1998

HIV-1 viral load and CD4 cell count in untreated children with vertically acquired asymptomatic or mild disease. Paediatric European Network for Treatment of AIDS (PENTA).: AIDS. 1998 Mar 5;12(4):F1-8. Unique Identifier : AIDSLINE MED/98178983; BACKGROUND: Plasma HIV-1 RNA levels are high in vertically infected infants. Information in older children is limited, particularly in those who have not received antiretroviral therapy. OBJECTIVES: To describe the relationships between HIV-1 RNA, age and CD4 cell count in untreated vertically infected children. DESIG
Suicidal behaviours, euthanasia and AIDS.: AIDS. 1998 Mar 5;12(4):339-47. Unique Identifier : AIDSLINE MED/98178984; Starace F; Sherr L; Department of Primary Care and Population Sciences, Royal Free; Hospital School of Medicine, London, UK.
Inhibition of HIV-1 gp120-induced apoptosis in neuroblastoma SK-N-SH cells by an antisense oligodeoxynucleotide against p53.: AIDS. 1998 Mar 5;12(4):349-54. Unique Identifier : AIDSLINE MED/98178985; Yeung MC; Geertsma F; Liu J; Lau AS; Department of Pediatrics, University of California, San Francisco,; USA.; OBJECTIVES: This study examines the cytotoxicity potential and the mechanism of toxicity of the HIV-1 gp120 on human neuroblastoma cells. DESIGN: Previous data from our group have suggested that the HIV-1 envelope protein gp120 promotes the secretion of tumor necrosis factor-alpha and other factors by astrocytes and m
Chronic exposure of human neurons to quinolinic acid results in neuronal changes consistent with AIDS dementia complex.: AIDS. 1998 Mar 5;12(4):355-63. Unique Identifier : AIDSLINE MED/98178986; Kerr SJ; Armati PJ; Guillemin GJ; Brew BJ; Centre for Immunology, St Vincent's Hospital, Sydney, Australia.; OBJECTIVE: Concentrations of quinolinic acid, an N-methyl-D-aspartate agonist, are often elevated for long periods of time in the cerebrospinal fluid (CSF) and brain tissue of patients with AIDS dementia complex (ADC). This study was designed to test the hypothesis that chronic exp
Human cytomegalovirus product UL44 downregulates the transactivation of HIV-1 long terminal repeat.: AIDS. 1998 Mar 5;12(4):365-72. Unique Identifier : AIDSLINE MED/98178987; Boccuni MC; Campanini F; Battista MC; Bergamini G; Dal Monte P; Ripalti A; Landini MP; Department of Clinical and Experimental Medicine, University of; Bologna, Italy.; OBJECTIVE: Human cytomegalovirus (HCMV) is often isolated from HIV-1-infected patients and the two viruses can infect the same cell type giving rise to direct bidirectional interactions. Whereas the long terminal repeat (LTR) transactivation ability of HCMV immediate early gene (IE
Impaired cytokine production by neutrophils isolated from patients with AIDS.: AIDS. 1998 Mar 5;12(4):373-9. Unique Identifier : AIDSLINE MED/98178988; Gasperini S; Zambello R; Agostini C; Trentin L; Tassinari C; Cadrobbi P; Semenzato G; Cassatella MA; Department of General Pathology, University of Verona, Italy.; OBJECTIVES: To determine the ability of neutrophils isolated from HIV-seropositive patients to produce proinflammatory cytokines. DESIGN: The in vitro responsiveness of polymorphonuclear neutrophils (PMN) and peripheral blood mononuclear cells (PBMC) to lipopolysaccharide (LPS), used in the presence or absence of inte
Does hepatitis C virus co-infection accelerate clinical and immunological evolution of HIV-infected patients?: AIDS. 1998 Mar 5;12(4):381-8. Unique Identifier : AIDSLINE MED/98178989; Piroth L; Duong M; Quantin C; Abrahamowicz M; Michardiere R; Aho LS; Grappin M; Buisson M; Waldner A; Portier H; Chavanet P; Service des Maladies Infectieuses et Tropicales, Hopital d'Enfants,; CHU Dijon, France.; OBJECTIVE: To study the influence of hepatitis C virus (HCV) co-infection on clinical and immunological evolution of HIV-infected patients. DESIGN: A longitudinal study of HIV-infected individuals with or without HCV infection, identified at the Infectious Diseases Department of Dijon University Hospital and enrolled
Cerebrospinal fluid HIV-1 RNA levels: correlation with HIV encephalitis.: AIDS. 1998 Mar 5;12(4):389-94. Unique Identifier : AIDSLINE MED/98178990; Cinque P; Vago L; Ceresa D; Mainini F; Terreni MR; Vagani A; Torri W; Bossolasco S; Lazzarin A; Infectious Diseases Division, San Raffaele Scientific Institute,; Milan, Italy.; OBJECTIVE: Neuropathological abnormalities induced by HIV-1 are not always predictable on the basis of the presence of HIV-related neurological symptoms. HIV-1 RNA load was measured in the cerebrospinal fluid (CSF) of HIV-infected patients to verify whether it could be a marker of HIV-induced neuropathology. DESIGN AN
Short-term evolution of HIV-1 viraemia and CD4+ cell counts in patients who have a primary mutation to zidovudine.: AIDS. 1998 Mar 5;12(4):395-8. Unique Identifier : AIDSLINE MED/98178991; Rubio A; Leal M; Rey C; Pineda JA; Sanchez-Quijano A; Lissen E; Department of Biochemistry, Virgen del Rocio University Hospital,; Seville, Spain.; OBJECTIVE: To investigate the different responses to antiretroviral treatment including zidovudine, of patients harbouring HIV with primary resistance to zidovudine, serum viral load, and CD4+ cell counts, for 24 weeks in a group of antiretroviral-naive patients with the codon 215 mutation of the HIV pol gene and in a
Reduction of the viral load of HIV-1 after the intraperitoneal administration of dextrin 2-sulphate in patients with AIDS.: AIDS. 1998 Mar 5;12(4):399-409. Unique Identifier : AIDSLINE MED/98178992; Shaunak S; Thornton M; John S; Teo I; Peers E; Mason P; Krausz T; Davies DS; Department of Infectious Diseases, Imperial College School of; Medicine, Hammersmith Hospital, London, UK.; OBJECTIVE: To determine the safety and efficacy of the sulphated polysaccharide, dextrin 2-sulphate, when delivered to the lymphatic circulation by the peritoneal route. DESIGN: An open Phase I/II dose-escalation clinical study in which six patients with AIDS were treated with seven courses of dextrin 2-sulphate each
Treatment of HIV-related fluconazole-resistant oral candidosis with D0870, a new triazole antifungal.: AIDS. 1998 Mar 5;12(4):411-6. Unique Identifier : AIDSLINE MED/98178993; Cartledge JD; Denning DW; Dupont B; Clumeck N; De Wit S; Midgley J; Hawkins DA; Gazzard BG; Chelsea and Westminster Hospital, London, UK.; OBJECTIVES: To evaluate the efficacy and tolerance of D0870 in the treatment of HIV-related fluconazole-resistant oro-oesophageal candidosis. DESIGN: Multicentre open study. PATIENTS: HIV-seropositive patients with oro-oesophageal candidosis despite at least 7 days of treatment with fluconazole at doses of 100 mg per
The relationship of clinic experience with advanced HIV and survival of women with AIDS.: AIDS. 1998 Mar 5;12(4):417-24. Unique Identifier : AIDSLINE MED/98178994; Laine C; Markson LE; McKee LJ; Hauck WW; Fanning TR; Turner BJ; Center for Research in Medical Education and Health Care, Division of; Internal Medicine, Jefferson Medical College, Thomas Jefferson; University, Philadelphia, Pennsylvania 19107, USA.; OBJECTIVE: Hospital and physician experience have been linked to improved outcomes for persons with HIV. Because many HIV-infected patients receive care in clinics, we studied clinic HIV experience and survival for women with AIDS. DESIGN: Retrospective cohort study of women with AIDS whose dominant sources of care we
HIV infection and risk factors among female sex workers in southern Vietnam.: AIDS. 1998 Mar 5;12(4):425-32. Unique Identifier : AIDSLINE MED/98178995; Thuy NT; Nhung VT; Thuc NV; Lien TX; Khiem HB; Pasteur Institute, Ho Chi Minh City, Vietnam.; OBJECTIVES: To determine the extent of HIV infection among female commercial sex workers (CSW), to identify risk factors, and to provide baseline data for developing and targeting prevention measures. SUBJECTS AND METHODS: A total of 968 female CSW were enrolled in a cross-sectional study from August 1995 to October 1
Safety evaluation of nonoxynol-9 gel in women at low risk of HIV infection.: AIDS. 1998 Mar 5;12(4):433-7. Unique Identifier : AIDSLINE MED/98178996; Van Damme L; Niruthisard S; Atisook R; Boer K; Dally L; Laga M; Lange JM; Karam M; Perriens JH; STD/HIV Research and Intervention Unit, Institute of Tropical; Medicine, Antwerp, Belgium.; OBJECTIVE: To determine the safety of a vaginal microbicide, COL-1492, containing 52.5 mg nonoxynol-9, applied once daily for 14 days among healthy volunteers. METHODS: A randomized, double-blind controlled trial with three arms, COL-1492 gel versus placebo gel versus no-treatment controls, was conducted. Outcomes of
Profound and unanticipated anemia with lamivudine-zidovudine combination therapy in zidovudine-experienced patients with HIV infection [letter]: AIDS. 1998 Mar 5;12(4):439-40. Unique Identifier : AIDSLINE MED/98178997; Hester EK; Peacock JE Jr
Indinavir-induced renal failure [letter]: AIDS. 1998 Mar 5;12(4):440-1. Unique Identifier : AIDSLINE MED/98178998; Chen SC; Nankivell BJ; Dwyer DE
Is the combination of hepatitis and indinavir potentially dangerous? [letter]: AIDS. 1998 Mar 5;12(4):441-2. Unique Identifier : AIDSLINE MED/98178999; Jeurissen FJ; Schneider MM; Borleffs JC
Quick and easy detection of cytomegalovirus retinitis using conjunctival swab and polymerase chain reaction in AIDS patients [letter]: AIDS. 1998 Mar 5;12(4):443-4. Unique Identifier : AIDSLINE MED/98179000; Chiou SH; Liu JH; Chung YM; Wong WW; Liu SM; Weng WS; Liu WT; Chen KY; Chow KC
CCR-5 genotype and sexual transmission of HIV-1 [letter]: AIDS. 1998 Mar 5;12(4):444-5. Unique Identifier : AIDSLINE MED/98179001; O'Brien TR; Padian NS; Hodge T; Goedert JJ; O'Brien SJ; Carrington M
Molecular epidemiology characterization of a multidrug-resistant Mycobacterium bovis outbreak amongst HIV-positive patients [letter]: AIDS. 1998 Mar 5;12(4):445-6. Unique Identifier : AIDSLINE MED/98179002; Gori A; Marchetti G; Catozzi L; Nigro C; Ferrario G; Rossi MC; Degli Esposti A; Orani A; Franzetti F
Is it necessary to conduct trials with trimethoprim-sulphamethoxazole amongst HIV-infected individuals in Africa? [letter]: AIDS. 1998 Mar 5;12(4):447. Unique Identifier : AIDSLINE MED/98179003; Samb B; Badiane M; Kony S; Larouze B; Faye MA; Sow PS; Badiane S; Metro A; Costagliola D; Ndoye I; Delaporte E; Coll-Seck AM; Coulaud JP
Reduction in oropharyngeal candidiasis following introduction of protease inhibitors [letter]: AIDS. 1998 Mar 5;12(4):447-8. Unique Identifier : AIDSLINE MED/98179004; Hood S; Bonington A; Evans J; Denning D
Progressive multifocal leukoencephalopathy regression with highly active antiretroviral therapy [letter]: AIDS. 1998 Mar 5;12(4):449. Unique Identifier : AIDSLINE MED/98179005; Teofilo E; Gouveia J; Brotas V; da Costa P
Lesbian sex and risk of HIV transmission [letter]: AIDS. 1998 Mar 5;12(4):450-1. Unique Identifier : AIDSLINE MED/98179006; Raiteri R; Baussano I; Giobbia M; Fora R; Sinicco A
CTLA4Ig inhibits airway eosinophilia and hyperresponsiveness by regulating the development of Th1/Th2 subsets in a murine model of asthma.: Am J Respir Cell Mol Biol. 1998 Apr;18(4):453-62. Unique Identifier : AIDSLINE MED/98202492; Padrid PA; Mathur M; Li X; Herrmann K; Qin Y; Cattamanchi A; Weinstock J; Elliott D; Sperling AI; Bluestone JA; Department of Medicine, University of Chicago, Chicago, Illinois; 60637, USA. ppadrid@flowcity.bsd.uchicago.edu; Complete T-cell activation requires two distinct signals, one delivered via the T-cell receptor, and the second co-stimulatory signal through CD28/B7 ligation. Previous studies showed that the blockade of CD28/B7 ligation alters differentiation of Th1/Th2 lymphocyte subsets in vitro and in vivo. The present study was
We should routinely offer HIV screening in pregnancy. Pregnancy Subgroup of the Herpes Simplex Advisory Panel [comment]: Br J Obstet Gynaecol. 1998 Mar;105(3):249-51. Unique Identifier : AIDSLINE MED/98194175; Mercey D; Nicoll A; Department of Sexually Transmitted Diseases, UCL Medical School,; London.
