection and polyclonal expansion of the target cells of this defective virus, which have been reported to belong to the B cell lineage. To further study t
De novo reverse transcription of HTLV-1 following cell-to-cell transmission of infection.: Virology. 1998 May 10;244(2):294-301. Unique Identifier : AIDSLINE MED/98263806; Benovic S; Kok T; Stephenson A; McInnes J; Burrell C; Li P; Department of Microbiology and Immunology, University of Adelaide,; Australia.; Analogous to transmission of human T-cell leukemia virus type 1 HTLV-1) in vivo, an in vitro cell-to-cell infection model was established by coculturing MT-2 cells as virus donors and HUT78 cells as recipients. At a donor:recipient ratio of 1:2, cell fusion occurred and a new round of HTLV-1 genome replication was ini
Detection of subgenomic cDNAs and mapping of feline foamy virus mRNAs reveals complex patterns of transcription.: Virology. 1998 May 10;244(2):417-26. Unique Identifier : AIDSLINE MED/98263816; Bodem J; Lochelt M; Delius H; Flugel RM; Abteilung Retrovirale Genexpression, Forschungsschwerpunkt Angewandte; Tumorvirologie, Deutsches Krebsforschungszentrum, Heidelberg, Federal; Republic of Germany.; Feline foamy virus (FeFV) belongs to the group of spumaretroviruses that contain in addition to gag, pol, and env accessory genes collectively called bel genes. Primate FVs have been shown to utilize internal promoters in addition to the 5 LTR promoters. In contrast to other known retroviruses, the FV pol genes are e
High SDF-1 expression in HIV-1 carriers does not correlate with CD8+ T-cell-mediated suppression of viral replication.: Virology. 1998 May 10;244(2):467-72. Unique Identifier : AIDSLINE MED/98263820; Ohashi T; Arai M; Kato H; Kubo M; Fujii M; Yamamoto N; Iwamoto A; Kannagi M; Department of Immunotherapeutics, Tokyo Medical and Dental University,; Japan. toha.impt@med.tmd.ac.jp; Stromal cell-derived factor 1 (SDF-1) inhibits T-cell tropic T-tropic) HIV-1 infection in vitro. In this study, we examined the regulatory role of SDF-1 on HIV-1 replication in peripheral blood mononuclear cells (PBMC) of HIV-infected individuals. We found that the amount of SDF-1 mRNA in freshly isolated PBMC of HIV-
Subcellular localization of human immunodeficiency virus type 1 RNAs, Rev, and the splicing factor SC-35.: Virology. 1998 May 10;244(2):473-82. Unique Identifier : AIDSLINE MED/98263821; Boe SO; Bjorndal B; Rosok B; Szilvay AM; Kalland KH; Department of Microbiology and Immunology, Gade Institute, Bergen High; Technology Center, University of Bergen, Norway. Stig.Boe@rmf.ulb.no; The HIV-1 protein Rev regulates the cytoplasmic levels of incompletely spliced HIV-1 mRNAs. The plasmid pSVc21, which contains a HIV-1 provirus, was introduced into COS cells by transient transfection. Simultaneous detection of HIV-1 RNAs and Rev proteins produced in transfected cells was then performed in order to de
Evidence that both HIV and HIV-induced immunodeficiency enhance HCV replication among HCV seroconverters.: Virology. 1998 May 10;244(2):504-12. Unique Identifier : AIDSLINE MED/98263824; Beld M; Penning M; Lukashov V; McMorrow M; Roos M; Pakker N; van den Hoek A; Goudsmit J; Department of Human Retrovirology, Academic Medical Centre, University; of Amsterdam, The Netherlands. M.Beld@AMC.UvA.NL; The objective of this retrospective cohort study is to assess the mechanism by which human immunodeficiency virus type 1 (HIV) influences hepatitis C virus (HCV) replication in injecting drug users. Virological (HCV and HIV RNA levels) and immunological CD4+, CD8+ cell counts, and anti-CD3 reactivity) parameters were
The bis-azo compound FP-21399 inhibits HIV-1 replication by preventing viral entry.: Virology. 1998 May 10;244(2):530-41. Unique Identifier : AIDSLINE MED/98263827; Zhang JL; Choe H; Dezube BJ; Farzan M; Sharma PL; Zhou XC; Chen LB; Ono M; Gillies S; Wu Y; Sodroski JG; Crumpacker CS; Division of Infectious Diseases, Beth Israel Deaconess Medical Center,; Boston, Massachusetts 02215, USA.; The bis-azo compound FP-21399 inhibits HIV-1 infection. We now show that FP-21399 acts on the HIV-1 envelope glycoprotein to prevent viral replication. This compound targets the entry step of the HIV-1 replication cycle as demonstrated by time-of-addition and single cycle viral entry assays. The entry of SIVmac239, wh
Production of HIV-1 by human B cells infected in vitro: characterization of an EBV genome-negative B cell line chronically synthetizing a low level of HIV-1 after infection.: Virology. 1998 May 10;244(2):542-51. Unique Identifier : AIDSLINE MED/98263828; Fritsch L; Marechal V; Schneider V; Barthet C; Rozenbaum W; Moisan-Coppey M; Coppey J; Nicolas JC; Laboratoire de Microbiologie, Hopital Rothschild, Paris, France.; Human immunodeficiency virus type 1 (HIV-1) has tropism for helper T lymphocytes and cells of the monocyte/ macrophage lineages. HIV-1 can also infect other cell types, including B cells. We show here that 10% of fresh circulating B cells from HIV-1-seronegative donors (i) express the CD4 receptor and CCR5 and CXCR4,
Improved envelope function selected by long-term cultivation of a translation-impaired HIV-1 mutant.: Virology. 1998 May 10;244(2):552-62. Unique Identifier : AIDSLINE MED/98263829; Das AT; van Dam AP; Klaver B; Berkhout B; Department of Human Retrovirology, Academic Medical Center, University; of Amsterdam, The Netherlands.; The untranslated leader region of the human immunodeficiency virus (HIV) RNA genome contains multiple regulatory elements that fold into stable hairpin structures. Because extensive secondary structure can block the scanning of ribosomes, an alternative mechanism for HIV translation seems feasible. To study the mechan
Type IV hypersensitivity in the pathogenesis of FIPV-induced lesions.: Zentralbl Veterinarmed [B]. 1998 Apr;45(3):151-9. Unique Identifier : AIDSLINE MED/98249708; Paltrinieri S; Cammarata Parodi M; Cammarata G; Mambretti M; Istituto di Patologia Generale Veterinaria, Milan, Italy.; In focal lesions of feline infectious peritonitis (FIP), the cells involved in the delayed-type hypersensitivity were identified in formalin-fixed paraffin-embedded and frozen samples taken from 35 affected cats. The clinical diagnosis of FIP was confirmed by necropsy, histology and direct immunofluorescence against t
Development and characterization of conditionally immortalized osteoblast precursor cell lines from human bone marrow stroma.: J Bone Miner Res. 1998 Feb;13(2):205-17. Unique Identifier : AIDSLINE MED/98154901; Hicok KC; Thomas T; Gori F; Rickard DJ; Spelsberg TC; Riggs BL; Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA.; Although the differentiation of mature osteoblasts has been well studied, there is still a need for a convenient way to study preosteoblast differentiation. Our laboratory has recently described a method for isolating small numbers of authentic osteoblast precursor cells from human bone marrow (Rickard et al., J Bone
Prostaglandin receptors of the EP2 and EP4 subtypes regulate B lymphocyte activation and differentiation to IgE-secreting cells.: Adv Exp Med Biol. 1997;433:153-7. Unique Identifier : AIDSLINE MED/98221895; Fedyk ER; Harris SG; Padilla J; Phipps RP; University of Rochester Cancer Center, New York, USA.
Analysis of autoprocessing of Mason-Pfizer monkey virus proteinase in vitro. Three active forms of proteinase.: Adv Exp Med Biol. 1998;436:105-8. Unique Identifier : AIDSLINE MED/98221977; Pichova I; Zabransky A; Kost'alova I; Hruskova-Heidingsfeldova O; Andreansky M; Hunter E; Ruml T; Department of Biochemistry, Institute of Organic Chemistry and; Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech; Republic.
The regulation of sequential processing of HIV-1 Gag by the viral protease.: Adv Exp Med Biol. 1998;436:15-25. Unique Identifier : AIDSLINE MED/98221965; Pettit SC; Sheng N; Tritch R; Erickson-Viitanen S; Swanstrom R; Lineberger Comprehensive Cancer Center, DuPont Merck Pharmaceutical; Co., Wilmington, Delaware 19880, USA.
Activation mechanism of pepsinogen as compared to the processing of HIV protease gag-pol precursor protein.: Adv Exp Med Biol. 1998;436:245-52. Unique Identifier : AIDSLINE MED/98221997; Koelsch G; Loy J; Lin X; Tang J; Protein Studies Program, Oklahoma Medical Research Foundation,; University of Oklahoma Health Sciences Center, Oklahoma City 73104,; USA.
A cellular anti-apoptosis protein is cleaved by the HIV-1 protease.: Adv Exp Med Biol. 1998;436:27-9. Unique Identifier : AIDSLINE MED/98221966; Korant BD; Strack P; Frey MW; Rizzo CJ; DuPont Merck Pharmaceutical Co., Experimental Station, Wilmington,; Delaware 19880-0336, USA.; Cleavage of non-viral proteins is rarely observed with the HIV-1 protease (HIV pr). One such cleavage event occurs with bcl-2, an important cytoprotective protein. The loss of bcl-2 has biological consequences, leading to enhanced HIV replication and programmed death of the host cell. A strategy is proposed to suppres
Engineering catalytically defective forms of HIV protease to modulate its activity.: Adv Exp Med Biol. 1998;436:31-9. Unique Identifier : AIDSLINE MED/98221967; Craik CS; Babe LM; Dauber D; McPhee F; Rose J; Unal A; Department of Pharmaceutical Chemistry, University of California at; San Francisco 94143, USA.
Thermodynamics and proton uptake for pepstatin binding to retroviral and eukaryotic aspartic proteases.: Adv Exp Med Biol. 1998;436:381-6. Unique Identifier : AIDSLINE MED/98222016; Xie D; Gulnik S; Collins L; Gustchina E; Bhat TN; Erickson JW; Structural Biochemistry Program, SAIC Frederick, National Cancer; Institute, Frederick Cancer Research and Development Center, Maryland; 21702-1201, USA.
The effect of substrates on the kinetics and the in vivo threshold activity of mutant HIV-1 proteases.: Adv Exp Med Biol. 1998;436:47-51. Unique Identifier : AIDSLINE MED/98221969; Ermolieff J; Lin X; Tang J; Protein Studies Program, Oklahoma Medical Research Foundation,; University of Oklahoma Health Sciences Center, Oklahoma City 73104,; USA.
A comparison of gag-pol precursor cleavage in naturally arising HIV variants.: Adv Exp Med Biol. 1998;436:53-7. Unique Identifier : AIDSLINE MED/98221970; Bloom G; Perez E; Parikh S; Kay J; Mills J; Goodenow M; Dunn BM; Department of Biochemistry and Molecular Biology, University of Wales,; Cardiff, United Kingdom.
X-ray crystallographic studies of the structure-function relationships of HIV-1 protease.: Adv Exp Med Biol. 1998;436:59-63. Unique Identifier : AIDSLINE MED/98221971; Hong L; Zhang C; Hartsuck JA; Foundling S; Tang J; Protein Studies Program, Oklahoma Medical Research Foundation,; University of Oklahoma Health Sciences Center, Oklahoma City 73104,; USA.
Optimization of a macromolecular inhibitor of HIV-1 protease.: Adv Exp Med Biol. 1998;436:65-70. Unique Identifier : AIDSLINE MED/98221972; Dauber DS; McPhee F; Unal A; Craik CS; Department of Pharmaceutical Chemistry, University of California, San; Francisco 94143, USA.
In vitro selection and characterization of VX-478 resistant HIV-1 variants.: Adv Exp Med Biol. 1998;436:75-83. Unique Identifier : AIDSLINE MED/98221973; Pazhanisamy S; Partaledis JA; Rao BG; Livingston DJ; Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts 02139,; USA.; VX-478 (141W94), a potent inhibitor of HIV protease, is in late stage clinical trials for the treatment of HIV infection and AIDS. Resistant viruses were raised in vitro by passage of HIV-1IIIB in the presence of increasing concentrations of VX-478 and the related hydroxyethylamino sulfonamide inhibitor VB-11,328. By
Sensitivity to inhibition and catalytic efficiency of HIV proteinase mutants.: Adv Exp Med Biol. 1998;436:85-9. Unique Identifier : AIDSLINE MED/98221974; Wilson SI; Phylip LH; Gulnik SV; Mills JS; Bur D; Dunn BM; Kay J; School of Molecular and Medical Biosciences, University of Wales,; Cardiff, United Kingdom.
Computer assisted evaluation of inhibitor sensitivity to HIV-1 PR mutants.: Adv Exp Med Biol. 1998;436:91-7. Unique Identifier : AIDSLINE MED/98221975; Sussman F; Martinez LA; Villaverde MC; Protein Studies Program, Oklahoma Medical Research Foundation,; Oklahoma City 73104, USA.
Investigation of an allosteric site of HIV-1 proteinase involved in inhibition by Cu2+.: Adv Exp Med Biol. 1998;436:99-103. Unique Identifier : AIDSLINE MED/98221976; Danielson H; Lindgren MT; Markgren PO; Nillroth U; Department of Biochemistry, University of Uppsala, Sweden.
Effect of seasonal exposure to pollen on nonspecific interleukin-4, interleukin-5, and interferon-gamma in vitro release by peripheral blood mononuclear cells from subjects with pollinosis.: Allergy. 1998 Apr;53(4):420-5. Unique Identifier : AIDSLINE MED/98234185; Munoz-Bellido FJ; Monteseirin FJ; Escribano MM; Delgado J; Velazquez E; Conde J; Service of Allergology and Clinical Immunology, University Hospital; Virgen Macarena, Seville, Spain.; The immune response to environmental allergens depends on both genetic and environmental factors. Allergen exposure triggers the activation of allergen-specific Th2 cells in allergic patients, as well as increased Th2-type cytokine mRNA expression and eosinophil recruitment. Nevertheless, different patterns of release
Analysis of T cell subsets present in the peripheral blood and synovial fluid of reactive arthritis patients.: Ann Rheum Dis. 1998 Feb;57(2):100-6. Unique Identifier : AIDSLINE MED/98276287; Beacock-Sharp H; Young JL; Gaston JS; University of Cambridge School of Clinical Medicine, Department of; Medicine, Addenbrooke's Hospital.; OBJECTIVE: Reactive arthritis (ReA), a HLA-B27 associated arthropathy, develops in susceptible people after infection with certain bacteria. T cells have been implicated in the pathogenesis of the arthritis but which of the different subsets is involved is still debated. This study has further elucidated the role of t
Shed mediastinal blood transfusion after cardiac operations: a cost-effectiveness analysis.: Ann Thorac Surg. 1998 May;65(5):1248-54. Unique Identifier : AIDSLINE MED/98257202; Kilgore ML; Pacifico AD; Department of Pathology, University of Alabama at Birmingham; 35233-7331, USA. kilgore@wp.path.uab.edu; BACKGROUND: Cardiac surgical patients consume a significant fraction of the annual volume of allogeneic blood transfused. Scavenged autologous blood may serve as a cost-effective means of conserving donated blood and avoiding transfusion-related complications. METHODS: This study examines 834 patients after cardiac op
Recent advances in clinical/molecular andrology.: Arch Androl. 1998 May-Jun;40(3):187-210. Unique Identifier : AIDSLINE MED/98242659; Hafez B; Andrology Laboratory, Hafez/Hafez Reproductive Health Center, Kiawah; Island, South Carolina 29455, USA.; During the last decade there were extensive investigations in clinical and molecular andrology with emphasis on assisted reproduction, micromanipulation techniques of gametes, sperm/egg interaction, male contraception, diabetes mellitus, varicocele, andropause versus menopause, sexual dysfunction, associated hypertens
Counselor prompts to increase condom taking during treatment for cocaine dependence.: Behav Modif. 1998 Jan;22(1):29-44. Unique Identifier : AIDSLINE MED/98229153; Kirby KC; Marlowe DB; Carrigan DR; Platt JJ; Counseling Psychology Program, Temple University, Philadelphia, PA; 19122-6085, USA.; This study examined whether active prompting would increase the number of free condoms taken from dispensers placed in counselors offices in a cocaine abuse treatment clinic. Using a combined multiple baseline and reversal design, two teams of counselors were instructed to actively prompt and encourage condom taking
Shifts in the TH1/TH2 balance during human pregnancy correlate with apoptotic changes.: Biochem Biophys Res Commun. 1998 Apr 28;245(3):933-8. Unique Identifier : AIDSLINE MED/98249817; Reinhard G; Noll A; Schlebusch H; Mallmann P; Ruecker AV; Department of Clinical Biochemistry, University of Bonn, Germany.; lab04@mailer.meb.uni-bonn.de; An important prerequisite for a successful pregnancy is that the maternal immune system does not reject the fetus. Down-regulation of the T helper 1 (TH1) associated cellular immune response could therefore be essential. With flow cytometric techniques, we show on a single cell level that both CD4+ and CD8+ T cells fr
Changes in antigen expression on B lymphocytes during HIV infection.: Pathobiology. 1998;66(1):17-23. Unique Identifier : AIDSLINE MED/98237072; Ginaldi L; De Martinis M; D'Ostilio A; Marini L; Quaglino D; Department of Internal Medicine and Public Health, University of; L'Aquila, Italy. ginaldi@sgol.it; Involvement of the B cell compartment during HIV infection plays an important role in the development of immune deficiency. The aim of this study was the identification of specific antigen expression changes on B lymphocytes in HIV infection as surrogate markers in this cell population of certain functional aspects th
Biological basis of the HLA-B8,DR3-associated progression of acquired immune deficiency syndrome.: Pathobiology. 1998;66(1):33-7. Unique Identifier : AIDSLINE MED/98237074; Candore G; Romano GC; D'Anna C; Di Lorenzo G; Gervasi F; Lio D; Modica MA; Potestio M; Caruso C; Istituti di Patologia Generale, Universita di Palermo, Italia.; The factors influencing the evolution of human immunodeficiency virus (HIV) infection are not fully known, but the host genotype undoubtedly plays a role in determining the outcome of the disease by affecting the immune response to HIV. The role of the host human leukocyte antigen (HLA) genotype in the regulation of s
The Reproductive Tract and HIV-1 Transmission. Papers presented at the two-day interdisciplinary conference. Bethesda, Maryland, USA. February 11-12, 1997.: AIDS Res Hum Retroviruses. 1998 Apr;14 Suppl 1:S1-130. Unique Identifier : AIDSLINE MED/98241031
Infectivity and dynamics of HIV type 1 replication in the blood and reproductive tract of HIV type 1-infected women.: AIDS Res Hum Retroviruses. 1998 Apr;14 Suppl 1:S105-18. Unique Identifier : AIDSLINE MED/98241050; Rasheed S; Laboratory of Viral Oncology and AIDS Research, University of Southern; California School of Medicine, Los Angeles 90032-3626, USA.; This article delineates several parameters that can influence compartmentalized virus shedding in relation to organ-specific factors and cofactors in the blood and reproductive tract compartments of women infected with the human immunodeficiency virus type 1 (HIV-1). Because a wide variety of techniques is currently u
Prevalence and correlates of HIV type 1 shedding in the female genital tract.: AIDS Res Hum Retroviruses. 1998 Apr;14 Suppl 1:S11-5. Unique Identifier : AIDSLINE MED/98241034; Mostad SB; Department of Epidemiology, University of Washington, Seattle 98195,; USA.; Heterosexual transmission is the predominant mode of transmission of HIV-1 in most of the world. Factors correlated with viral shedding from the female reproductive tract (and thus infectivity of women) are discussed in this review. Hormonal contraceptive use, cervical ectopy, pregnancy, abnormal cervical and vaginal
Vaginal transmission of SIV: assessing infectivity and hormonal influences in macaques inoculated with cell-free and cell-associated viral stocks.: AIDS Res Hum Retroviruses. 1998 Apr;14 Suppl 1:S119-23. Unique Identifier : AIDSLINE MED/98241051; Sodora DL; Gettie A; Miller CJ; Marx PA; Aaron Diamond AIDS Research Center, The Rockefeller University, New; York, New York 10016, USA.; Cell associated and cell-free simian immunodeficiency virus (SIV) were used to investigate transmission of SIV across the vaginal mucosa of rhesus macaques. The intact vaginal epithelium was found to be a strong but penetrable barrier to cell-free SIV infection. We found that 10,000-fold more cell-free SIV was needed
Effects of two progestin-only contraceptives, Depo-Provera and Norplant-II, on the vaginal epithelium of rhesus monkeys.: AIDS Res Hum Retroviruses. 1998 Apr;14 Suppl 1:S125-30. Unique Identifier : AIDSLINE MED/98241052; Hild-Petito S; Veazey RS; Larner JM; Reel JR; Blye RP; BIOQUAL, Inc., Rockville, Maryland 20850, USA.; The objective of this study was to determine whether progestin-only contraceptives induce thinning of the vaginal epithelium in nonhuman primates. Eight intact rhesus monkeys four per group) were treated with either a single intramuscular injection of 30 mg of Depo-Provera or a subcutaneous insertion of Norplant-II (2
Effect of Depo-Provera on the vaginal epithelium and cervical ectopy: report on a study in progress [letter]: AIDS Res Hum Retroviruses. 1998 Apr;14 Suppl 1:S131. Unique Identifier : AIDSLINE MED/98241053; Mauck C
The vaginal microbial ecosystem and resistance to HIV.: AIDS Res Hum Retroviruses. 1998 Apr;14 Suppl 1:S17-21. Unique Identifier : AIDSLINE MED/98241035; Hillier SL; Department of Obstetrics, Gynecology, and Reproductive Sciences,; University of Pittsburgh School of Medicine, Pennsylvania 15213, USA.
Urological manifestations of HIV infection.: AIDS Res Hum Retroviruses. 1998 Apr;14 Suppl 1:S23-5. Unique Identifier : AIDSLINE MED/98241036; Coburn M; Department of Urology, Baylor College of Medicine, Ben Taub General; Hospital, Houston, Texas 77030, USA.; HIV-1 disease is associated with many infectious and neoplastic complications. This is particularly true of the genitourinary tract, where high rates of renal disease, neoplasms, voiding and erectile dysfunction, hematuria, opportunistic genitourinary infections, and epididymo-orchitis are found in HIV-1-infected indi
Factors associated with changes in HIV shedding in semen.: AIDS Res Hum Retroviruses. 1998 Apr;14 Suppl 1:S27-31. Unique Identifier : AIDSLINE MED/98241037; Fiscus SA; Vernazza PL; Gilliam B; Dyer J; Eron JJ; Cohen MS; Department of Microbiology and Immunology, University of North; Carolina at Chapel Hill, 27599, USA.; The efficiency and duration of transmissibilty of HIV seems to be highly variable and dependent on a number of factors related to both the donor and the recipient as well as characteristics intrinsic to the virus itself. Some of the factors likely to be important in sexual transmission of HIV include stage of disease,
Toward an understanding of a vector-free pandemic: the reproductive tract as conduit for the explosive global spread of HIV-1 infection.: AIDS Res Hum Retroviruses. 1998 Apr;14 Suppl 1:S3-4. Unique Identifier : AIDSLINE MED/98241032; Beckerman KP; Department of Obstetrics, Gynecology and Reproductive Sciences,; University of California, San Francisco 94141-9100, USA.
Human immunodeficiency virus in semen arises from a genetically distinct virus reservoir.: AIDS Res Hum Retroviruses. 1998 Apr;14 Suppl 1:S33-41. Unique Identifier : AIDSLINE MED/98241038; Kiessling AA; Fitzgerald LM; Zhang D; Chhay H; Brettler D; Eyre RC; Steinberg J; McGowan K; Byrn RA; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard; Medical School, Boston, Massachusetts 02115, USA.; The reservoir of human immunodeficiency virus (HIV) in semen is unknown. Several lines of evidence suggest that semen HIV may not arise from the same reservoir of infection as peripheral blood. If true, the viral burden in the two compartments could be qualitatively and quantitatively different, a scenario of potentia
Quantitation of mediators of inflammation and immunity in genital tract secretions and their relevance to HIV type 1 transmission.: AIDS Res Hum Retroviruses. 1998 Apr;14 Suppl 1:S43-9. Unique Identifier : AIDSLINE MED/98241039; Anderson DJ; Politch JA; Tucker LD; Fichorova R; Haimovici F; Tuomala RE; Mayer KH; Department of Obstetrics, Gynecology, and Reproductive Biology,; Brigham and Women's Hospital, Harvard Medical School, Boston,; Massachusetts 02115, USA.