Mandatory prenatal screening for the human immunodeficiency virus: the experience in south-eastern France of a national policy, 1992-1994 [see comments]: Br J Obstet Gynaecol. 1998 Mar;105(3):269-74. Unique Identifier : AIDSLINE MED/98194179; Rey D; Carrieri MP; Obadia Y; Pradier C; Moatti JP; Regional Center for Disease Control of South-Eastern France,; Marseille.; OBJECTIVE: To evaluate the impact of the 1993 French National Policy which made it mandatory to offer screening for the presence of human immunodeficiency virus (HIV) to all pregnant women who planned to give birth, although women remained free to refuse the test. DESIGN: Successive surveys in April 1992 and May 1994
A randomised trial of mode of delivery in women infected with the human immunodeficiency virus.: Br J Obstet Gynaecol. 1998 Mar;105(3):281-5. Unique Identifier : AIDSLINE MED/98194181; Newell ML; Parazzini F; Mandelbrot L; Peckham C; Semprini A; Bazin B; Darbyshire J; Sanchez E; Pardi G; Institute of Child Health, London, UK.; OBJECTIVE: During the pilot phase of a trial to evaluate the effectiveness of caesarean section delivery compared with vaginal delivery in reducing mother-to-child transmission of human immunodeficiency virus (HIV) infection, the feasibility of randomisation to mode of delivery was assessed. DESIGN: At 36 weeks of pre
RNA-protein interactions in the Tat-trans-activation response element complex determined by site-specific photo-cross-linking.: Biochemistry. 1998 Mar 24;37(12):4235-43. Unique Identifier : AIDSLINE MED/98190001; Wang Z; Rana TM; Department of Pharmacology, Robert Wood Johnson Medical School,; University of Medicine and Dentistry of New Jersey, Piscataway 08854,; USA.; Transcriptional regulation in human immunodeficiency virus type 1 HIV-1) requires specific interactions of Tat protein with the trans-activation responsive region (TAR) RNA, a 59-base stem-loop structure located at the 5 -end of all HIV transcripts. We have used a site-specific cross-linking method based on 6-thioguan
'Unsafe protected sex': qualitative insights on measures of sexual risk.: AIDS Care. 1998 Feb;10(1):105-14. Unique Identifier : AIDSLINE MED/98197268; Quirk A; Rhodes T; Stimson GV; Department of Social Science and Medicine, Imperial College School of; Medicine, London, UK.; To describe forms of unsafe protected sex (vaginal or anal intercourse where condoms are used unsafely) among a sample of drug users in London, data are drawn from a qualitative study of the sexual and drug taking lifestyles of opioid and stimulant users. Depth one-to-one interviews (n = 96) elicited detailed descript
Psychological and socio-medical aspects of HIV/AIDS: a reflection on publications in AIDS care (1989-1995).: AIDS Care. 1998 Feb;10(1):115-21. Unique Identifier : AIDSLINE MED/98197269; Bennett L; Rose D; Jackson A; Thomas S; Department of Behavioural and Social Sciences, University of Sydney,; NSW, Australia.; It is necessary to consider the content and methods of AIDS social research publications for these represent research advances as well as current issues of concern for practitioners, communities and researchers alike. This article critically examines some of the research that has been conducted to date into social asp
Secondary prevention for youths living with HIV.: AIDS Care. 1998 Feb;10(1):17-34. Unique Identifier : AIDSLINE MED/98197261; Rotheram-Borus MJ; Miller S; Department of Psychiatry, University of California, Los Angeles, USA.; As the number of youths infected with HIV rises, secondary prevention programmes are needed to help youths living with HIV meet three goals: (1) increase self-care behaviours, medical adherence and health-related interactions; (2) reduce transmission acts; and (3) enhance their quality of life. This article describes
Safe sex or safe love: competing discourses?: AIDS Care. 1998 Feb;10(1):35-47. Unique Identifier : AIDSLINE MED/98197262; Rosenthal D; Gifford S; Moore S; Centre for the Study of Sexually Transmissible Diseases, La Trobe; University, Victoria, Australia.; The way in which sex may be constructed as safe through its relationship with love is the concern of this study. Interviews with 112 heterosexual women and men from discos and bars in Melbourne, Australia , catering to single adults revealed the pervasive construction of sex wi
The role of disclosure in coping with HIV infection.: AIDS Care. 1998 Feb;10(1):49-60. Unique Identifier : AIDSLINE MED/98197263; Holt R; Court P; Vedhara K; Nott KH; Holmes J; Snow MH; Department of Psychology, The University, Newcastle upon Tyne, UK.; A qualitative investigation was conducted to explore the role of disclosure in HIV infection. Forty homosexual and bisexual men completed a short demographic questionnaire and participated in a one-to-one, semi-structured interview. The interview was designed to address a variety of personal, interpersonal and organiz
HIV/AIDS, micro-ethics and macro-ethics [editorial]: AIDS Care. 1998 Feb;10(1):5-6. Unique Identifier : AIDSLINE MED/98197259; Mann JM
A multicentre study on the causes of death among Italian injecting drug users. AIDS has overtaken overdose as the principal cause of death.: AIDS Care. 1998 Feb;10(1):61-7. Unique Identifier : AIDSLINE MED/98197264; Mezzelani P; Quaglio GL; Venturini L; Lugoboni F; Friedman SR; Des Jarlais DC; Institute of Clinica Medica, University of Verona, Italy.; mezzelani@cmib.univr.it; The causes of death among injecting drug users. (IDUs) are still being discussed worldwide. We analysed the causes of death among IDUs attending 26 centres for drug users in North-Eastern Italy from 1985 to 1994. The study of a total number of 1,022 deaths reveals the following: (1)
Changes in prostitution and the AIDS epidemic in Thailand.: AIDS Care. 1998 Feb;10(1):69-79. Unique Identifier : AIDSLINE MED/98197265; Hanenberg R; Rojanapithayakorn W; Family Health International, Bangkok, Thailand.; The HIV/AIDS epidemic which broke out in Thailand 1988 was mainly caused by the widespread patronage of prostitutes. The Thai authorities responded with programmes which encouraged the use of condoms in commercial sex. These programmes were highly successful. However, prostitutio
Social care of children born to HIV-infected mothers in Europe. European Collaborative Study.: AIDS Care. 1998 Feb;10(1):7-16. Unique Identifier : AIDSLINE MED/98197260; Thorne C; Newell ML; Peckham C; Department of Paediatric Epidemiology, Institute of Child Health,; London, UK. M.Newell@ich.ucl.ac.uk; Children of HIV-infected women are likely to be profoundly affected by their mothers infection, regardless of their own infection status and their number will increase with the spread of infection among women in Europe. This article describes the family circumstances and social care of 1,123 children born to HIV-infe
Safer sex and social class: findings from a study of men using the 'gay scene' in the West Midlands region of the United Kingdom.: AIDS Care. 1998 Feb;10(1):81-8. Unique Identifier : AIDSLINE MED/98197266; Hope VD; MacArthur C; Department of Public Health and Epidemiology, Medical School,; University of Birmingham, Edgbaston, UK. vhope@phls.co.uk; This article reports on associations between socio-demographic factors and safer sexual behaviour among gay and bisexual men in an English region. A cross-sectional survey using an anonymous self-complete questionnaire collected information on sexual behaviour and socio-demographic characteristics. All men using speci
Comparison of the clientele of an anonymous HIV test centre and persons tested in the general population.: AIDS Care. 1998 Feb;10(1):89-103. Unique Identifier : AIDSLINE MED/98197267; Rossi I; Jeannin A; Dubois-Arber F; Guex P; Vannotti M; Faculty of Medicine, University of Lausanne, Switzerland.; Ilario.Rossi@hospvd.ch; This study compares the clientele of a Swiss anonymous test centre with the general population tested. Information was obtained through similar questionnaires submitted to two samples of HIV-tested people aged from 17 to 45 years: the first administered in the context of a general population telephone survey (n = 245)
Construction of vectors expressing bioactive heterodimeric and single-chain murine interleukin-12 for gene therapy.: Hum Gene Ther. 1998 Mar 1;9(4):457-65. Unique Identifier : AIDSLINE MED/98184219; Lee YL; Tao MH; Chow YH; Chiang BL; Graduate Institute of Microbiology, National Taiwan University,; Taipei, Republic of China.; It has been well demonstrated that interleukin-12 (IL-12) could be useful to defend against a variety of pathogens, to suppress tumor growth and metastasis, and even to be employed as an adjuvant of vaccines to enhance beneficial type 1 T helper (Th1) cell response over detrimental type 2 T helper (Th2) cell responses
Stable integration of human immunodeficiency virus-based retroviral vectors into the chromosomes of nondividing cells.: Hum Gene Ther. 1998 Mar 1;9(4):467-75. Unique Identifier : AIDSLINE MED/98184220; Miyake K; Suzuki N; Matsuoka H; Tohyama T; Shimada T; Department of Biochemistry and Molecular Biology, Nippon Medical; School, Tokyo, Japan.; Human immunodeficiency virus type 1 (HIV-1)-based vectors are thought to be useful for gene transfer into nondividing cells. We examined whether HIV vectors can really integrate into the chromosomes of nondividing cells. CD4+HeLa cells arrested at the G2 or G1/S phase were incubated with the HIV vector pseudotyped wit
Inhibition of human immunodeficiency virus replication and growth advantage of CD4+ T cells from HIV-infected individuals that express intracellular antibodies against HIV-1 gp120 or Tat.: Hum Gene Ther. 1998 Mar 1;9(4):487-96. Unique Identifier : AIDSLINE MED/98184222; Poznansky MC; Foxall R; Mhashilkar A; Coker R; Jones S; Ramstedt U; Marasco W; The Dept. of Genito-Urinary Medicine and Communicable Diseases,; Imperial College School of Medicine at St. Mary's, London, UK.; Current clinical gene therapy protocols for the treatment of human immunodeficiency virus type 1 (HIV-1) infection often involve the ex vivo transduction and expansion of CD4+ T cells derived from HIV-positive patients at a late stage in their disease (CD4 count
Expression of the human immunodeficiency virus type 1 primer binding sequence inhibits HIV-1 replication.: Hum Gene Ther. 1998 Mar 1;9(4):587-90. Unique Identifier : AIDSLINE MED/98184231; Kechli AM; Freiden PJ; Rossi JJ; Brenner MK; Choueiry MA; Garcia JV; Slobod KS; Department of Hematology/Oncology, St. Jude Children's Research; Hospital, Memphis, TN 38105, USA.; Optimal targets for anti-human immunodeficiency virus (HIV) moieties are those regions of the viral genome that are greatly conserved. The primer binding site (PBS) of HIV is an 18-nucleotide sequence complementary to the 3 end of tRNA(Lys3) that serves as the primer for HIV-1 reverse transcription. All HIV-1 isolate
Oral Candida infections--a review.: Indian J Dent Res. 1995 Jul-Sep;6(3):69-82. Unique Identifier : AIDSLINE MED/98156231; Samaranayake LP; Nair RG; Oral Biology Unit, Faculty of Dentistry, University of Hong Kong.; Candida species are the commonest agents of oral mycoses. They cause a variety of diseases including the new variant, erythematous candidosis, which is frequently described in HIV infection. Due to these and other reasons the classification of oral candidosis has been recently revised, and further more new therapeutic
Detection of HIV antibodies in saliva and its implications.: Indian J Dent Res. 1995 Jul-Sep;6(3):95-8. Unique Identifier : AIDSLINE MED/98156233; Anil S; Beena VT; Nair RG; Varghese BJ; Department of Periodontia, Dental College, Trivandrum.; Human immunodeficiency virus has been detected in almost all body fluids. With a silent disease such as HIV infection, testing for HIV antibodies currently is the most cost effective means for determining the incidence and prevalence of HIV infection in the community and for identifying HIV infection in the individual
[Primary HIV infection with esophageal candidiasis and acute toxoplasmosis (letter)]: An Med Interna. 1998 Jan;15(1):50-1. Unique Identifier : AIDSLINE MED/98182984; Mateos Rodriguez F; Fuertes Martin A; Marcos Toledano M; Jimenez Lopez A
AIDS drug scandal in South Africa continues [news]: BMJ. 1998 Mar 14;316(7134):800. Unique Identifier : AIDSLINE MED/98210616; Sidley P
Informed consent and research.: BMJ. 1998 Mar 28;316(7136):1008. Unique Identifier : AIDSLINE MED/98212323; Benatar D; Benatar SR; Department of Philosophy, University of Cape Town, Rondebosch, South; Africa dbenatar@socsci.uct.ac.za
[Evaluation of the quality of life in pediatrics: how to collect the point of view of children]: Arch Pediatr. 1997 Dec;4(12):1238-46. Unique Identifier : AIDSLINE MED/98199231; Manificat S; Dazord A; Cochat P; Nicolas J; Script Inserm et Apret 290, Lyon, France.; There are very few available child quality of life questionnaires. We describe here a French questionnaire (AUQUEI) which consists of a structured format scale (26 items). The first part of the questionnaire studies child satisfaction. Response levels are measured by checking faces expressing different emotional state
Steroid-responsive HIV optic neuropathy.: J Neuroophthalmol. 1998 Mar;18(1):25-9. Unique Identifier : AIDSLINE MED/98193714; Burton BJ; Leff AP; Plant GT; National Hospital for Neurology and Neurosurgery, London, England.; A 37-year-old man with bilateral optic neuropathy who recovered on steroid treatment is described. He was subsequently found to be human immunodeficiency virus 1 (HIV-1) positive prior to the onset of his visual symptoms, and no other cause of his optic neuropathy could be found. There is some evidence that HIV itself
Intracerebral HIV glycoprotein (gp120) enhances tumor metastasis via centrally released interleukin-1.: Brain Res. 1998 Jan 19;781(1-2):244-51. Unique Identifier : AIDSLINE MED/98176052; Hodgson DM; Yirmiya R; Chiappelli F; Taylor AN; Dept. of Neurobiology and Brain Research Institute, School of; Medicine, University of California, Los Angeles, CA 90095, USA.; hodgson@psych.ucla.edu; Infection with the human immunodeficiency virus (HIV) is associated with a high incidence of cancers. This relationship does not appear to be due to a direct effect of the virus, and may be mediated by neuroimmune interactions since the HIV glycoprotein, gp120, enters the brain soon after infection with HIV, and intra
Capture of an early fusion-active conformation of HIV-1 gp41.: Nat Struct Biol. 1998 Apr;5(4):276-9. Unique Identifier : AIDSLINE MED/98206292; Furuta RA; Wild CT; Weng Y; Weiss CD; Office of Vaccines, Center for Biologics Evaluation and Research, Food; and Drug Administration, Bethesda, Maryland 20892-4555, USA.; Using an inhibitory synthetic peptide (DP-178) from HIV-1 gp41, we have trapped HIV-1 envelope glycoprotein (Env) undergoing conformational changes during virus entry. Our data show that DP-178 binds gp41 and inhibits Env-mediated membrane fusion after gp120 interacts with cellular receptors, indicating that conformat
Protease inhibitors for the treatment of human immunodeficiency virus infection.: Am J Health Syst Pharm. 1998 Feb 1;55(3):233-54. Unique Identifier : AIDSLINE MED/98151218; Kakuda TN; Struble KA; Piscitelli SC; Division of Clinical Pharmacology, University of Minnesota Academic; Health Center, Minneapolis, USA.; The pharmacology, pharmacokinetics, efficacy, adverse effects, drug interactions, and dosage and administration of protease inhibitors are reviewed. Protease inhibitors are a novel class of drugs used for the treatment of human immunodeficiency virus HIV) infection.
Preventing and treating azole-resistant oropharyngeal candidiasis in HIV-infected patients.: Am J Health Syst Pharm. 1998 Feb 1;55(3):279-83. Unique Identifier : AIDSLINE MED/98151224; Penzak SR; Gubbins PO; Department of Pharmacy Practice, College of Pharmacy, University of; Arkansas for Medical Sciences, Little Rock 72205-7122, USA.
Use of nonnucleoside reverse-transcriptase inhibitors.: Am J Health Syst Pharm. 1998 Feb 1;55(3):283-7. Unique Identifier : AIDSLINE MED/98151225; Holtzer CD; Coleman RL; UCSF AIDS Program, San Francisco General Hospital, CA 94110, USA.; choltzer@sfaids.ucsf.edu
Anonymous anti-HIV agent [editorial]: Nat Med. 1998 Apr;4(4):371. Unique Identifier : AIDSLINE MED/98206841
Indian state plans compulsory HIV testing, segregation and branding [news]: Nat Med. 1998 Apr;4(4):378. Unique Identifier : AIDSLINE MED/98206848; Jayaraman KS
Tipping the scales of herpes simplex virus reactivation: the important responses are local.: Nat Med. 1998 Apr;4(4):381-2. Unique Identifier : AIDSLINE MED/98206850; Posavad CM; Koelle DM; Corey L; Department of Laboratory Medicine, Univ. of Washington, Seattle 98104,; USA.
Mother knows best [news; comment]: Nat Med. 1998 Apr;4(4):390-1. Unique Identifier : AIDSLINE MED/98206855; Scadden DT
Retroviral zoonoses [news; comment]: Nat Med. 1998 Apr;4(4):391-2. Unique Identifier : AIDSLINE MED/98206856; Weiss RA
Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara.: Nat Med. 1998 Apr;4(4):397-402. Unique Identifier : AIDSLINE MED/98206860; Schneider J; Gilbert SC; Blanchard TJ; Hanke T; Robson KJ; Hannan CM; Becker M; Sinden R; Smith GL; Hill AV; Institute of Molecular Medicine, Nuffield Department of Medicine,; University of Oxford, John Radcliffe Hospital, UK.; joerg.schneider@ndm.ox.ac.uk; Immunization with irradiated sporozoites can protect against malaria infection and intensive efforts are aimed at reproducing this effect with subunit vaccines. A particular sequence of subunit immunization with pre-erythrocytic antigens of Plasmodium berghei, consisting of single dose priming with plasmid DNA followe
Antigenic stimulation by BCG vaccine as an in vivo driving force for SIV replication and dissemination.: Nat Med. 1998 Apr;4(4):421-7. Unique Identifier : AIDSLINE MED/98206864; Cheynier R; Gratton S; Halloran M; Stahmer I; Letvin NL; Wain-Hobson S; Unite de Retrovirologie Moleculaire, Institut Pasteur, Paris.; The impact of antigenic stimulation on the dynamics of simian immunodeficiency virus (SIV) replication was studied following repeated intravenous BCG inoculation of a SIV infected macaque. At the site of a delayed type hypersensitivity reaction to purified protein derivative of M. tuberculosis, a distinctive SIV varia
Effects of a urinary factor from women in early pregnancy on HIV-1, SIV and associated disease [see comments]: Nat Med. 1998 Apr;4(4):428-34. Unique Identifier : AIDSLINE MED/98206865; Lunardi-Iskandar Y; Bryant JL; Blattner WA; Hung CL; Flamand L; Gill P; Hermans P; Birken S; Gallo RC; Institute of Human Virology, University of Maryland, Baltimore; 21201-1192, USA.; The effects of clinical grade crude preparations of human chorionic gonadotropin (hCG) on Kaposi s sarcoma, HIV, SIV and hematopoiesis were examined in vitro and in vivo. In contrast to previous studies, we report that the antiviral activity of hCG associated factors is not due to the native hCG heterodimer, including
Deregulation of cell growth by the K1 gene of Kaposi's sarcoma-associated herpesvirus.: Nat Med. 1998 Apr;4(4):435-40. Unique Identifier : AIDSLINE MED/98206866; Lee H; Veazey R; Williams K; Li M; Guo J; Neipel F; Fleckenstein B; Lackner A; Desrosiers RC; Jung JU; New England Regional Primate Research Center, Harvard Medical School,; Southborough, MA 01772-9102, USA.; At a position equivalent to the gene encoding the saimiri transforming protein (STP) of herpesvirus saimiri (HVS), Kaposi s sarcoma-associated herpesvirus (KSHV) contains a distinct open reading frame called K1. Although KSHV and HVS are related members of the rhadinovirus subgroup of gamma herpesviruses, K1 and STP e
Novel role of human CD4 molecule identified in neurodegeneration.: Nat Med. 1998 Apr;4(4):441-6. Unique Identifier : AIDSLINE MED/98206867; Buttini M; Westland CE; Masliah E; Yafeh AM; Wyss-Coray T; Mucke L; Department of Neurology, University of California, San Francisco; 94141-9100, USA.; The human CD4 molecule (hCD4) is expressed on T lymphocytes and macrophages and acts as a key component of the cellular receptor for HIV. At baseline, hCD4 transgenic mice expressed hCD4 on microglia, the resident mononuclear phagocytes of the brain, and showed no neuronal damage. Activation of brain microglia by peri
In vitro antiviral activity on dengue virus of marine natural products.: Cell Mol Life Sci. 1998 Feb;54(2):167-70. Unique Identifier : AIDSLINE MED/98200779; Laille M; Gerald F; Debitus C; Institut Pasteur, Noumea (New Caledonia). laille@pasteur.nc; Metabolites isolated from marine invertebrates, callipeltin A, crambescidin, ptilomycalin A, celeromycalin, gymnochrome B, gymnochrome D and isogymnochrome D previously shown bioactive on either herpes simplex virus 1 or human immunodeficiency virus, were tested on a new in vitro bioassay using the dengue virus 1. Onl
Immunologic features of tumor-infiltrating lymphocytes and peripheral blood lymphocytes in ovarian cancer patients.: J Soc Gynecol Investig. 1998 Mar-Apr;5(2):102-7. Unique Identifier : AIDSLINE MED/98170128; Schondorf T; Engel H; Kurbacher CM; Brenne U; Kolhagen H; Gohring UJ; Scharl A; Mallmann P; Department of Gynecology and Obstetrics, University of Cologne,; Germany.; OBJECTIVE: To determine the immunologic characteristics of tumor infiltrating lymphocytes (TILs) in comparison with the corresponding peripheral blood lymphocytes (PBLs) of patients with ovarian cancer in order to detect specific antitumor-reactive-immunocompetent cells. METHODS: Tumor infiltrating lymphocytes and PBL
Molecular detection and isolation of human T-cell lymphotropic virus type I (HTLV-I) from patients with HAM/TSP in Sao Paulo, Brazil.: Clin Diagn Virol. 1998 Jan;9(1):17-23. Unique Identifier : AIDSLINE MED/98223947; Segurado AA; Domingues RB; Muniz MR; Fink MC; Marchiori PE; Scaff M; Lal RB; Department of Infectious Diseases, School of Medicine, University of; Sao Paulo, Brazil. segurado@usp.br; BACKGROUND: Infection with HTLV-I is etiologically linked with HTLV-I-associated myelopathy/tropical spastic paraparesis HAM/TSP). However some patients with chronic progressive paraparesis resembling HAM/TSP have been shown to be infected with HTLV-II. OBJECTIVE: To clarify the role of each of these human retroviruse
Introduction of HIV-1 subtypes C, E and A into Austria.: Clin Diagn Virol. 1998 Jan;9(1):25-8. Unique Identifier : AIDSLINE MED/98223948; Puchhammer-Stockl E; Kunz C; Faatz E; Kasper P; Heinz FX; Institute of Virology, University of Vienna, Austria.; BACKGROUND: Different subtypes of HIV-1 are prevalent in various geographical regions. Knowledge of their distribution is of importance with respect to possible differences in biological properties (such as reported for subtype E) as well as to diagnostic problems that may arise when specific subtypes are not recogniz
Prevalence of infection with HIV, hepatitis B and C viruses, in four high risk groups in Eritrea.: Clin Diagn Virol. 1998 Jan;9(1):29-35. Unique Identifier : AIDSLINE MED/98223949; Ghebrekidan H; Cox S; Wahren B; Grandien M; Department of Virology, Swedish Institute for Infectious Disease; Control, Karolinska Institute, Stockholm, Sweden.; BACKGROUND: Little is known about the prevalence of infections in different population groups in Africa, and about the influence of living conditions on the spread of infections. This study is the first of its kind in the state of Eritrea and is expected to serve as an evaluation
Liposomal doxorubicin in pulmonary Kaposi's sarcoma: improved survival as compared to patients without liposomal doxorubicin.: Eur J Med Res. 1998 Feb 21;3(1-2):13-9. Unique Identifier : AIDSLINE MED/98174147; Grunaug M; Bogner JR; Loch O; Goebel FD; Medizinische Poliklinik, Ludwig-Maximilians-University, Munich,; Germany.; OBJECTIVE: Pulmonary Kaposi s sarcoma (KS) in HIV-infected patients is characterised by a poor prognosis with a mean survival time of 2 to 6 months. Our goal was to evaluate survival in patients with pulmonary KS treated with Stealth liposomal doxorubicin (SL-DOX) and to compare it with patients without SL-DOX therapy
Neurobehavioral functioning in asymptomatic HIV-1 infected women.: J Int Neuropsychol Soc. 1998 Mar;4(2):172-8. Unique Identifier : AIDSLINE MED/98190732; Stern RA; Arruda JE; Somerville JA; Cohen RA; Boland RJ; Stein MD; Martin EM; Brown University School of Medicine, Providence, RI, USA.; rstern@lifespan.org; Numerous reports have assessed the neuropsychological functioning of medically asymptomatic HIV-1 infected men. However, to date there have been no published studies of the neuropsychological functioning of asymptomatic HIV-1 infected women, even though women represent the fastest-growing demographic group of HIV-1 in
Chemotherapeutic agents for human immunodeficiency virus infection: mechanism of action, pharmacokinetics, metabolism, and adverse reactions.: Clin Ther. 1998 Jan-Feb;20(1):2-25; discussion l. Unique Identifier : AIDSLINE MED/98182568; Beach JW; Department of Pharmaceutical and Biomedical Sciences, College of; Pharmacy, University of Georgia, Athens, USA.; Since the mid-1980s, four new nucleoside reverse transcriptase RT) inhibitors (zalcitabine, didanosine, stavudine , and lamivudine), two nonnucleoside RT inhibitors ( nevirapine and
Oropharyngeal candidiasis: a review of its clinical spectrum and current therapies.: Clin Ther. 1998 Jan-Feb;20(1):40-57. Unique Identifier : AIDSLINE MED/98182570; Epstein JB; Polsky B; Department of Dentistry, Vancouver Hospital & Health Sciences Center,; British Columbia.; With the increased use of antibiotics and immunosuppressive agents, oropharyngeal candidiasis is becoming more common. This infection is also associated with such advances in medical management as chemotherapy and organ transplantation and with human immunodeficiency virus infection. Various topical and systemic agent
Reaching seriously at-risk populations: health interventions in criminal justice settings.: Health Educ Behav. 1998 Feb;25(1):99-120. Unique Identifier : AIDSLINE MED/98134843; Hammett TM; Gaiter JL; Crawford C; Abt Associates, Inc., Cambridge, MA 02138-1168, USA.; ted_hammett@abtassoc.com; More than 6 million people are under some form of criminal justice supervision in the United States on any given day. The vast majority are arrested in and return to urban, low-income communities. These are men, women, and adolescents with high rates of infectious diseases such as HIV/
A study of chest infections in HIV seropositive patients in Kuala Lumpur.: Int J Clin Pract. 1998 Jan-Feb;52(1):23-6. Unique Identifier : AIDSLINE MED/98197628; Wood E; Cheong I; Lee C; Department of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur,; Malaysia.; A retrospective study of 144 adults with HIV infection was conducted to investigate the prevalence of upper and lower respiratory tract infections (URTIs and LRTIs). The patients were divided into two groups: those with acquired HIV through intravenous drug abuse (IVDA), and those who had acquired HIV through other
Host and viral factors influencing heterosexual HIV transmission.: Rev Reprod. 1998 Jan;3(1):42-51. Unique Identifier : AIDSLINE MED/98168806; Miller CJ; California Regional Primate Research Center and Department of; Pathology, Microbiology and Immunology, School of Veterinary Medicine,; University of California, Davis 95616, USA.; The World Health Organization estimates that 28-30 million people have been infected with human immunodeficiency virus (HIV). Although many important questions remain, much has been learned regarding the biology of heterosexual HIV transmission. For example, most sexual transmission of
Optima: a windows-based program for computer-aided optimization of controlled-release dosage forms.: Pharm Dev Technol. 1996 Dec;1(4):405-14. Unique Identifier : AIDSLINE MED/98177749; Lu DR; Abu-Izza K; Chen W; Department of Pharmaceutics, College of Pharmacy, University of; Georgia, Athens 30602, USA. rlu@merc.rx.uga.edu; The purpose of this work was to develop a computer program that assists optimization of controlled-release devices, both visually and mathematically, using response surface methodology (RSM). A Windows-based computer program, Optima, which interactively implemented a number of subroutines for the optimization procedur
Topical lithium succinate ointment (Efalith) in the treatment of AIDS-related seborrhoeic dermatitis.: Clin Exp Dermatol. 1997 Sep;22(5):216-9. Unique Identifier : AIDSLINE MED/98197605; Langtry JA; Rowland Payne CM; Staughton RC; Stewart JC; Horrobin DF; Department of Dermatology, Westminster Hospital, London, UK.; A randomised, double-blind, placebo-controlled trial with lithium succinate ointment was conducted in patients with AIDS-associated facial seborrhoeic dermatitis. Twice daily applications of the ointment brought about a rapid (2.5 days) and highly significant P = 0.007) improvement in the severity of the condition. Li
Erythema elevatum diutinum and AIDS: are they related? [letter]: Clin Exp Dermatol. 1997 Sep;22(5):250-1. Unique Identifier : AIDSLINE MED/98197615; Revenga F; Vera A; Munoz A; De la Llana FG; Alejo M; Rodriguez-Peralto JL
Relation between hospital HIV/AIDS caseload and mortality among persons with HIV/AIDS in Canada.: Clin Invest Med. 1998 Feb;21(1):27-32. Unique Identifier : AIDSLINE MED/98174066; Hogg RS; Raboud J; Bigham M; Montaner JS; O'Shaughnessy M; Schechter MT; British Columbia Centre for Excellence in HIV/AIDS, St. Paul's; Hospital.; OBJECTIVE: To assess the relation between HIV/AIDS hospital caseload and mortality in Canada . DESIGN: Descriptive, population-based study. SETTING: All hospitals in Canada that admitted any patients with HIV or AIDS between Mar. 31, 1987, and Apr. 1, 1994. PATIENTS: All patients wi
[Strongyloides stercoralis infection in a patient with AIDS and non-Hodgkin lymphoma]: Dtsch Med Wochenschr. 1998 Mar 27;123(13):381-5. Unique Identifier : AIDSLINE MED/98217439; Muller A; Fatkenheuer G; Salzberger B; Schrappe M; Diehl V; Franzen C; Klinik I fur Innere Medizin, Universitat zu Koln.; HISTORY AND CLINICAL FINDINGS: The patient, now 50 years old, an immigrant miner from the former Yugoslavia who was known to have AIDS, was in 1992 found to have non-Hodgkin lymphoma of the oesophagus and given five cycles of multiple chemotherapy (CHOP) with complete remission. Subsequently he complained of retroster
Proteolytic refolding of the HIV-1 capsid protein amino-terminus facilitates viral core assembly.: EMBO J. 1998 Mar 16;17(6):1555-68. Unique Identifier : AIDSLINE MED/98169372; von Schwedler UK; Stemmler TL; Klishko VY; Li S; Albertine KH; Davis DR; Sundquist WI; Department of Biochemistry, University of Utah, Salt Lake City, UT; 84132, USA.; After budding, the human immunodeficiency virus (HIV) must mature into an infectious viral particle. Viral maturation requires proteolytic processing of the Gag polyprotein at the matrix-capsid junction, which liberates the capsid (CA) domain to condense from the spherical protein coat of the immature virus into the
Cooperative interaction of ets-1 with USF-1 required for HIV-1 enhancer activity in T cells.: EMBO J. 1998 Mar 16;17(6):1728-39. Unique Identifier : AIDSLINE MED/98169389; Sieweke MH; Tekotte H; Jarosch U; Graf T; EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany.; The distal enhancer region of the human immunodeficiency virus 1 HIV-1) long terminal repeat (LTR) is known to be essential for HIV replication and to contain immediately adjacent E-box and Ets binding sites. Based on a yeast one-hybrid screen we have identified the E-box binding protein USF-1 as a direct interaction
Cytomegalovirus retinitis in patients with AIDS in Europe. AIDS in Europe Study Group.: Eur J Clin Microbiol Infect Dis. 1997 Dec;16(12):876-82. Unique Identifier : AIDSLINE MED/98155055; Burke M; Yust I; Katlama C; Vardinon N; Clumeck N; Pinching AJ; Ledergerber B; Gatell JM; Chiesi A; Barton SE; Lundgren JD; Pedersen C; Department of Medicine A and Clinical Immunology, Ichilov Hospital,; Tel Aviv, Israel.; The incidence of cytomegalovirus ( CMV ) retinitis and risk factors associated with the condition were studied in patients with the acquired immune deficiency syndrome (AIDS) in a multicenter retrospective cohort study of 6458
Visceral leishmaniasis in patients infected with the human immunodeficiency virus.: Eur J Clin Microbiol Infect Dis. 1997 Dec;16(12):898-903. Unique Identifier : AIDSLINE MED/98155058; Laguna F; Adrados M; Alvar J; Soriano V; Valencia ME; Moreno V; Polo R; Verdejo J; Jimenez MI; Martinez P; Martinez ML; Gonzalez-Lahoz JM; Servicio de Enfermedades Infecciosas, Centro Nacional de Investigacion; Clinica, Instituto de Salud Carlos III, Madrid, Spain.; The experience with 52 episodes of visceral leishmaniasis diagnosed in 43 patients is reported. The most common symptoms were fever (81%), splenomegaly (65%), hepatomegaly (63%), and pancytopenia (73%). In 79% of the patients, CD4+ cell counts were
Influence of hepatitis G virus infection on liver disease.: Eur J Clin Microbiol Infect Dis. 1997 Dec;16(12):916-9. Unique Identifier : AIDSLINE MED/98155061; Diamantis ID; Kouroumalis E; Koulentaki M; Fasler-Kan E; Schmid PA; Hirsch HH; Buhler H; Gyr K; Battegay M; Outpatient Department of Internal Medicine, University Hospital Basel,; Switzerland.; The influence of hepatitis G virus (HGV) infection on disease activity in hepatitis C related and unrelated liver disease was investigated in 254 individuals using an EIA polymerase chain reaction assay for HGV. One hundred patients had chronic hepatitis C, 26 primary biliary cirrhosis, and 30 alcoholic liver cirrhosi
Bacteremia and respiratory involvement by Alcaligenes xylosoxidans in patients infected with the human immunodeficiency virus.: Eur J Clin Microbiol Infect Dis. 1997 Dec;16(12):933-8. Unique Identifier : AIDSLINE MED/98155065; Manfredi R; Nanetti A; Ferri M; Chiodo F; Dipartimento di Medicina Clinica Specialistica e Sperimentale,; Universita di Bologna, Italy.; Seven cases of Alcaligenes xylosoxidans bacteremia and/or respiratory disease in patients infected with the human immunodeficiency virus (HIV) are described. Reported only thrice previously in this setting, these bacterial complications occurred during different phases of HIV infection and were associated with leukope
Pneumocystis carinii meningoradiculitis in a patient with AIDS.: Eur J Clin Microbiol Infect Dis. 1997 Dec;16(12):940-2. Unique Identifier : AIDSLINE MED/98155067; Villanueva JL; Cordero E; Caballero-Granado FJ; Regordan C; Becerril B; Pachon J; Infectious Disease Unit and Service of Microbiology, Hospital; Universitario Virgen del Rocio, Seville, Spain.; Pneumocystis carinii is a common opportunistic pathogen in patients infected with the human immunodeficiency virus (HIV). Pneumocystis carinii pneumonia is common, while extrapulmonary infections with Pneumocystis carinii have been reported sparingly. The clinical features are frequently nonspecific. The detection of
Thyroid abscess due to Rhodococcus equi in a patient infected with the human immunodeficiency virus.: Eur J Clin Microbiol Infect Dis. 1998 Jan;17(1):55-7. Unique Identifier : AIDSLINE MED/98171138; Martin-Davila P; Quereda C; Rodriguez H; Navas E; Fortun J; Meseguer M; Moreno A; Guerrero A; Department of Microbiology, Hospital Ramon y Cajal, Madrid, Spain.; A case of thyroid abscess due to Rhodococcus equi in an HIV-positive patient with previous pulmonary abscess is reported. Rhodococcus equi is a gram-positive rod that can cause infections in both immunocompetent and immunocompromised patients, though it occurs more frequently in patients with dysfunctional cellular im
Raynaud's phenomenon and acral necrosis after chemotherapy for AIDS-related Kaposi's sarcoma.: Eur J Clin Microbiol Infect Dis. 1998 Jan;17(1):58-60. Unique Identifier : AIDSLINE MED/98171139; Reiser M; Bruns C; Hartmann P; Salzberger B; Diehl V; Fatkenheuer G; Medizinische Klinik I, University Hospital, Cologne, Germany.; Raynaud s phenomenon is a common vascular side effect of chemotherapy drug regimens. Chemotherapy-induced Raynaud s phenomenon leading to acral gangrene has rarely been reported. In this report, one patient who developed gangrene after bleomycin and vincristine/vinblastine chemotherapy for AIDS-related Kaposi s sarcom
Frequent chronic hepatitis B virus infection in HIV-infected patients positive for antibody to hepatitis B core antigen only. Swiss HIV Cohort Study.: Eur J Clin Microbiol Infect Dis. 1998 Jan;17(1):6-13. Unique Identifier : AIDSLINE MED/98171127; Hofer M; Joller-Jemelka HI; Grob PJ; Luthy R; Opravil M; Division of Infectious Diseases and Hospital Epidemiology, University; Hospital, Zurich, Switzerland.; Persons with immune deficiency may present with atypical results in serological tests for hepatitis B virus (HBV). Frozen serum specimens that were sequentially obtained over time from a cohort of 57 HIV-infected patients, all of whom tested positive only for antibody to hepatitis B core antigen (anti-HBcAg), were the
First isolation in Europe of Legionella feeleii from two cases of pneumonia [letter]: Eur J Clin Microbiol Infect Dis. 1998 Jan;17(1):64-6. Unique Identifier : AIDSLINE MED/98171142; Lo Presti F; Riffard S; Neyret C; Celard M; Vandenesch F; Etienne J
Expression of dipeptidylaminopeptidase IV/CD26 in peripheral blood lymphocytes of hemophilic subjects.: Eur J Haematol. 1998 Mar;60(3):145-52. Unique Identifier : AIDSLINE MED/98208190; Invernizzi R; Montani N; Giusto M; Mosconi E; Lorenzutti F; Comolli G; Pecci A; Gamba G; Department of Internal Medicine, University of Pavia, Italy.; CD26 antigen, a 110 kDa membrane glycoprotein with exopeptidase activity (DAP IV), is an activation marker of T lymphocytes preferentially expressed on CD4+ memory cells and involved in T cell proliferation and IL-2 production after antigenic stimulation. We employed c
Modulatory function on autologous myeloid progenitor cells of clonal T-lymphocytes following autologous bone marrow transplantation.: Eur J Haematol. 1998 Mar;60(3):189-96. Unique Identifier : AIDSLINE MED/98208196; Hokland P; Carlsen I; Hokland M; Nielsen B; Department of Haematology, Aarhus University Hospital, Denmark.; hokland@gjallar.daimi.aau.dk; We have studied the regulatory capacity of clonal T-lymphocytes from patients undergoing autologous bone marrow transplantation ABMT) on the generation of CFU-GM from their harvest marrow preparations. To this end, T-lymphocytes from peripheral blood from 5 patients undergoing ABMT isolated 10 d before and 7, 14 and 2
Letting minors consent to HIV tests.: Fam Plann Perspect. 1998 Jan-Feb;30(1):2. Unique Identifier : AIDSLINE MED/98155909
Inching toward HIV goals.: Fam Plann Perspect. 1998 Jan-Feb;30(1):2-3. Unique Identifier : AIDSLINE MED/98155910
Does the pill help spread HIV?: Fam Plann Perspect. 1998 Jan-Feb;30(1):3. Unique Identifier : AIDSLINE MED/98155911
[AIDS: when a nightmare becomes controllable... (news)]: Fortschr Med. 1998 Jan 30;116(3):10-1. Unique Identifier : AIDSLINE MED/98183017
[Safer sex--do new therapies promote risk taking? (interview)]: Fortschr Med. 1998 Jan 30;116(3):11-2. Unique Identifier : AIDSLINE MED/98183018; Zippel S; Dermatologischen Klinik und Poliklinik, Munchen.