Heterosexual transmission of human immunodeficiency virus type 1 HIV): interactions of conventional sexually transmitted diseases, hormonal contraception and HIV-1.: AIDS Res Hum Retroviruses. 1998 Apr;14 Suppl 1:S5-10. Unique Identifier : AIDSLINE MED/98241033; Plummer FA; Department of Medical Microbiology, University of Nairobi, Kenya.; The interactions between HIV-1 and other viral sexually transmitted infections (STI) are complex. The presence of ulcerative and nonulcerative STD increase susceptibility of exposed individuals to HIV-1 infection by several folds. In HIV-1 infected individuals, STD increase genital tract shedding of HIV-1 and enhance
Mucosal immunity in the female reproductive tract: correlation of immunoglobulins, cytokines, and reproductive hormones in human cervical mucus around the time of ovulation.: AIDS Res Hum Retroviruses. 1998 Apr;14 Suppl 1:S51-5. Unique Identifier : AIDSLINE MED/98241040; Kutteh WH; Moldoveanu Z; Mestecky J; Department of Obstetrics and Gynecology, The University of Tennessee,; Memphis 38163-2116, USA.; Mucosal surfaces serve as the portal of entry for many viral, bacterial, and parasitic infections. Understanding the immunity at mucosal membranes is essential to enhancing protection and decreasing infections. To evaluate the humoral and cellular immunity in the female reproductive tract, 15 reproductive-age women wi
The mucosal immune system in the human female reproductive tract: potential insights into the heterosexual transmission of HIV.: AIDS Res Hum Retroviruses. 1998 Apr;14 Suppl 1:S57-62. Unique Identifier : AIDSLINE MED/98241041; Yeaman GR; White HD; Howell A; Prabhala R; Wira CR; Department of Microbiology, Dartmouth Medical School, Lebanon, New; Hampshire 03756-0001, USA.; Using isolated cell suspensions and in situ techniques, we have partially characterized the organization, functional capacity, and sex hormone regulation of the mucosal immune system in the human female reproductive tract. Isolated cells suspensions have been used to demonstrate that the uterus contains antigen-presen
Mucosal phenotype of antiviral cytotoxic T lymphocytes in the vaginal mucosa of SIV-infected rhesus macaques.: AIDS Res Hum Retroviruses. 1998 Apr;14 Suppl 1:S63-6. Unique Identifier : AIDSLINE MED/98241042; McChesney MB; Collins JR; Miller CJ; California Regional Primate Research Center, University of; California-Davis, 95616-8542, USA.; CD8+ T lymphocytes are present in the vaginal epithelium and submucosa of women and female rhesus macaques. Antiviral cytotoxic T lymphocyte precursors were detected in the vaginal intraepithelial lymphocyte (IEL) population of SIV-infected monkeys. Monoclonal antibodies to adhesion molecules distinguish lymphocytes t
Mechanism of monocyte-macrophage-mediated transmission of HIV.: AIDS Res Hum Retroviruses. 1998 Apr;14 Suppl 1:S67-70. Unique Identifier : AIDSLINE MED/98241043; Phillips DM; Tan X; Perotti ME; Zacharopoulos VR; Population Council, New York, New York 10021, USA.; Observations from our laboratory support the theory that HIV-infected monocyte-macrophages present in genital tract secretions have an important role in sexual transmission of HIV. Light and electron microscopy were used to study the behavior of HIV-infected, primary human monocytes. These cells progress on surfaces,
SIV replication and the dendritic cell.: AIDS Res Hum Retroviruses. 1998 Apr;14 Suppl 1:S71-3. Unique Identifier : AIDSLINE MED/98241044; Pope M; Laboratory of Cellular Physiology and Immunology, Rockefeller; University, New York, New York 10021, USA.; To evaluate the potential involvement of dendritic cells (DCs) in the mucosal transmission of HIV-1 we have used a model system of skin-derived DCs to study the cell-virus interactions in vitro. More recently we have extended these studies to the macaque system to further investigate DCs from a variety of more accessi
Does viral tropism play a role in heterosexual transmission of HIV? Findings in the SIV-rhesus macaque model.: AIDS Res Hum Retroviruses. 1998 Apr;14 Suppl 1:S79-82. Unique Identifier : AIDSLINE MED/98241045; Miller CJ; California Regional Primate Research Center, and Department of; Pathology, Microbiology, and Immunology, School of Veterinary; Medicine, University of California-Davis, 95616, USA.; Substantial effort is being directed toward generating vaccines that can prevent the heterosexual transmission of HIV-1. If selection for specific variants during sexual intercourse occurs, then vaccines should be designed to prevent transmission of these specific viruses. Using the SIV-rhesus macaque model to test t
Mucosal transmission of virulent and avirulent lentiviruses in macaques.: AIDS Res Hum Retroviruses. 1998 Apr;14 Suppl 1:S83-7. Unique Identifier : AIDSLINE MED/98241046; Pauza CD; Horejsh D; Wallace M; Wisconsin Regional Primate Center and Department of Pathology and; Laboratory Medicine, University of Wisconsin-Madison, 53706, USA.; Sexual transmission of human immunodeficiency virus provides an efficient mode for virus spread and poses unique challenges to vaccine developers. Host and viral factors that affect transmission have been studied by epidemiological approaches in the human population, and some of these factors have been modeled with ex
The HIV type 1 coreceptor CCR5 and its role in viral transmission and disease progression.: AIDS Res Hum Retroviruses. 1998 Apr;14 Suppl 1:S89-92. Unique Identifier : AIDSLINE MED/98241047; Paxton WA; Kang S; Koup RA; Aaron Diamond AIDS Research Center, and The Rockefeller University,; New York, New York 10016, USA.; The purified CD4+ lymphocytes of a group of highly exposed but HIV-1-uninfected individuals were determined to be less susceptible to infection with multiple non-syncytium-inducing NSI) primary isolates of HIV-1 than were CD4+ lymphocytes from nonexposed control individuals. This relative resistance to HIV-1 infection
Natural endogenous reverse transcription of HIV type 1.: AIDS Res Hum Retroviruses. 1998 Apr;14 Suppl 1:S93-5. Unique Identifier : AIDSLINE MED/98241048; Zhang H; Dornadula G; Pomerantz RJ; Center for Human Virology, Department of Medicine, Jefferson Medical; College, Thomas Jefferson University, Philadelphia, Pennsylvania; 19107, USA.; Molecular mechanisms by which human lentiviruses, such as human immunodeficiency virus type 1 (HIV-1), are sexually transmitted have yet to be fully elucidated. It is now demonstrated that endogenous reverse transcription of lentiviruses can occur within the intact virion, before infection of target cells. This is a b
Oral SIV, SHIV, and HIV type 1 infection.: AIDS Res Hum Retroviruses. 1998 Apr;14 Suppl 1:S97-103. Unique Identifier : AIDSLINE MED/98241049; Ruprecht RM; Baba TW; Liska V; Ayehunie S; Andersen J; Montefiori DC; Trichel A; Murphey-Corb M; Martin L; Rizvi TA; Bernacky BJ; Buchl SJ; Keeling M; Dana-Farber Cancer Institute, Harvard Medical School, Boston,; Massachusetts 02115, USA.; Several strains of simian immunodeficiency virus (SIV), including uncloned and molecularly cloned SIV strains, can cross intact mucosal surfaces after oral exposure in both adult and neonatal rhesus macaques, resulting in viremia and disease. Cell-free SIV strains as well as infected whole blood have resulted in syste
HLA-DR/DQ transgenic, class II deficient mice as a novel model to select for HSP T cell epitopes with immunotherapeutic or preventative vaccine potential.: Biotherapy. 1998;10(3):191-6. Unique Identifier : AIDSLINE MED/98218900; Geluk A; Taneja V; van Meijgaarden KE; de Vries RR; David CS; Ottenhoff TH; Department of Immunohematology and Blood Bank, University Hospital; Leiden, The Netherlands. Geluk@Rullf2.Medfac.Leidenuniv.nl; Protective immunity against mycobacteria is dependent on antigen/MHC class II specific, CD4+ Th1 cells. HLA-DR3-restricted Th1 cells respond to a subset of mycobacterial antigens, including the immunodominant hsp65, and recognize a single epitope in hsp65, notably p1-20. Altered peptide ligands (APL) of p1-20 can inhi
Functional analysis of the p53 protein in AIDS-related non-Hodgkin's lymphomas and polymorphic lymphoproliferations.: Br J Haematol. 1998 May;101(2):311-7. Unique Identifier : AIDSLINE MED/98270690; Martin A; Flaman JM; Frebourg T; Davi F; El Mansouri S; Amouroux J; Raphael M; Service d'Anatomie et Cytologie Pathologiques, Hopital Avicenne,; Bobigny, France.; Alteration of the tumour suppressor gene p53 is frequent in AIDS-related non-Hodgkin s lymphomas (AIDS-NHL), particularly in Burkitt s or Burkitt s-like lymphomas (BL/BLL). Since mechanisms of inactivation other than mutations have been advanced, the transcriptional activity of the p53 protein was studied in a functio
Epitope mapping of HTLV envelope seroreactivity in LGL leukaemia.: Br J Haematol. 1998 May;101(2):318-24. Unique Identifier : AIDSLINE MED/98270691; Loughran TP Jr; Hadlock KG; Perzova R; Gentile TC; Yang Q; Foung SK; Poiesz BJ; Department of Medical Oncology and Hematology, H. Lee Moffitt Cancer; Center and Research Institute at the University of South Florida,; Tampa 33612, USA.; Sera from approximately 50% of patients with large granular lymphocyte (LGL) leukaemia react with a recombinant human T-cell leukaemia/lymphoma virus (HTLV) transmembrane envelope protein, p21e. Two immunodominant epitopes within env p21e have been defined by reactivity against recombinant proteins GD21 and BA21. In t
Long-term immune reconstitution and outcome after HLA-nonidentical T-cell-depleted bone marrow transplantation for severe combined immunodeficiency: a European retrospective study of 116 patients.: Blood. 1998 May 15;91(10):3646-53. Unique Identifier : AIDSLINE MED/98241407; Haddad E; Landais P; Friedrich W; Gerritsen B; Cavazzana-Calvo M; Morgan G; Bertrand Y; Fasth A; Porta F; Cant A; Espanol T; Muller S; Veys P; Vossen J; Fischer A; Unite d'Immunologie et d'Hematologie Pediatriques, Departement de; Pediatrie, Hopital Necker-Enfants Malades, Paris, France.; ehaddad@igr.fr; We have performed a retrospective analysis of the development of T- and B-cell functions after HLA-nonidentical T-cell-depleted bone marrow transplantation (BMT) performed in 193 patients with severe combined immunodeficiency (SCID) at 18 European centers between December 1982 and December 31, 1993. One hundred sixtee
Toxicity and efficacy of defined doses of CD4(+) donor lymphocytes for treatment of relapse after allogeneic bone marrow transplant.: Blood. 1998 May 15;91(10):3671-80. Unique Identifier : AIDSLINE MED/98241410; Alyea EP; Soiffer RJ; Canning C; Neuberg D; Schlossman R; Pickett C; Collins H; Wang Y; Anderson KC; Ritz J; Divisions of Hematologic Malignancies and Biostatistics, Dana-Farber; Cancer Institute, Boston, MA, USA. edwin_alyea@dfci.harvard.edu; Donor lymphocyte infusions (DLI) can induce remissions in patients who have relapsed after allogeneic bone marrow transplantation (BMT). However, DLI frequently also result in significant acute and/or chronic graft-versus-host disease GVHD). Several clinical and experimental lines of evidence have suggested that CD8(+
Effect of L-carnitine on human immunodeficiency virus-1 infection-associated apoptosis: a pilot study.: Blood. 1998 May 15;91(10):3817-24. Unique Identifier : AIDSLINE MED/98241426; Moretti S; Alesse E; Di Marzio L; Zazzeroni F; Ruggeri B; Marcellini S; Famularo G; Steinberg SM; Boschini A; Cifone MG; De Simone C; Department of Infectious Diseases, University La Sapienza, Rome,; Italy.; The Fas/Fas ligand system is involved in uncontrolled apoptosis, which ultimately leads to the loss of T lymphocytes in human immunodeficiency virus (HIV)-infected individuals. The signal transduced by Fas receptor involves the activation of an acidic sphingomyelinase, sphingomyelin breakdown, and ceramide production.
Demonstration of Kaposi's sarcoma-associated herpes virus cyclin D homolog in cutaneous Kaposi's sarcoma by colorimetric in situ hybridization using a catalyzed signal amplification system.: Blood. 1998 May 15;91(10):3825-32. Unique Identifier : AIDSLINE MED/98241427; Reed JA; Nador RG; Spaulding D; Tani Y; Cesarman E; Knowles DM; Department of Pathology, The New York Hospital-Cornell Medical Center,; New York, NY, USA.; Kaposi s sarcoma-associated herpes virus (KSHV)/human herpes virus 8 (HHV8) DNA sequences have been demonstrated in Kaposi s sarcoma (KS), as well as in some acquired immunodeficiency syndrome (AIDS)-related non-Hodgkin s lymphomas (NHL) and in multicentric Castleman s disease. Although KSHV DNA generally is abundant
Functional diversity of the CD8(+) T-cell response to Epstein-Barr virus (EBV): implications for the pathogenesis of EBV-associated lymphoproliferative disorders.: Blood. 1998 May 15;91(10):3875-83. Unique Identifier : AIDSLINE MED/98241432; Nazaruk RA; Rochford R; Hobbs MV; Cannon MJ; Department of Microbiology, University of Arkansas for Medical; Sciences, Little Rock, AR, USA.; Epstein-Barr virus (EBV)-specific CD8(+) cytotoxic T cells are thought to be critical for the control of EBV, which persists in healthy individuals as a latent infection of B cells. However, recent observations have indicated that CD8(+) T-cell responses are not uniformly cytotoxic and that CD8(+) T cells may be subdi
Constitutive chemokine production results in activation of leukocyte function-associated antigen-1 on adult T-cell leukemia cells.: Blood. 1998 May 15;91(10):3909-19. Unique Identifier : AIDSLINE MED/98241436; Tanaka Y; Mine S; Figdor CG; Wake A; Hirano H; Tsukada J; Aso M; Fujii K; Saito K; van Kooyk Y; Eto S; The First Department of Internal Medicine , University of Occupational; and Environmental Health, Japan.; Adult T-cell leukemia (ATL) is characterized by massive infiltration of circulating ATL cells into a variety of tissues, a finding often associated with poor prognosis. Leukocyte migration from circulation into tissue depends on integrin-mediated adhesion to endothelium, and integrins are tightly regulated by several
Mutation of CD95 (Fas/Apo-1) gene in adult T-cell leukemia cells.: Blood. 1998 May 15;91(10):3935-42. Unique Identifier : AIDSLINE MED/98241439; Tamiya S; Etoh K; Suzushima H; Takatsuki K; Matsuoka M; The Second Department of Internal Medicine, Kumamoto University School; of Medicine, Kumamoto, Japan.; CD95 antigen (also known as Fas or Apo-1) and Fas ligand play key roles in apoptosis of cells of the immune system, function as effector molecules of cytotoxic T lymphocytes, and function in the elimination of activated lymphocytes during the downregulation of the immune response. The critical roles of the Fas-Fas lig
Recombinant human growth hormone for AIDS-associated wasting.: Ann Pharmacother. 1998 Apr;32(4):437-45. Unique Identifier : AIDSLINE MED/98220609; Windisch PA; Papatheofanis FJ; Matuszewski KA; Clinical Practice Advancement Center, University HealthSystem; Consortium, Oak Brook, IL 60521, USA. windisch@msgate.uhc.edu; OBJECTIVE: To review the current literature regarding the role of recombinant human growth hormone (rhGH) in the treatment of AIDS-associated wasting and to briefly describe alternative therapies. DATA SOURCES: A literature search was performed on MEDLINE and AIDSLINE for the period from January 1985 through September
HIV wasting syndrome: treatment update.: Ann Pharmacother. 1998 Apr;32(4):446-58. Unique Identifier : AIDSLINE MED/98220610; Balog DL; Epstein ME; Amodio-Groton MI; Montefiore Medical Center, Bronx, NY 10467, USA.; OBJECTIVE: To review the pathophysiology and treatment of HIV wasting syndrome. DATA SOURCES AND STUDY SELECTION: MEDLINE searches (January 1987-September 1997) of the English-language medical literature were conducted. Bibliographies were also selected during a manual review. DATA SYNTHESIS: HIV-related weight loss,
Rheumatoid arthritis and apoptosis.: Intern Med. 1998 Feb;37(2):184-8. Unique Identifier : AIDSLINE MED/98209974; Sumida T; Hasunuma T; Asahara H; Maeda T; Nishioka K; The Division of Rheumatology, Immunology, and Genetic Program,; Institute of Medical Science, St. Marianna University School of; Medicine, Kawasaki.
NetOglyc: prediction of mucin type O-glycosylation sites based on sequence context and surface accessibility.: Glycoconj J. 1998 Feb;15(2):115-30. Unique Identifier : AIDSLINE MED/98216950; Hansen JE; Lund O; Tolstrup N; Gooley AA; Williams KL; Brunak S; Center for Biological Sequence Analysis, The Technical University of; Denmark, Lyngby. janhan@cbs.dtu.dk; The specificities of the UDP-GalNAc:polypeptide Nacetylgalactosaminyltransferases which link the carbohydrate GalNAc to the side-chain of certain serine and threonine residues in mucin type glycoproteins, are presently unknown. The specificity seems to be modulated by sequence context, secondary structure and surface
[Cloning and characterization of CCRS receptors of chemokines, principal receptors of the AIDS virus]: Bull Mem Acad R Med Belg. 1997;152(7-9):311-6; discussion 317. Unique Identifier : AIDSLINE MED/98286144; Parmentier M; IRIBHN et Service de Genetique medicale, Campus Erasme de l'Universite; libre de Bruxelles.; Chemokine receptors belong to G protein-coupled receptors. The chemokine receptor CCR5, that binds M1P-1 alpha, M1P-1 beta and RANTES, was characterized as the main coreceptors for M-tropic strains of HIV-1, the most important for the transmission of the disease. This receptor is necessary, together with CD4, for the
The Leishmania promastigote surface antigen-2 (PSA-2) is specifically recognised by Th1 cells in humans with naturally acquired immunity to L. major.: FEMS Immunol Med Microbiol. 1998 Mar;20(3):209-18. Unique Identifier : AIDSLINE MED/98226143; Kemp M; Handman E; Kemp K; Ismail A; Mustafa MD; Kordofani AY; Bendtzen K; Kharazmi A; Theander TG; Center for Medical Parasitology, Department of Clinical Microbiology,; University Hospital (Rigshospitalet), University of Copenhagen,; Denmark. mke@ssi.dk; The promastigote surface antigen-2 (PSA-2) is a Leishmania parasite antigen, which can induce Th1-mediated protection against murine leishmaniasis when used as a vaccine. To evaluate PSA-2 as a human vaccine candidate the specific T-cell response to PSA-2 was characterised in individuals immune to cutaneous leishmania
AIDS and HIV infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1998 Apr 24;8(17):155-8. Unique Identifier : AIDSLINE MED/98267883
Thymoma and cellular immune deficiency in an adolescent.: Pediatr Allergy Immunol. 1998 Feb;9(1):49-52. Unique Identifier : AIDSLINE MED/98221615; Sicherer SH; Cabana MD; Perlman EJ; Lederman HM; Matsakis RR; Winkelstein JA; Eudowood Division of Allergy and Immunology, Johns Hopkins University; School of Medicine, Baltimore, Maryland.; Thymoma has been associated with both humoral immunodeficiency and cellular immunodeficiency, but the latter association has never been described in the pediatric age group. We report a 15-year-old female with thymoma, recalcitrant oropharyngeal candidiasis, recurrent generalized cutaneous herpes simplex virus type 2
Adolescent girls and pelvic inflammatory disease: experience and practices of emergency department pediatricians.: Arch Pediatr Adolesc Med. 1998 May;152(5):449-54. Unique Identifier : AIDSLINE MED/98266063; Benaim J; Pulaski M; Coupey SM; Tafnit Institute for Adolescents, Jerusalem, Israel.; OBJECTIVE: To describe the experience and practices of emergency department pediatricians in the United States related to the diagnosis and management of pelvic inflammatory disease (PID) in adolescent girls and to compare this experience with Centers for Disease Control and Prevention
[Importance of molecular biology in retrovirus and herpesvirus infections]: Transfus Clin Biol. 1998 Feb;5(1):39-46. Unique Identifier : AIDSLINE MED/98238859; Agut H; Laboratoire de virologie du Cervi, groupe hospitalier; Pitie-Salpetriere, France.; Molecular biology has long been used as a tool for basic research in virology. Its medical use is recent and has been supported both by numerous technical improvements and the discovery of new human viruses. This is illustrated by the emergence of human immunodeficiency virus (HIV)-1, HIV-2, human T-cell leukemia viru
Distribution of brain HIV load in AIDS.: Brain Pathol. 1998 Apr;8(2):277-84. Unique Identifier : AIDSLINE MED/98206362; Wiley CA; Soontornniyomkij V; Radhakrishnan L; Masliah E; Mellors J; Hermann SA; Dailey P; Achim CL; Department of Pathology, University of Pittsburgh Medical Center, PA; 15213, USA. wiley@np.awing.upmc.edu; Approximately one quarter of patients with AIDS develop severe cognitive deficits called HIV-associated dementia complex (ADC). There is some controversy regarding the importance of viral load in mediating neurologic disease. With the advent of sensitive, quantitative and reproduci
[HIV infections in gynecology and obstetrics]: Ceska Gynekol. 1997 Aug;62(4):240-3. Unique Identifier : AIDSLINE MED/98263018; Pavlista D; Gynek.-porod. oddeleni nemocnice v Koline.
[Approaches in the prevention of STD as related to the status of HIV/AIDS infection among prostitutes in Holland]: Bratisl Lek Listy. 1998 Feb;99(2):123-4. Unique Identifier : AIDSLINE MED/98249693; Kliment M; Slovenska spolocnost pre planovane rodicovstvo a vychovu k; rodicovstvu, Bratislava.
Clinical, cellular, and molecular factors that contribute to antifungal drug resistance.: Clin Microbiol Rev. 1998 Apr;11(2):382-402. Unique Identifier : AIDSLINE MED/98225756; White TC; Marr KA; Bowden RA; Department of Pathobiology, School of Public Health and Community; Medicine, University of Washington, Seattle Biomedical Research; Institute, Washington, USA. tedwhite@u.washington.edu; In the past decade, the frequency of diagnosed fungal infections has risen sharply due to several factors, including the increase in the number of immunosuppressed patients resulting from the AIDS epidemic and treatments during and after organ and bone marrow transplants. Linked with the increase in fungal infections
CD4+ and CD8+ cell cytokine profiles in neonates, older children, and adults: increasing T helper type 1 and T cytotoxic type 1 cell populations with age.: Cell Immunol. 1998 Feb 1;183(2):149-56. Unique Identifier : AIDSLINE MED/98269882; Chipeta J; Komada Y; Zhang XL; Deguchi T; Sugiyama K; Azuma E; Sakurai M; Department of Pediatrics, Mie University School of Medicine, Japan.; The growing body of evidence suggestive of T helper types 1 and 2 Th1/Th2) including their counterparts T cytotoxic types 1 and 2 Tc1/Tc2) cell responses during various human disease states necessitates determination of normal T cell subsets cytokine profiles. We show here, using intracellular cytokine staining and f
Gangliosides enhance apoptosis of thymocytes.: Cell Immunol. 1998 Feb 1;183(2):90-8. Unique Identifier : AIDSLINE MED/98269875; Zhou J; Shao H; Cox NR; Baker HJ; Ewald SJ; Scott-Ritchey Research Center, College of Veterinary Medicine, Auburn; University, Alabama 36849, USA.; Monosialogangliosides, normal components of cell membranes, regulate cell development and differentiation in several organs. Our previous observation of dramatic premature thymic involution in cats with feline GM1 gangliosidosis, whose thymocytes have abnormally high cell surface gangliosides, suggested that excess GM
[Theophylline--anti-inflammatory drug (editorial)]: Pol Merkuriusz Lek. 1998 Feb;4(20):61-5. Unique Identifier : AIDSLINE MED/98253660; Chazan R; Kliniki Pneumonologii Akademii Medycznej w Warszawie.; Since many years the theophylline have been noted for their bronchodilator properties. Several studies have indicated an inhibitory action of theophylline on the late response following allergen challenge and his effect was demonstrated at lower plasma levels then the so called therapeutic range of 10-20 micrograms/ml
Association of Kaposi's sarcoma associated herpesvirus (KSHV) DNA in bronchoalveolar lavage fluid of HIV infected individuals with bronchoscopically diagnosed tracheobronchial Kaposi's sarcoma.: Sex Transm Infect. 1998 Feb;74(1):27-31. Unique Identifier : AIDSLINE MED/98276550; Howard MR; Brink NS; Whitby D; Tedder RS; Miller RF; Department of Virology, University College London Medical School,; University College London Hospitals.; OBJECTIVES: To determine the frequency of detection of Kaposi s sarcoma associated herpesvirus (KSHV), also known as human herpesvirus (HHV) type 8, DNA in bronchoalveolar lavage (BAL) fluid from HIV infected individuals with and without KS and to compare this with the detection rate in peripheral blood. Also to ident
Comparison of clinical, histological, and virological symptoms of HPV in HIV-1 infected men and immunocompetent subjects.: Sex Transm Infect. 1998 Feb;74(1):32-4. Unique Identifier : AIDSLINE MED/98276551; Aynaud O; Piron D; Barrasso R; Poveda JD; Department Urology-Andrology, Leopold Bellan Hospital, Paris, France.; OBJECTIVE: We assessed the clinical, histological, and virological features of anogenital human papillomavirus (HPV) infection, according to their immune status in HIV-1 infected men, referred for an anogenital examination or treatment, in comparison with immunocompetent patients. METHODS: The study population compris
Racial origin, sexual behaviour, and genital infection among heterosexual men attending a genitourinary medicine clinic in London (1993-4).: Sex Transm Infect. 1998 Feb;74(1):40-4. Unique Identifier : AIDSLINE MED/98276553; Evans BA; Bond RA; MacRae KD; Department of Genitourinary Medicine, Charing Cross Hospital, London.; OBJECTIVES: To compare variables of sexual behaviour and incidence of genital infections among heterosexual men of different racial origins. DESIGN: A prospective cross sectional study of sexual behaviour reported by a standardised self administered questionnaire in new patients who presented for screening and diagnos
Racial origin, sexual lifestyle, and genital infection among women attending a genitourinary medicine clinic in London (1992).: Sex Transm Infect. 1998 Feb;74(1):45-9. Unique Identifier : AIDSLINE MED/98276554; Evans BA; Kell PD; Bond RA; MacRae KD; Department of Genitourinary Medicine, Charing Cross Hospital, London.; OBJECTIVES: To compare variables of sexual behaviour and incidence of genital infections among women of different racial origins and lifestyles. DESIGN: A prospective cross sectional study of sexual behaviour reported by a standardised self administered questionnaire in new patients who presented for screening and dia
HIV infection among family planning clinic attenders in Glasgow: why prevalence has remained low in this general population group.: Sex Transm Infect. 1998 Feb;74(1):50-3. Unique Identifier : AIDSLINE MED/98276555; Goldberg D; Carr S; Cameron S; Codere G; Scottish Centre for Infection and Environmental Health, Ruchill; Hospital, Glasgow.; OBJECTIVE: During 1991-2, unlinked anonymous testing of dried blood spots from neonatal metabolic screening cards showed the prevalence of HIV among childbearing women from Glasgow to be extremely low at 0.01%. A study was conducted to determine if non-pregnant sexually active women who engaged in unprotected sexual i
Evaluation of a targeted HIV prevention programme among female commercial sex workers in the south of Thailand.: Sex Transm Infect. 1998 Feb;74(1):54-8. Unique Identifier : AIDSLINE MED/98276556; van Griensven GJ; Limanonda B; Ngaokeow S; Ayuthaya SI; Poshyachinda V; Division of Public Health, Municipal Health Service, Amsterdam,; Netherlands.; OBJECTIVE: To evaluate a targeted HIV prevention programme among female commercial sex workers (CSWs) in the south of Thailand . SUBJECTS AND METHODS: A pretest-post-test comparison group study was carried out in Sungai Kolok and Betong between June and December 1994. In June 408
Oral sex and the transmission of viral STIs.: Sex Transm Infect. 1998 Feb;74(1):6-10. Unique Identifier : AIDSLINE MED/98276547; Edwards S; Carne C; Department of Genitourinary Medicine, Addenbrooke's Hospital,; Cambridge.; OBJECTIVE: To review the literature on the role of oral sex in the transmission of viral sexually transmitted infections (STIs). METHOD: A Medline search was performed using the keywords oro-genital sex, and those specific to each infection. Further references from each article identified by Medline were also included
Sixth European Conference on Clinical Aspects and Treatment of HIV Infection, Hamburg, Germany, 11-15 October 1997.: Sex Transm Infect. 1998 Feb;74(1):71. Unique Identifier : AIDSLINE MED/98291786; Radcliffe KW; Ross JD
Age and sexual risk behaviour [letter]: Sex Transm Infect. 1998 Feb;74(1):74-5. Unique Identifier : AIDSLINE MED/98276560; Wells H; Sherr L; Norton J; Miller R; Johnson MA; Elford J
Severe hyponatraemia and severe hyperkalaemia in an HIV positive patient who received high dose co-trimoxazole [letter]: Sex Transm Infect. 1998 Feb;74(1):75-6. Unique Identifier : AIDSLINE MED/98276561; David LM; Ross J
Visualisation and quantification of HIV related brain atrophy using registered serial magnetic resonance imaging [letter]: Sex Transm Infect. 1998 Feb;74(1):76. Unique Identifier : AIDSLINE MED/98276562; Wilkinson ID; Fox NC; Freeborough PA; Miller RF
Do junior doctors know what to do if they have a needlestick injury? [letter]: Sex Transm Infect. 1998 Feb;74(1):76-7. Unique Identifier : AIDSLINE MED/98276563; Rich AE; Fisher M
Second generation heterosexual transmission of HIV-1 infection from women infected in the United Kingdom [letter]: Sex Transm Infect. 1998 Feb;74(1):77. Unique Identifier : AIDSLINE MED/98276564; Pakianathan MR; Scott GR; McMillan A
Molecular events in uterine cervical cancer.: Sex Transm Infect. 1998 Apr;74(2):101-9. Unique Identifier : AIDSLINE MED/98287355; Southern SA; Herrington CS; Department of Pathology, University of Liverpool, Royal Liverpool; University Hospital.; OBJECTIVE: To review the literature regarding the molecular events which occur in the development of uterine cervical cancer, with particular reference to human papillomavirus (HPV) infection. METHODOLOGY: Bibliographic searches of Medline and the ISI citation databases using appropriate keywords, including the follow
Community based study of sexually transmitted diseases in rural women in the highlands of Papua New Guinea: prevalence and risk factors.: Sex Transm Infect. 1998 Apr;74(2):120-7. Unique Identifier : AIDSLINE MED/98287358; Passey M; Mgone CS; Lupiwa S; Suve N; Tiwara S; Lupiwa T; Clegg A; Alpers MP; Papua New Guinea Institute of Medical Research, Goroka, Papua New; Guinea.; OBJECTIVE: To estimate the prevalence of sexually transmitted diseases (STDs) and determine their risk factors/markers among a rural population of women in the highlands of Papua New Guinea . METHODS: Community based random cluster s
HIV infection and high risk behavior among patients attending an STD referral clinic in Prague, Czech Republic.: Sex Transm Infect. 1998 Apr;74(2):128-30. Unique Identifier : AIDSLINE MED/98287359; Mikl J; Sudar Z; Smith PF; Bruckova M; Jedlicka J; Kastankova V; Tryzna R; DeHovitz J; New York State Department of Health, Albany, New York, USA.; OBJECTIVE: This survey was conducted to determine the prevalence of HIV infection and associated risk behaviour in a high risk population of clients attending an STD clinic in Prague, Czech Republic . METHODS: Between September 1994 and January 1995, clients entering the Apol
Characteristics associated with prevalent HIV infection among a cohort of sex workers in Cameroon.: Sex Transm Infect. 1998 Apr;74(2):131-5. Unique Identifier : AIDSLINE MED/98287360; Ryan KA; Roddy RE; Zekeng L; Weir SS; Tamoufe U; Family Health International, Durham, NC. USA.; OBJECTIVE: To determine prevalence of HIV infection in a cohort of female sex workers in Cameroon , and to describe characteristics associated with HIV infection in this population. METHODS: In a cross sectional study, 2260 female sex workers in Cameroon were interviewed and scree
Extragenital donovanosis in a patient with AIDS.: Sex Transm Infect. 1998 Apr;74(2):142-3. Unique Identifier : AIDSLINE MED/98287363; Sanders CJ; City of Bulawayo, Health Services Department, Zimbabwe.; A case of extragenital donovanosis in a patient with AIDS is reported from Zimbabwe . Despite the rarity of donovanosis in Zimbabwe it is important that health workers are familiar with this disease since donovanosis increases the risk of HIV transmission and appropriate treatment
Should preventive antiretroviral treatment be offered following sexual exposure to HIV? The case for.: Sex Transm Infect. 1998 Apr;74(2):144-5. Unique Identifier : AIDSLINE MED/98287364; Desmond NM; Coker RJ; Garden Clinic, Sexual Health Service, Upton Hospital, Slough,; Berkshire.
Should preventive antiretroviral treatment be offered following sexual exposure to HIV? Not yet!: Sex Transm Infect. 1998 Apr;74(2):146-8. Unique Identifier : AIDSLINE MED/98287365; Evans B; Darbyshire J; Cartledge J; PHLS AIDS & STD Center, London.
Can we predict the prognosis of HIV infection? How to use the findings of a prospective study.: Sex Transm Infect. 1998 Apr;74(2):149-54. Unique Identifier : AIDSLINE MED/98287366; Low N; Egger M; Department of Genitourinary Medicine, King's College School of; Medicine and Dentistry, London.
Peer education and community based HIV prevention for homosexual men: peer led, evidence based, or fashion driven? [editorial]: Sex Transm Infect. 1998 Apr;74(2):87-9. Unique Identifier : AIDSLINE MED/98287351; Hart GJ
Lymphocytes in asthma.: Can Respir J. 1998 Jan-Feb;5(1):27-30. Unique Identifier : AIDSLINE MED/98223694; Kotsimbos AT; Hamid Q; Meakins-Christie Laboratories, McGill University, Montreal, Canada.
An overview of topical antifungal therapy in dermatomycoses. A North American perspective.: Drugs. 1998 May;55(5):645-74. Unique Identifier : AIDSLINE MED/98246954; Gupta AK; Einarson TR; Summerbell RC; Shear NH; Department of Medicine, Sunnybrook Health Science Center, Toronto,; Ontario, Canada. agupta@execulink.com; Dermatophytes cause fungal infections of keratinised tissues, e.g. skin, hair and nails. The organisms belong to 3 genera, Trichophyton, Epidermophyton and Microsporum. Dermatophytes may be grouped into 3 categories based on host preference and natural habitat. Anthropophilic species predominantly infect humans, geoph
Abacavir.: Drugs. 1998 May;55(5):729-36; discussion 737-8. Unique Identifier : AIDSLINE MED/98246961; Foster RH; Faulds D; Adis International Limited, Auckland, New Zealand.; Abacavir is a nucleoside analogue reverse transcriptase inhibitor that inhibits clinical isolates of HIV in vitro with a potency similar to that of zidovudine. Resistance to abacavir develops relatively slowly. Cross-resistance between abacavir and di
Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes.: EMBO J. 1998 May 1;17(9):2472-81. Unique Identifier : AIDSLINE MED/98232493; Piguet V; Chen YL; Mangasarian A; Foti M; Carpentier JL; Trono D; Department of Genetics and Microbiology, Centre Medical Universitaire,; 1, rue Michel-Servet, 1211 Geneve 4, Switzerland.; The Nef protein of primate lentiviruses down-regulates the cell surface expression of CD4 and probably MHC I by connecting these receptors with the endocytic machinery. Here, we reveal that Nef interacts with the mu chains of adaptor complexes, key components of clathrin-coated pits. For human immunodeficiency virus t
Modulation of HIV-1 infectivity by MAPK, a virion-associated kinase.: EMBO J. 1998 May 1;17(9):2607-18. Unique Identifier : AIDSLINE MED/98232506; Jacque JM; Mann A; Enslen H; Sharova N; Brichacek B; Davis RJ; Stevenson M; University of Massachusetts Medical School, Program in Molecular; Medicine, Worcester, MA 01605, USA.; Infection of a cell by human immunodeficiency virus type 1 HIV-1) results in the formation of a reverse transcription complex in which viral nucleic acids are synthesized. Efficient disengagement of the reverse transcription complex from the cell membrane and subsequent nuclear translocation require phosphorylation of
Efficient HIV-1 replication can occur in the absence of the viral matrix protein.: EMBO J. 1998 May 1;17(9):2699-708. Unique Identifier : AIDSLINE MED/98232514; Reil H; Bukovsky AA; Gelderblom HR; Gottlinger HG; Department of Cancer Immunology and AIDS, Dana-Farber Cancer; Institute, and Department of Pathology, Harvard Medical School,; Boston, MA 02115, USA.; Matrix (MA), a major structural protein of retroviruses, is thought to play a critical role in several steps of the HIV-1 replication cycle, including the plasma membrane targeting of Gag, the incorporation of envelope (Env) glycoproteins into nascent particles, and the nuclear import of the viral genome in non-dividi
Autoantibodies directed against phospholipids or human beta 2-glycoprotein I in HIV-seropositive patients: relationship with endothelial activation and antimalonic dialdehyde antibodies.: Eur J Clin Invest. 1998 Feb;28(2):115-22. Unique Identifier : AIDSLINE MED/98200195; Constans J; Guerin V; Couchouron A; Seigneur M; Ryman A; Blann AD; Amiral J; Amara A; Peuchant E; Moreau JF; Pellegrin I; Pellegrin JL; Fleury H; Leng B; Conri C; Hopital Saint-Andre, Bordeaux, France.; BACKGROUND: We investigated the possible role of antiphospholipid APA) and anti-human 2-glycoprotein I (beta2-GPI) antibodies (Ab) in thrombosis and atherosclerosis in human immunodeficiency HIV)-positive patients, in whom they seem to be more frequent. METHODS: We measured APA and anti-beta2-GPI Ab in 58 HIV-positive
Glutathione homeostasis is disturbed in CD4-positive lymphocytes of HIV-seropositive individuals.: Eur J Clin Invest. 1998 Mar;28(3):187-93. Unique Identifier : AIDSLINE MED/98229885; van der Ven AJ; Blom HJ; Peters W; Jacobs LE; Verver TJ; Koopmans PP; Demacker P; van der Meer JW; University Hospital Nijmegen, The Netherlands.; BACKGROUND: Numerous in vitro tests have suggested that a disturbed cellular glutathione homeostasis plays an important role in the pathogenesis of human immunodeficiency virus (HIV) infection. METHODS: Using validated high-performance liquid chromatography (HPLC) methods, glutathione concentrations were determined in
Glutathione and HIV infection: reduced reduced, or increased oxidized?: Eur J Clin Invest. 1998 Mar;28(3):194-6. Unique Identifier : AIDSLINE MED/98229886; Staal FJ; Department of Immunology, Utrecht State University Hospital,; Netherlands. F.Staal@lab.azu.nl; Glutathione is the main intracellular defence against oxidative stress and regulates the cellular redox potential. HIV infection is accompanied by severe metabolic and immune dysfunctions. Several laboratories have demonstrated that the intracellular redox balance is disturbed in CD4+ T cells from HIV-seropositive sub
Squamous cell carcinoma of the gingiva in an HIV-positive patient: a case report.: Dent Update. 1996 Dec;23(10):424-5. Unique Identifier : AIDSLINE MED/98273194; Anil S; Beena VT; Nair RG; Government Dental College and Hospital, Trivandrum.; This article presents a case of gingival squamous cell carcinoma in a patient who was HIV positive but who had no history of pan chewing, smoking, alcohol consumption or nutritional deficiency. Investigations also revealed the presence of superimposed pseudomembranous candidiasis. The case reported reveals that squamo
Extensive ulcerative colitis and extraintestinal manifestations in a patient with HIV infection and significant CD4 T-cell lymphopenia.: Gastroenterol Clin Biol. 1997;21(11):884-7. Unique Identifier : AIDSLINE MED/98249122; Louis E; Moutschen MP; De Marneffe P; Malherbe R; Closon T; T'Jean M; Demonty J; Belaiche J; Department of (1) Gastroenterology, CHU Sart-Tilman, Liege.; We report a heterosexual patient with HIV infection and a CD4 T-cell count of 0.45 x 10(9)/L who developed mild ulcerative proctitis, sacroileitis and oligoarthiritis. While he was treated with 5-aminosalicylic enemas, the patient rapidly developed severe pancolitis. An emergency colectomy without procetectomy was per
Pathogenesis of inflammatory bowel disease: transcription factors in the spotlight.: Gut. 1998 Apr;42(4):458-9. Unique Identifier : AIDSLINE MED/98279275; Neurath MF; Laboratory of Immunology, University of Mainz, Germany.
Cleaning and disinfection of equipment for gastrointestinal endoscopy. Report of a Working Party of the British Society of Gastroenterology Endoscopy Committee.: Gut. 1998 Apr;42(4):585-93. Unique Identifier : AIDSLINE MED/98279298; Two per cent glutaraldehyde is the most commonly used disinfectant in endoscopy units within the UK. Unfortunately adverse reactions to glutaraldehyde are common among endoscopy personnel and the Health and Safety Commission has recommended substantial reductions in atmospheric levels of glutaraldehyde in order to com
Prevention of lung eosinophilic inflammation by oral tolerance.: Immunol Lett. 1998 Mar;61(1):15-23. Unique Identifier : AIDSLINE MED/98220842; Russo M; Jancar S; Pereira de Siqueira AL; Mengel J; Gomes E; Ficker SM; Caetano de Faria AM; Departmento de Imunologia, Instituto de Ciencias Biomedicas, ICB-III,; Universidade de Sao Paulo, SP, Brazil. momrusso@biomed.icb2.usp.br; Airway inflammation plays a major role in human asthma. Increasing evidence points to a close correlation between eosinophil infiltration and allergic lung disease. A new murine model of eosinophilic lung inflammation has recently been developed; it consists of immunizing mice with small fragments of solidified hen eg
Altered receptor expression and decreased sensitivity of T-cells to the stimulatory cytokines IL-2, IL-7 and IL-12 in HIV infection.: Immunol Lett. 1998 Mar;61(1):53-61. Unique Identifier : AIDSLINE MED/98220846; Vingerhoets J; Bisalinkumi E; Penne G; Colebunders R; Bosmans E; Kestens L; Vanham G; Laboratory of Immunology, Institute of Tropical Medicine, Antwerpen,; Belgium. jvingerhoets@itg.be; A dysregulated production of regulatory cytokines has been proposed as a determinant in the progression of HIV infection. The sensitivity of T-cells to these cytokines has, however, not fully been investigated. Therefore, the responses of PBMC and T-cell subsets to the stimulatory cytokines
Interleukin-12-dependent activation of human lymphocyte subsets.: Immunol Lett. 1998 Mar;61(1):7-13. Unique Identifier : AIDSLINE MED/98220841; Cordero OJ; Salgado FJ; Vinuela JE; Nogueira M; Department of Biochemistry and Molecular Biology, University of; Santiago de Compostela, Spain. bnojcord@usc.es; Recently, we reported that IL-12 increased expression and function of CD26/DPPIV, this may be a new cellular pathway of the Th1-like immune responses. Here, we looked for a specific subset which would respond to CD26 upregulation by IL-12. Contrary to previously described results, under our culture conditions (1 micro
Tubular cell and HIV-1 gp120 interaction products promote migration of monocytes.: Inflammation. 1998 Apr;22(2):137-44. Unique Identifier : AIDSLINE MED/98222737; Kapasi A; Bhat P; Singhal PC; Department of Medicine, Long Island Jewish Medical Center, New Hyde; Park, New York 11040, USA.; Renal interstitial accumulation of monocytes is an important feature of HIV-associated nephropathy. We studied the effects of proximal tubular cell products (TCP) and proximal tubular cell-gp120 interaction products (TC-120IP) on the migration of monocytes across a modified Boyden chamber. TC-120IP promoted (P
IL-4R expression in AIDS-KS cells and response to rhIL-4 and IL-4 toxin (DAB389-IL-4).: Invest New Drugs. 1997;15(4):279-87. Unique Identifier : AIDSLINE MED/98208886; Cai J; Zheng T; Murphy J; Waters CA; Lin GY; Gill PS; Department of Medicine, University of Southern California, Los; Angeles, USA.; Interleukin-4 (IL-4) is a pleiotropic cytokine affecting growth and differentiation of various cell types as well as regulating other cytokines. To study the effect of IL-4 on AIDS-related Kaposi s sarcoma (AIDS-KS) cells, we first examined the tumor cells for IL-4 receptor (IL-4R) expression. KS cells express a singl
Fluconazole penetration into the prostatic fluid of patients with AIDS-associated cryptococcal meningitis [letter]: J Antimicrob Chemother. 1998 Mar;41(3):423-4. Unique Identifier : AIDSLINE MED/98237287; Luzzati R; Gatti G; Lazzarini L; Limonta D; Vento S; Concia E
Experimental evaluation of roxithromycin combined with dapsone or sulphamethoxazole on Pneumocystis carinii and Toxoplasma gondii dual infections in a rat model.: J Antimicrob Chemother. 1998 Mar;41 Suppl B:57-62. Unique Identifier : AIDSLINE MED/98239317; Brun-Pascaud M; Chau F; Derouin F; Girard PM; Inserm U13, Hopital Bichat-Claude Bernard, Paris, France.; We have developed a dual infection model in immunosuppressed rats for evaluating drugs against Pneumocystis carinii and Toxoplasma gondii, two important opportunistic pathogens in patients with AIDS. Using this model, we reported that the macrolide roxithromycin was effective at a daily dose of 400 mg/kg in preventing