[Effects of physical exhaustion on immune systems]: Hokkaido Igaku Zasshi. 1998 Jan;73(1):61-71. Unique Identifier : AIDSLINE MED/98207815; Takahashi K; Department of Hygiene and Preventive Medicine, Hokkaido University; School of Medicine, Sapporo, Japan.; The present study was performed to elucidate the effects of physical fatigue on immune parameters of peripheral blood and splenic T cells in rats. Male Wistar rats aged 20 to 45 weeks were used for the experiment. Swimming was employed as a physical fatigue load. The rats in the single-load group with a weight equal t
Systematic method for determining intravenous drug treatment strategies aiding the humoral immune response.: IEEE Trans Biomed Eng. 1998 Apr;45(4):429-39. Unique Identifier : AIDSLINE MED/98217708; Rundell AE; DeCarlo R; Balakrishnan V; HogenEsch H; School of Electrical and Computer Engineering, Purdue University, West; Lafayette, IN 47906, USA. rundell@ecn.purdue.edu; This paper delineates a systematic method for determining optimal intravenous drug delivery strategies for patients having illnesses that primarily evoke a humoral immune response and are treatable by antibiotics. The method derives from a nonlinear, distributed predator-prey model that captures the dominant antigen
A common immunological epitope existing between HIV-1 gp41 and human interferon-alpha and -beta.: Immunobiology. 1998 Feb;198(4):333-42. Unique Identifier : AIDSLINE MED/98223953; Chen YH; Dierich MP; Department of Biological Science and Biotechnology, Tsinghua; University, Beijing, China.; Based on the similar effects that HIV-1 gp41 like human type I interferons (IFN-alpha and -beta) upregulated MHC expression and inhibited lymphocyte proliferation, we compared amino acid sequences of gp41 and human type I interferons (IFN-alpha and beta), and found sequence-similarity existing between the immunosuppre
Lack of protection from HIV infection by the mutant HIV coreceptor CCR5 in intravenously HIV infected hemophilia patients.: Immunobiology. 1998 Feb;198(4):485-8. Unique Identifier : AIDSLINE MED/98223965; Malo A; Rommel F; Bogner J; Gruber R; Schramm W; Goebel FD; Riethmuller G; Wank R; Institut fur Immunologie, Universitat Munchen, Germany.; The CCR5 chemokine receptor is an important coreceptor for macrophage-tropic HIV strains. Homozygous carriers of the mutated CCR5 receptor with a 32 bp deletion (delta 32-CCR5) are highly protected against HIV infection. A protective effect has also been described for heterozygous individuals carrying both mutated and
Perinatal transmission of HIV and diagnosis of HIV infection in infants: a review.: Ir J Med Sci. 1998 Jan-Mar;167(1):28-32. Unique Identifier : AIDSLINE MED/98201119; Nourse CB; Butler KM; Department of Paediatrics, University College Dublin, Crumlin, Dublin.; Paediatric HIV infection has become a major burden on families, communities and health services worldwide. The vast majority of children now acquire HIV as a result of mother to infant vertical) transmission. Recent major advances have occurred following the greater understanding of the risk factors for perinatal tran
Cyclin D1 overexpression detected by a simple competitive reverse transcription-polymerase chain reaction assay for lymphoid malignancies.: Jpn J Cancer Res. 1998 Feb;89(2):159-66. Unique Identifier : AIDSLINE MED/98208222; Taniguchi T; Fujita A; Takahashi S; Uchimaru K; Yoshikawa M; Asano S; Fujita T; Motokura T; Fourth Department of Internal Medicine, University of Tokyo, School of; Medicine.; t(11;14)(q13;q32) observed in B-cell malignancies is associated with cyclin D1 (bcl-1, PRAD1, CCND1) overexpression. We devised a simple competitive reverse transcription-polymerase chain reaction (RT-PCR) assay for rapid detection of cyclin D1 overexpression. Sharing a single upstream primer derived from a homologous
Management of the orthopaedic complications of haemophilia [editorial]: J Bone Joint Surg Br. 1998 Mar;80(2):191-6. Unique Identifier : AIDSLINE MED/98206518; Rodriguez-Merchan EC
Identification of biological activity profiles using substructural analysis and genetic algorithms.: J Chem Inf Comput Sci. 1998 Mar-Apr;38(2):165-79. Unique Identifier : AIDSLINE MED/98199332; Gillet VJ; Willett P; Bradshaw J; Department of Information Studies, University of Sheffield, Western; Bank, United Kingdom. V.GILLET@SHEFFIELD.AC.UK; A substructural analysis approach is used to calculate biological activity profiles, which contain weights that describe the differential occurrences of generic features (specifically, the numbers of hydrogen-bond donors and acceptors, the numbers of rotatable bonds and aromatic rings, the molecular weights, and the 2
Determination of HCV RNA concentration by direct quantitation of the products from a single RT-PCR.: J Virol Methods. 1997 Dec;69(1-2):113-24. Unique Identifier : AIDSLINE MED/98163285; Perez-Ruiz M; Torres C; Garcia-Lopez PA; Ruiz-Extremera A; Salmeron J; Berzal-Herranz A; Instituto de Parasitologia y Biomedicina Lopez Neyra CSIC, Hospital; Clinico Universitario, Granada, Spain.; A novel method for the estimation of HCV RNA levels in vivo was developed, based on competitive RT-PCR. The use of the Tth DNA polymerase and 5 32P-labeled antisense primer respectively reduced cross-contamination and permitted the direct quantification of viral loads by the analysis of the radioactivity of PCR produ
Semi-quantitative detection of cytomegalovirus DNA from native serum and plasma by nested PCR: influence of DNA extraction procedures.: J Virol Methods. 1997 Dec;69(1-2):125-35. Unique Identifier : AIDSLINE MED/98163286; Hamprecht K; Mikeler E; Jahn G; Abt. Medizinische Virologie und Epidemiologie der Viruskrankheiten,; Hygiene-Institut der Universitat Tubingen, Germany.; klaus.hamprecht@uni-tuebingen.de; The diagnostic implications of different procedures of DNA extraction were examined for the detection of HCMV DNA from sera and plasma of immunosuppressed patients. The detection limit of HCMV plasmid DNA from cell free seronegative plasma and serum by limiting dilution nested PCR decreased in the following sequence:
Quantification of HIV-1 proviral DNA from peripheral blood mononuclear cells using a high throughput four-competitor competitive PCR.: J Virol Methods. 1997 Dec;69(1-2):171-80. Unique Identifier : AIDSLINE MED/98163290; Comandini UV; Sonnerborg A; Vahlne A; Yun Z; Department of Immunology, Microbiology, Pathology and Infectious; Diseases, Karolinska Institute, Huddinge Hospital, Sweden.; A multiple competitor PCR (mcPCR) was developed to quantify HIV-1 proviral DNA from peripheral blood mononuclear cells (PBMC). DNA extracted from a mixture of HIV infected PBMC and four size-mutated DNA competitors were co-amplified. The Cy5-fluorescence labelled PCR products were denatured by heating, separated using
Quantification of hepatitis B virus DNA using competitive PCR and a scintillation proximity assay.: J Virol Methods. 1997 Dec;69(1-2):197-208. Unique Identifier : AIDSLINE MED/98163293; Simpson PR; Yu XH; Redza ZM; Anson JG; Chan SH; Lin Y; Scitech Genetics Ltd., The Maxwell, Singapore, Singapore.; A rapid assay for the quantification of hepatitis B virus DNA in human serum was developed. The principle of the method combines competitive polymerase chain reaction (cPCR) (for the controlled amplification of hepatitis B virus DNA) and scintillation proximity assay (SPA) technology (for rapid detection and quantitat
HPV 16 DNA and mRNA in cervical brush samples quantified by PCR and microwell hybridization.: J Virol Methods. 1997 Dec;69(1-2):209-22. Unique Identifier : AIDSLINE MED/98163294; Forslund O; Lindqvist P; Haadem K; Czegledy J; Hansson BG; Clinical Virology Section, Department of Medical Microbiology, Malmo,; Sweden. Ola.Forslund@mikrobiol.mas.lu.se; To quantitate HPV 16 DNA and mRNA, biotinylated amplicons from PCR and reverse transcription PCR were captured on streptavidin-coated microtitre plates. The amount of amplicon was determined by colorimetric detection after hybridization with an alkaline phosphatase-labelled probe. Dynamic ranges of between 4 and 6 log
Reactivity of a new HIV-1 group O third generation A-HIV-1/-2 assay with an unusual HIV-1 seroconversion panel and HIV-1 group O/group M subtyped samples.: J Virol Methods. 1997 Dec;69(1-2):29-37. Unique Identifier : AIDSLINE MED/98163276; van Binsbergen J; Keur W; v.d. Graaf M; Siebelink A; Jacobs A; de Rijk D; Toonen J; Zekeng L; Afane Ze E; Gurtler LG; Organon Teknika, Boxtel, The Netherlands.; It was shown previously that about 97% of the anti-HIV-1 group O strain-positive samples were detected by crossreaction with native HIV-1 gp160 (Van Binsbergen et al., Evaluation of a new third generation anti-HIV-1/anti-HIV-2 assay with increased sensitivity for HIV-1 group O, J. Virol. Methods 60 (1996) 131-137). Fo
Genetic subtyping and epidemiological study of feline immunodeficiency virus by nested polymerase chain reaction-restriction fragment length polymorphism analysis of the gag gene.: J Virol Methods. 1998 Jan;70(1):107-11. Unique Identifier : AIDSLINE MED/98165664; Hohdatsu T; Motokawa K; Usami M; Amioka M; Okada S; Koyama H; Department of Veterinary Infectious Diseases, School of Veterinary; Medicine and Animal Sciences, Kitasato University, Towada, Aomori,; Japan. hohdatsu@vmas.kitasato-u.ac.jp; Genetic subtyping of feline immunodeficiency virus (FIV) was carried out by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. A 329-base pair fragment in the FIV gag gene was amplified by nested PCR, then digested with restriction enzymes, HindIII, PvuII and BamHI. Using the
Safety factors involved in the extraction of biologically active proteins from human immunodeficiency virus.: J Virol Methods. 1998 Jan;70(1):113-5. Unique Identifier : AIDSLINE MED/98165665; White EL; Bowdon BJ; Shannon WM; Southern Research Institute, Birmingham, AL 35205, USA. white@sri.org; The disruption of the viral coat of human immunodeficiency virus by Triton X-100, a nonionic detergent, is a time-dependent process which requires incubation times of 30 min or longer. Conditions for the production of a noninfectious sample from a viral pellet that can be used to measure reverse transcriptase activity
A recombinant protein based immunoassay for the combined detection of antibodies to HIV-1, HIV-2 and HTLV-I.: J Virol Methods. 1998 Jan;70(1):85-91. Unique Identifier : AIDSLINE MED/98165661; Benitez J; Palenzuela D; Rivero J; Gavilondo JV; Immunotechnology and Diagnostics Division, Center for Genetic; Engineering and Biotechnology, Havana, Cuba.; Lab.diagnostico@cigb.edu.cu; The aim of this study was to develop and evaluate a combined assay for the detection of antibodies to HIV-1, HIV-2 and HTLV-I human T-cell leukemia virus type I). A mixture of recombinant proteins and synthetic peptides was fixed to the surface of microELISA wells and a protein A peroxidase conjugate was used as trace
Characterization of endometrial T lymphocyte subpopulations in spontaneous early pregnancy loss.: Hum Reprod. 1998 Jan;13(1):44-7. Unique Identifier : AIDSLINE MED/98171179; Vassiliadou N; Bulmer JN; Department of Pathology, University of Newcastle, Royal Victoria; Infirmary, Newcastle upon Tyne, UK.; T lymphocyte subpopulations were compared in normal first trimester human decidua and in decidua associated with spontaneous abortion. Cryostat sections were labelled using a panel of monoclonal antibodies specific for CD3, CD8, CD4 and for the alphabeta and gammadelta heterodimers of the T cell receptor using an avid
Clinical comparison of an enhanced-sensitivity branched-DNA assay and reverse transcription-PCR for quantitation of human immunodeficiency virus type 1 RNA in plasma.: J Clin Microbiol. 1998 Mar;36(3):716-20. Unique Identifier : AIDSLINE MED/98167726; Nolte FS; Boysza J; Thurmond C; Clark WS; Lennox JL; Department of Pathology, Emory University School of Medicine, Atlanta,; Georgia 30322, USA. fnolte@emory.edu; The performance characteristics of an enhanced-sensitivity branched-DNA assay (bDNA) (Quantiplex HIV-1 version 2.0; Chiron Corp., Emeryville, Calif.) and a reverse transcription (RT)-PCR assay (AMPLICOR HIV-1 Monitor; Roche Diagnostic Systems, Inc., Branchburg, N.J.) were compared in a molecular diagnostic laboratory.