AIDS-related cryptosporidial diarrhoea: an open study with roxithromycin.: J Antimicrob Chemother. 1998 Mar;41 Suppl B:85-91. Unique Identifier : AIDSLINE MED/98239322; Sprinz E; Mallman R; Barcellos S; Silbert S; Schestatsky G; Bem David D; Department of Internal Medicine, Hospital de Clinicas de Porto Alegre,; Universidade Federal Do Rio Grande do Sul, Brazil.; In immunocompromised patients, cryptosporidial diarrhoea is a debilitating and potentially life-threatening infection for which no effective specific therapy exists. In an uncontrolled study of 24 AIDS patients with diarrhoea exclusively due to Cryptosporidium spp., treatment with roxithromycin, 300 mg bd for 4 weeks,
Roxithromycin treatment for diarrhoea caused by Cryptosporidium spp. in patients with AIDS.: J Antimicrob Chemother. 1998 Mar;41 Suppl B:93-7. Unique Identifier : AIDSLINE MED/98239323; Uip DE; Lima AL; Amato VS; Boulos M; Neto VA; Bem David D; Department of Infectious and Parasitic Diseases, Clinics Hospital of; Sao Paulo University, Brazil.; In view of the action of newer macrolide antibiotics on intracellular protozoa, we have investigated the efficacy of roxithromycin in the treatment of cryptosporidiosis in 26 patients with AIDS. Cryptosporidiosis was confirmed either by faecal examination for parasites (modified Kinyoun method) or by detection of the
Risk factor profile: men who have sex with men.: J Ark Med Soc. 1998 Apr;94(11):499-501. Unique Identifier : AIDSLINE MED/98236635; From 1983 through January 12 of this year, the cumulative number of HIV-positive persons reported is 3,919. Of that number, 2,369 meet AIDS case definition. For the 30-day period ending January 12, 27 new cases of HIV and 16 new cases of AIDS were reported. Of the 2,369 AIDS cases reported since 1983, 1,200 (51%) are
Molecular recognition of cyclic urea HIV-1 protease inhibitors.: J Biol Chem. 1998 May 15;273(20):12325-31. Unique Identifier : AIDSLINE MED/98241600; Ala PJ; DeLoskey RJ; Huston EE; Jadhav PK; Lam PY; Eyermann CJ; Hodge CN; Schadt MC; Lewandowski FA; Weber PC; McCabe DD; Duke JL; Chang CH; DuPont Merck Pharmaceutical Company, Experimental Station, Wilmington,; Delaware 19880, USA.; As long as the threat of human immunodeficiency virus (HIV) protease drug resistance still exists, there will be a need for more potent antiretroviral agents. We have therefore determined the crystal structures of HIV-1 protease in complex with six cyclic urea inhibitors: XK216, XK263, DMP323, DMP450, XV638, and SD146
Identification and characterization of a tannic acid-responsive negative regulatory element in the mouse mammary tumor virus promoter.: J Biol Chem. 1998 May 15;273(20):12499-508. Unique Identifier : AIDSLINE MED/98241623; Uchiumi F; Sato T; Tanuma S; Department of Biochemistry, Faculty of Pharmaceutical Sciences,; Science University of Tokyo, Shinjuku-ku, Tokyo 162, Japan.; Tannic acid, which comprises polyphenolic compounds from tea leaves, suppresses the glucocorticoid-induced gene expression of mouse mammary tumor virus (MMTV) integrated into 34I cells. To investigate whether this suppression is due to promoter responsiveness to tannic acid, we performed chloramphenicol acetyltransfer
Pyogenic vertebral osteomyelitis [letter]: J Bone Joint Surg Am. 1998 May;80(5):764. Unique Identifier : AIDSLINE MED/98272594; Hidalgo-Ovejero AM; Otermin I; Garcia-Mata S
Acute and chronic effects of cocaine on the immune system and the possible link to AIDS.: J Neuroimmunol. 1998 Mar 15;83(1-2):133-8. Unique Identifier : AIDSLINE MED/98272212; Baldwin GC; Roth MD; Tashkin DP; Department of Medicine, UCLA School of Medicine, Los Angeles, CA; 90095, USA.; The pathogenesis of AIDS is a complex and prolonged process that is affected by a variety of cofactors, including the abuse of both intravenous and smoked (crack) cocaine. The exact mechanisms by which cocaine facilitates this disease are yet to be proven, but likely include a combination of increased risk due to coca
In vivo effects of cocaine on immune cell function.: J Neuroimmunol. 1998 Mar 15;83(1-2):139-47. Unique Identifier : AIDSLINE MED/98272213; Pellegrino T; Bayer BM; Georgetown University Medical Center, Department of Pharmacology,; Washington, DC 20007, USA.; Cocaine use has been shown to increase the risk of HIV infection in humans, and this increased risk cannot be explained by i.v. drug use alone. It is thought that this increased susceptibility may be a result of decreased immune responsiveness in cocaine addicts. Scientists are now using animal models to study the eff
Immunomodulation by nitrite inhalants may predispose abusers to AIDS and Kaposi's sarcoma.: J Neuroimmunol. 1998 Mar 15;83(1-2):157-61. Unique Identifier : AIDSLINE MED/98272215; Soderberg LS; Department of Microbiology and Immunology, University of Arkansas for; Medical Sciences, Little Rock 72205, USA.; soderberglees@exchange.uams.edu; Epidemiological studies indicating that nitrite inhalant abuse is a co-factor in HIV infection and in Kaposi s sarcoma are supported by recent experimental studies, described in this review. Inhalation exposure to the nitrites produce a nonspecific cytotoxicity, depleting many cells of the immune system. Apparently di
The opioid-cytokine connection.: J Neuroimmunol. 1998 Mar 15;83(1-2):63-9. Unique Identifier : AIDSLINE MED/98272205; Peterson PK; Molitor TW; Chao CC; Neuroimmunobiology and Host Defense Laboratory, Minneapolis Medical; Research Foundation, MN 55404, USA. peter137@maroon.tc.umn.edu; Opioids (exogenous opiates and endogenous opioid peptides) have a diversity of effects on the immune system. Although numerous studies have shown that opioid-induced immunosuppression can be mediated indirectly via the central nervous system (CNS) or through direct interactions with immunocytes, the precise cellular m
Opiates as potential cofactors in progression of HIV-1 infections to AIDS.: J Neuroimmunol. 1998 Mar 15;83(1-2):77-87. Unique Identifier : AIDSLINE MED/98272207; Donahoe RM; Vlahov D; Department of Psychiatry and Behavioral Sciences, Emory University; School of Medicine, Georgia Mental Health Institute, Atlanta 30322,; USA.; Because of the widely documented association of AIDS with opiate abuse, there is considerable interest in knowing whether opiates alter progression of HIV-1 infections to AIDS. The main reason for this interest is that opiates and opiate-abuse have been shown to have broad influence on immune processes as well as in v
Cocaine abuse and HIV-1 infection: epidemiology and neuropathogenesis.: J Neuroimmunol. 1998 Mar 15;83(1-2):88-101. Unique Identifier : AIDSLINE MED/98272208; Goodkin K; Shapshak P; Metsch LR; McCoy CB; Crandall KA; Kumar M; Fujimura RK; McCoy V; Zhang BT; Reyblat S; Xin KQ; Kumar AM; Department of Psychiatry and Behavioral Sciences, University of Miami; School of Medicine, FL 33136, USA. kgoodkin@mednet.med.miami.edu; The epidemiology of cocaine abuse and potential relationships of cocaine withdrawal to human immunodeficiency virus type 1 HIV-1)-associated dementia (HAD) are discussed. Neuroendocrinological changes in HIV-1 infection of the central nervous system (CNS) are discussed with the rel
A phase I/II evaluation of oral L-2-oxothiazolidine-4-carboxylic acid in asymptomatic patients infected with human immunodeficiency virus.: J Clin Pharmacol. 1998 Apr;38(4):357-63. Unique Identifier : AIDSLINE MED/98250345; Barditch-Crovo P; Noe D; Skowron G; Lederman M; Kalayjian RC; Borum P; Buier R; Rowe WB; Goldberg D; Lietman P; Department of Medicine, The Johns Hopkins School of Medicine,; Baltimore, Maryland, USA.; A randomized double-blind, placebo-controlled study was conducted in 37 asymptomatic HIV-infected individuals (mean CD4 count 707 cells/mm3) to characterize the safety, pharmacokinetics, and effect on blood thiols of three dosage levels of a cysteine prodrug, L-2-oxothiazolidine-4-carboxylic acid (OTC; Procysteine; Cl
Pediatric infection with the human immunodeficiency virus.: J Colo Dent Assoc. 1993 Jul;72(1):25-8. Unique Identifier : AIDSLINE MED/98183268; Asher RS; McDowell J; Acs G; Belanger G; Department of Applied Dentistry, University of Colorado School of; Dentistry, USA.; While rates of infection with the HIV virus are decreasing, the number of children infected continues to increase. There are multiple implications for the practicing pediatric dentist. Many of these children will seek or be referred by other health care providers for treatment of resulting oral pathology. Dentists mus
Detection of human papillomavirus in verrucous carcinoma from HIV-seropositive patients.: J Cutan Pathol. 1998 Mar;25(3):165-70. Unique Identifier : AIDSLINE MED/98209686; Cuesta KH; Palazzo JP; Mittal KR; Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson; University Hospital, Philadelphia, Pennsylvania 19107, USA.; Anogenital squamous cell carcinoma has been noted with increased frequency in HIV-seropositive patients. Verrucous carcinoma is a variant of squamous cell carcinoma that tends to be locally invasive and non-metastasizing. Although human papillomavirus HPV) has been strongly implicated in other squamous neoplasms, it h
Detection of squirrel monkey retroviral sequences in interferon samples.: J Hepatol. 1998 Mar;28(3):396-403. Unique Identifier : AIDSLINE MED/98211398; Pienkowska M; Seth A; Laboratory of Molecular Pathology, Women's College Hospital, Toronto,; Ontario, Canada.; BACKGROUND/AIMS: Interferons have been used therapeutically in viral infections, and as immunomodulants in the treatment of different types of cancers. Interferons have been prepared from human lymphoid cell-lines, such as Namalwa, that contain integrated copies of squirrel monkey retrovirus proviral DNA. Squirrel mon
Transient emergence of hepatitis B variants in a patient with chronic hepatitis B resistant to lamivudine.: J Hepatol. 1998 Mar;28(3):510-3. Unique Identifier : AIDSLINE MED/98211413; Buti M; Jardi R; Cotrina M; Rodriguez-Frias F; Esteban R; Guardia J; Liver Unit, Hospital General Universitario Valle Hebron, Barcelona,; Spain.; BACKGROUND: Lamivudine is a cytosine nucleoside analogue that inhibits hepatitis B virus replication. Resistance to lamivudine monotherapy has been reported in patients who received lamivudine to prevent recurrent hepatitis B virus infection after liv
Lack of benefit of protease inhibitors on HCV viremia in HIV-infected patients [letter]: J Hepatol. 1998 Mar;28(3):526-7. Unique Identifier : AIDSLINE MED/98211419; Garcia-Samaniego J; Bravo R; Castilla J; Gomez-Cano M; Laguna F; Munoz F; Soriano V
Diffuse necrotic hepatic lesions due to visceral leishmaniasis in AIDS.: J Infect. 1998 Mar;36(2):167-9. Unique Identifier : AIDSLINE MED/98230575; Angarano G; Maggi P; Rollo MA; Larocca AM; Quarto M; Scalone A; Gradoni L; Clinic of Infectious Disease and Institute of Hygiene of the; University of Bari, Policlinico, Italy.; A rare case of an AIDS patient who developed scattered necrotic involvement of the liver caused by Leishmania infantum is described. Of interest, marked splenomegaly, hypergammaglobulinemia and serum anti-Leishmania antibodies were absent and an incomplete response to therapy was observed. Diagnosis of visceral leishm
Visceral leishmaniasis (Kala-azar) in two patients with HIV-1 infection: atypical features and response to therapy.: J Infect. 1998 Mar;36(2):217-20. Unique Identifier : AIDSLINE MED/98230585; Hamour AA; Skelly R; Jowitt SN; Wilson GE; Curry A; Wilkins EG; Mandal BK; Department of Infectious Diseases & Tropical Medicine, (Monsall Unit),; Manchester General Hospital, UK.; Visceral leishmaniasis (VL) is a well recognized opportunistic infection in patients with HIV-1 infection, which may occasionally present with atypical features. We describe two patients with advanced HIV-1 infection (CD4
Enterocytozoon bieneusi multiorgan microsporidiosis in a HIV-infected patient.: J Infect. 1998 Mar;36(2):223-5. Unique Identifier : AIDSLINE MED/98230587; Georges E; Rabaud C; Amiel C; Kures L; Guedenet JC; Allamagny E; May T; Canton P; Laboratoire de Parasitologie, Centre Hospitalier Universitaire de; Nancy, France.; Multiorgan microsporidiosis due to Enterocytozoon bieneusi was diagnosed in an HIV-infected patient. The parasite was found and identified as E. bieneusi by transmission electron microscopy in stools, duodenal biopsy, nasal discharge and sputum. No clinical improvement
Meningitis due to a combined infection with Cryptococcus neoformans and Streptococcus pneumoniae in an AIDS patient.: J Infect. 1998 Mar;36(2):231-2. Unique Identifier : AIDSLINE MED/98230591; John MA; Coovadia Y; Department of Medical Microbiology, University of Natal Medical; School, Durban, South Africa.; We report on a case of dual infection with Cryptococcus neoformans and Streptococcus pneumoniae in the cerebrospinal fluid of a patient with AIDS. To our knowledge this represents the first case to be reported in the English literature. In immunocompromised patients the importance of performing both the Gram- and Indi
Detection of HTLV-II proviral sequences in HIV-immunosuppressed patients with HTLV indeterminate serological patterns [letter]: J Infect. 1998 Mar;36(2):243-4. Unique Identifier : AIDSLINE MED/98230596; Soriano V; Gutierrez M; Gonzalez-Lahoz J
Characterization of the cutaneous exanthem in macaques infected with a Nef gene variant of SIVmac239.: J Invest Dermatol. 1998 Jun;110(6):894-901. Unique Identifier : AIDSLINE MED/98281606; Sasseville VG; Rottman JB; Du Z; Veazey R; Knight HL; Caunt D; Desrosiers RC; Lackner AA; Division of Comparative Pathology, Harvard Medical School, New England; Regional Primate Research Center, Southborough, Massachusetts; 01772-9102, USA.; The molecularly cloned viruses known as SIVmac239/R17Y and SIVmac239/YEnef cause extensive lymphocyte activation and induce an acute disease syndrome in macaque monkeys. One manifestation of this syndrome is a severe diffuse cutaneous maculopapular exanthem that is similar to the exanthem associated with HIV-1 infecti
Antigen receptor beta chain variable region usage by CD4+ and CD8+ T cells in psoriasis [letter]: J Invest Dermatol. 1998 Jun;110(6):987-8. Unique Identifier : AIDSLINE MED/98281622; Camp RD; Vekony MA
Perinatal transmission of hepatitis C virus from human immunodeficiency virus type 1-infected mothers. Women and Infants Transmission Study.: J Infect Dis. 1998 Jun;177(6):1480-8. Unique Identifier : AIDSLINE MED/98268839; Thomas DL; Villano SA; Riester KA; Hershow R; Mofenson LM; Landesman SH; Hollinger FB; Davenny K; Riley L; Diaz C; Tang HB; Quinn TC; Division of Infectious Diseases, Johns Hopkins University School of; Medicine, Baltimore, Maryland 21205, USA.; Antepartum plasma hepatitis C virus (HCV) RNA was quantified in 155 mothers coinfected with HCV and human immunodeficiency virus type 1 (HIV-1), and HCV RNA was serially assessed in their infants. Of 155 singleton infants born to HCV antibody-positive mothers, 13 (8.4%) were HCV infected. The risk of HCV infection was
Down-regulation of interleukin-10 expression and production is associated with spontaneous proliferation by lymphocytes from human T lymphotropic virus type II-infected persons.: J Infect Dis. 1998 Jun;177(6):1489-96. Unique Identifier : AIDSLINE MED/98268840; Dezzutti CS; Sasso DR; Rudolph DL; Lal RB; Retrovirus Diseases Branch, Division of AIDS, STD, and Tuberculosis; Laboratory Research, Centers for Disease Control and Prevention,; Atlanta, Georgia 30333, USA. cyd5@cdc.gov; Cytokines from peripheral blood mononuclear cells (PBMC) from human T lymphotropic virus (HTLV)-II-infected persons were studied to delineate the mechanism(s) of spontaneous lymphocyte proliferation (SLP). Culturing HTLV-II-infected PBMC that spontaneously proliferate (SLP+) resulted in greater mRNA expression and pro
Virus burden in lymph nodes and blood of subjects with primary human immunodeficiency virus type 1 infection on bitherapy.: J Infect Dis. 1998 Jun;177(6):1497-501. Unique Identifier : AIDSLINE MED/98268841; Perrin L; Yerly S; Marchal F; Schockmel GA; Hirschel B; Fox CH; Pantaleo G; AIDS Centre, Department of Otho-Rhino-Laryngology, Geneva University; Hospital, Switzerland. Luc.Perrin@hcuge.ch; At present, it is not known whether undetectable plasma viremia corresponds to an absence of human immunodeficiency virus type 1 HIV-1) replication in lymphoid tissues. This issue has been explored in 11 subjects with primary HIV-1 infection treated with zidovudine plus didanosine by evaluating virologic markers in bl
JC virus remains latent in peripheral blood B lymphocytes but replicates actively in urine from AIDS patients.: J Infect Dis. 1998 Jun;177(6):1502-5. Unique Identifier : AIDSLINE MED/98268842; Lafon ME; Dutronc H; Dubois V; Pellegrin I; Barbeau P; Ragnaud JM; Pellegrin JL; Fleury HJ; Laboratoire de Virologie, Institut Federatif de Recherches en; Pathologies Infectieuses, Universite Bordeaux 2, France.; Marie-Edith.Lafon@viro.U-Bordeaux2.fr; JC virus (JCV) is thought to reach the central nervous system by a vascular route. To determine whether JCV is conveyed in peripheral blood as latent or reactivated virus, blood leukocytes, plasma, and urine from 50 AIDS patients and plasma and B lymphocytes from 60 AIDS patients were investigated. Peripheral blood fr
Emergence of multi-dideoxynucleoside-resistant human immunodeficiency virus type 1 variants, viral sequence variation, and disease progression in patients receiving antiretroviral chemotherapy.: J Infect Dis. 1998 Jun;177(6):1506-13. Unique Identifier : AIDSLINE MED/98268843; Kavlick MF; Wyvill K; Yarchoan R; Mitsuya H; Experimental Retrovirology Section, Medicine Branch, National Cancer; Institute, National Institutes of Health, Bethesda, Maryland 20892,; USA.; A set of five reverse transcriptase mutations, which include Q151M, is known to confer multi-dideoxynucleoside resistance MDR) in human immunodeficiency virus type 1 (HIV-1). MDR mutations were found in 6 (17%) HIV-1 isolates from 36 patients, most of whom were receiving long-term
A pilot study of nevirapine, indinavir, and lamivudine among patients with advanced human immunodeficiency virus disease who have had failure of combination nucleoside therapy.: J Infect Dis. 1998 Jun;177(6):1514-20. Unique Identifier : AIDSLINE MED/98268844; Harris M; Durakovic C; Rae S; Raboud J; Fransen S; Shillington A; Conway B; Montaner JS; St. Paul's Hospital/University of British Columbia, Vancouver, Canada.; The effects of nevirapine , indinavir , and lamivudine in combination were studied among 22 human immunodeficiency virus HIV)-infected patients with CD4 cell counts
Dual resistance to zidovudine and lamivudine in patients treated with zidovudine-lamivudine combination therapy: association with therapy failure.: J Infect Dis. 1998 Jun;177(6):1521-32. Unique Identifier : AIDSLINE MED/98268845; Miller V; Phillips A; Rottmann C; Staszewski S; Pauwels R; Hertogs K; de Bethune MP; Kemp SD; Bloor S; Harrigan PR; Larder BA; Zentrum der Inneren Medizin, Klinikum der J.W. Goethe-Universitat,; Frankfurt, Germany. miller@em.uni-frankfurt.de; Human immunodeficiency virus type 1 (HIV-1) strains dually resistant to zidovudine and lamivudine ( 3TC ) may arise during zidovudine-3TC combination therapy . The objective of this cross-sectional study
A preliminary evaluation of nelfinavir mesylate, an inhibitor of human immunodeficiency virus (HIV)-1 protease, to treat HIV infection.: J Infect Dis. 1998 Jun;177(6):1533-40. Unique Identifier : AIDSLINE MED/98268846; Markowitz M; Conant M; Hurley A; Schluger R; Duran M; Peterkin J; Chapman S; Patick A; Hendricks A; Yuen GJ; Hoskins W; Clendeninn N; Ho DD; Aaron Diamond AIDS Research Center, Rockefeller University, New York,; New York 10016, USA.; A phase I/II dose-ranging open-label 28-day monotherapy study of the safety, pharmacokinetics, and antiviral activity of nelfinavir mesylate ( Viracept ), an inhibitor of human immunodeficiency virus (HIV)-1 protease, was done in 65 HIV-1-infected subje
The risk of disease progression is determined during the first year of human immunodeficiency virus type 1 infection.: J Infect Dis. 1998 Jun;177(6):1541-8. Unique Identifier : AIDSLINE MED/98268847; Lefrere JJ; Roudot-Thoraval F; Mariotti M; Thauvin M; Lerable J; Salpetrier J; Morand-Joubert L; Institut National de la Transfusion Sanguine Laboratoire de Virologie,; Hopital Saint-Antoine, Paris, France. lefrere@worldnet.fr; A cohort of 103 human immunodeficiency virus type 1 HIV-1)-infected persons with well-defined dates of seroconversion were studied to determine whether baseline plasma HIV RNA loads 6-12 months after seroconversion have prognostic value. Baseline plasma virus loads had predictive value for the disease-free survival ra
CCR5/delta(ccr5) heterozygosity: a selective pressure for the syncytium-inducing human immunodeficiency virus type 1 phenotype. NIAID AIDS Clinical Trials Group Protocol 241 Virology Team.: J Infect Dis. 1998 Jun;177(6):1549-53. Unique Identifier : AIDSLINE MED/98268848; D'Aquila RT; Sutton L; Savara A; Hughes MD; Johnson VA; Massachusetts General Hospital, Harvard Medical School, Boston, USA.; daquila@helix.mgh.harvard.edu; Mechanisms underlying the delay in dominance of syncytium-inducing (SI) phenotype HIV-1 (human immunodeficiency virus type 1) in vivo are unknown. Both random mutational events and selective pressures operative only late in the disease process have been suggested to underlie the shift from CCR5 to alternative corecept
Human immunodeficiency virus infection alters antigen-induced cytokine responses in patients with active mycobacterial diseases.: J Infect Dis. 1998 Jun;177(6):1554-62. Unique Identifier : AIDSLINE MED/98268849; Sousa AO; Lee FK; Freiji R; Lagrange PH; Nahmias A; Department of Pediatrics, Emory University School of Medicine,; Atlanta, Georgia 30303, USA.; Peripheral blood cells from 29 patients with active Mycobacterium avium (MAC) or Mycobacterium tuberculosis diseases were tested for mycobacterial antigen-induced interferon (IFN)-gamma and interleukin (IL)-4 production. Among MAC patients, human immunodeficiency virus (HIV) infection was associated with an 80% decrea
High prevalence of antibodies to human herpesvirus 8 in relatives of patients with classic Kaposi's sarcoma from Sardinia.: J Infect Dis. 1998 Jun;177(6):1715-8. Unique Identifier : AIDSLINE MED/98268871; Angeloni A; Heston L; Uccini S; Sirianni MC; Cottoni F; Masala MV; Cerimele D; Lin SF; Sun R; Rigsby M; Faggioni A; Miller G; Department of Experimental Medicine, University of Rome La Sapienza,; Italy.; A survey for antibodies to a recombinant small viral capsid antigen (sVCA) of human herpesvirus type 8 (HHV-8) was conducted in Sardinia, one of the world s highest incidence areas for classic Kaposi s sarcoma (KS). Prevalence of antibodies to HHV-8 sVCA was greatest in patients with KS (95%), followed by family membe
GB virus C infection in patients with primary antibody deficiency.: J Infect Dis. 1998 Jun;177(6):1719-22. Unique Identifier : AIDSLINE MED/98268872; Morris A; Webster AD; Brown D; Harrison TJ; Dusheiko G; Department of Clinical Immunology, Medical Research Council; Immunodeficiency Clinic, Royal Free Hospital, London, United Kingdom.; Sera from 77 patients with common variable immunodeficiency CVID) were tested for GB virus C (GBV-C) RNA, because they are prone to unexplained chronic hepatitis, and from 28 patients with X-linked agammaglobulinemia (XLA) who have a similar primary antibody deficiency but are not prone to hepatitis. Eight CVID and 8
GB virus C/hepatitis G virus infection: a favorable prognostic factor in human immunodeficiency virus-infected patients?: J Infect Dis. 1998 Jun;177(6):1723-6. Unique Identifier : AIDSLINE MED/98268873; Heringlake S; Ockenga J; Tillmann HL; Trautwein C; Meissner D; Stoll M; Hunt J; Jou C; Solomon N; Schmidt RE; Manns MP; Department of Gastroenterology, Medizinische Hochschule, Hannover,; Germany.; To investigate a possible influence of GB virus C (GBV-C) in immunocompromised patients, the prevalences of GBV-C RNA and anti-E2 antibody in 197 human immunodeficiency virus HIV)-infected patients and in 120 control blood donors were studied. GBV-C RNA was detected in 33 of 197 HIV-infected patients (16.8%) compared
Cross-clade inhibition of human immunodeficiency virus type 1 primary isolates by monoclonal anti-CD4.: J Infect Dis. 1998 Jun;177(6):1727-9. Unique Identifier : AIDSLINE MED/98268874; Shearer MH; Timanus DK; Benton PA; Lee DR; Kennedy RC; Department of Microbiology and Immunology, University of Oklahoma; Health Sciences Center, Oklahoma City 73190, USA.; A murine monoclonal antibody (MAb) with human CD4 specificity was tested for the ability to inhibit primary human immunodeficiency virus type 1 (HIV-1) isolates clades A through E. Human peripheral blood mononuclear cells (PBMC) were used as target cells for infectivity. The HIV-1 primary isolates were examined for th
Human immunodeficiency virus proviral DNA from peripheral blood and lymph nodes demonstrates concordant resistance mutations to zidovudine (codon 215) and didanosine (codon 74). Division of AIDS Treatment Research Initiative 003 Study Group.: J Infect Dis. 1998 Jun;177(6):1730-3. Unique Identifier : AIDSLINE MED/98268875; Mayers D; Bethel J; Wainberg MA; Weislow O; Schnittman S; Naval Medical Research Institute and Division of AIDS, National; Institute of Allergy and Infectious Diseases, National Institutes of; Health, Bethesda, Maryland, USA. dmayers@pasteur.hjf.org; Genotypes that confer drug resistance were evaluated in human immunodeficiency virus (HIV) proviral DNA obtained from peripheral blood mononuclear cells (PBMC) and lymphoid tissue at baseline and after 8 weeks of therapy with zidovudine alone or in combination with didanosine from 22 patients (8 zidovudine-naive and 1
Effect of granulocyte colony-stimulating factor (G-CSF) in human immunodeficiency virus-infected patients: increase in numbers of naive CD4 cells and CD34 cells makes G-CSF a candidate for use in gene therapy or to support antiretroviral therapy.: J Infect Dis. 1998 Jun;177(6):1733-6. Unique Identifier : AIDSLINE MED/98268876; Nielsen SD; Afzelius P; Dam-Larsen S; Nielsen C; Nielsen JO; Mathiesen L; Hansen JE; Department of Infectious Diseases, Hvidovre Hospital, Denmark.; The potential of granulocyte colony-stimulating factor (G-CSF) to mobilize CD4 cells and/or CD34 cells for use in gene therapy or to support antiretroviral therapy was examined. Ten human immunodeficiency virus-infected patients were treated with G-CSF 300 microg/day) for 5 days. Numbers of CD4 and CD34 cells were mea
Apparent enhancement of perinatal transmission of human immunodeficiency virus type 1 by high maternal anti-gp160 antibody titer.: J Infect Dis. 1998 Jun;177(6):1737-41. Unique Identifier : AIDSLINE MED/98268877; Pancino G; Leste-Lasserre T; Burgard M; Costagliola D; Ivanoff S; Blanche S; Rouzioux C; Sonigo P; Genetique des Virus et Immunopharmacologie Moleculaire, Institut; Cochin de Genetique Moleculaire, Laboratoire de Virologie, Paris,; France. pancino@cochin.inserm.fr; The presence of antibodies able to enhance infection in vitro in sera from human immunodeficiency virus (HIV)-1-infected patients raises the possibility that antibodies exert a deleterious activity during natural infection. The anti-HIV-1 humoral response and plasma HIV-1 RNA were measured in a cohort of 98 infected m
High levels of human immunodeficiency virus type 1 in blood and semen of seropositive men in sub-Saharan Africa.: J Infect Dis. 1998 Jun;177(6):1742-6. Unique Identifier : AIDSLINE MED/98268878; Dyer JR; Kazembe P; Vernazza PL; Gilliam BL; Maida M; Zimba D; Hoffman IF; Royce RA; Schock JL; Fiscus SA; Cohen MS; Eron JJ Jr; Department of Medicine, University of North Carolina, Chapel Hill; 27599-7030, USA.; High levels of human immunodeficiency virus type 1 (HIV-1) replication, as reflected in HIV-1 RNA concentrations in blood and semen, probably contribute to both rapid disease progression and enhanced sexual transmission. Semen and blood were collected from 49 Malawian and 61 US and Swiss (US/Swiss) HIV-1-seropositive
Proinflammatory cytokine and human immunodeficiency virus RNA levels during early Mycobacterium avium complex bacteremia in advanced AIDS.: J Infect Dis. 1998 Jun;177(6):1746-9. Unique Identifier : AIDSLINE MED/98268879; Haas DW; Lederman MM; Clough LA; Wallis RS; Chernoff D; Crampton SL; Department of Medicine, Microbiology, and Immunology, Vanderbilt; University School of Medicine, Nashville, Tennessee 37212, USA.; david.w.haas@vanderbilt.edu; The relationship between Mycobacterium avium complex (MAC) bacteremia and proinflammatory cytokine and human immunodeficiency virus type 1 (HIV-1) RNA levels in AIDS was investigated. During a prospective study, blood samples were drawn monthly for mycobacterial cultures. Sera were available at baseline and onset of M
High incidence of early postnatal transmission of human immunodeficiency virus type 1 in Bangui, Central African Republic [letter]: J Infect Dis. 1998 Jun;177(6):1770-1. Unique Identifier : AIDSLINE MED/98268885; Becquart P; Garin B; Sepou A; Hocini H; Brogan T; Menu E; Barre-Sinoussi F; Kazatchkine M; Belec L
Antiviral CD4 cell response in simian immunodeficiency virus-infected macaques [letter]: J Infect Dis. 1998 Jun;177(6):1771-2. Unique Identifier : AIDSLINE MED/98268886; Dittmer U; Hunsmann G
Nondiagnostic bone marrow in parvovirus B19-related anemia in AIDS: confounding effect of prior transfusion? [letter]: J Infect Dis. 1998 Jun;177(6):1773. Unique Identifier : AIDSLINE MED/98268888; Koduri PR; Kumapley R; Khokha ND
Survival of HIV-positive and HIV-negative leprosy patients in Mwanza, Tanzania [letter]: Int J Lepr Other Mycobact Dis. 1998 Mar;66(1):53-6. Unique Identifier : AIDSLINE MED/98277046; van den Broek J; Mfinanga S; Moshiro C; O'Brien R; Mugomela A
Analysis of human immunodeficiency virus type 1 env and gag sequence variants derived from a mother and two vertically infected children provides evidence for the transmission of multiple sequence variants.: J Gen Virol. 1998 May;79 ( Pt 5):1055-68. Unique Identifier : AIDSLINE MED/98264482; Wade CM; Lobidel D; Brown AJ; Centre for HIV Research, Institute of Cell, Animal and Population; Biology, The University of Edinburgh, UK. pdzcmw@evol.nott.ac.uk; In order to investigate the transmission of human immunodeficiency virus type 1 (HIV-1) from mother-to-child we have examined serial plasma RNA samples obtained from a mother over an eight year period spanning four pregnancies. Child 1 and 2 (born January 1987 and June 1990) were uninfected whilst child 3 and 4 (born
Interaction and co-encapsidation of human immunodeficiency virus type 1 Gag and Vif recombinant proteins.: J Gen Virol. 1998 May;79 ( Pt 5):1069-81. Unique Identifier : AIDSLINE MED/98264483; Huvent I; Hong SS; Fournier C; Gay B; Tournier J; Carriere C; Courcoul M; Vigne R; Spire B; Boulanger P; Laboratoire de Virologie Moleculaire et Pathogenese Virale CNRS; UMR-5812), Institut de Biologie, Faculte de Medecine, Montpellier,; France.; Human immunodeficiency virus type 1 (HIV-1) wild-type (WT) virion infectivity factor (Vif) protein (Vifwt) and full-length Gag precursor (Pr55Gag) were found to be co-encapsidated into extracellular, membrane-enveloped virus-like particles released by budding from Sf9 cells co-expressing the two recombinant proteins i
A role for human immunodeficiency virus type 1 Vpr during infection of peripheral blood mononuclear cells.: J Gen Virol. 1998 May;79 ( Pt 5):1083-7. Unique Identifier : AIDSLINE MED/98264484; Rey F; BouHamdan M; Navarro JM; Agostini I; Willetts K; Bouyac M; Tamalet C; Spire B; Vigne R; Sire J; INSERM U372, Marseille, France.; Studies analysing human immunodeficiency virus type 1 replication in primary cells have demonstrated that Vpr, although dispensable, plays a role along with the matrix (MA) protein in allowing nuclear localization of viral preintegration complexes in non-dividing monocyte-derived macrophages (MDMs). In the current stu
Nucleotide substitutions in the long terminal repeat are not required for development of neurovirulence by simian immunodeficiency virus strain mac.: J Gen Virol. 1998 May;79 ( Pt 5):1089-100. Unique Identifier : AIDSLINE MED/98264485; Stephens EB; Sahni M; Leung K; Raghavan R; Joag SV; Narayan O; Department of Microbiology, Molecular Genetics and Immunology, Marion; Merrell Dow Laboratory of Viral Pathogenesis, University of Kansas; Medical Center, Kansas City 66160-7240, USA. estephen@kumc.edu; The question of whether consensus nucleotide substitutions in the long terminal repeat (LTR) region of simian immunodeficiency virus strain mac (SIVmac) are important for neurovirulence was investigated in this report. Brains and lymph nodes from two macaques that developed AIDS and encephalitis following inoculation
Cerebrospinal fluid interleukin 6 in amyotrophic lateral sclerosis: immunological parameter and comparison with inflammatory and non-inflammatory central nervous system diseases.: J Neurol Sci. 1998 Feb 5;154(2):194-9. Unique Identifier : AIDSLINE MED/98220779; Sekizawa T; Openshaw H; Ohbo K; Sugamura K; Itoyama Y; Niland JC; Department of Neurology, Tohoku University School of Medicine, Sendai,; Japan.; We assayed IL-6 in 105 cerebrospinal fluid (CSF) samples from patients with ALS, MS, HTLV-1 associated myelopathy (HAM), and controls. There was considerable overlap in IL-6 levels in all patient groups. The mean IL-6 in 27 patients with ALS was significantly higher than in 21 patients in the other neurological diseas
Elevated cerebrospinal fluid and serum nitrate and nitrite levels in patients with central nervous system complications of HIV-1 infection: a correlation with blood-brain-barrier dysfunction.: J Neurol Sci. 1998;156(1):53-8. Unique Identifier : AIDSLINE MED/98218914; Giovannoni G; Miller RF; Heales SJ; Land JM; Harrison MJ; Thompson EJ; Department of Neuroimmunology, The Natioinal Hospital for Neurology; and Neurosurgery, London, UK. ggiovan@ion.ucl.ac.uk; As nitric oxide (.NO) is hypothesised to play a role in the immunopathogenesis of neurological complications associated with inflammation, we compared levels of cerebrospinal fluid (CSF) and serum .NO metabolites in 24 patients with HIV-1 infection, to those in 58 non-HIV infected patients with neurological disorders.
The oral effects of AIDS. Seven most common lesions explored.: J Oreg Dent Assoc. 1995 Spring;64(3):31-7. Unique Identifier : AIDSLINE MED/98181343; Chiodo GT; Rosenstein DI; Dept. of Public Health Dentistry, Oregon Health Sciences University; School of Dentistry, USA.
Encephalopathy and progression of human immunodeficiency virus disease in a cohort of children with perinatally acquired human immunodeficiency virus infection. Women and Infants Transmission Study Group.: J Pediatr. 1998 May;132(5):808-12. Unique Identifier : AIDSLINE MED/98264900; Cooper ER; Hanson C; Diaz C; Mendez H; Abboud R; Nugent R; Pitt J; Rich K; Rodriguez EM; Smeriglio V; Boston University School of Medicine, Massachusetts, USA.; OBJECTIVE: To describe the incidence, predictors, and survival of children with human immunodeficiency virus (HIV) encephalopathy followed in the Women and Infants Transmission Study cohort. STUDY DESIGN: Retrospective review of clinical and immunologic staging of perinatally HIV-infected infants, based on the 1994 Ce
Nondepleting humanized anti-CD4 monoclonal antibody in patients with refractory rheumatoid arthritis.: J Rheumatol. 1998 Feb;25(2):221-8. Unique Identifier : AIDSLINE MED/98149454; Moreland LW; Haverty TP; Wacholtz MC; Knowles RW; Bucy RP; Heck LW Jr; Koopman WJ; Department of Medicine, The University of Alabama at Birmingham,; 35294-7201, USA.; OBJECTIVE: To investigate the safety, tolerability, pharmacokinetics, and immunologic activity of single intravenous infusions (0.2-10 mg/kg) of Orthoclone OKTcdr4a, a nondepleting humanized anti-CD4 monoclonal antibody (Mab) in patients with rheumatoid arthritis. METHODS: Eighteen patients were treated with a single
Divergent cytokine production profile in Behcet's disease. Altered Th1/Th2 cell cytokine pattern.: J Rheumatol. 1998 Feb;25(2):329-33. Unique Identifier : AIDSLINE MED/98149473; Raziuddin S; al-Dalaan A; Bahabri S; Siraj AK; al-Sedairy S; Department of Immunology, King Faisal Specialist Hospital and Research; Center, Riyadh, Saudi Arabia.; OBJECTIVE: To determine Th1/Th2 cell response cytokine production profile in Behcet s disease (BD). METHODS: Interleukin 2 ( IL-2 ), interferon-gamma (IFN-gamma) and IL-12 (Th1 cell response), and IL-4, IL-10, and IL-13 (Th2 cell response) cytokine production from anti-C
Current management of infectious complications in the injecting drug user.: J Subst Abuse Treat. 1998 Mar-Apr;15(2):95-106. Unique Identifier : AIDSLINE MED/98222760; Contoreggi C; Rexroad VE; Lange WR; Division of Intramural Research, National Institute on Drug Abuse,; National Institutes of Health, Baltimore, MD 21224, USA.; ccontore@irp.nida.nih.gov; The diagnosis and management of infectious complications associated with injection drug use (IDU) are among some of the more challenging aspects of working with substance abusing populations. As the population of injection drug users age, we expect the number and severity of these complications to increase. Commonly s
Pictorial essay: thoracic cardiovascular complications of acquired immunodeficiency syndrome.: J Thorac Imaging. 1998 Apr;13(2):116-22. Unique Identifier : AIDSLINE MED/98215575; Schwartz ED; Fishman JE; Mandel AS; Bauerlein EJ; Ezuddin S; Guerra JJ; Department of Radiology, University of Miami School of Medicine,; Jackson Memorial Hospital, Florida 33136, USA.; Patients with acquired immunodeficiency syndrome frequently develop complications of cardiac, pericardial, and thoracic vascular origin. The purpose of this pictorial essay is to review the most common etiologic and diagnostic imaging findings of these diseases. Patients with acquired immunodeficiency syndrome often d
Analysis of ritonavir for the treatment of HIV disease in children: abstract and commentary.: JAMA. 1998 Jun 10;279(22):1831. Unique Identifier : AIDSLINE MED/98290683; Oleske JM; Bagnoud FX; Department of Pediatrics-UMD/New Jersey Medical School, Newark, USA.; joleske@daijd.umdnj.edu
Comparison of total parenteral nutrition and an oral, semielemental diet on body composition, physical function, and nutrition-related costs in patients with malabsorption due to acquired immunodeficiency syndrome.: JPEN J Parenter Enteral Nutr. 1998 May-Jun;22(3):120-6. Unique Identifier : AIDSLINE MED/98246200; Kotler DP; Fogleman L; Tierney AR; Department of Medicine, St Luke's-Roosevelt Hospital Center, College; of Physicians and Surgeons, Columbia University, New York, NY 10025,; USA.; BACKGROUND: The nutrition management of patients with malabsorption syndromes due to acquired immunodeficiency syndrome AIDS) is problematic. The aim of this study was to compare the effects of total parenteral nutrition (TPN) and an oral, semielemental diet (SED) on body weight, body composition, quality of life, sur
Antiretroviral therapy, 1998.: J S C Med Assoc. 1998 May;94(5):207-17. Unique Identifier : AIDSLINE MED/98272883; Postic B; Horvath JA; Green PA; Bryan CS; In summary, during 1996 and 1997 important improvements occurred in HIV therapy. The introduction of new drugs benefited patients with access to these medications. The use of antiretrovirals remains complex and is rapidly evolving. This is an inspiring challenge for physicians and health workers caring for HIV-infecte
Update on HIV chemoprophylaxis following exposure.: J Tenn Dent Assoc. 1997 Oct;77(4):42-4. Unique Identifier : AIDSLINE MED/98181379; Flaxman NA; Reed HS; Dental Service, John L. McClellen Memorial Veterans Hospital, Little; Rock, Arkansas, USA.
Neonatal thymectomy: does it affect immune function?: J Thorac Cardiovasc Surg. 1998 May;115(5):1041-6. Unique Identifier : AIDSLINE MED/98266109; Wells WJ; Parkman R; Smogorzewska E; Barr M; Division of Cardiothoracic Surgery, Childrens Hospital, Los Angeles,; Calif 90027, USA.; OBJECTIVE: The purpose of this study was to determine whether thymectomy in the newborn has a negative effect on immune function. METHODS: Twenty-five neonates (
Absence of human herpesvirus 8 DNA sequences in vascular tumors of the liver.: Liver. 1998 Apr;18(2):124-7. Unique Identifier : AIDSLINE MED/98248185; Ishak KG; Bijwaard KE; Makhlouf HR; Taubenberger JK; Lichy JH; Goodman ZD; Department of Hepatic and Gastrointestinal Pathology, Armed Forces; Institute of Pathology, Washington, DC 20306-6000, USA.; Kaposi s sarcoma-associated herpes virus (KSHV), also designated human herpesvirus 8 (HHV8), has been detected consistently in Kaposi s sarcoma, body cavity lymphoma and multicentric Castleman s disease, both in human immunodeficiency virus HIV)-positive and -negative patients. Identification of KSHV/HHV8 DNA sequence
Nucleoside analogue therapy in fibrosing cholestatic hepatitis--a case report in an HBsAg positive renal transplant recipient [see comments]: Liver. 1998 Apr;18(2):134-9. Unique Identifier : AIDSLINE MED/98248187; Brind AM; Bennett MK; Bassendine MF; Centre for Liver Research, School of Clinical Medical Sciences,; Newcastle upon Tyne, UK.; A 45-year-old HBsAg carrier (HBeAb positive with normal liver function tests) underwent renal transplantation for mesangioproliferative glomerulonephritis. Sixteen months later he developed jaundice. Investigations showed he remained HBeAb positive, but HBV-DNA levels were 99 pg/ml, indicating active replication of a
Chronic hepatitis B: interferon-monotherapy or combination with nucleoside analogues? [editorial; comment]: Liver. 1998 Apr;18(2):71-2. Unique Identifier : AIDSLINE MED/98248179; Tassopoulos NC
Michigan AIDS fund. A helping hand for patients.: Mich Med. 1998 May;97(5):10-1. Unique Identifier : AIDSLINE MED/98263502; DeVries K
Syphilis screening among women arrestees at the Cook County Jail--Chicago, 1996.: MMWR Morb Mortal Wkly Rep. 1998 Jun 5;47(21):432-3. Unique Identifier : AIDSLINE MED/98287254; Cook County (Chicago) Department of Corrections (i.e., Cook County Jail [CCJ]) is one of the largest jail systems in the United States , with a daily census of approximately 10,000 arrestees. CCJ contracts with Cermak Health Services (CHS) to provide medical services, including routine
Interaction of beta-L-2',3'-dideoxy-2',3'-didehydro-5-fluoro-CTP with human immunodeficiency virus-1 reverse transcriptase and human DNA polymerases: implications for human immunodeficiency virus drug design.: Mol Pharmacol. 1998 May;53(5):801-7. Unique Identifier : AIDSLINE MED/98252878; Kukhanova M; Li X; Chen SH; King I; Doyle T; Prusoff W; Cheng YC; Department of Pharmacology, Yale University School of Medicine, New; Haven, Connecticut 06510, USA.; The work reported in this article has evaluated the relative molecular activity of the 5 -triphosphate of a novel beta-L-nucleoside with an unsaturated ribose residue, beta-L-2 , 3 -dideoxy-2 ,3 -didehydro-5-fluorocytidine (beta-L-Fd4CTP), with that of beta-L-2 ,3 -dideoxy-5-fluorocytidine (beta-L-FddCTP) and 2 , 3 -d
Involvement of TFIID and USA components in transcriptional activation of the human immunodeficiency virus promoter by NF-kappaB and Sp1.: Mol Cell Biol. 1998 Jun;18(6):3234-44. Unique Identifier : AIDSLINE MED/98252911; Guermah M; Malik S; Roeder RG; Laboratory of Biochemistry and Molecular Biology, The Rockefeller; University, New York, New York 10021, USA.; The purified Rel/NF-kappaB (p50/p65) complex and Sp1 markedly activate transcription from the human immunodeficiency virus type 1 (HIV-1) promoter in a highly purified HeLa reconstituted transcription system. Transcriptional activation by NF-kappaB and Sp1 requires both TFIID and the USA fraction. The USA-derived coac
Human T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb.: Mol Cell Biol. 1998 Jun;18(6):3620-32. Unique Identifier : AIDSLINE MED/98252950; Neuveut C; Low KG; Maldarelli F; Schmitt I; Majone F; Grassmann R; Jeang KT; Laboratory of Molecular Microbiology, National Institute of Allergy; and Infectious Diseases, Bethesda, Maryland 20892-0460, USA.; Human T-cell leukemia virus type 1 is etiologically linked to the development of adult T-cell leukemia and various human neuropathies. The Tax protein of human T-cell leukemia virus type I has been implicated in cellular transformation. Like other oncoproteins, such as Myc, Jun, and Fos, Tax is a transcriptional activ
Asking pregnant women about HIV risk [letter]: N Z Med J. 1998 May 8;111(1065):175. Unique Identifier : AIDSLINE MED/98275435; Eberhart-Phillips J; Dickson N; Williams S; Clarke R; Fonua L; Kini GP; Logan K; Millar C; Muir K; Simmers H; Weston H
Syphilis exposure and uveitis [letter]: Ophthalmology. 1998 Jun;105(6):945. Unique Identifier : AIDSLINE MED/98291108; Lee AG
Phosphorylation of bovine leukemia virus Tax protein is required for in vitro transformation but not for transactivation.: Oncogene. 1998 Apr 30;16(17):2165-76. Unique Identifier : AIDSLINE MED/98281124; Willems L; Grimonpont C; Kerkhofs P; Capiau C; Gheysen D; Conrath K; Roussef R; Mamoun R; Portetelle D; Burny A; Adam E; Lefebvre L; Twizere JC; Heremans H; Kettmann R; Department of Molecular Biology, Faculte Universitaire des Sciences; Agronomiques, Gembloux, Belgium.; The Tax proteins of the oncovirinae viruses are phosphorylated transcriptional activators that exhibit oncogenic potential. The role of phosphorylation in their functional activities remains unknown. As a model for the Human T-cell leukemia virus type I HTLV-I), Bovine Leukemia Virus (BLV) permits the characterization
Synthesis and RNA polymerase incorporation of the degenerate ribonucleotide analogue rPTP.: Nucleic Acids Res. 1998 May 1;26(9):2105-11. Unique Identifier : AIDSLINE MED/98213737; Moriyama K; Negishi K; Briggs MS; Smith CL; Hill F; Churcher MJ; Brown DM; Loakes D; Gene Research Centre, Okayama University, Tsushima, Okayama 700,; Japan, Nycomed Amersham plc, Amersham Laboratories, White Lion Road,; Amersham, Buckinghamshire HP7 9LL, UK.; The synthesis and enzymatic incorporation into RNA of the hydrogen bond degenerate nucleoside analogue 6-(beta-d-ribofuranosyl)-3, 4-dihydro-8H-pyrimido[4,5-c]-[1,2]oxazin-7-one (P) is described. The 5 -triphosphate of this analogue is readily incorporated by T3, T7 and SP6 RNA polymerases into RNA transcripts, being
A light goes out.: Nurs Times. 1998 Mar 25-31;94(12):14-5. Unique Identifier : AIDSLINE MED/98279603; Coombes R
[Prophylaxis after occupational exposure to human immunodeficiency virus (HIV)]: Pol Arch Med Wewn. 1997 Nov;98(11):431-40. Unique Identifier : AIDSLINE MED/98256917; Rogowska-Szadkowska D; Borzuchowska A; Wiercinska-Drapalo A; Chlabicz S; Klinika Obserwacyjno-Zakazna Akademii Medycznej w Bialymstoku.; Reasons for seeking consultation among health care workers due to potential or supposed risk of HIV infection were analyzed. From August 1990 till July 1996 41 health care providers were consulted including: 22 nurses, 1 student of nursing college, 3 midwives, 4 laboratory workers and 7 physicians (surgeons and gynaec
Effects of dietary vitamin E on the immune system in broilers: altered proportions of CD4 T cells in the thymus and spleen.: Poult Sci. 1998 Apr;77(4):529-37. Unique Identifier : AIDSLINE MED/98224906; Erf GF; Bottje WG; Bersi TK; Headrick MD; Fritts CA; Department of Poultry Science, Center of Excellence for Poultry; Science, University of Arkansas, Fayetteville 72701, USA.; gferf@comp.uark.edu; To gain insight into the immunomodulatory effects of vitamin E VE), immune cell population analyses were conducted using thymus and spleen from male broilers fed diets with various levels of VE supplementation (0, 17, 46, and 87 mg dl-alpha-tocopherol acetate/kg of feed). At 2 and 7 wk of age, the percentages of B cel