Highly sensitive method for amplification of human immunodeficiency virus type 2 DNA.: J Clin Microbiol. 1998 Mar;36(3):809-11. Unique Identifier : AIDSLINE MED/98167743; Damond F; Loussert-Ajaka I; Apetrei C; Descamps D; Souquiere S; Lepretre A; Matheron S; Brun-Vezinet F; Simon F; Laboratoire de Virologie, Hopital Bichat-Claude Bernard, Paris,; France.; We evaluated a new human immunodeficiency virus type 2 (HIV-2) DNA amplification strategy based on peripheral blood mononuclear cell long PCR (XL PCR) followed by nested PCR amplification. The primers used were located in the highly conserved long terminal repeat and in the pol regions of the genome. Five primer pairs
Intra-assay performance characteristics of five assays for quantification of human immunodeficiency virus type 1 RNA in plasma.: J Clin Microbiol. 1998 Mar;36(3):835-9. Unique Identifier : AIDSLINE MED/98167752; Lin HJ; Pedneault L; Hollinger FB; Division of Molecular Virology, Baylor College of Medicine, Houston,; Texas 77030, USA.; Three kits (Roche AMPLICOR human immunodeficiency virus type 1 [HIV-1] Monitor, Chiron enhanced-sensitivity bDNA, and Organon Teknika NASBA HIV-1 QT) and two in-house assays (from National Genetics Institute and Baylor College of Medicine) were compared with a blinded panel. The results were evaluated as to intra-assa
Detection and direct typing of herpes simplex virus in perianal ulcers of patients with AIDS by PCR.: J Clin Microbiol. 1998 Mar;36(3):848-9. Unique Identifier : AIDSLINE MED/98167756; do Nascimento MC; Sumita LM; de Souza VA; Pannuti CS; Instituto de Infectologia Emilio Ribas, Sao Paulo, SP, Brazil.; The presence of herpes simplex virus type 1 (HSV-1) and HSV-2 in perianal ulcerations of 41 AIDS patients was assessed by virus culture and a type-specific PCR-based assay. HSV was isolated from the lesion site in 24 of 41 (58.5%) patients, and HSV DNA was detected by PCR in all 24 (100%) of these specimens. Additiona
Stability of free and complexed human immunodeficiency virus p24 antigens during storage for various intervals [letter]: J Clin Microbiol. 1998 Mar;36(3):855. Unique Identifier : AIDSLINE MED/98167760; Arya SC
Senate voting and social construction of target populations: a study of AIDS policy making, 1987-1992.: J Health Polit Policy Law. 1998 Feb;23(1):107-32. Unique Identifier : AIDSLINE MED/98182752; Schroedel JR; Jordan DR; Claremont Graduate University.; Scholars have devoted considerable attention to analyzing the social construction of AIDS. To explore the politics of AIDS policymaking, this research uses Schneider and Ingram s (1993) theory of the social construction of target populations to evaluate the U.S. Senate s response to AIDS between 1987 and 1992. Our stu
Respiratory isolation of tuberculosis patients using clinical guidelines and an automated clinical decision support system.: Infect Control Hosp Epidemiol. 1998 Feb;19(2):94-100. Unique Identifier : AIDSLINE MED/98168925; Knirsch CA; Jain NL; Pablos-Mendez A; Friedman C; Hripcsak G; Department of Medicine, College of Physicians and Surgeons, Columbia; University, New York City, USA.; OBJECTIVE: To evaluate a clinical guideline and an automated computer protocol for detection and respiratory isolation of tuberculosis (TB) patients. DESIGN: An automated computer protocol was tested on a retrospective cohort of adult culture-positive TB patients admitted from 1992 to 1993 to Columbia-Presbyterian Med
T helper 1 response is dominant and localized to the synovial fluid in patients with Lyme arthritis.: J Immunol. 1998 Jan 15;160(2):1022-8. Unique Identifier : AIDSLINE MED/98211669; Gross DM; Steere AC; Huber BT; Tufts University School of Medicine, Department of Pathology, Boston,; MA 02111, USA.; Cytokines produced by subsets of CD4+ T helper cells responding to an infection influences the efficiency with which the host is able to mount a protective immune response. In an attempt to elucidate the population of active cells involved in the propagation of Lyme arthritis we have utilized intracellular cytokine st
Development of murine allergic asthma is dependent upon B7-2 costimulation.: J Immunol. 1998 Jan 15;160(2):1036-43. Unique Identifier : AIDSLINE MED/98211671; Keane-Myers AM; Gause WC; Finkelman FD; Xhou XD; Wills-Karp M; Department of Environmental Health Sciences, School of Hygiene and; Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.; Allergic asthma is thought to be mediated by CD4+ T lymphocytes producing the Th2-associated cytokines, IL-4, and IL-5. Recently, the costimulatory molecules B7-1 and B7-2, which are expressed on the surface of APC, have been suggested to influence the development of Th1 vs Th2 immune responses. We examined the in viv
T helper 1 and T helper 2 cells respond differentially to chemokines.: J Immunol. 1998 Jan 15;160(2):550-4. Unique Identifier : AIDSLINE MED/98211611; Siveke JT; Hamann A; Abteilung fur Immunologie, Medizinische Klinik,; Universitatskrankenhaus Eppendorf, Hamburg, Germany.; T effector subsets, such as Th1 or Th2 cells, are key players in inflammatory reactions. It is not known whether chemokines are able to recruit these subsets differentially, as has been shown for memory vs naive T cells. Here we demonstrate that Th1 and Th2 cells differ in their intrinsic migratory properties and thei
Suppression of immune responses by CD8 cells. I. Superantigen-activated CD8 cells induce unidirectional Fas-mediated apoptosis of antigen-activated CD4 cells.: J Immunol. 1998 Jan 15;160(2):559-65. Unique Identifier : AIDSLINE MED/98211613; Noble A; Pestano GA; Cantor H; Department of Cancer Immunology and AIDS, Dana Farber Cancer; Institute, Boston, MA 02115, USA.; Stimulation of mature CD4 cells through the TCR induces cellular activation and expansion that are often followed by clonal elimination by a form of apoptosis termed activation-induced cell death. This process of CD4 cell apoptosis is generally thought to reflect clonal suicide and to be independent of other cell type
Suppression of immune responses by CD8 cells. II. Qa-1 on activated B cells stimulates CD8 cell suppression of T helper 2 responses.: J Immunol. 1998 Jan 15;160(2):566-71. Unique Identifier : AIDSLINE MED/98211614; Noble A; Zhao ZS; Cantor H; Department of Cancer Immunology and AIDS, Dana Farber Cancer; Institute, Boston, MA 02115, USA.; We have investigated the role of MHC class I products and CD8 T cells in regulating Ab responses using beta2-microglobulin deficient (beta2m-/-) mice. Beta2m-/- mice produced stronger IgM and IgG responses than did control beta2m+/+ mice to both cellular and viral Ags. These Ab responses could be suppressed by infusio
Reduced T helper 1 responses in IL-12 p40 transgenic mice.: J Immunol. 1998 Jan 15;160(2):588-94. Unique Identifier : AIDSLINE MED/98211617; Yoshimoto T; Wang CR; Yoneto T; Waki S; Sunaga S; Komagata Y; Mitsuyama M; Miyazaki J; Nariuchi H; Department of Allergology, Institute of Medical Science, The; University of Tokyo, Japan.; To investigate the antagonistic effect of IL-12 p40 on IL-12 activity in vivo, we generated transgenic (Tg) mice in which p40 gene was regulated by a liver-specific promoter. Three Tg mouse lines were generated, and they expressed the p40 transgene predominantly in liver. Serum p40 level was extremely high, and it con
MHC class II expression in double mutant mice lacking invariant chain and DM functions.: J Immunol. 1998 Jan 15;160(2):606-14. Unique Identifier : AIDSLINE MED/98211619; Kenty G; Martin WD; Van Kaer L; Bikoff EK; Department of Molecular and Cellular Biology, The Biological; Laboratories, Harvard University, Cambridge, MA 02138, USA.; Invariant (Ii) chain and DM functions are required at distinct stages during class II maturation to promote occupancy by diverse peptide ligands. The class II molecules expressed by mutant mouse strains lacking Ii chain or DM activities display discrete structural and functional abnormalities. The present report descr
The level of CD4 surface protein influences T cell selection in the thymus.: J Immunol. 1998 Jan 15;160(2):634-42. Unique Identifier : AIDSLINE MED/98211622; Frank GD; Parnes JR; Department of Medicine, Stanford University School of Medicine, CA; 94305, USA.; During T cell development thymocytes are subjected to positive and negative selection criteria to ensure that the mature T cell repertoire is MHC restricted, yet self tolerant at the same time. The CD4 and CD8 coreceptors are thought to play a crucial role in this developmental process. To elucidate the role of CD4 in
Opposite CD4/CD8 lineage decisions of CD4+8+ mouse and rat thymocytes to equivalent triggering signals: correlation with thymic expression of a truncated CD8 alpha chain in mice but not rats.: J Immunol. 1998 Jan 15;160(2):700-7. Unique Identifier : AIDSLINE MED/98211630; Mitnacht R; Bischof A; Torres-Nagel N; Hunig T; Institute for Virology and Immunobiology, University of Wurzburg,; Germany.; Unselected CD4+8+ rat thymocytes, generated in vitro from their direct precursors, are readily converted to functional TCRhigh T cells by stimulation with immobilized TCR-specific mAb plus IL-2 . Lineage decision invariably occurs toward CD4-8+, regardless of the timing
Positive selection of thymocytes expressing the same TCR by different MHC ligands results in the production of functionally distinct thymocytes distinguished by differential expression of the heat stable antigen.: J Immunol. 1998 Jan 15;160(2):718-27. Unique Identifier : AIDSLINE MED/98211632; Teh HS; Motyka B; Teh SJ; Department of Microbiology and Immunology, University of British; Columbia, Vancouver, Canada.; The issue of whether the signaling process during positive selection can affect the efficiency by which the positively selected T cells respond to antigenic stimulation has not been addressed. We approached this question by determining the consequences of positive selection of a particular transgenic TCR 2C TCR) in th
Lack of local suppression in orally tolerant CD8-deficient mice reveals a critical regulatory role of CD8+ T cells in the normal gut mucosa.: J Immunol. 1998 Jan 15;160(2):754-62. Unique Identifier : AIDSLINE MED/98211636; Grdic D; Hornquist E; Kjerrulf M; Lycke NY; Department of Medical Microbiology and Immunology, University of; Goteborg, Sweden.; We found that feeding keyhole limpet hemocyanin (KLH) to CD8-deficient (CD8-/-) mice induced oral tolerance that was comparable in both magnitude and quality to that induced in wild-type (wt) mice. The tolerance was dose dependent, and only higher doses of KLH caused significant reduction in specific Ab and T cell res
Presence of activated antigen-binding B cells during immunization enhances relative levels of IFN-gamma in T cell responses.: J Immunol. 1998 Jan 15;160(2):778-87. Unique Identifier : AIDSLINE MED/98211639; Pasare C; Morafo V; Entringer M; Bansal P; George A; Bal V; Rath S; Durdik JM; National Institute of Immunology, New Delhi, India.; To examine the influence of Ag presentation by B cells on immune responses, we have used mice transgenic for an Ig heavy chain from a monoclonal anti-azobenzenearsonate (Ars) Ab to deliver Ag to B cells during immunization. A large proportion of transgene-expressing B cells in these mice binds Ars, while transgenic se
CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen.: J Immunol. 1998 Jan 15;160(2):870-6. Unique Identifier : AIDSLINE MED/98211649; Davis HL; Weeranta R; Waldschmidt TJ; Tygrett L; Schorr J; Krieg AM; Loeb Research Institute, Ottawa Civic Hospital, ON, Canada.; hdavis@civich.ottawa.on.ca; Unmethylated CpG dinucleotides in bacterial DNA or synthetic oligodeoxynucleotides (ODN) cause B cell proliferation and Ig secretion, monocyte cytokine secretion, and activation of NK cell lytic activity and IFN-gamma secretion in vivo and in vitro. The potent immune activation by CpG ODN suggests possible utility for
Identification and characterization of the CXCR4 chemokine receptor in human T cell lines: ligand binding, biological activity, and HIV-1 infectivity.: J Immunol. 1998 Jan 15;160(2):877-83. Unique Identifier : AIDSLINE MED/98211650; Hesselgesser J; Liang M; Hoxie J; Greenberg M; Brass LF; Orsini MJ; Taub D; Horuk R; Department of Immunology, Berlex BioSciences, Richmond, CA 94804, USA.; The CXCR4 chemokine receptor has been shown to respond to the C-X-C chemokine stromal-derived factor (SDF-1) and has recently been shown to be an important coreceptor for HIV-1 infection. In the present paper we have tested a number of human lymphocyte cell lines, including Jurkat, HUT78, CEM, and Sup-T1 for the prese
Perforin-deficient CD8+ T cells provide immunity to Listeria monocytogenes by a mechanism that is independent of CD95 and IFN-gamma but requires TNF-alpha.: J Immunol. 1998 Jan 15;160(2):898-905. Unique Identifier : AIDSLINE MED/98211653; White DW; Harty JT; Interdisciplinary Graduate Program in Immunology, University of Iowa,; Iowa City 52242, USA.; CD8+ T cells are effective mediators of immunity against Listeria monocytogenes, but the mechanisms by which they provide antilisterial immunity are poorly understood. CD8+ T cells efficiently lyse target cells in vitro by at least two independent pathways. To test the hypothesis that CD8+ T cell-mediated immunity to
Gene organization and promoter function for CC chemokine receptor 5 (CCR5).: J Immunol. 1998 Jan 15;160(2):985-92. Unique Identifier : AIDSLINE MED/98211664; Guignard F; Combadiere C; Tiffany HL; Murphy PM; Laboratory of Host Defenses, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892, USA.; CC chemokine receptor 5 (CCR5) functions physiologically as a receptor for the leukocyte chemoattractants macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, and RANTES, and functions pathologically as a key cell entry coreceptor for HIV-1. The factors that regulate CCR5 expression may be us
Disseminated Rhodococcus equi and Nocardia farcinica infection in a patient with sarcoidosis [letter]: J Infect. 1998 Jan;36(1):134-5. Unique Identifier : AIDSLINE MED/98175443; Mohammedi I; Vedrinne JM; Floccard B; Reverdy ME; Duperret S; Motin J
Ganciclovir and foscarnet efficacy in AIDS-related CMV polyradiculopathy.: J Infect. 1998 Jan;36(1):29-33. Unique Identifier : AIDSLINE MED/98175416; Anders HJ; Weiss N; Bogner JR; Goebel FD; The Medical Policlinic, Ludwigs-Maximilian University, Munich,; Germany.; Cytomegalovirus ( CMV ) polyradiculopathy is a rare complication of AIDS in which ascending motor weakness, sensory loss and urinary retention are associated with polymorphonuclear pleocytosis and positive CMV polymerase chain reaction in the cerebrospinal fluid C
Variation in morphotype, karyotype and DNA type of fluconazole resistant Candida albicans from an AIDS patient.: J Infect. 1998 Jan;36(1):57-62. Unique Identifier : AIDSLINE MED/98175421; Takasuka T; Baily GG; Birch M; Anderson MJ; Law D; Denning DW; Department of Medicine, University of Manchester School of Medicine,; UK.; Azole-resistant oropharyngeal and oesophageal candidiasis is a recent phenomenon observed in patients with AIDS usually previously treated with fluconazole. Some variation has been observed in antifungal susceptibility testing among separate colonies of Candida albicans from the same patient. This raises the question
Antibodies to mycoplasma fermentans in HIV-positive heterosexual patients: seroprevalence and association with AIDS.: J Infect. 1998 Jan;36(1):79-84. Unique Identifier : AIDSLINE MED/98175425; Horowitz S; Horowitz J; Hou L; Fuchs E; Rager-Zisman B; Jacobs E; Alkan M; Department of Microbiology and Immunology, Faculty of Health Sciences,; Soroka Medical Centre, Ben-Gurion University of the Negev, Beer-Sheva,; Israel.; There are conflicting reports concerning the prevalence of Mycoplasma fermentans in HIV-positive patients and its association with AIDS. Serum antibodies to M. fermentans were measured by a modified immunoblotting technique in 48 HIV-positive heterosexual patients and in 30 HIV-negative heterosexual controls. Antibodi
The role of CD40/CD154 interactions in the priming, differentiation, and effector function of helper and cytotoxic T cells.: J Leukoc Biol. 1998 Apr;63(4):418-28. Unique Identifier : AIDSLINE MED/98204129; Mackey MF; Barth RJ Jr; Noelle RJ; Department of Microbiology, Dartmouth Medical School and the Norris; Cotton Cancer Center, Lebanon, New Hampshire 03756, USA.; This review focuses on the emerging body of literature suggesting a critical role for CD40/CD154 interactions in antigen-presenting cell (APC) activation, CD4+ and CD8+ T cell priming, and effector T cell maturation. In this context effective antigen presentation involves not only T cell expansion and long-term surviv
HIV-1 induces human monocyte-derived macrophages to produce C3 and to fix C3 on their surface.: J Leukoc Biol. 1998 Apr;63(4):463-8. Unique Identifier : AIDSLINE MED/98204134; Bajtay Z; Kacani L; Erdei A; Dierich MP; Department of Immunology, Eotvos Lorand University, God, Hungary.; Complement components, particularly C3, are known to be involved in the pathogenesis of AIDS and macrophages may serve as a source of C3 at sites of infection. We investigated whether the interaction between HIV-1 and monocytes has any effect on C3 production by the cells. Monocytes isolated from the blood of healthy
Detection of HIV proviral DNA on toothbrushes: a preliminary study.: J Okla Dent Assoc. 1994 Winter;84(3):17-20. Unique Identifier : AIDSLINE MED/98186984; Glass RT; Carson SR; Barker RL; Peiper SC; Shapiro S; Department of Oral Pathology, University of Oklahoma College of; Dentistry, USA.