Risk assessment for periodontal disease.: Probe. 1996 May-Jun;30(3):100-4. Unique Identifier : AIDSLINE MED/98274363; Goulding M
Ethics case study.: Probe. 1996 Jul-Aug;30(4):148-9. Unique Identifier : AIDSLINE MED/98274368; Neish N; Fortune B
Hodgkin's disease-like lymphoproliferative disorders in patients with different underlying immunodeficiency states.: Mod Pathol. 1998 Apr;11(4):307-12. Unique Identifier : AIDSLINE MED/98237190; Tinguely M; Vonlanthen R; Muller E; Dommann-Scherrer CC; Schneider J; Laissue JA; Borisch B; Institute of Pathology, University of Berne, Switzerland.; Epstein-Barr virus (EBV)-associated lymphoproliferative diseases are a frequent occurrence in immunodeficient patients. Most commonly seen are polymorphic B-cell lymphoproliferative disorders and malignant B-cell lymphomas. Classical Hodgkin s disease (HD), however, is rare in these patients. In the present study, we
Perforin and granzyme expression in cytotoxic T-cell lymphomas.: Mod Pathol. 1998 Apr;11(4):313-23. Unique Identifier : AIDSLINE MED/98237191; Yamashita Y; Yatabe Y; Tsuzuki T; Nakayama A; Hasegawa Y; Kojima H; Nagasawa T; Mori N; First Department of Pathology, Nagoya University School of Medicine,; Japan. k46581anucc.cc.nagoya-u.ac.jp.; We studied the morphologic and immunohistochemical features of 10 peripheral T-cell lymphomas of a cytotoxic phenotype CD3+/CD4-/CD8+), encountered among 98 peripheral T-cell lymphomas (PTCLs). Nine tumors were positive for both cytotoxic molecules, namely perforin (Pf) and granzyme B (GrB), and strong positivity was
Pulmonary lymphomatoid granulomatosis in acquired immunodeficiency syndrome: lesions with Epstein-Barr virus infection.: Mod Pathol. 1998 Apr;11(4):347-56. Unique Identifier : AIDSLINE MED/98237196; Haque AK; Myers JL; Hudnall SD; Gelman BB; Lloyd RV; Payne D; Borucki M; Department of Pathology, University of Texas Medical Branch, Galveston; 77555-0743, USA.; We report the clinicopathologic characteristics of pulmonary lymphomatoid granulomatosis (LYG) in 11 patients (identified from a series of 330 consecutive patients who underwent autopsy between 1984 and 1995 at the University of Texas Medical Branch at Galveston, Texas) with a diagnosis of acquired immunodeficiency sy
Observations of sexually transmitted disease consultations in India.: Public Health. 1998 Mar;112(2):123-8. Unique Identifier : AIDSLINE MED/98242556; Mertens TE; Smith GD; Kantharaj K; Mugrditchian D; Radhakrishnan KM; World Health Organization, Geneva, Switzerland.; OBJECTIVES: To assess the quality of sexually transmitted disease STD) case management provided in public and private health facilities in selected areas of Madras, Tamil Nadu, India , in order to make recommendations for improving the quality of care and promote the syndromic approa
Interleukin-4 regulation of cytokine-induced HIV1 and interleukin-8 expression in promonocytic U1 cells is concentration- and cytokine-dependent.: Res Virol. 1998 Jan-Feb;149(1):21-7. Unique Identifier : AIDSLINE MED/98222346; Tiemessen CT; Kilroe B; Martin DJ; MRC AIDS Virus Research Unit, National Institute for Virology,; University of the Witwatersrand, Johannesburg, South Africa.; IL4 has been shown to differentially modulate HIV1 replication in primary cells of the monocyte/macrophage lineage. Its effects on chronic HIV1 infection, however, are unknown. To address IL4-mediated effects on promonocytic cells chronically infected with HIV1, U1 cells were incubated in the presence or absence of IL
Curcumin and curcumin derivatives inhibit Tat-mediated transactivation of type 1 human immunodeficiency virus long terminal repeat.: Res Virol. 1998 Jan-Feb;149(1):43-52. Unique Identifier : AIDSLINE MED/98222348; Barthelemy S; Vergnes L; Moynier M; Guyot D; Labidalle S; Bahraoui E; Laboratoire de Synthese, Physico-Chimie et Radiobiologie, Faculte de; Pharmacie, Toulouse, France.; The transcription of HIV1 provirus is regulated by both cellular and viral factors. Various evidence suggests that Tat protein secreted by HIV1-infected cells may have additional action in the pathogenesis of AIDS because of its ability to also be taken up by non-infected cells. Curcumin [diferuloylmethane or 1,7-bis-
Study of the immunogenicity of different recombinant Mengo viruses expressing HIV1 and SIV epitopes.: Res Virol. 1998 Jan-Feb;149(1):5-20. Unique Identifier : AIDSLINE MED/98222345; Van der Ryst E; Nakasone T; Habel A; Venet A; Gomard E; Altmeyer R; Girard M; Borman AM; Unite de Virologie moleculaire, Institut Pasteur, Paris.; Recombinant Mengo viruses expressing heterologous genes have proven to be safe and immunogenic in both mice and primates, and to be able to induce both humoral and cellular immune responses Altmeyer et al., 1995, 1996). Several recombinant Mengo viruses expressing either a large region (aa 65-206) of the HIV1 nef gene
Variation in virological parameters and antibody responses in macaques after atraumatic vaginal exposure to a pathogenic primary isolate of SIVmac251.: Res Virol. 1998 Jan-Feb;149(1):53-68. Unique Identifier : AIDSLINE MED/98222349; Neildez O; Le Grand R; Cheret A; Caufour P; Vaslin B; Matheux F; Theodoro F; Roques P; Dormont D; CEA, Service de Neurovirologie, CRSSA, DSV/DRM, Fontenay aux Roses,; France.; We developed an animal model for the male-to-female transmission of human immunodeficiency virus, consisting of an atraumatic vaginal application of simian immunodeficiency virus onto the intact vaginal mucosa of cynomolgus macaques. Different doses of a pathogenic isolate of SIVmac251, with or without seminal plasma,
[Recommendations for active immunization in patients with altered immunocompetence and/or with specific risks. Consulting Committee on Immunizations, Chilean Society of Infectology]: Rev Med Chil. 1997 Sep;125(9):1082-90. Unique Identifier : AIDSLINE MED/98258165; Although vaccines are powerful public health tools, are unwarrantedly denied or incompletely administered to patients with altered immunocompetence. The Advisory Immunization Committee presents an updated revision, according to the local epidemiological reality, that may guide the care of these patients. Recommendatio
[HIV/tuberculosis co-infection: a request for a better surveillance]: Rev Saude Publica. 1997 Jun;31(3):217-20. Unique Identifier : AIDSLINE MED/98176233; Lima MM; Belluomini M; Almeida MM; Arantes GR; Departamento de Epidemiologia da Faculdade de Saude Publica da; Universidade de Sao Paulo, Brasil. monlima@usp.br; The increasing endemicity of tuberculosis resulting from causes such as immigration, poverty, a declining public health infrastructure and co-infection by HIV/Mycobacterium tuberculosis, is leading to a change in tuberculosis control programmes. One of the main reasons for the resurgence of tuberculosis is HIV infecti
AIDS office head picked [news]: Science. 1998 May 22;280(5367):1181. Unique Identifier : AIDSLINE MED/98288446
Requirement for gammadelta T cells in allergic airway inflammation.: Science. 1998 May 22;280(5367):1265-7. Unique Identifier : AIDSLINE MED/98259085; Zuany-Amorim C; Ruffie C; Haile S; Vargaftig BB; Pereira P; Pretolani M; Unite de Pharmacologie Cellulaire, Unite Associee Institut; Pasteur/INSERM U485, Paris, France.; The factors that contribute to allergic asthma are unclear but the resulting condition is considered a consequence of a type-2 T helper (TH2) cell response. In a model of pulmonary allergic inflammation, mice that lacked gammadelta T cells had decreases in specific immunoglobulin E (IgE) and IgG1 and pulmonary interle
The ethics of AIDS vaccine trials [letter]: Science. 1998 May 29;280(5368):1327,1329; discussion 1330-1. Unique Identifier : AIDSLINE MED/98295405; Mann JM
The ethics of AIDS vaccine trials [letter]: Science. 1998 May 29;280(5368):1329-30; discussion 1331-2. Unique Identifier : AIDSLINE MED/98295406; Zion D
The ethics of AIDS vaccine trials [letter]: Science. 1998 May 29;280(5368):1330; discussion 1330-1. Unique Identifier : AIDSLINE MED/98295407; Macpherson CC
Treating needlestick injuries from HIV-positive patients always imperative [news]: Tex Dent J. 1997 Sep;114(9):61. Unique Identifier : AIDSLINE MED/98263583
[Neuropathogenic murine retrovirus]: Uirusu. 1997 Dec;47(2):187-94. Unique Identifier : AIDSLINE MED/98207474; Masuda M; Department of Microbiology, Graduate School of Medicine, University of; Tokyo. mmasuda@m.u-tokyo.ac.jp
[Gene transfer into non-dividing cells by a lentiviral vector]: Uirusu. 1997 Dec;47(2):213-9. Unique Identifier : AIDSLINE MED/98207477; Miyake K; Shimada T; Department of Biochemistry and Molecular Biology, Nippon Medical; School, Tokyo, Japan.
Needlesticks: what to do after it happens.: Va Dent J. 1996 Jan-Mar;73(1):11-6. Unique Identifier : AIDSLINE MED/98201576; Kaugars GE; Page DG; Abbey LM; Burns JC; Svirsky JA; Department of Oral Pathology, MCV School of Dentistry, USA.; A needlestick injury can be a frightening and even potentially a life-threatening event. It needs to be treated with compassion and some urgency. The dentist-employer should act with knowledge of the current law and with the desire to do whatever is best for the affected people.
Subacute measles encephalitis with AIDS diagnosed by fine needle aspiration biopsy. A case report.: Acta Cytol. 1998 May-Jun;42(3):729-33. Unique Identifier : AIDSLINE MED/98285899; Poon TP; Tchertkoff V; Win H; Department of Pathology, New York Medical College, Metropolitan; Hospital Center, New York 10029, USA.; BACKGROUND: Subacute measles encephalitis (SME), or measles inclusion body encephalitis (MIBE), is a rare central nervous system (CNS) complication following infection by the measles rubeola) virus. It usually occurs in young patients with defective cellular immunity from either congenital or acquired causes. In the
Provider attitudes toward IUD provision in Zimbabwe: perception of HIV risk and training implications.: Adv Contracept. 1998 Mar;14(1):27-39. Unique Identifier : AIDSLINE MED/98246418; Gaffikin L; Phiri A; McGrath J; Zinanga A; Blumenthal PD; Johns Hopkins Program for International Education in Reproductive; Health, Baltimore, MD, USA.; This study was conducted to assess providers attitudes toward the provision of long-term methods of contraception, in particular the IUD, and provider concerns about human immunodeficiency virus (HIV) in the context of family planning FP) services. The data were collected using self-administered structured questionna
Infection and America's blood supply: a 1998 status report [editorial; comment]: Am J Clin Pathol. 1998 Jun;109(6):659-61. Unique Identifier : AIDSLINE MED/98281319; Popovsky MA
Seroprevalence of HHV-8 antibodies in HIV-positive homosexual men without Kaposi's sarcoma and their clinical follow-up.: Am J Clin Pathol. 1998 Jun;109(6):778-83. Unique Identifier : AIDSLINE MED/98281338; Verbeek W; Frankel M; Miles S; Said J; Koeffler HP; Division of Hematology, Cedars-Sinai Medical Center, Los Angeles,; California 90048, USA.; Human herpesvirus 8 (HHV-8) has been associated with Kaposi s sarcoma (KS). Because KS is most frequently seen in HIV-positive homosexual men, we retrospectively evaluated the seroprevalence of HHV-8 in this risk group and compared the clinical history and clinical course of the HHV-8-negative and HHV-8-positive group
A longitudinal study of human papillomavirus carriage in human immunodeficiency virus-infected and human immunodeficiency virus-uninfected women.: Am J Obstet Gynecol. 1998 May;178(5):982-6. Unique Identifier : AIDSLINE MED/98270734; Minkoff H; Feldman J; DeHovitz J; Landesman S; Burk R; Department of Obstetrics and Gynecology of the State University Health; Science Center at Brooklyn, New York, USA.; OBJECTIVE: We sought to determine the relationship of human immunodeficiency virus serostatus to carriage of oncogenic human papillomavirus. MATERIAL AND METHODS: A total of 268 human immunodeficiency virus-infected and 265 human immunodeficiency virus-uninfected women were seen every 6 months, at which time they had
Annotation: prevention of HIV, other sexually transmitted diseases, and unwanted pregnancy--testing physical barriers available to women.: Am J Public Health. 1998 Jun;88(6):872-4. Unique Identifier : AIDSLINE MED/98282309; Stein Z; Susser M
Health benefits and risks of reporting HIV-infected individuals by name.: Am J Public Health. 1998 Jun;88(6):876-9. Unique Identifier : AIDSLINE MED/98282311; Colfax GN; Bindman AB; San Francisco Department of Public Health, AIDS Office, CA 94102-6033,; USA. grant_colfax@dph.sf.ca.us; With more treatment options emerging for human immunodeficiency virus (HIV) infection, the policy of reporting HIV-infected individuals by name merits reevaluation. This paper reviews the benefits and risks of name reporting of persons infected with HIV. Public health departments have linked name reporting with medica
Multiple concurrent reverse transcriptase and protease mutations and multidrug resistance of HIV-1 isolates from heavily treated patients [see comments]: Ann Intern Med. 1998 Jun 1;128(11):906-11. Unique Identifier : AIDSLINE MED/98285334; Shafer RW; Winters MA; Palmer S; Merigan TC; Stanford University Medical Center, California 94305, USA.; rshafer@cmgm.stanford.edu; BACKGROUND: Drug resistance of HIV-1 is an obstacle to the long-term efficacy of antiretroviral therapy. OBJECTIVE: To characterize reverse transcriptase and protease genes of multidrug-resistant HIV-1 isolates. DESIGN: Descriptive case series. SETTING: Academic medical center. PATIENTS: Four consecutive patients with
Nodular cutaneous microsporidiosis in a patient with AIDS and successful treatment with long-term oral clindamycin therapy.: Ann Intern Med. 1998 Jun 1;128(11):911-4. Unique Identifier : AIDSLINE MED/98285335; Kester KE; Turiansky GW; McEvoy PL; Walter Reed Army Institute of Research, Walter Reed Army Medical; Center, Washington, DC 20307-5100, USA. kesterk@wrsmtp-ccmail.army.mil; BACKGROUND: In AIDS, nodular skin disease can result from various causes. OBJECTIVE: To report a new manifestation of microsporidial infection presenting as nodular skin disease with underlying osteomyelitis. DESIGN: Case report. SETTING: Tertiary-care military medical center in Washington, D.C. PATIENT: A 36-year-old
Resisting resistance: maximizing the durability of antiretroviral therapy [editorial; comment]: Ann Intern Med. 1998 Jun 1;128(11):951-4. Unique Identifier : AIDSLINE MED/98285342; Condra JH
Cellular and humoral immune responses associated with HTLV-I associated myelopathy/tropical spastic paraparesis.: Ann N Y Acad Sci. 1997 Dec 19;835:142-52. Unique Identifier : AIDSLINE MED/98279741; Levin MC; Jacobson S; Viral Immunology Section, National Institute of Neurological Disorders; and Stroke, National Institutes of Health, Bethesda, Maryland 20892,; USA.
Immune responses and dementia.: Ann N Y Acad Sci. 1997 Dec 19;835:91-110. Unique Identifier : AIDSLINE MED/98279737; Giulian D; Department of Neurology, Baylor College of Medicine, Houston, Texas; 77031, USA.
Combination gene therapy for salivary gland cancer.: Ann N Y Acad Sci. 1998 Apr 15;842:163-70. Unique Identifier : AIDSLINE MED/98261672; O'Malley BW Jr; Li D; Department of Otolaryngology-HNS, Johns Hopkins University, Baltimore,; Maryland 21203-6402, USA. bomalle@gwgate1.jhmi.jhu.edu; An established combination gene therapy strategy involving adenovirus vector delivery of the herpes thymidine kinase (tk) and murine interleukin-2 genes was adapted to treat salivary gland cancer in a murine model. Salivary tumors were generated by transcutaneous injection of 5 x 10(5) murine squamous carcinoma cells
Distinguishing the states of latency and reactivation is important for human herpesvirus 8 [letter]: Arch Dermatol. 1998 May;134(5):633-4. Unique Identifier : AIDSLINE MED/98269182; Drago F; Rebora A
Ultrastructure of atypical (teratoid) sporogonial stages of Enterocytozoon bieneusi (Microsporidia) in naturally infected rhesus monkeys (Macacca mulatta).: Arch Pathol Lab Med. 1998 May;122(5):423-9. Unique Identifier : AIDSLINE MED/98254175; Schwartz DA; Anderson DC; Klumpp SA; McClure HM; Department of Pathology, Emory University School of Medicine and Grady; Memorial Hospital, Atlanta, GA 30335, USA.; OBJECTIVE: To demonstrate the ultrastructural features of normal and atypical (teratoid) developmental stages of Enterocytozoon bieneusi in naturally infected rhesus monkeys (Macacca mulatta). DESIGN AND METHODS: Two rhesus monkeys with chronic simian immunodeficiency virus infection developed naturally acquired micro
Irreversible telomere shortening by 3'-azido-2',3'-dideoxythymidine (AZT) treatment.: Biochem Biophys Res Commun. 1998 May 8;246(1):107-10. Unique Identifier : AIDSLINE MED/98262925; Gomez DE; Tejera AM; Olivero OA; Laboratory of Molecular Oncology, National University of Quilmes,; Bernal, Argentina.; Telomeres shorten by 30 to 50 bp with each cell division. Germ line, tumor and stem cells overcome progressive shortening by elongating their telomeres with telomerase. Previously we demonstrated that 3 -azido-2 ,3 -dideoxythymidine ( AZT ), incorporate
Sequential interaction of CD4 and HIV-1 gp120 with a reconstituted membrane patch of ganglioside GM3: implications for the role of glycolipids as potential HIV-1 fusion cofactors.: Biochem Biophys Res Commun. 1998 May 8;246(1):117-22. Unique Identifier : AIDSLINE MED/98262927; Hammache D; Yahi N; Pieroni G; Ariasi F; Tamalet C; Fantini J; Laboratoire de Biochimie et Biologie de la Nutrition, UPRESA-CNRS; 6033, Faculte des Sciences de St. Jerome, Marseille, France.; The fusion of HIV-1 with CD4+ cells involves, in addition to CD4, specific cell surface molecules acting as fusion cofactors. Recently, we reported that the V3 loop of HIV-1 gp120 binds to GM3, a ganglioside abundantly expressed on CD4+ lymphocytes and macrophages. In the present study, we show that CD4 interacts with
The antiviral activity of a synthetic peptide derived from the envelope SU glycoprotein of feline immunodeficiency virus maps in correspondence of an amphipathic helical segment.: Biochem Biophys Res Commun. 1998 May 8;246(1):160-5. Unique Identifier : AIDSLINE MED/98262935; Massi C; Indino E; Lami C; Fissi A; Pieroni O; La Rosa C; Esposito F; Galoppini C; Rovero P; Bandecchi P; Bendinelli M; Garzelli C; Department of Biomedicine, University of Pisa, Italy.; In a previous paper (Lombardi et al., Virology 220, 274-284, 1996), we-reported that a 20-amino acid synthetic peptide derived from a conserved region of the SU glycoprotein of feline immunodeficiency virus (FIV), i.e., 225EGPTLGNWAREIWATLFKKA244, bound the surface of FIV-permissive cells and inhibited FIV infection o
Cobalamin inhibition of HIV-1 integrase and integration of HIV-1 DNA into cellular DNA.: Biochem Biophys Res Commun. 1998 May 19;246(2):393-7. Unique Identifier : AIDSLINE MED/98273290; Weinberg JB; Shugars DC; Sherman PA; Sauls DL; Fyfe JA; VA Medical Center, Durham, North Carolina 27705, USA.; Our prior studies showed that certain cobalamins inhibit productive HIV-1 infection of primary cultures of blood lymphocytes and monocytes. We demonstrate here that this antiviral activity may be mediated by an inhibition of HIV-1 integrase, an enzyme required for productive infection. Purified recombinant HIV-1 integ
HIV prevention strategies: quo vadis? [editorial]: Aids Patient Care STDS. 1998 Mar;12(3):165-6. Unique Identifier : AIDSLINE MED/98220323; Laurence J
New onset diabetes mellitus in an HIV-positive adolescent.: Aids Patient Care STDS. 1998 Mar;12(3):167-9. Unique Identifier : AIDSLINE MED/98220324; Abdel-Khalek I; Moallem HJ; Fikrig S; Castells S; Department of Pediatrics, SUNY Health Science Center at Brooklyn, USA.; The authors report an 18-year-old girl with HIV infection who developed new-onset insulin-dependent diabetes mellitus (IDDM) in association with anemia. IDDM among patients with HIV infection has been infrequently reported and suggested to be caused by different etiologies. Susceptibility to autoimmune diseases, such
Visual dysfunction in HIV-positive patients without infectious retinopathy.: Aids Patient Care STDS. 1998 Mar;12(3):171-9. Unique Identifier : AIDSLINE MED/98220325; Plummer DJ; Sample PA; Freeman WR; Department of Ophthalmology, Shiley Eye Center, University of; California at San Diego, La Jolla, USA.; Persons with HIV disease are susceptible to various manifestations of retinal damage, such as infectious retinopathies (e.g., cytomegalovirus [ CMV ] retinitis and toxoplasmosis) and noninfectious complications (microangiopathi
CMV retinitis and the controversies associated with highly active antiretroviral therapy and the immune recovery hypothesis.: Aids Patient Care STDS. 1998 Mar;12(3):181-5. Unique Identifier : AIDSLINE MED/98220326; Reed JB; Morse LS; Department of Ophthalmology, University of California at Davis,; Sacramento, USA.; The aggressive multidrug regimen of highly active antiretroviral therapy (HAART) has offered some degree of promise of immune reconstitution in AIDS patients, a phenomenon that theoretically would impact positively on the incidence and severity of opportunistic infections. Some studies already have noted complete regr
Interleukin-2 therapy in HIV infection.: Aids Patient Care STDS. 1998 Mar;12(3):187-97. Unique Identifier : AIDSLINE MED/98220327; Pahwa S; Morales M; Department of Pediatrics, North Shore University Hospital-New York; University School of Medicine, Manhasset, USA.; Immune cells secrete a variety of cytokines that have a profoundly significant influence on the immune system. For example, cytokines secreted by T-helper cells have a role in cellular immune response (Th1 cytokines) and in antibody production (Th2 cytokines). Interleukin 2 (
Hepatitis C virus and HIV coinfection.: Aids Patient Care STDS. 1998 Mar;12(3):199-207. Unique Identifier : AIDSLINE MED/98220328; Sabin CA; Department of Primary Care and Population Sciences, Royal Free; Hospital and School of Medicine, London, England.; The world-wide prevalence of hepatitis C virus (HCV) is approximately 1%. Being primarily a blood-borne virus, the major risk factors for HCV include the receipt of blood and blood products, as well as intravenous drug use. As a result, many individuals infected with HIV are also infected with HCV. Any effect of coinf
HIV rounds at Cornell: selected neurologic complications of HIV disease.: Aids Patient Care STDS. 1998 Mar;12(3):209-15. Unique Identifier : AIDSLINE MED/98220329; Simpson D; Department of Neurology, Mount Sinai Medical Center, New York, New; York, USA.; Neurological disorders are among the most frequent and devastating complications of HIV infection and AIDS. As patients survive longer with the availability of highly active anti-retrovital therapy, it is likely that the frequency of some of these disorders will increase, since patients will survive long enough to dev
Pediatric primary care provider's knowledge of HIV/AIDS care.: Aids Patient Care STDS. 1998 Mar;12(3):217-25. Unique Identifier : AIDSLINE MED/98220330; Rutstein RM; Kershaw DL; Harwell TS; Rudy BJ; Ricksecker MA; Spence MR; Division of General Pediatrics, Children's Hospital of Philadelphia,; Pennsylvania, USA.; To respond to the difficulties that community-based providers face in keeping abreast of the rapid changes in HIV-related care, an intensive pediatric HIV mentoring program (Pediatric HIV Miniresidency [MR]) was developed, linking a regional AIDS Education and Training Center (AETC) with an urban children s hospital H
HIV/AIDS case histories: diagnostic problem. Necrotizing stomatitis.: Aids Patient Care STDS. 1998 Mar;12(3):227-8. Unique Identifier : AIDSLINE MED/98220331; Freedman PD; Section of Oral Pathology, New York Hospital Medical Center of Queens,; USA.