Optimal conditions of immune complex transfer enzyme immunoassay for p24 antigen of HIV-1.: J Clin Lab Anal. 1998;12(2):115-20. Unique Identifier : AIDSLINE MED/98184982; Hashida S; Ishikawa S; Hashinaka K; Nishikata I; Saito A; Takamizawa A; Shinagawa H; Ishikawa E; Department of Biochemistry, Miyazaki Medical College, Kiyotake, Japan.; In the immune complex transfer enzyme immunoassay for HIV-1 p24 antigen, different preparations of anti-p24 Fab -beta-D-galactosidase conjugate, various periods of time for immunoreactions involved, and shaking for incubations with polystyrene beads were tested. On the basis of the results of these experiments, p24 an
Optimal conditions of immune complex transfer enzyme immunoassays for antibody IgGs to HIV-1 using recombinant p17, p24, and reverse transcriptase as antigens.: J Clin Lab Anal. 1998;12(2):98-107. Unique Identifier : AIDSLINE MED/98184980; Hashida S; Ishikawa S; Hashinaka K; Nishikata I; Oka S; Shimada K; Saito A; Takamizawa A; Shinagawa H; Ishikawa E; Department of Biochemistry, Miyazaki Medical College, Japan.; The immune complex transfer enzyme immunoassays for antibody IgGs to p17, p24, and reverse transcriptase (RT) of HIV-1 were tested under various conditions. Antibody IgGs to HIV-1 were reacted for up to 20 hr with 2,4-dinitrophenyl-bovine serum albumin-recombinant HIV-1 protein conjugates and recombinant HIV-1 protein
A pilot study of combination therapy with indinavir, stavudine d4T), and didanosine (ddI) in children infected with the human immunodeficiency virus.: J Pediatr. 1998 Mar;132(3 Pt 1):543-6. Unique Identifier : AIDSLINE MED/98204481; Kline MW; Fletcher CV; Harris AT; Evans KD; Brundage RC; Remmel RP; Calles NR; Kirkpatrick SB; Simon C; Department of Pediatrics, Baylor College of Medicine and Texas; Children's Hospital, Houston 77030, USA.; Twelve children infected with the human immunodeficiency virus were treated orally with indinavir , stavudine , plus didanosine for 12 to 48 weeks. Therapy was limited in some cases by
[12th World AIDS Conference announces call for abstracts--Geneva to host world's foremost AIDS Conference; focus on "bridging the gap"]: Nippon Seirigaku Zasshi. 1997;59(12):469-70. Unique Identifier : AIDSLINE MED/98187495
The costs of triple-drug anti-HIV therapy for adults in the Americas [letter]: JAMA. 1998 Apr 22-29;279(16):1263-4. Unique Identifier : AIDSLINE MED/98224676; Montaner JS; Hogg RS; Weber AE; Anis AH; O'Shaughnessy MV; Schechter MT
Sex-related alcohol expectancies as moderators of the relationship between alcohol use and risky sex in adolescents.: J Stud Alcohol. 1998 Jan;59(1):71-7. Unique Identifier : AIDSLINE MED/98158083; Dermen KH; Cooper ML; Agocha VB; Research Institute on Addictions, Buffalo, New York 14203, USA.; OBJECTIVE: Alcohol is frequently identified as a potential contributor to HIV-related sexual risk taking. Drawing on alcohol expectancy explanations for postdrinking behavior, the present study tested the hypothesis that adolescents who drink alcohol on a given occasion will be more likely to engage in sexual risk-tak
Heterogeneity in the relationship between the time tradeoff and Short Form-36 for HIV-infected and primary care patients.: Med Care. 1998 Apr;36(4):523-32. Unique Identifier : AIDSLINE MED/98204150; Bult JR; Hunink MG; Tsevat J; Weinstein MC; Monitor Company, Cambridge, MA, USA.; OBJECTIVES: Evidence in the literature suggests that the overall correlation between descriptive and valuational measures of health are weak to moderate. In this study, the relationship between descriptive health status measures, obtained using the Short-Form 36, and health values, measured with the time tradeoff, was
Functional status transitions and survival in HIV disease: evidence from the AIDS Costs and Service Utilization Survey.: Med Care. 1998 Apr;36(4):533-43. Unique Identifier : AIDSLINE MED/98204151; Fleishman JA; Crystal S; Center for Cost and Financing Studies, Agency for Health Care Policy; and Research, Rockville, MD 20852, USA.; OBJECTIVE: The authors examined the prevalence of limitations in physical functioning in a large sample of people with human immunodeficiency virus (HIV) infection and the patterns of change in their functional status with time. METHODS: Patients receiving treatment for HIV infection were sampled from 26 providers in
[Recommendations on antiretroviral treatment. The AIDS Study Group of the Spanish Society of Infectious Diseases and Clinical Microbiology]: Med Clin (Barc). 1998 Jan 31;110(3):109-16. Unique Identifier : AIDSLINE MED/98195631; Moreno S; Arrizabalaga J; Gatell JM; Clotet B; Aguirrebengoa K; Antela A; Iribarren JA; Laguna F; Miro JM; Ocana I; Rubio R; Viciana P; Podzamczer D; Hospital Morales Meseguer, Murcia.
[Prevalence of oral lesions diagnosed in a group of intravenous drug addict prisoners with AIDS and their correlation with CD4 lymphocyte count (letter)]: Med Clin (Barc). 1998 Jan 31;110(3):119. Unique Identifier : AIDSLINE MED/98195635; Esparza Gomez GC; Garcia-Pola Vallejo MJ; Aguirre Urizar JM; Giron Morazo FJ
Antiretrovirals during pregnancy in HIV-1-positive women in New York City [letter]: Lancet. 1998 Apr 4;351(9108):1029-30. Unique Identifier : AIDSLINE MED/98206588; Fischer C; Rosenwald V; Harewood L; Blum C
US court to rule whether HIV infection constitutes disability [news]: Lancet. 1998 Apr 4;351(9108):1041. Unique Identifier : AIDSLINE MED/98206600; McCarthy M
Highly active antiretroviral therapy [letter]: Lancet. 1998 Apr 4;351(9108):1056; discussion 1058-9. Unique Identifier : AIDSLINE MED/98206605; Di Perri G; Bonora S; Vento S; Allegranzi B; Concia E
Highly active antiretroviral therapy [letter]: Lancet. 1998 Apr 4;351(9108):1056-7; discussion 1058-9. Unique Identifier : AIDSLINE MED/98206606; French M; Lenzo N; John M; Mallal S; Price P
Highly active antiretroviral therapy [letter]: Lancet. 1998 Apr 4;351(9108):1057-8; discussion 1058-9. Unique Identifier : AIDSLINE MED/98206607; Behrens G; Knuth C; Schedel I; Mendila M; Schmidt RE
Highly active antiretroviral therapy [letter]: Lancet. 1998 Apr 4;351(9108):1058; discussion 1058-9. Unique Identifier : AIDSLINE MED/98206608; Harindra V; Foley E
Highly active antiretroviral therapy [letter]: Lancet. 1998 Apr 4;351(9108):1058; discussion 1058-9. Unique Identifier : AIDSLINE MED/98206609; Vento S; Renzini C; Casali F; Ghironzi G; Concia E
Highly active antiretroviral therapy [letter]: Lancet. 1998 Apr 4;351(9108):1059-60. Unique Identifier : AIDSLINE MED/98206610; Drobniewski F; Eltringham I
[Genetic predisposition to infectious diseases]: Med Trop (Mars). 1997;57(3 Suppl):10-2. Unique Identifier : AIDSLINE MED/98174357; Dessein A; INSERM U399 Immunologie et Genetique des Maladies Parasitaires,; Faculte de Medecine, Marseille, France.; At the present time more is known about barriers to transmission of infectious agents between species than barriers to transmission within the same species. However differences in resistance to infection have been well-established within given species of various plants and domestic farm animals. Unsurprisingly several
HIV-protease inhibitors.: N Engl J Med. 1998 Apr 30;338(18):1281-92. Unique Identifier : AIDSLINE MED/98213300; Flexner C; Department of Medicine, Johns Hopkins University School of Medicine,; Baltimore, MD, USA.
Hepatitis B virus infection [letter]: N Engl J Med. 1998 Apr 30;338(18):1311-2; discussion 1312-3. Unique Identifier : AIDSLINE MED/98213306; Abramowicz D; Blanpain C; Knoop C
Hepatitis B virus infection [letter]: N Engl J Med. 1998 Apr 30;338(18):1312; discussion 1312-3. Unique Identifier : AIDSLINE MED/98213307; Koblin BA; Taylor PE; Stevens CE
AIDS therapy in Brazil [letter]: Nature. 1998 Apr 2;392(6675):431. Unique Identifier : AIDSLINE MED/98208020; Castello-Branco LR; Linhares-Carvalho MI; Ponce de Leon AC
[Longitudinal echocardiographic study of HIV positive patients]: Minerva Cardioangiol. 1997 Nov;45(11):573-9. Unique Identifier : AIDSLINE MED/98210457; Cottini E; Raspagliesi M; Giacone G; Cosentino M; Rando G; Vintaloro G; Cirino A; Spagnoli R; Istituto di Clinica Medica II L. Condorellio, Universita degli Studi,; Catania.; BACKGROUND: From May 1992 to June 1996 the authors have studied a group of 39 subjects with positive anti-HIV, with echo 2D color Doppler examination, to evaluate with semi-annual controls, the wide variety of cardiac complications in the various phases of clinical evolution of the illness. METHODS: At the moment of r
[Laboratory diagnosis of intestinal micro-parasitosis in AIDS patients: state of the art]: Minerva Med. 1998 Jan-Feb;89(1-2):23-7. Unique Identifier : AIDSLINE MED/98221793; Terra L; Pellicano S; Milano M; Ospedale S. Giovanni di Dio, Divisione di Malattie Infettive, ASL n.; 5, Crotone.; BACKGROUND: The diarrhea, often associated with growing thin and weight loss, is important for nutritional state and quality of life in AIDS patients. It was demonstrated that patients with AIDS who present diarrhea have a greater degree of immunosuppression than those without diarrhea, predisposing the gastrointestin
Human renal allograft rejection: molecular characterization.: Nephrol Dial Transplant. 1998;13 Suppl 1:21-4. Unique Identifier : AIDSLINE MED/98168336; Suthanthiran M; Department of Medicine, New York Hospital-Cornell Medical Center, NY,; USA.
Donor insemination and human immunodeficiency virus transmission.: Obstet Gynecol. 1998 Apr;91(4):515-8. Unique Identifier : AIDSLINE MED/98200002; Wortley PM; Hammett TA; Fleming PL; Division of HIV/AIDS Prevention, National Centers for HIV, STD, and TB; Prevention, Centers for Disease Control and Prevention, Atlanta,; Georgia 30333, USA. pmwl@cdc.gov; OBJECTIVE: To describe cases of AIDS attributed to donor insemination identified through national human immunodeficiency virus (HIV)/AIDS surveillance and to compare the number identified through surveillance with our estimate of the number of women infected as a result of donor insemination before the initiation of d
Human immunodeficiency virus test refusal in pregnancy: a challenge to voluntary testing.: Obstet Gynecol. 1998 Apr;91(4):540-5. Unique Identifier : AIDSLINE MED/98200006; Carusi D; Learman LA; Posner SF; Department of Obstetrics, Gynecology and Reproductive Sciences,; University of California, San Francisco, USA.; OBJECTIVE: To determine if awareness of methods to reduce vertical transmission of human immunodeficiency virus (HIV) is associated with HIV test acceptance and to clarify patients attitudes toward routine versus elective prenatal HIV testing. METHODS: In a cross-sectional study, 247 antenatal patients were surveyed
Characterization of receptors with a new negative image: use in molecular docking and lead optimization.: Proteins. 1998 Feb 15;30(3):321-36. Unique Identifier : AIDSLINE MED/98176724; Oshiro CM; Kuntz ID; Department of Pharmaceutical Chemistry, University of California, San; Francisco 94143, USA.; The characterization of receptor binding sites is an important aspect of molecular docking, molecular recognition, and the structure-based design process. This characterization can take several forms: the receptor surface itself can be delineated or described, the space adjacent to the surface can be chemically mapped
[Diabetes and hyperglycemia in patients under treatment for HIV infection with the protease inhibitors indavir, ritonavir, saquinavir as well as nelfinavir (in development, but not yet released (news)]: Pharm Unserer Zeit. 1997 Dec;26(6):317. Unique Identifier : AIDSLINE MED/98174761
The relationship of mood, endocrine, and sexual disorders in human immunodeficiency virus positive (HIV+) women: an exploratory study.: Psychosom Med. 1998 Jan-Feb;60(1):11-6. Unique Identifier : AIDSLINE MED/98151197; Goggin K; Engelson ES; Rabkin JG; Kotler DP; Aaron Diamond Foundation, New York State Psychiatric Institute,; Cornell Medical College, USA.; OBJECTIVE: This exploratory study assessed the prevalence of mood disorders, sexual disorders, and endocrine abnormalities, and explored the relationship between these parameters in a sample of HIV+ women. METHOD: Fifty-four HIV+ women were evaluated with the Structured Clinical Interview for DSM-III-R (SCID) and meas
Epstein-Barr virus-induced lymphoblastoid cell lines from patients with primary immunodeficiency diseases.: Scand J Immunol. 1980;11(2):155-62. Unique Identifier : AIDSLINE MED/98198145; Tsuchiya S; Konno T; Tada K; Ono Y; Department of Pediatrics, Tohoku University School of Medicine,; Sendai, Japan.; Peripheral lymphocytes from eight patients with congenital immunodeficiency diseases were infected with Epstein-Barr virus EBV) in an attempt to establish B lymphoblastoid cell lines LCL). These patients included three boys with congenital agammaglobulinaemia, two girls with hypogammaglobulinaemia, one boy with common
Lives in the balance [news]: Sci Am. 1998 Apr;278(4):17-8. Unique Identifier : AIDSLINE MED/98193960; Beardsley T
Viruses have many ways to be unwelcome guests [news]: Science. 1998 Apr 10;280(5361):204-5. Unique Identifier : AIDSLINE MED/98225996; Balter M
The numbers game for virus-specific CD8+ T cells.: Science. 1998 Apr 10;280(5361):227. Unique Identifier : AIDSLINE MED/98225998; Doherty PC; Department of Immunology, St. Jude Children's Research Hospital,; Memphis, TN 38105, USA. peter.doherty@stjude.org
Crystal structure and evolution of a transfer RNA splicing enzyme.: Science. 1998 Apr 10;280(5361):279-84. Unique Identifier : AIDSLINE MED/98202609; Li H; Trotta CR; Abelson J; Division of Biology, Mail Code 147-75, California Institute of; Technology, Pasadena, CA 91125, USA.; The splicing of transfer RNA precursors is similar in Eucarya and Archaea. In both kingdoms an endonuclease recognizes the splice sites and releases the intron, but the mechanism of splice site recognition is different in each kingdom. The crystal structure of the endonuclease from the archaeon Methanococcus jannaschi
Medical management of the pregnant woman infected with human immunodeficiency virus type 1 and her child.: Semin Perinatol. 1998 Feb;22(1):72-86. Unique Identifier : AIDSLINE MED/98184002; Andiman WA; Department of Pediatrics, Yale University School of Medicine, New; Haven, CT 06520, USA.; Heterosexual contact and intravenous drug use continue to result in new cases of human immunodeficiency virus type 1 (HIV-1) infection among adolescents and women of childbearing age. In North American and European surveys, 0.1% to 0.3% of childbearing women are infected with HIV; rates are 10 to 20 times higher in so
Depletion of mitochondrial DNA by ddC in untransformed human cell lines.: Somat Cell Mol Genet. 1997 Jul;23(4):287-90. Unique Identifier : AIDSLINE MED/98203657; Nelson I; Hanna MG; Wood NW; Harding AE; Department of Clinical Neurology, Institute of Neurology, Queen; Square, London.; In order to study the interaction between the nuclear and mitochondrial genomes we have developed a non-transformed cell system. It is based upon the complete removal of mtDNA from fibroblasts by treatment with a nucleoside analogue, 2 ,3 dideoxycytidine (
Prenatal human immunodeficiency virus and sexually transmitted disease screening. Getting the message across [editorial]: Sex Transm Dis. 1998 Mar;25(3):137-8. Unique Identifier : AIDSLINE MED/98185678; Greenblatt RM
Do spermicides containing nonoxynol-9 prevent sexually transmitted infections? A meta-analysis.: Sex Transm Dis. 1998 Mar;25(3):144-50. Unique Identifier : AIDSLINE MED/98185680; Cook RL; Rosenberg MJ; Robert Wood Johnson Clinical Scholars Program, University of North; Carolina at Chapel Hill, USA.; BACKGROUND AND OBJECTIVES: There are conflicting opinions on whether to recommend spermicides containing nonoxynol-9 for prevention of sexually transmitted diseases, including human immunodeficiency virus (HIV). GOAL: To systematically review and summarize the medical literature on the effect of spermicides containing
Physicians' practices and opinions regarding prenatal screening for human immunodeficiency virus and other sexually transmitted diseases.: Sex Transm Dis. 1998 Mar;25(3):169-75. Unique Identifier : AIDSLINE MED/98185684; Mills WA; Martin DL; Bertrand JR; Belongia EA; Acute Disease Epidemiology Section, Minnesota Department of Health,; Minneapolis 55440, USA.; BACKGROUND AND OBJECTIVES: Early prenatal diagnosis of sexually transmitted diseases (STDs), particularly human immunodeficiency virus (HIV), is critical for maternal and infant health. We conducted a survey to assess physicians prenatal STD screening practices and opinions. STUDY DESIGN: A random sample of obstetric
Oral malignancies diagnosed in an HIV-dedicated dental clinic.: Tex Dent J. 1996 Jun;113(6):49-57. Unique Identifier : AIDSLINE MED/98179352; Flaitz CM; Nichols CM; Hicks MJ; Division of Oral Pathology, University of Texas-Houston, Health; Science Center Dental Branch 77030-3402, USA.