Expanded claim for assay approved [news]: Aids Patient Care STDS. 1998 Mar;12(3):229. Unique Identifier : AIDSLINE MED/98220333
Warning against rechallenge with abacavir [news]: Aids Patient Care STDS. 1998 Mar;12(3):229. Unique Identifier : AIDSLINE MED/98220332
Collaboration studies co-receptor drug research [news]: Aids Patient Care STDS. 1998 Mar;12(3):230. Unique Identifier : AIDSLINE MED/98220334
Criteria expanded for efavirenz [news]: Aids Patient Care STDS. 1998 Mar;12(3):230. Unique Identifier : AIDSLINE MED/98220335
Drug found effective against E. intestinalis [news]: Aids Patient Care STDS. 1998 Mar;12(3):231. Unique Identifier : AIDSLINE MED/98220337
Human vaccine testing set [news]: Aids Patient Care STDS. 1998 Mar;12(3):231. Unique Identifier : AIDSLINE MED/98220336
Lymphoma treatment approved [news]: Aids Patient Care STDS. 1998 Mar;12(3):231. Unique Identifier : AIDSLINE MED/98220338
Congress passes bill to increase CDC funding for STD Prevention Programs [news]: Aids Patient Care STDS. 1998 Mar;12(3):233. Unique Identifier : AIDSLINE MED/98220339; Makulowich GS
Epidemiology of syphilis [news]: Aids Patient Care STDS. 1998 Mar;12(3):233-4. Unique Identifier : AIDSLINE MED/98220340; Makulowich GS
Misperceptions about symptoms [news]: Aids Patient Care STDS. 1998 Mar;12(3):234. Unique Identifier : AIDSLINE MED/98220341; Makulowich GS
Persons remain reluctant to seek care [news]: Aids Patient Care STDS. 1998 Mar;12(3):234. Unique Identifier : AIDSLINE MED/98220342; Makulowich GS
Local partnering, education, and outbreak response teams [news]: Aids Patient Care STDS. 1998 Mar;12(3):234-5. Unique Identifier : AIDSLINE MED/98220343; Makulowich GS
Differences of HIV envelope protein between HIV-1 and HIV-2: possible relation to the lower virulence of HIV-2.: Viral Immunol. 1998;11(1):1-8. Unique Identifier : AIDSLINE MED/98246104; Sekigawa I; Kaneko H; Neoh LP; Takeda-Hirokawa N; Akimoto H; Hishikawa T; Hashimoto H; Hirose S; Yamamoto N; Kaneko Y; Department of Medicine, Juntendo University, Izu-Nagaoka Hospital,; Shizuoka, Japan.
Activation of lymphocytes by HHV-6 antigen in normal children and adults.: Viral Immunol. 1998;11(1):19-25. Unique Identifier : AIDSLINE MED/98246106; Koide W; Ito M; Torigoe S; Ihara T; Kamiya H; Sakurai M; Department of Pediatrics, Mie University School of Medicine, Tsu,; Japan.; We investigated the immune reaction of lymphocytes in response to human herpes virus-6 (HHV-6) in normal children and adults. Cell proliferation was assayed by measurement of the incorporation of 5-bromo-2 -deoxyuridine (BrdU) by enzyme-linked immunosorbent assay (ELISA), and changes in expression of interleukin-2 rec
Autoimmune T-cell response to the CD4 molecule in HIV-infected patients.: Viral Immunol. 1998;11(1):9-17. Unique Identifier : AIDSLINE MED/98246105; Caporossi AP; Bruno G; Salemi S; Mastroianni C; Falciano M; Salotti A; Bergami N; Santilio I; Nisini R; Barnaba V; Istituto I Clinica Medica, Universita di Roma La Sapienza, Rome,; Italy.; In a previous study, we demonstrated that by downregulating plasma membrane CD4 and increasing its processing, human immunodeficiency (HIV)-1-gp120 unveils hidden CD4 epitopes, inducing an in vitro anti-CD4-specific T-cell response. We report herein that this mechanism may potentially have important implications in HI
New study finds Florida dental AIDS patients victims of serial homicide [news]: J Gt Houst Dent Soc. 1995 Jan;66(6):22. Unique Identifier : AIDSLINE MED/98245710
Thiophene-2-carbaldehyde N-(2,4-dinitrophenyl)-N-methylhydrazone.: Acta Crystallogr C. 1998 Apr 15;54 ( Pt 4):527-9. Unique Identifier : AIDSLINE MED/98267668; Aygun M; Isik S; Ocal N; Tahir MN; Kaban S; Buyukgungor O; Department of Physics, Ondokuz May's University, Samsun, Turkey.; aygunm@samsun.omu.edu.tr; Molecules of the title compound, C12H10N4O4S, are linked through intermolecular hydrogen bonds to form a dimeric structure. The crystal structure of the dimer is stabilized by two intermolecular hydrogen bonds of the C-H...O type. The C...O intermolecular contact distance is 3.339(3) A, and the C=N and N-N distances a
Adherence of Staphylococcus aureus, Klebsiella pneumoniae and Candida albicans to human buccal epithelial cells, from healthy persons and HIV carriers, under the influence of Broncho Vaxom in vitro and ascorbic acid in vivo.: APMIS. 1998 Apr;106(4):441-8. Unique Identifier : AIDSLINE MED/98299335; Fortis AA; Lianou PE; Papavassilliou JT; Centre for Infectious Diseases, Department of Microbiology, Athens; Medical School, Athens University, Greece.; We examined the in vitro effect of Broncho Vaxom (BV) (an immunobiotherapeutic preparation containing a lysate made from bacteria often involved in respiratory tract infections) on adherence of Staphylococcus aureus, Klebsiella pneumoniae and Candida albicans to human buccal epithelial cells (BEC) of healthy volunteer
HIV infection in the first heart transplantation in Italy: fatal outcome. Case report.: APMIS. 1998 Apr;106(4):470-4. Unique Identifier : AIDSLINE MED/98299339; Calabrese F; Angelini A; Cecchetto A; Valente M; Livi U; Thiene G; Department of Pathology and Cardiovascular Surgery, University of; Padua, Italy.; A 46-year-old man with alcoholic dilated cardiomyopathy underwent heart transplantation on November 14, 1985. It was the first cardiac transplant in Italy and at that time no HIV antibody screening test was available in this country. The patient remained in good health for 6 years p
Public health, communicable diseases, and managed care: Will managed care improve or weaken communicable disease control?: Am J Prev Med. 1998 Apr;14(3 Suppl):53-9. Unique Identifier : AIDSLINE MED/98226591; Rutherford GW; School of Public Health, University of California, Berkeley; 94720-7360, USA.; BACKGROUND: Several changes can be anticipated in the practice of communicable disease control as a result of the health care delivery system s transition from a predominantly fee-for-service system to a predominantly managed care system. These changes will clearly involve clinical services provided by public health a
Human immunodeficiency virus (HIV) in America, 1981 to 1997: epidemiologic and therapeutic considerations.: Semin Ultrasound CT MR. 1998 Apr;19(2):122-7. Unique Identifier : AIDSLINE MED/98228715; Reiter GS; University of Massachusetts Medical Center Worcester, MA, USA.; In the last 16 years, acquired immunodeficiency syndrome (AIDS) has evolved from a mysterious syndrome apparently afflicting only gay men, into a viral illness affecting every segment of society. Until the advent of combination antiretroviral therapy, HIV appeared to be universally fatal. New therapies and technologie
Clinical correlates of human immunodeficiency virus (HIV)-related immunosuppression.: Semin Ultrasound CT MR. 1998 Apr;19(2):128-32. Unique Identifier : AIDSLINE MED/98228716; Reiter GS; University of Massachusetts Medical Center Worcester, MA, USA.; Opportunistic infections and cancers, collectively referred to as opportunistic diseases (OD), occur with increasing frequency as HIV-related immunosuppression advances. Knowledge of an individual s degree of immunosuppression, as measured by his or her CD4 cell count, will assist a clinician in constructing a differe
Diagnostic imaging of the brain in acquired immunodeficiency syndrome (AIDS).: Semin Ultrasound CT MR. 1998 Apr;19(2):133-53. Unique Identifier : AIDSLINE MED/98228717; Chiang FL; Walot I; Sinow RM; Mehringer CM; Department of Radiology, Harbor-UCLA Medical Center, Torrance 90509,; USA.; The central nervous system is commonly involved in acquired immunodeficiency syndrome (AIDS), resulting in a variety of lesions and diseases. They can be divided into the primary effects of human immunodeficiency virus (HIV), opportunistic infections, tumors, and vascular disease. This article is a review of the major
The role of computed tomography in the diagnosis and management of human immunodeficiency virus (HIV)-related pulmonary diseases.: Semin Ultrasound CT MR. 1998 Apr;19(2):154-66. Unique Identifier : AIDSLINE MED/98228718; Mason AC; Muller NL; Department of Radiology, St. Paul's Hospital, Vancouver, BC, Canada.; This review summarizes the current role of CT in the diagnosis and management of respiratory disease in human immunodeficiency virus (HIV)-positive patients. Recommendations are made concerning optimum technique for diagnostic CT as well as practical considerations concerning the use of CT in biopsy and thoracic inter
CT manifestations of human immunodeficiency virus (HIV)-related pulmonary infections.: Semin Ultrasound CT MR. 1998 Apr;19(2):167-74. Unique Identifier : AIDSLINE MED/98228719; Shah RM; Salazar AM; Department of Radiology, Medical College of Pennsylvania, Philadelphia; 19129, USA.; The infectious pulmonary complications of acquired immunodeficiency syndrome (AIDS) are reviewed, with emphasis on the spectrum of CT imaging findings and diagnostic accuracy and limitations as reported in the current literature. Changes in epidemiologic trends for common AIDS-related infections and the associated ran
Acquired immunodeficiency syndrome (AIDS) of the abdominal organs: imaging features.: Semin Ultrasound CT MR. 1998 Apr;19(2):175-89. Unique Identifier : AIDSLINE MED/98228720; Gore RM; Miller FH; Yaghmai V; Department of Radiology, Northwestern University Medical School,; Chicago, IL, USA.; The liver, spleen, biliary tract, pancreas, and kidneys are commonly affected by opportunistic infection, malignancy, and inflammatory disorders during the course of human immunodeficiency virus (HIV) infection. Clinical manifestations of solid abdominal visceral involvement are protean and usually nonspecific, but it
Radiologic evaluation of the acute abdomen in the patient with acquired immunodeficiency syndrome (AIDS): the role of CT scanning.: Semin Ultrasound CT MR. 1998 Apr;19(2):190-9. Unique Identifier : AIDSLINE MED/98228721; Wu CM; Davis F; Fishman EK; Department of Radiology, Johns Hopkins Hospital, Baltimore, MD 21287,; USA.; Abdominal complaints are common in the HIV-infected patient, and the signs and symptoms of disease may be masked by concurrent illness and a weak immune response, making accurate diagnosis difficult. Patients with acquired immunodeficiency syndrome AIDS) are susceptible to diseases common to the general population; ho
Musculoskeletal complications of the patient with acquired immunodeficiency syndrome (AIDS): CT evaluation.: Semin Ultrasound CT MR. 1998 Apr;19(2):200-8. Unique Identifier : AIDSLINE MED/98228722; Wu CM; Davis F; Fishman EK; Russell H. Morgan Department of Radiology and Radiological Science,; Johns Hopkins Hospital, Baltimore, MD 21287, USA.; Musculoskeletal disorders are infrequent complications of HIV infection in this country. However, AIDS patients are susceptible to a wide range of musculoskeletal complications, from the common to the otherwise uncommon. The following is a summary of some of the more frequently encountered musculoskeletal manifestatio
Bloodborne pathogens and procedure safety in interventional radiology.: Semin Ultrasound CT MR. 1998 Apr;19(2):209-14. Unique Identifier : AIDSLINE MED/98228723; Hansen ME; Department of Radiology, University of Texas Southwestern, Medical; Center, Dallas, USA.; Concern about possible transmission of bloodborne pathogens during medical procedures is growing among patients and healthcare workers alike. This fear has primarily been focused on nosocomial transmission of human immunodeficiency virus (HIV), but other bloodborne infectious agents may also be transmitted during proc
Female condom acceptability among sex workers in Costa Rica.: AIDS Educ Prev. 1998 Apr;10(2):105-13. Unique Identifier : AIDSLINE MED/98234490; Madrigal J; Schifter J; Feldblum PJ; Instituto Latinoamericano de Prevencion y Educacion en Salud, San; Jose, Costa Rica.; This study measured short-term female condom acceptability among 51 female sex workers in San Jose, Costa Rica . Each woman was trained in use of the female condom and was asked to use the device if clients refused to use male condoms during a 2-week study period (male condoms we
Barriers and pathways to testing among HIV-infected women.: AIDS Educ Prev. 1998 Apr;10(2):114-27. Unique Identifier : AIDSLINE MED/98234491; Siegel K; Raveis VH; Gorey E; Center for the Psychosocial Study of Health & Illness, Columbia; University School of Public Health, New York, New York 10032, USA.; Through in-depth interviews the testing experiences of HIV-infected women were examined. The barriers that impeded the women from recognizing their at-risk status and from seeking testing once their vulnerability was acknowledged are discussed. Also described are the pathways that led women into testing. The data reve
The Healthy for Life project: sexual risk behavior outcomes.: AIDS Educ Prev. 1998 Apr;10(2):128-48. Unique Identifier : AIDSLINE MED/98234492; Moberg DP; Piper DL; Center for Health Policy and Program Evaluation, University of; Wisconsin, Madison, WI 53703-2703, USA.; Sexual risk behavior outcome data from the Healthy for Life (HFL) project is presented. Using a social influences model, the intervention was designed to positively affect the health behaviors of middle school students in five related areas: alcohol use, tobacco use, marijuana use, nutrition, and sexuality. The in-sch
Predictors of AIDS-preventive behavioral intentions among adult heterosexuals at risk for HIV-infection: extending current models and measures.: AIDS Educ Prev. 1998 Apr;10(2):149-72. Unique Identifier : AIDSLINE MED/98234493; Buunk BP; Bakker AB; Siero FW; van den Eijnden RJ; Yzer MC; Department of Psychology, University of Groningen, The Netherlands.; This study examined the predictors of the intention to use condoms with new sexual partners. A sample of heterosexual adult females and males (n = 711) was recruited through various channels. A substantial part of the sample had engaged in risky sexual behavior. Predictors were based on various theoretical models. Com
Development of the AIDS Health Belief Scale (AHBS).: AIDS Educ Prev. 1998 Apr;10(2):173-9. Unique Identifier : AIDSLINE MED/98234494; Zagumny MJ; Brady DB; Department of Psychology, Tennessee Technological University,; Cookeville 38505, USA.; The AIDS Health Belief Scale (AHBS) was developed to measure the four components of the health belief model (HBM): perceived susceptibility to disease, perceived severity of a specific disease, perceived benefits of preventive behavior, and barriers to preventive behavior. Sixteen items were developed for the original
Parental drug use and the socialization of AIDS knowledge and attitudes in children.: AIDS Educ Prev. 1998 Apr;10(2):180-92. Unique Identifier : AIDSLINE MED/98234495; Sigelman CK; Goldenberg JL; Siegel CB; Dwyer KM; George Washington University, USA.; Children aged 6 to 18 who had a parent enrolled in drug treatment were matched on the child s age, sex, and ethnicity and on the parent s level of education with children from a community sample. They were compared with respect to parents knowledge of HIV transmission, parents efforts to teach their children (ages 6
Biochemical characterization of the HIV-1 integrase 3'-processing activity and its inhibition by phosphorothioate oligonucleotides.: Biochemistry. 1998 May 19;37(20):7237-43. Unique Identifier : AIDSLINE MED/98254509; Tramontano E; Colla PL; Cheng YC; Dipartimento di Biologia Sperimentale, Universita degli Studi di; Cagliari, Italy.; To better understand HIV-1 integrase (IN) functions, we determined the kinetic parameters of the 3 -processing reaction. Steady-state kinetic analysis performed using Dixon plots indicated that the concentration of active enzyme was 10-fold lower than that calculated by protein determination. The turnover number was l
Physicochemical and biochemical properties of 2',5'-linked RNA and 2',5'-RNA:3',5'-RNA "hybrid" duplexes.: Biochemistry. 1998 May 19;37(20):7478-86. Unique Identifier : AIDSLINE MED/98254534; Wasner M; Arion D; Borkow G; Noronha A; Uddin AH; Parniak MA; Damha MJ; Department of Chemistry, McGill University, Montreal, Quebec, Canada.; In recent publications, oligonucleotides joined by 2 ,5 -linkages were found to bind to complementary single-stranded RNA but to bind weakly, or not at all, to single-stranded DNA [e.g., P. A. Giannaris and M. J. Damha (1993) Nucleic Acids Res. 21, 4742-4749]. In this work, the biochemical and physicochemical properti
[Nutritional status of patients with HIV infection. Spontaneous evolution during the hospital stay]: Nutr Hosp. 1997 Jul-Aug;12(4):206-9. Unique Identifier : AIDSLINE MED/98280170; del Olmo D; Alcazar V; Barba R; Fernandez C; Koning MA; Vazquez C; S. de Endocrinologia y Nutricion, Hospital Severo Ochoa, Leganes,; Madrid, Espana.; BASICS: Evaluate the nutritional status of HIV positive patients who are admitted to hospital for some acute process, and their evaluation, without nutritional support, during the admission. METHODS: Prospective study in HIV positive patients. Nutritional evaluation (on admission and on release); (1) anthropometric we
Successful treatment of cytomegalovirus encephalitis in a patient with Hodgkin's disease in remission.: Ann Hematol. 1998 Mar-Apr;76(3-4):179-81. Unique Identifier : AIDSLINE MED/98281036; Van Droogenbroeck J; De Ceuninck M; Snoeck HW; Schroyens W; Berneman Z; Antwerp University Hospital, Division of Hematology, Edegem, Belgium.; Jan.Van.Droogenbroeck@uza.uia.ac.be; Cytomegalovirus encephalitis is a rare but life-threatening infection in non-AIDS patients. To our knowledge, no case that followed conventional treatment for Hodgkin s lymphoma has been reported. We present a patient with Hodgkin s disease in complete remission after combined modality treatment who was succesfully tr
Changes in thyroid function and immunological parameters long after subtotal thyroidectomy for Graves' disease.: Eur J Surg. 1998 Mar;164(3):173-8. Unique Identifier : AIDSLINE MED/98220745; Kasuga Y; Kobayashi S; Fujimori M; Shingu K; Asanuma K; Hama Y; Ito K; Maruyama M; Amano J; Department of Surgery, Shinshu University School of Medicine, Asahi,; Matsumoto, Japan.; OBJECTIVE: To find out whether subtotal thyroidectomy results in long term stable functional and immunological remission in patients with Graves disease. DESIGN: Retrospective study. SETTING: Teaching hospital, Japan . SUBJECTS: 176 patients who underwent subtotal thyroidectomy for
Structure and evolution of Cyclops: a novel giant retrotransposon of the Ty3/Gypsy family highly amplified in pea and other legume species.: Plant Mol Biol. 1998 May;37(2):363-75. Unique Identifier : AIDSLINE MED/98278369; Chavanne F; Zhang DX; Liaud MF; Cerff R; Institut fur Genetik, Technische Universitat Braunschweig, Germany.; We characterized a novel giant Gypsy-like retrotransposon, Cyclops, present in about 5000 copies in the genome of Pisum sativum. The individual element Cyclops-2 measures 12 314 bp including long terminal repeats (LTRs) of 1504 bp and 1594 bp, respectively, showing 4.1% sequence divergence between one another. Cyclops
Biochemical and immunological characterization of rice homologues of the human immunodeficiency virus-1 Tat binding protein and subunit 4 of human 26S proteasome subunits.: Plant Mol Biol. 1998 Jun;37(3):495-504. Unique Identifier : AIDSLINE MED/98278378; Suzuka I; Yanagawa Y; Yamazaki K; Ueda T; Nakagawa H; Hashimoto J; Department of Molecular Genetics, National Institute of Agrobiological; Resources, Tsukuba, Ibaraki, Japan.; Previously, we isolated two cDNA clones, TBPOs-1 and TBPOs-2, encoding putative ATPases that are the rice homologues of human immunodeficiency virus-1 (HIV-1) Tat binding protein-1 and subunit 4 of human 26S proteasome. In order to determine the RNA-dependent ATPase activity of these putative proteins, the subclones f
Oral isotretinoin in HIV-positive women with acne: report of three cases.: Dermatology. 1998;196(1):163-4. Unique Identifier : AIDSLINE MED/98218007; Harms M; Pechere M; Krischer J; Studer E; Saurat JH; Department of Dermatology, Hopital Cantonal Universitaire, Geneva,; Switzerland.
Infectious disease transmission and infection-dependent matching.: Math Biosci. 1998 Mar;148(2):161-80. Unique Identifier : AIDSLINE MED/98273025; Philipson T; Dow WH; Department of Economics, University of Chicago, IL 60637, USA.; t-philipson@uchicago.edu; This paper uses commonly available prevalence estimates to bound future incidence. The bounds rely on restricting the fraction of contacts between individuals of different infection statuses. It is argued that these bounds can be further tightened by restrictions of economic models of infectious disease that imply tha
[Detection of unintegrated forms of proviral DNA in HIV infections]: Vestn Ross Akad Med Nauk. 1998;(3):13-7. Unique Identifier : AIDSLINE MED/98271197; Gashnikova NM; Pyasek A; Iagudin BI; Mamaeva OA; Pokrovskii AG; The content of 1-LTR and 2-LTR circular forms of HIV-1 proviral DNA was determined by nested PCR. Outer and inner primers for the first and second stages of PCR were selected in the env and gag regions that allowed the authors to simultaneously test 1- and 2 LTR of DNA HIV-1 forms in the analyzed samples. The accumula
[Development of sera reference panels for quality control of ELISA diagnostic kits in Russia]: Vestn Ross Akad Med Nauk. 1998;(3):47-51. Unique Identifier : AIDSLINE MED/98271205; Kanev AN; Vorob'eva MS; Shalunova NV; Karpovich LG; Netesov SV; Maksiutov AZ; Usova SV; In the past 5 years, the investigators of the VECTOR SRB VB and the L.A. Tarasevich State Institute of Standardization and Control of Medical Biological Preparations have jointly designed sera reference panels containing anti-HIV-1 IgG, anti-HCV IgG, and anti-HAV IgM which have been approved as national standard pan
Age-related macular degeneration.: Nurse Pract Forum. 1998 Mar;9(1):4-6. Unique Identifier : AIDSLINE MED/98288065; Elfervig LS; Vitreo-Retinal Foundation, Memphis, TN, USA.; Age-related macular degeneration (AMD) is one of the leading causes of legal blindness among older adults. Early recognition of AMD is important because treatment can enable patients to maintain central vision longer. Nurses who understand the effects of AMD can teach their elderly patients ways to slow its progressio
Cryptococcosis in Alabama [editorial; comment]: Ann Epidemiol. 1998 May;8(4):209-11. Unique Identifier : AIDSLINE MED/98250480; Casadevall A
Surveillance of cryptococcosis in Alabama, 1992-1994 [see comments]: Ann Epidemiol. 1998 May;8(4):212-6. Unique Identifier : AIDSLINE MED/98250481; Thomas CJ; Lee JY; Conn LA; Bradley ME; Gillespie RW; Dill SR; Pinner RW; Pappas PG; University of Alabama at Birmingham, USA.; PURPOSE: Although cryptococcosis is a significant opportunistic infection among patients with human immunodeficiency virus (HIV), there is conflicting information on rates of cryptococcosis among HIV-positive and HIV-negative patients. Precise state-wide epidemiologic data for cryptococcosis are not available in Alaba
Simulated microgravity conditions enhance differentiation of cultured PC12 cells towards the neuroendocrine phenotype.: In Vitro Cell Dev Biol Anim. 1998 Apr;34(4):316-25. Unique Identifier : AIDSLINE MED/98250387; Lelkes PI; Galvan DL; Hayman GT; Goodwin TJ; Chatman DY; Cherian S; Garcia RM; Unsworth BR; Laboratory of Cell Biology, University of Wisconsin Medical School,; Milwaukee Clinical Campus, 53201-0342, USA.; We are studying microenvironmental cues which contribute to neuroendocrine organ assembly and tissue-specific differentiation. As our in vitro model, we cultured rat adrenal medullary PC12 pheochromocytoma cells in a novel cell culture system, the NASA rotating wall vessel (RWV) bioreactors. This simulated microgravit
Amebic osteomyelitis in a child with acquired immunodeficiency syndrome: a case report.: Pediatr Pathol Lab Med. 1998 Jan-Feb;18(1):89-95. Unique Identifier : AIDSLINE MED/98227414; Selby DM; Chandra RS; Rakusan TA; Loechelt B; Markle BM; Visvesvara GS; Department of Pathology, Children's National Medical Center,; Washington, DC 20010-2970, USA. dselby@cnmc.org; Disseminated Acanthamoeba infection has been described in immunocompromised or debilitated patients. The usual sites of involvement are skin, sinus, and brain. Sporadic reports of Acanthamoeba infection in patients infected with the human immunodeficiency virus are present in recent literature, predominantly in adults
Rationale for the use of immunotoxins in the treatment of HIV-infected humans.: J Drug Target. 1998;5(2):75-91. Unique Identifier : AIDSLINE MED/98248278; Van Oijen MG; Preijers FW; Department of Hematology, University Hospital St. Radboud, Nijmegen,; The Netherlands.; The first step in the replication of human immunodeficiency virus HIV) is selective binding of the envelope glycoprotein (gp120) to CD4 receptors on T cells or macrophages. After penetration in these cells, the genome of the virus is integrated in the human genome. HIV-infection causes depletion of CD4-positive cells
Cognitive impairment in families with pure autosomal dominant hereditary spastic paraparesis.: Brain. 1998 May;121 ( Pt 5):923-9. Unique Identifier : AIDSLINE MED/98282953; Webb S; Hutchinson M; Department of Neurology, St Vincent's Hospital, Dublin, Ireland.; In the course of a study of a large family with pure autosomal dominant hereditary spastic paraparesis (AD-HSP), mild cognitive impairment was found in older family members. In order to determine if cognitive impairment occurred more frequently in families with pure AD-HSP than normally expected, a case control study
Chemokine receptor CCR2b 64I polymorphism and its relation to CD4 T-cell counts and disease progression in a Danish cohort of HIV-infected individuals. Copenhagen AIDS cohort.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jun 1;18(2):110-6. Unique Identifier : AIDSLINE MED/98299688; Eugen-Olsen J; Iversen AK; Benfield TL; Koppelhus U; Garred P; Department of Infectious Diseases, Copenhagen University Hospitals,; Hvidovre, Denmark. jeo@biobase.dk; We have investigated the role of the recently described mutation in CCR2b named 64I in relation to HIV resistance, CD4 T-cell counts, and disease progression in Danish individuals by polymerase chain reaction (PCR)-based methods as well as sequenced full-length CXCR4 and CCR5 genes from HIV-infected long-term nonprogr
Adherence to antiretroviral and pneumocystis prophylaxis in HIV disease.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jun 1;18(2):117-25. Unique Identifier : AIDSLINE MED/98299689; Eldred LJ; Wu AW; Chaisson RE; Moore RD; Department of Medicine, Johns Hopkins University School of Medicine,; Baltimore, Maryland, USA.; BACKGROUND: Medication nonadherence in the treatment of chronic diseases compromises the effectiveness of therapy. Little information is available about the extent of medication adherence or determinants of medication adherence in HIV disease, an issue of increasing importance in this new therapeutic era of combinatio
Maternal cell-free viremia in the natural history of perinatal HIV-1 transmission: a meta-analysis.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jun 1;18(2):126-35. Unique Identifier : AIDSLINE MED/98299690; Contopoulos-Ioannidis DG; Ioannidis JP; Department of Pediatric Infectious Diseases, Children's National; Medical Center, George Washington University School of Medicine,; Washington, DC, USA.; We performed a meta-analysis of the predictive value of maternal cell-free viral load in vertical HIV-1 transmission, including 9 cohorts with 1115 mother-infant pairs (696 untreated and 419 treated women). The pooled rate of transmission in untreated women was 21.3% (95% confidence interval [CI], 18.3%-24.5%). The ra
Pilot randomized trial of education to improve self-management skills of men with symptomatic HIV/AIDS.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jun 1;18(2):136-44. Unique Identifier : AIDSLINE MED/98299691; Gifford AL; Laurent DD; Gonzales VM; Chesney MA; Lorig KR; U.S. Veterans Administration San Diego Healthcare System, Department; of Medicine, the University of California San Diego School of; Medicine, La Jolla 92161, USA.; OBJECTIVE: To evaluate the acceptability, practicality, and short-term efficacy of a health education program to improve disease self-management in patients with symptomatic HIV/AIDS. DESIGN: Randomized controlled trial, baseline and 3-month follow-up questionnaire assessments. SETTING: San Francisco Bay communities.