Selective quasispecies transmission after systemic or mucosal exposure of macaques to simian immunodeficiency virus.: Virology. 1998 Mar 30;243(1):12-20. Unique Identifier : AIDSLINE MED/98201641; Neildez O; Le Grand R; Caufour P; Vaslin B; Cheret A; Matheux F; Theodoro F; Roques P; Dormont D; CEA, Service de Neurovirologie, CRSSA, Fontenay aux Roses, France.; Sexual transmission is the major cause of the AIDS epidemic. For the development of new antiviral and vaccine strategies, we therefore need to understand the mechanisms by which lentiviruses cross the mucosal barrier and the subsequent pathogenic consequences. For this purpose, experimental approaches are greatly faci
Reactivities of human sera with human herpesvirus-8-infected BCBL-1 cells and identification of HHV-8-specific proteins and glycoproteins and the encoding cDNAs.: Virology. 1998 Mar 30;243(1):208-17. Unique Identifier : AIDSLINE MED/98201660; Chandran B; Smith MS; Koelle DM; Corey L; Horvat R; Goldstein E; Department of Microbiology, Molecular Genetics and Immunology,; University of Kansas Medical Center, Kansas City 66160, USA.; bchandra@kumc.edu; The reactivates of human sera with uninduced and phorbol ester TPA)-induced human herpesvirus-8 (HHV-8)-infected BCBL-1 cells were examined by immunofluorescence assay (IFA) and by radioimmunoprecipitation reactions (RIP). The seroprevalence of HHV-8 infections is low in the United States
Identification and characterization of virus assembly intermediate complexes in HIV-1-infected CD4+ T cells.: Virology. 1998 Mar 30;243(1):78-93. Unique Identifier : AIDSLINE MED/98201647; Lee YM; Yu XF; Department of Molecular Microbiology and Immunology, School of Hygiene; and Public Health, Johns Hopkins University, Baltimore, Maryland; 21205, USA.; For type-C and lentiviruses, including human immunodeficiency virus type 1 (HIV-1), the pathway of virus assembly remains poorly defined, and the assembly and budding of capsids are believed to occur simultaneously at the plasma membrane of the infected cell. We have now identified two putative HIV-1 assembly intermed
Activation of BLV transcription by NF-kappa B and Tax.: Virology. 1998 Mar 30;243(1):94-8. Unique Identifier : AIDSLINE MED/98201648; Brooks PA; Cockerell GL; Nyborg JK; Department of Pathology, Colorado State University, Fort Collins; 80523, USA.; Bovine leukemia virus (BLV) is the causative agent of bovine leukosis, a naturally occurring fatal disease in cattle. BLV transcription is regulated by cellular transcription factors and the virally encoded oncoprotein Tax. In this report, we investigated the functional role of the putative NF-kappa B binding site rec
The origin and evolution of human T-cell lymphotropic virus types I and II.: Virus Genes. 1998;16(1):69-84. Unique Identifier : AIDSLINE MED/98223987; Suzuki Y; Gojobori T; Center for Information Biology, National Institute of Genetics,; Mishima, Japan.; Studies on human T-cell lymphotropic virus types I (HTLV-I) and II (HTLV-II) are briefly reviewed from the viewpoint of molecular evolution, with special reference to the evolutionary rate and evolutionary relationships among these viruses. In particular, it appears that, in contrast to the low level of variability of
Angioimmunoblastic lymphadenopathy with dysproteinemia: emphasis on pathogenesis and treatment.: Acta Haematol. 1998;99(2):57-64. Unique Identifier : AIDSLINE MED/98213113; Sallah S; Gagnon GA; Division of Hematology/Oncology, East Carolina University Medical; School, Greenville, NC 27858, USA.; Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is a rare lymphoproliferative disorder characterized by diffuse lymphadenopathy, fever, hepatosplenomegaly, hemolytic anemia, and polyclonal hypergammaglobulinemia. Morphologically, the involved lymph nodes demonstrate complete effacement of the normal arch
Antiretroviral therapy in human immunodeficiency virus-infected individuals.: Adv Intern Med. 1998;43:373-402. Unique Identifier : AIDSLINE MED/98167088; Spooner KM; Department of Internal Medicine, National Naval Medical Center,; Bethesda, Maryland, USA.
AIDS in persons 50 years of age and older [news]: Am Fam Physician. 1998 Apr 1;57(7):1691-2. Unique Identifier : AIDSLINE MED/98217399
Volunteer participation in context: motivations and political efficacy within three AIDS organizations.: Am J Community Psychol. 1997 Dec;25(6):809-37. Unique Identifier : AIDSLINE MED/98195709; Stewart E; Weinstein RS; Department of Psychology, University of Illinois at Urbana-Champaign; 61820, USA.; Employed quantitative and qualitative data in a contextual examination of participation in three San Francisco-area HIV/AIDS organizations: an urban, gay community-based social change setting; an urban, broadly focused information/referral setting; and a suburban individual support setting. The settings attracted diff
Regression of cytomegalovirus retinitis associated with protease-inhibitor treatment in patients with AIDS [letter]: Am J Ophthalmol. 1998 Apr;125(4):567-8. Unique Identifier : AIDSLINE MED/98218654; Tanguilig GG; Rutzen AR; Ortega-Larrocea G
Post-transcriptional induction of p21cip1 protein in condylomata and dysplasias is inversely related to human papillomavirus activities.: Am J Pathol. 1998 Apr;152(4):1015-24. Unique Identifier : AIDSLINE MED/98206438; Schmidt-Grimminger DC; Wu X; Jian Y; Broker TR; Chow LT; The Department of Biochemistry and Molecular Genetics, University of; Alabama at Birmingham, 35294-0005, USA.; Infections of the genital and oral epithelia by human papillomaviruses cause condylomata, papillomas, and squamous intraepithelial neoplasms, some of which can progress to invasive cancers. We describe an induction of p21cip1/WAF1/sdi1 protein in a fraction of the spinous cells in benign lesions and in cervical intrae
Histologic and immunophenotypic features prior to transformation in patients with transformed cutaneous T-cell lymphoma: is CD25 expression in skin biopsy samples predictive of large cell transformation in cutaneous T-cell lymphoma?: Am J Dermatopathol. 1998 Feb;20(1):1-6. Unique Identifier : AIDSLINE MED/98163189; Stefanato CM; Tallini G; Crotty PL; Department of Pathology, Yale University Medical School, New Haven,; CT, USA.; Large cell transformation (LCT) in cutaneous T-cell lymphoma CTCL) is estimated to occur up to approximately 20% of patients. This morphologic change is associated with aggressive behavior and shortened survival. Our purpose was to identify morphologic and/or immunophenotypic features in CTCL skin biopsies that are pr
The evaluation of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) in cutaneous lesions of Kaposi's sarcoma: a study of formalin-fixed paraffin-embedded tissue.: Am J Dermatopathol. 1998 Feb;20(1):7-11. Unique Identifier : AIDSLINE MED/98163190; Herman PS; Shogreen MR; White WL; Department of Pathology, Bowman Gray School of Medicine/Wake Forest; University, Winston-Salem, North Carolina 27157, USA.; The etiologic role of human herpesvirus 8 (HHV8) in Kaposi s sarcoma (KS) remains controversial. This polymerase chain reaction (PCR)-based study was undertaken to evaluate the relationship of HHV8 in KS from our geographical region and to determine its utility in formalin-fixed, paraffin-embedded biopsy specimens. Fo
Correlates of infection control practices in dentistry.: Am J Infect Control. 1998 Feb;26(1):29-34. Unique Identifier : AIDSLINE MED/98163840; Gershon RR; Karkashian C; Vlahov D; Grimes M; Spannhake E; Department of Environmental Health Science, School of Public Health,; Johns Hopkins University, Baltimore, MD 21205, USA.; BACKGROUND: Studies conducted in the first decade of the AIDS epidemic indicated that, in general, dentists had suboptimal levels of compliance with standard infection control practices, including work practices designed to reduce exposure to bloodborne pathogens. This study was designed to assess current rates of com
[Human herpesvirus 8]: Ann Med Interne (Paris). 1997;148(5):385-9. Unique Identifier : AIDSLINE MED/98199215; Agut H; Dupin N; Aubin JT; Huraux JM; Laboratoire de Virologie du CERVI, Groupe Hospitalier; Pitie-Salpetriere, Paris.; Human herpesvirus 8 (HHV-8, KSHV) is a novel virus for which fragments of genomic sequence were identified in 1994. This was done by means of a differential amplification technique applied to the DNA of Kaposi s sarcoma lesions and normal tissues obtained from the same individual. The analysis of nucleotide sequence h
[HTLV I virus infection disclosed by recurrent scabies associated with genital condylomatosis]: Ann Med Interne (Paris). 1997;148(5):406-7. Unique Identifier : AIDSLINE MED/98199218; Dupin M; Guennoc B; Zimmermann R; Martin L; Verrier B; Flechaire A; Combemale P; Service de Dermatologie, Hopital d'Instruction des Armees Desgenettes,; Lyon.
[Specific bronchial sites of Mycobacterium kansasii in 2 patients with human immunodeficiency virus infection]: Ann Med Interne (Paris). 1997;148(8):577-8. Unique Identifier : AIDSLINE MED/98199205; Boudon P; Lepennec MP; Malbec D; Mathieu M; Choudat L; Valeyre D; Service de Medecine Interne, Hopital Robert Ballanger,; Aulnay-sous-Bois.
Optic neuritis heralding varicella zoster virus retinitis in a patient with acquired immunodeficiency syndrome.: Ann Neurol. 1998 Apr;43(4):534-6. Unique Identifier : AIDSLINE MED/98206414; Meenken C; van den Horn GJ; de Smet MD; van der Meer JT; Department of Ophthalmology, Academic Medical Center, University of; Amsterdam, The Netherlands.; We report on a 29-year-old severely compromised acquired immunodeficiency syndrome patient who developed retrobulbar optic neuritis 5 weeks after an episode of cutaneous herpes zoster infection. During the optic neuritis, varicella zoster virus could be demonstrated in the cerebrospinal fluid. The neuritis responded w
Treatment of cytomegalovirus retinitis with intraocular implants.: AORN J. 1998 Feb;67(2):356-60, 362-5, 368; quiz 369-72. Unique Identifier : AIDSLINE MED/98166016; Costabile BS; Ophthalmology Department, National Naval Medical Center, Bethesda, MD,; USA.; Cytomegalovirus ( CMV ) retinitis affects 20% to 40% of patients with AIDS and is the leading cause of vision loss associated with AIDS. Three treatment options currently exist (ie, IV administration of antiviral medications, intravitreal injections of ganciclovir
Lymphoma of the tympanic membrane in acquired immunodeficiency syndrome.: Auris Nasus Larynx. 1998 Jan;25(1):89-94. Unique Identifier : AIDSLINE MED/98173955; Goodarzi MO; Broberg TG; Lalwani AK; Department of Otolaryngology-Head and Neck Surgery, University of; California, San Francisco 94143-0342, USA.; Lymphoproliferative disease is more common in the immunocompromised host and can occur at unusual sites. Lymphomas of the temporal bone are rare. We present the first case of a large B-cell Lymphoma of the tympanic membrane in a patient with acquired immunodeficiency syndrome. The tympanic membrane is a site rich with
Arthralgias and cryoglobulinemia during protease inhibitor therapy in a patient infected with human immunodeficiency virus and hepatitis C virus.: Arthritis Rheum. 1998 Apr;41(4):740-3. Unique Identifier : AIDSLINE MED/98209857; Monsuez JJ; Vittecoq D; Musset L; Alemanni M; Dussaix E; Autran B; Hopital Paul Brousse, Villejuif, France.; We present the case of a woman who had a chronic infection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV). She developed severe polyarthralgias associated with type II mixed cryoglobulinemia during therapy with an HIV-1 protease inhibitor. This therapy resulted in a dramatic increase in her CD4+ T
Vaginal immunization with recombinant gram-positive bacteria.: Am J Reprod Immunol. 1998 Mar;39(3):199-208. Unique Identifier : AIDSLINE MED/98187357; Medaglini D; Oggioni MR; Pozzi G; Dipartimento di Biologia Molecolare, Universita di Siena, Italy.; PROBLEM: Many viral and bacterial pathogens enter the body through the genital mucosa. Therefore, one of the major goals of a vaccine against sexually transmitted diseases (STDs) should be to induce an immune response in the genital mucosa capable of controlling the entry of the pathogen. Our approach for the developm
Influence of the estrous cycle on the presence and distribution of immune cells in the rat reproductive tract.: Am J Reprod Immunol. 1998 Mar;39(3):209-16. Unique Identifier : AIDSLINE MED/98187358; Kaushic C; Frauendorf E; Rossoll RM; Richardson JM; Wira CR; Department of Physiology, Dartmouth Medical School, Lebanon, New; Hampshire 03756-0001, USA.; PROBLEM: Previous studies have shown that the uterus and vagina contain cells that can present antigen to ovalbumin-specific T-cells. The objective of the present study was to systematically characterize the immune cells [major histocompatibility complex MHC) class-II+, macrophages, granulocytes, dendritic cells, and
HIV transmission via breastfeeding: reflection on the issues [letter]: J Hum Lact. 1998 Mar;14(1):13. Unique Identifier : AIDSLINE MED/98205533; Spangler AK
Inhibition of human immunodeficiency virus type 1 replication by a bioavailable serine/threonine kinase inhibitor, fasudil hydrochloride.: AIDS Res Hum Retroviruses. 1998 Mar 1;14(4):293-8. Unique Identifier : AIDSLINE MED/98178711; Sato T; Asamitsu K; Yang JP; Takahashi N; Tetsuka T; Yoneyama A; Kanagawa A; Okamoto T; Department of Molecular Genetics, Nagoya City University Medical; School, Nagoya, Japan.; Replication of human immunodeficiency virus type 1 (HIV-1) is regulated by a host transcription factor, nuclear factor kappaB NF-kappaB). NF-kappaB belongs to a group of inducible transcription factors and its activity is regulated by multiple cellular signal transduction pathways, including kinases. These kinases are
The maximal tolerable intravenous dosage of pentoxifylline in AIDS patients does not inhibit lipopolysaccharide-stimulated tumor necrosis factor alpha production.: AIDS Res Hum Retroviruses. 1998 Mar 1;14(4):299-303. Unique Identifier : AIDSLINE MED/98178712; Heijligenberg R; Romijn JA; Ackermans M; Endert E; Timmer JG; Sauerwein HP; Department of Endocrinology and Metabolism, Academic Hospital of; Amsterdam University, The Netherlands.; Tumor necrosis factor alpha (TNF-alpha) may be involved in the pathogenesis of metabolic and endocrine changes in HIV infection. Pentoxifylline (PTX) is able to suppress the production of TNF-alpha in vitro. The effect of two dosages of intravenously administered PTX on clinical symptoms and ex vivo LPS-stimulated TNF
Analysis of a biallelic polymorphism in the tumor necrosis factor alpha promoter and HIV type 1 disease progression.: AIDS Res Hum Retroviruses. 1998 Mar 1;14(4):305-9. Unique Identifier : AIDSLINE MED/98178713; Knuchel MC; Spira TJ; Neumann AU; Xiao L; Rudolph DL; Phair J; Wolinsky SM; Koup RA; Cohen OJ; Folks TM; Lal RB; Retrovirus Diseases Branch, DPD, NCID, CDC, Atlanta, Georgia 30333,; USA.; The relevance of a TNF-alpha promoter polymorphism, a G-to-A polymorphic sequence at position-308, was examined to test whether variant alleles of TNF-alpha affect susceptibility to infection with HIV-1 and progression to AIDS. Analysis of specimens from cohorts of HIV-1 positive homosexual men demonstrated that 3 of
Serotyping of HIV type 1 infections: definition, relationship to viral genetic subtypes, and assay evaluation. UNAIDS Network for HIV-1 Isolation and Characterization.: AIDS Res Hum Retroviruses. 1998 Mar 1;14(4):311-8. Unique Identifier : AIDSLINE MED/98178714; Cheingsong-Popov R; Osmanov S; Pau CP; Schochetman G; Barin F; Holmes H; Francis G; Ruppach H; Dietrich U; Lister S; Weber J; Department of Genito-Urinary Medicine and Communicable Diseases,; Imperial College School of Medicine at St Mary's, London, United; Kingdom.; V3 serotyping refers to a system based on binding of antibody in patient sera to V3-loop peptides derived from HIV-1 env genetic subtypes. The V3x serotype represents reactivity of serum from an HIV-1-infected patient (regardless of viral genetic subtype), which reacts preferentially to a V3 peptide derived from the X
HIV type 1 in Thailand, 1994-1995: persistence of two subtypes with low genetic diversity.: AIDS Res Hum Retroviruses. 1998 Mar 1;14(4):319-27. Unique Identifier : AIDSLINE MED/98178715; Subbarao S; Limpakarnjanarat K; Mastro TD; Bhumisawasdi J; Warachit P; Jayavasu C; Young NL; Luo CC; Shaffer N; Kalish ML; Schochetman G; Centers for Disease Control and Prevention, Atlanta, Georgia 30333,; USA.; Extensive transmission of human immunodeficiency virus type 1 HIV-1) in Thailand began in 1988, resulting in an estimated 800,000 cumulative infections by 1994. During 1994 and 1995, we collected blood specimens from 215 asymptomatic HIV-1-infected people with various risk behavi