Cardiac manifestations of HIV/AIDS: a review of disease spectrum and clinical management.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jun 1;18(2):145-54. Unique Identifier : AIDSLINE MED/98299692; Yunis NA; Stone VE; Department of Medicine and HOPE Center for HIV Care, Memorial Hospital; of Rhode Island, Brown University School of Medicine, Providence; 02860, USA.; HIV and AIDS involve multiple organ systems. Lungs, brain, skin, gastrointestinal tract, kidneys, and heart are the major organs targeted by the direct effects of HIV infection and the secondary opportunistic complications of AIDS. Although most other organ system involvement has been extensively described in numerous
Longitudinal HIV-1 RNA levels in a cohort of homosexual men.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jun 1;18(2):155-61. Unique Identifier : AIDSLINE MED/98299693; O'Brien TR; Rosenberg PS; Yellin F; Goedert JJ; Viral Epidemiology Branch, National Cancer Institute, Public Health; Service, U.S. Department of Health and Human Services, Rockville,; Maryland 20852, USA.; HIV-1 RNA levels measured during early chronic infection strongly predict subsequent clinical events. In the short term, HIV-1 is in a steady state, but the stability of viral levels over time is incompletely understood. We used reverse transcriptase polymerase chain reaction (RT-PCR) to examine changes in serum HIV-1
Accelerated changes (inflection points) in levels of serum immune activation markers and CD4+ and CD8+ T cells prior to AIDS onset.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jun 1;18(2):162-70. Unique Identifier : AIDSLINE MED/98299694; Nishanian P; Taylor JM; Manna B; Aziz N; Grosser S; Giorgi JV; Detels R; Fahey JL; Center for Interdisciplinary Research in Immunology and Disease,; Department of Medicine, University of California--Los Angeles School; of Medicine, 90095-1747, USA.; The trajectories of change in CD4+ and CD8+ lymphocytes and serum neopterin and beta2-microglobulin (beta2M) levels were determined in 158 HIV-seropositive individuals during 5.5 years before a clinical AIDS diagnosis. Each patient was evaluated separately using a two-piece regression model with seven possible change
Motivation, recruitment, and screening of volunteers for a phase I/II HIV preventive vaccine trial in Thailand.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jun 1;18(2):171-7. Unique Identifier : AIDSLINE MED/98299695; Jenkins RA; Chinaworapong S; Morgan PA; Ruangyuttikarn C; Sontirat A; Chiu J; Michael RA; Nitayaphan S; Khamboonruang C; Armed Forces Research Institute of Medical Sciences and Henry M.; Jackson Foundation, Bangkok, Thailand. rjenkins@mozart.inet.co.th; Data from recruitment and screening for a phase I/II preventive HIV-1 vaccine trial in Thailand were evaluated with respect to correlates of participation at each phase. Correlates included demographic variables, motivation for interest in the trial, and factors related to commun
Expansion of clonotypic T-cell populations in the peripheral blood of asymptomatic Gran Chaco Amerindians infected with HTLV-IIB.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jun 1;18(2):178-85. Unique Identifier : AIDSLINE MED/98299696; Love JL; Marchioli CC; Dube S; Bryz-Gornia V; Loughran TP Jr; Glaser JB; Esteban E; Feldman L; Ferrer JF; Poiesz BJ; Department of Medicine, State University of New York Health Science; Center at Syracuse, 13210, USA.; Peripheral blood mononuclear cells from asymptomatic HTLV-II-infected and uninfected Gran Chaco Amerindians were analyzed using polymerase chain reaction (PCR) for expansions of T-cell receptor (TCR) V-beta gene clonotypes. Analyses were performed using primer pairs designed to identify expanded T-cell familial clonot
Associations among HTLV-I, HTLV-II, and HIV in injecting drug users in Salvador, Brazil [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jun 1;18(2):186-7. Unique Identifier : AIDSLINE MED/98299697; Andrade TM; Dourado I; Galvao-Castro B
HTLV-I/II seropositivity in populations at high risk for HIV-1 infection in Cordoba City, Argentina [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jun 1;18(2):187-8. Unique Identifier : AIDSLINE MED/98299698; Medeot S; Nates S; Gallego S; Sileoni S; Maturano E; Recalde Y; Giordano M; Alvarez RB
Immunomodulatory effects of concurrent HTLV-I infection in strongyloidiasis [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jun 1;18(2):188-90. Unique Identifier : AIDSLINE MED/98299699; Atkins NS; Lindo JF; Lee MG; Hanchard B; Robinson RD; Bundy DA
First report of HIV-2 infection in Argentina [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jun 1;18(2):190-1. Unique Identifier : AIDSLINE MED/98299700; Libonatti O; Avila M; Zlatkes R; Pampuro S; Peralta LM; Rud E; Wainberg M; Salomon H
Role of the thymus in pediatric HIV-1 infection.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jun 1;18(2):95-109. Unique Identifier : AIDSLINE MED/98299687; Kirschner DE; Mehr R; Perelson AS; Department of Microbiology, University of Michigan Medical School, Ann; Arbor 48109-0620, USA. kirschne@umich.edu; Several lines of evidence suggest that HIV-1 is present in the thymus during HIV-1 infection. Precursors to mature CD4+ T lymphocytes develop in the thymus, which suggests that thymic infection may play a role in the CD4+ T-cell decline observed during the course of pediatric HIV-1 infection. We illustrate, through ma
[Human immunodeficiency virus and acute renal insufficiency]: Bull Acad Natl Med. 1997 Dec;181(9):1763-79. Unique Identifier : AIDSLINE MED/98274332; Sraer JD; Peraldie MN; Service de Nephrologie A, Hopital Tenon, Paris.; We describe here the broad spectrum of acute renal insufficiency occurring in the course of human immunoinsufficiency virus infection. In our renal unit in Tenon hospital, 90 human immunoinsufficiency virus-infected adult patients were admitted for acute renal insufficiency between June 1988 and December 1996. Sixty o
Liver biopsy pathology in human immunodeficiency virus infection.: Eur J Gastroenterol Hepatol. 1998 Mar;10(3):255-8. Unique Identifier : AIDSLINE MED/98244430; Kennedy M; O'Reilly M; Bergin CJ; McDonald GS; Department of Histopathology, St James's Hospital and Trinity College,; Dublin, Ireland.; OBJECTIVES: To determine the hepatic changes in patients with human immunodeficiency virus (HIV) infection in Dublin and to assess the usefulness of liver biopsy in this condition. DESIGN: A consecutive series of liver biopsies was examined retrospectively and correlated with clinical findings. METHODS: A histological
Intravitreal and plasma cidofovir concentrations after intravitreal and intravenous administration in AIDS patients with cytomegalovirus retinitis.: J Ocul Pharmacol Ther. 1998 Apr;14(2):147-51. Unique Identifier : AIDSLINE MED/98232252; Taskintuna I; Rahhal FM; Capparelli EV; Cundy KC; Freeman WR; Department of Ophthalmology, University of California, San Diego, La; Jolla 92093-0946, USA.; This study was undertaken to evaluate the intravitreal and plasma concentrations of cidofovir (HPMPC) after intravitreal and intravenous administration in AIDS patients with cytomegalovirus retinitis. Cohort series; undiluted vitreous and blood were collected from 9 patients at the
Induction of apoptosis in the rheumatoid synovium by Fas ligand gene transfer.: Gene Ther. 1998 Mar;5(3):331-8. Unique Identifier : AIDSLINE MED/98276736; Okamoto K; Asahara H; Kobayashi T; Matsuno H; Hasunuma T; Kobata T; Sumida T; Nishioka K; Rheumatology, Immunology, and Genetics Program, St Marianna University; School of Medicine, Kawasaki, Japan.; We have recently reported that local administration of anti-Fas monoclonal antibody (MAb) in human T cell leukemia virus type 1 HTLV-1) carrying mice improved arthritis due to the induction of apoptosis. This finding strongly indicated the beneficial therapeutic effect of Fas-mediated apoptosis in rheumatoid arthritis
Interferon-alpha: evolving therapy for AIDS-associated Kaposi's sarcoma.: J Interferon Cytokine Res. 1998 Apr;18(4):209-14. Unique Identifier : AIDSLINE MED/98227672; Krown SE; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New; York, New York 10021, USA. krowns@mskcc.org; This article reviews developments over nearly 15 years in the application of interferon-alpha (IFN-alpha) to the treatment of Kaposi s sarcoma (KS) in patients with acquired immunodeficiency syndrome (AIDS). The initial success of IFN treatment for selected patients with AIDS-associated KS occurred before identificati
IFN-gamma primes macrophage responses to bacterial DNA.: J Interferon Cytokine Res. 1998 Apr;18(4):263-71. Unique Identifier : AIDSLINE MED/98227680; Sweet MJ; Stacey KJ; Kakuda DK; Markovich D; Hume DA; Centre for Molecular and Cellular Biology, Department of Microbiology,; University of Queensland, Brisbane, Australia.; Macrophages recognize and are activated by unmethylated CpG motifs in bacterial DNA. Here we demonstrate that production of nitric oxide (NO) from murine RAW 264 macrophages and bone marrow-derived macrophages (BMM) in response to bacterial DNA is absolutely dependent on interferon-gamma (IFN-gamma) priming. Similarly
Improved injection practices after the introduction of treatment and sterility guidelines in Tanzania.: Trop Med Int Health. 1998 Apr;3(4):291-6. Unique Identifier : AIDSLINE MED/98285411; Vos J; Gumodoka B; van Asten HA; Berege ZA; Dolmans WM; Borgdorff MW; Bugando Medical Centre, Mwanza, Tanzania. Martien.Borgdorff@wxs.nl; OBJECTIVE: To evaluate the effect of introduction of treatment and sterilization guidelines on the number of avoidable injections and on the sterility of needles and syringes. METHODS: In 1991, 66 randomly selected health units in Mwanza Region, Tanzania , were visited and factors
The effect of trimeric 2',5'-oligoadenylic acid and its epoxy-derivative on human immunodeficiency virus (HIV-1) reproduction and retroviruses reverse transcriptase activity.: New Microbiol. 1998 Apr;21(2):197-201. Unique Identifier : AIDSLINE MED/98240507; Tkachuk ZYu; Rybalko SL; Semernikova LI; Tkachuk VV; Zavelevich MP; Tkachuk LV; Eremenko T; Mikhailopulo IA; Matsuka GK; Institute of Molecular Biology and Genetics of the National Academy of; Sciences of Ukraine, Kiev.; The effect of trimeric 2 ,5 -oligoadenylic acid (2 ,5 A3) and its epoxy-derivative (2 ,5 -A2 (RAA) on human immunodeficiency virus (HIV-1) reproduction was studied. An HIV-1 infectivity titer decrease was shown on the model of limphoblastoid cells when the substances under study were used. The interferonogenic effect
Evaluation of the Abbott LCx Mycobacterium tuberculosis assay in comparison with culture methods in selected Italian patients.: New Microbiol. 1998 Apr;21(2):97-103. Unique Identifier : AIDSLINE MED/98240496; Fadda G; Ardito F; Sanguinetti M; Posteraro B; Ortona L; Chezzi C; Polonelli L; Dettori G; Conti S; Fanti F; Galli C; Institute of Microbiology, Catholic University Sacro Cuore, Rome,; Italy.; A ligase chain reaction (LCR) DNA amplification method for the molecular diagnosis of Mycobacterium tuberculosis (Abbott LCx MTB) was evaluated in comparison with solid and liquid phase culture on 622 selected samples collected in two large Italian hospitals, of which 310 obtained from HIV-1 positive patients and 312
Managing AIDS in pregnancy.: Med Health R I. 1998 Apr;81(4):137-40. Unique Identifier : AIDSLINE MED/98260124; Star JA; Powrie R; Department of Obstetrics and Gynecology, Brown University School of; Medicine, USA.
Varicella zoster infection in the immunocompromised child.: J Soc Pediatr Nurs. 1998 Jan-Mar;3(1):13-20; quiz 21-2. Unique Identifier : AIDSLINE MED/98229999; Pawlik KM; Children's Hospital of Michigan, Detroit, USA. kpawlik@ameritech.net; PURPOSE: To describe varicella zoster virus infection in the immunocompromised child and provide guidelines to decrease the risk of infection and complications for these children. POPULATION: Children infected with varicella zoster virus, particularly those with a compromised immune system. CONCLUSIONS: Varicella zost
HIV-related discrimination: a survey of New South Wales general practitioners.: Aust N Z J Public Health. 1998 Feb;22(1):92-7. Unique Identifier : AIDSLINE MED/98262593; Bermingham S; Kippax S; National Centre in HIV Social Research, Macquarie University, Sydney,; NSW.; This study aimed to investigate the correlates of human immunodeficiency virus (HIV)-related discrimination among general practitioners. The survey, conducted in 1993-1994, covered a random sample of 878 general practitioners from six of the 12 New South Wales health areas, augmented by 44-general practitioners from t
Substance use disorders in gay/bisexual men with HIV and AIDS.: Am J Addict. 1998 Winter;7(1):51-60. Unique Identifier : AIDSLINE MED/98182470; Ferrando S; Goggin K; Sewell M; Evans S; Fishman B; Rabkin J; HIV Clinical Research Program, Cornell University Medical College, New; York, New York, USA. sjferran@mail.med.cornell.edu; The authors conducted a longitudinal study of psychological adaptation to AIDS in subjects with and without lifetime and current substance use disorders (SUD), in a cohort of HIV+ gay/bisexual subjects. A sample of HIV+ gay/bisexual men (n = 183) and an HIV- comparison group (n = 84) were assessed for SUD, depression,
HIV risk factors in dually diagnosed patients.: Am J Addict. 1998 Winter;7(1):74-80. Unique Identifier : AIDSLINE MED/98182472; Krakow DS; Galanter M; Dermatis H; Westreich LM; Department of Psychiatry, New York University School of; Medicine/Bellevue Hospital Center, New York 10016, USA.; The authors examined correlates of HIV seropositivity in a sample of dually diagnosed inpatients. The subjects were 147 consecutively admitted patients to a specialized dual-diagnosis unit in a municipal hospital who were given a structured interview and HIV testing. The HIV seroprevalence was 19%, with women having a
Identification of HHV8 in early Kaposi's sarcoma: implications for Kaposi's sarcoma pathogenesis.: Mol Pathol. 1998 Feb;51(1):14-20. Unique Identifier : AIDSLINE MED/98287497; Kennedy MM; Cooper K; Howells DD; Picton S; Biddolph S; Lucas SB; McGee JO; O'Leary JJ; Nuffield Department of Pathology and Bacteriology, University of; Oxford, UK.; AIMS: Kaposi s sarcoma is a vascular tumour of uncertain pathogenesis possibly caused by an infectious agent, identified in high risk groups. Accumulating solution phase polymerase chain reaction (PCR) and seroepidemiological data suggest that a previously undescribed herpes DNA virus (human herpesvirus 8 HHV8)) is th
In vitro cytopathogenicity of the human immunodeficiency virus HIV)-1 predicts survival in HIV-infected hemophiliacs independent from CD4 cell count.: Eur J Med Res. 1998 May 12;3(5):223-30. Unique Identifier : AIDSLINE MED/98248697; Rockstroh JK; Woitas RP; Brackmann HH; Kupfer B; Kaiser R; Schneweis KE; Sudhop T; Spengler U; Department of Internal Medicine, University of Bonn,; Sigmund-Freud-Strasse, D-53105 Bonn, Germany.; In addition to quantification of viral load the graded cytopathogenicity of the human immunodeficiency virus may provide prognostic information for the course of HIV infection. However, the prognostic value of graded cytopathogenicity in addition to the CD4 count has not been evaluated in a large longitudinal study. T
Asymptomatic pneumatosis intestinalis and free abdominal air in a patient with AIDS.: Eur J Med Res. 1998 May 12;3(5):265-7. Unique Identifier : AIDSLINE MED/98248703; Hegener P; Horst E; Hartmann P; Franzen C; Diehl V; Salzberger B; Fatkenheuer G; Department of Internal Medicine I, University of Cologne,; Joseph-Stelzmann-Str. 9, D-50924 Koln, Germany.; petra.hegener@uni-koeln.de; Detection of free abdominal air requires in most cases immediate surgical intervention. However, there may be situations, where invasive procedures are not indicated. We present a case of asymptomatic pneumatosis intestinalis and free abdominal air in a patient with Aids. Pneumatosis intestinalis is a rare entity with
When the patient asks the doctor's help in ending life: a request for assisted suicide by a man with AIDS.: Harv Rev Psychiatry. 1998 Mar-Apr;5(6):326-32. Unique Identifier : AIDSLINE MED/98220105; O'Neill SF; Silverman DC; Department of Social Medicine, Harvard Medical School, Boston, Mass.,; USA.
The strange case of David Acer: myth and reality.: CDS Rev. 1996 Mar;89(2):10-20. Unique Identifier : AIDSLINE MED/98188920; Smith C
Fuzzy science: a look at CDC's analysis of the Acer case.: CDS Rev. 1996 Mar;89(2):22-7. Unique Identifier : AIDSLINE MED/98188921; Neiburger EJ; Center for Dental AIDS Research, Waukegan, IL 60085, USA.
Managing the HIV-positive dental patient in the general dental office.: CDS Rev. 1996 Mar;89(2):28-36. Unique Identifier : AIDSLINE MED/98188922; Lampiris LN; Midwest AIDS Training and Education Center, University of Illinois at; Chicago 60612-7303, USA.
The legal considerations of referring patients who have AIDS.: CDS Rev. 1996 Mar;89(2):42-3. Unique Identifier : AIDSLINE MED/98188923; Kempf TS; Sfikas EM; Bell, Boyd & Lloyd, Chicago, USA.
Acer and AIDS addressed again [editorial]: CDS Rev. 1996 Mar;89(2):6-7. Unique Identifier : AIDSLINE MED/98188919; Socher JC
HIV and AIDS in dental practice: an evolution in care.: CDS Rev. 1996 Mar;89(2):68. Unique Identifier : AIDSLINE MED/98188924; Scholle RH
The immunomodulator AS101 restores T(H1) type of response suppressed by Babesia rodhaini in BALB/c mice.: Cell Immunol. 1998 Feb 25;184(1):12-25. Unique Identifier : AIDSLINE MED/98289633; Rosenblatt-Bin H; Kalechman Y; Vonsover A; Xu RH; Da JP; Shalit F; Huberman M; Klein A; Strassmann G; Albeck M; Sredni B; CAIR Institute, Marilyn Finkler Cancer Research Center, Bar Ilan; University, Ramat Gan, Israel.; The immunomodulator AS101 has been previously shown to confer protection upon BALB/c mice infected with the intraerythrocytic parasite Babesia rodhaini (B. rodhaini). The present study focuses on the effect of AS101 administration on the acute phase of babesial infection where T helper cell subset patterns-TH1/TH2-wer
Mechanism of gamma sigma T-cell-mediated inhibition of stem cell differentiation in vitro: possible relevance for myelosuppression in HIV-infected individuals.: Cell Immunol. 1998 Feb 25;184(1):26-36. Unique Identifier : AIDSLINE MED/98289634; Dobmeyer TS; Dobmeyer JM; Klein SA; Wesch D; Wagner S; Helm EB; Hoelzer D; Rossol R; Kabelitz D; Paul-Ehrlich-Institute, Department of Immunology, Langen, Germany.; We investigated whether gamma delta T cells contribute to the suppression of myelopoiesis in HIV infection. Freshly isolated gamma delta T cells from HIV seropositive patients suppressed CFU-GM growth in vitro. Preactivation of gamma delta T cells with IL-2 and/or IL-1
Analysis of the envelope region of hepatitis G virus isolated from Korean patients.: Mol Cells. 1998 Feb 28;8(1):117-23. Unique Identifier : AIDSLINE MED/98233133; Kim CK; Park SW; Kim PK; Cho M; Lee TH; Jun HK; Jang KL; Department of Microbiology, College of Natural Science, Pusan National; University, Korea.; The genetic diversity of hepatitis G virus (HGV) was investigated. By using a RT-PCR procedure, 14% of either HBV hepatitis B virus)- or HCV (hepatitis C virus)-positive Korean hepatitis patients were proved to be HGV positives. Nucleotide sequences in the E1 region of the eight isolates from Korean patients and the s
Interplay between positive and negative elongation factors: drawing a new view of DRB.: Genes Cells. 1998 Jan;3(1):9-15. Unique Identifier : AIDSLINE MED/98241134; Yamaguchi Y; Wada T; Handa H; Department of Biomolecular Engineering, Faculty of Bioscience and; Biotechnology, Tokyo Institute of Technology, Yokohama, Japan.; DRB is a classic inhibitor of transcription by RNA polymerase II pol II). Although it has been demonstrated that DRB inhibits the el