Diversity of the human immunodeficiency virus type 1 envelope glycoprotein in San Francisco Men's Health Study participants.: AIDS Res Hum Retroviruses. 1998 Mar 1;14(4):329-37. Unique Identifier : AIDSLINE MED/98178716; McCutchan FE; Sanders-Buell E; Salminen MO; Carr JK; Sheppard WH; Henry M. Jackson Foundation for the Advancement of Military Medicine,; Rockville, Maryland 20850, USA.; Multiple genetic subtypes of HIV-1, differing by up to 30% of nucleotides in their envelope coding sequences, have been identified in the global epidemic. In the United States , where HIV-1 infection with subtype B predominates, the interisolate diversity in envelope is 15% or more. It
Proliferation-dependent replication in primary macrophages of macrophage-tropic HIV type 1 variants.: AIDS Res Hum Retroviruses. 1998 Mar 1;14(4):339-45. Unique Identifier : AIDSLINE MED/98178717; Kootstra NA; Schuitemaker H; Department of Clinical Viral Immunology, Central Laboratory of The; Netherlands Red Cross Blood Transfusion Service, Academic Medical; Center, University of Amsterdam.; We previously demonstrated that completion of reverse transcription in macrophages inoculated with the HIV-1 Ba-L variant was established only in the subpopulation of cells with proliferative capacity. In our present study we further extended this observation with three additional HIV-1 isolates, being the macrophage-
Differences in reverse transcriptase activity versus p24 antigen detection in cell culture, when comparing a homogeneous group of HIV type 1 subtype B viruses with a heterogeneous group of divergent strains.: AIDS Res Hum Retroviruses. 1998 Mar 1;14(4):347-52. Unique Identifier : AIDSLINE MED/98178718; Corrigan GE; Al-Khalili L; Malmsten A; Thorstensson R; Fenyo EM; Kallander CF; Gronowitz JS; Cavidi Tech AB, Uppsala Science Park, Staben, Sweden.; Failure to detect infection with HIV-1 non-B subtypes in some antibody screening assays has been shown. To date, however, no studies have been published evaluating the capacity of standard tests to quantify replication of divergent HIV-1 in cell culture. Reverse transcriptase (RT) activity and p24 antigen assays are t
Secretion of extracellular factor(s) induced by X-irradiation activates the HIV type 1 long terminal repeat through its kappaB motif.: AIDS Res Hum Retroviruses. 1998 Mar 1;14(4):353-65. Unique Identifier : AIDSLINE MED/98178719; Faure E; Rameil P; Lecine P; Rey F; Sire J; Kahn-Perles B; Imbert J; UPRES 2202 Biodiversite, ICB, Universite de Provence, Marseille,; France.; X-irradiation has been used in the treatment of several human diseases, including AIDS-related-malignancies. X-irradiation might induce the transcription and the replication of human immunodeficiency virus type 1 (HIV-1) and enhance nuclear factor kappa B (NF-kappaB). In the present article we show that the activation
Simian T cell leukemia virus type I-induced malignant adult T cell leukemia-like disease in a naturally infected African green monkey: implication of CD8+ T cell leukemia.: AIDS Res Hum Retroviruses. 1998 Mar 1;14(4):367-71. Unique Identifier : AIDSLINE MED/98178720; Akari H; Ono F; Sakakibara I; Takahashi H; Murayama Y; Hiyaoka A; Terao K; Otani I; Mukai R; Adachi A; Yoshikawa Y; Tsukuba Primate Center, National Institute of Infectious Diseases,; Ibaraki, Japan.; Spontaneous T cell leukemia was found in an African green monkey Cercopithecus aethiops, AGM) naturally infected with simian T cell leukemia virus type I (STLV-I). The hematological features and the evidence for monoclonal integration of provirus DNA in the leukemic cells revealed that the leukemia was an ATL-like dis
Increase in Vdelta1+ gammadelta T cells in the peripheral blood and bone marrow as a selective feature of HIV-1 but not other virus infections.: Br J Haematol. 1998 Mar;100(4):728-34. Unique Identifier : AIDSLINE MED/98189829; Rossol R; Dobmeyer JM; Dobmeyer TS; Klein SA; Rossol S; Wesch D; Hoelzer D; Kabelitz D; Helm EB; Department of Internal Medicine III, University Hospital, Frankfurt,; Germany.; Dysregulation of T-cell receptor (TCR) alphabeta bearing lymphocytes and an increase in Vdelta1+ gammadelta T cells are typical features of HIV-1 infection. However, the role of gammadelta T cells remains unclear. Therefore, peripheral blood mononuclear cells (PBMC) of 103 HIV-1-infected patients were investigated wit
Dendritic cells cultured from mononuclear cells and CD34 cells in myeloma do not harbour human herpesvirus 8.: Br J Haematol. 1998 Mar;100(4):793-6. Unique Identifier : AIDSLINE MED/98189839; Cull GM; Timms JM; Haynes AP; Russell NH; Irving WL; Ball JK; Thomson BJ; Department of Clinical and Laboratory Sciences, University of; Nottingham at Nottingham City Hospital.; Dendritic cells (DC) are antigen-presenting cells with the potential to be a powerful adjuvant in the immunotherapy of haematological malignancy, including myeloma. Recently, human herpesvirus 8 (HHV-8) infection of dendritic cells in the long-term bone marrow stromal cultures of patients with myeloma has been reporte
Human herpesvirus 8 in premalignant and cancerous skin lesions in a Japanese patient with adult T-cell leukaemia [letter]: Br J Haematol. 1998 Mar;100(4):802-3. Unique Identifier : AIDSLINE MED/98189844; Daibata M; Chikazawa M; Taguchi H; Miyoshi I
Regulation of T cell autoreactivity to MHC class II by controlling CD80 (B7-1) expression on B cells.: Int Immunol. 1998 Feb;10(2):147-58. Unique Identifier : AIDSLINE MED/98192113; Hasegawa A; Ueno Y; Yamashita M; Nakayama T; Tada T; Research Institute for Biological Sciences and Faculty of; Pharmaceutical Sciences, Science University of Tokyo, Chiba, Japan.; Regulatory mechanisms of T cell autoreactivity to MHC class II molecules were studied in transgenic (Tg) mice with auto-I-Ak-reactive TCR alphabeta transgenes (designated as MS Tg mice). Our previous study revealed that the T cell tolerance established in autoreactive MS Tg mice was not due to either clonal deletion i
Does the IL-2 receptor alpha chain induced on dendritic cells have a biological function?: Int Immunol. 1998 Feb;10(2):237-40. Unique Identifier : AIDSLINE MED/98192123; Kronin V; Vremec D; Shortman K; The Walter and Eliza Hall Institute of Medical Research, Melbourne,; Victoria, Australia.; The IL-2 receptor (IL-2R) alpha chain (CD25), but not the IL-2R beta chain, is induced on dendritic cells (DC) by brief periods of culture. To test if this IL-2R alpha is important for DC function, DC were isolated from the spleens of mutant mice with the IL-2R alpha g
[HIV viral load. Current situation and perspectives (editorial)]: Enferm Infecc Microbiol Clin. 1997 Dec;15(10):507-9. Unique Identifier : AIDSLINE MED/98182989; Arnal J
[Cryptococcal arthritis as the initial form of human immunodeficiency syndrome (letter)]: Enferm Infecc Microbiol Clin. 1997 Dec;15(10):560. Unique Identifier : AIDSLINE MED/98183001; Mauri M; Castells L; Ruiz I; Vargas V; Guardia J
[Pulmonary and subcutaneous nocardiosis in an HIV-positive patient [letter]: Enferm Infecc Microbiol Clin. 1997 Dec;15(10):560-1. Unique Identifier : AIDSLINE MED/98183002; Locutura J; Lorenzo JF; Megias G; Ojeda E
[Mycobacterium simiae disseminated infection in HIV patient letter(]: Enferm Infecc Microbiol Clin. 1997 Dec;15(10):564-5. Unique Identifier : AIDSLINE MED/98183006; Minguez S; Carratala C; Aguirre A; Knobel H; Salvado M; Lonca J
Multiple imputation for early stopping of a complex clinical trial.: Biometrics. 1998 Mar;54(1):229-42. Unique Identifier : AIDSLINE MED/98206162; Betensky RA; Department of Biostatistics, Harvard School of Public Health, Boston,; Massachusetts 02115, USA. betensky@hsph.harvard.edu; It is desirable to have procedures available for stopping a clinical trial early if there appears to be no treatment effect. Conditional power procedures allow for early stopping in favor of the null hypothesis if the probability of rejecting H0 at the planned end of the trial given the current data and a value of the
A Bayesian framework for intent-to-treat analysis with missing data.: Biometrics. 1998 Mar;54(1):265-78. Unique Identifier : AIDSLINE MED/98206165; Kleinman KP; Ibrahim JG; Laird NM; Department of Biostatistics, University of Michigan, Ann Arbor 48106,; USA.; In longitudinal clinical trials, one analysis of interest is an intention-to-treat analysis, which groups subjects according to the randomized treatment regardless of whether they stayed on that treatment or not. When in addition to going off the randomized treatment subjects may also drop out of the study and be lost
Nurses and assisted dying: taking our roles to heart and mind [editorial; comment]: J Assoc Nurses AIDS Care. 1998 Mar-Apr;9(2):15-7. Unique Identifier : AIDSLINE MED/98174316; Saunders JM; Hughes A
End-of-life issues: a survey of English-speaking Canadian nurses in AIDS care [see comments]: J Assoc Nurses AIDS Care. 1998 Mar-Apr;9(2):18-25. Unique Identifier : AIDSLINE MED/98174317; Young MG; Ogden RD; University of Victoria.; This anonymous postal survey explored attitudes and experiences concerning end-of-life decisions. Respondents were English-speaking members of the Canadian Association for Nurses in AIDS Care (CANAC) and other nurses identified as working primarily in HIV/AIDS settings. Seventy-three percent believed that the law shou
Nurses' attitudes and beliefs toward assisted suicide in AIDS [see comments]: J Assoc Nurses AIDS Care. 1998 Mar-Apr;9(2):26-33. Unique Identifier : AIDSLINE MED/98174318; Leiser RJ; Mitchell TF; Hahn J; Slome L; Abrams DI; University of California San Francisco AIDS Program, San Francisco; General Hospital, USA.; This report of a 1995 survey presents data regarding nurses attitudes and beliefs about assisted suicide in AIDS. The authors surveyed 428 nurses working at facilities serving AIDS patients in the San Francisco Bay Area, using an anonymous, self-administered questionnaire. They received 215 responses 50%). There was
Historical, ethical, and legal aspects of assisted suicide.: J Assoc Nurses AIDS Care. 1998 Mar-Apr;9(2):34-44. Unique Identifier : AIDSLINE MED/98174319; Benedict S; Pierce AG; Sweeney S; College of Nursing, Medical University of South Carolina, USA.; This article explores the historical, ethical, and legal antecedents of assisted suicide. Following a differentiation between assisted suicide and euthanasia, the historical aspects of suicide in the United States and other countries are described. Four cardinal principles form the bas
Palliative care.: J Assoc Nurses AIDS Care. 1998 Mar-Apr;9(2):45-7. Unique Identifier : AIDSLINE MED/98174320; Bloomer SC; Johns Hopkins Home Care Group, Baltimore, Maryland, USA.
Is anybody listening? A phenomenological study of pain in hospitalized persons with AIDS.: J Assoc Nurses AIDS Care. 1998 Mar-Apr;9(2):57-67. Unique Identifier : AIDSLINE MED/98174321; Newshan G; St. Vincent's Hospital, Section of HIV Medicine, New York, USA.; Pain is a common problem among hospitalized persons with AIDS PWAs), yet it has not been well studied. The purpose of this study was to understand, using the phenomenological method, the experience of pain in hospitalized PWAs. Multiple sources of data, including interviews with 11 hospitalized PWAs, literature, poetr
Oral mucosal transudate testing for HIV-1 antibodies: a clinical update.: J Assoc Nurses AIDS Care. 1998 Mar-Apr;9(2):68-72. Unique Identifier : AIDSLINE MED/98174322; Ferri RS; The HIV epidemic and the social and clinical responses to it have changed dramatically in recent years in ways that significantly affect the nursing profession. In scope, the HIV epidemic has broadened demographically and geographically, shifting the burden of the epidemic and continuing to place stress on our health
HIV-associated distal symmetrical polyneuropathy: clinical features and nursing management.: J Assoc Nurses AIDS Care. 1998 Mar-Apr;9(2):77-80. Unique Identifier : AIDSLINE MED/98174323; Swanson B; Zeller JM; Paice JA; Women's Interagency HIV Study, University of Illinois at Chicago, USA.; DSPN is a common manifestation of HIV infection and/or its treatment that can have adverse effects on quality of life and functional status. The pathogenesis remains unclear but likely involves the elaboration of neurotoxic inflammatory cytokines and their metabolites. DSPN is often refractory to available pharmacolog
HIV subterfuge [news]: J Assoc Nurses AIDS Care. 1998 Mar-Apr;9(2):82. Unique Identifier : AIDSLINE MED/98174324
Should complex medication regimens be prescribed to people with a low probability of compliance? [letter]: J Assoc Nurses AIDS Care. 1998 Mar-Apr;9(2):85. Unique Identifier : AIDSLINE MED/98174325; Longley SB
[Immunologic aspects of cellular therapy]: Biull Eksp Biol Med. 1998 Feb;125(2):124-9. Unique Identifier : AIDSLINE MED/98219871; Sukhikh GT; Bogdanova IM; Malaitsev VV
A natural immunity-activating plant lectin, Viscum album agglutinin-I, induces apoptosis in human lymphocytes, monocytes, monocytic THP-1 cells and murine thymocytes.: Nat Immun. 1996-97;15(6):295-311. Unique Identifier : AIDSLINE MED/98183882; Hostanska K; Hajto T; Weber K; Fischer J; Lentzen H; Sutterlin B; Saller R; Department of Internal Medicine, University Hospital Zurich,; Switzerland.; A galactoside-specific plant lectin, Viscum album agglutinin-I VAA-I) with protein synthesis-inhibiting properties, has been shown to be cytotoxic in various eukaryotic cells, in vitro above a 10 ng/ml concentration. Noncytotoxic concentrations of VAA-I induced mRNA expression and enhanced secretion of proinflammatory
Structural characterization of the N-linked oligosaccharides derived from HIVgp120 expressed in lepidopteran cells.: Glycoconj J. 1998 Jan;15(1):83-8. Unique Identifier : AIDSLINE MED/98189444; Butters TD; Yudkin B; Jacob GS; Jones IM; Glycobiology Institute, Department of Biochemistry, University of; Oxford, UK. terry@oxglua.glycob.ox.ac.uk; The oligosaccharides of recombinant HIV gp120 expressed in lepidopteran Sf9 cells were analysed after hydrazine release by gel permeation and high pH anion exchange chromatography. N-Linked glycans were exclusively of the oligomannose series and no evidence for charged complex or hybrid type glycans was found. However
Epidemiology of permanent childhood hearing impairment in Trent Region, 1985-1993.: Br J Audiol. 1997 Dec;31(6):409-46. Unique Identifier : AIDSLINE MED/98138774; Fortnum H; Davis A; MRC Institute of Hearing Research, Nottingham.; This retrospective study of permanent childhood hearing impairment (PCHI) > or = 40 dB HL in children born between 1985 and 1993 and resident in Trent Health Region, achieved an ascertainment of 92.9% of that expected from previous studies and 100% for the subset of children born between 1985 and 1990. The prevalence
Sequence analysis of a compound coding-region microsatellite in Candida albicans resolves homoplasies and provides a high-resolution tool for genotyping.: FEMS Immunol Med Microbiol. 1998 Feb;20(2):103-9. Unique Identifier : AIDSLINE MED/98204337; Metzgar D; Field D; Haubrich R; Wills C; Department of Biology, University of California at San Diego, La Jolla; 92093-0116, USA. dmetzgar@biomail.ucsd.edu; Sequence diversity at a coding-region microsatellite locus of two diploid Candida species was surveyed. Twenty-one alleles from fourteen strains of Candida albicans and three alleles from two strains of the closely related Candida dubliniensis were sequenced. Results show independent length variation in two contiguous
Influence of risk factors on the pathogenesis of periodontitis.: Periodontol 2000. 1997 Jun;14:173-201. Unique Identifier : AIDSLINE MED/98229389; Salvi GE; Lawrence HP; Offenbacher S; Beck JD; Department of Dental Ecology University of North Carolina, Chapel; Hill, USA.
Social class and medical decisionmaking: a neglected topic in bioethics.: Camb Q Healthc Ethics. 1998 Winter;7(1):41-56. Unique Identifier : AIDSLINE MED/98183641; Levin BW; Schiller NG; Department of Health and Nutrition Sciences, Brooklyn College, City; University of New York, USA.
Acute lung injury in the medical ICU: comorbid conditions, age, etiology, and hospital outcome.: Am J Respir Crit Care Med. 1998 Apr;157(4 Pt 1):1159-64. Unique Identifier : AIDSLINE MED/98223223; Zilberberg MD; Epstein SK; Department of Medicine, Tupper Research Institute, New England Medical; Center, Tufts University School of Medicine, Boston, Massachusetts; 02111, USA.; The independent effects of chronic disease, age, severity of illness, lung injury score (LIS) and etiology, and preceding nonpulmonary organ-system dysfunction (OSD) on the outcome of acute lung injury (ALI) have not been examined in an exclusively medical-intensive-care-unit (MICU) population. Therefore, 107 consecut
Tumor necrosis factor and interleukin-1 inhibitors as markers of disease activity of tuberculosis.: Am J Respir Crit Care Med. 1998 Apr;157(4 Pt 1):1328-31. Unique Identifier : AIDSLINE MED/98223247; Juffermans NP; Verbon A; van Deventer SJ; van Deutekom H; Speelman P; van der Poll T; Department of Internal Medicine, Tropical Medicine and AIDS, Academic; Medical Center, University of Amsterdam, The Netherlands.; N.Juffermans@amc.uva.nl; Serum concentrations of tumor necrosis factor-alpha (TNF), interleukin (IL)-1beta, and their circulating inhibitors soluble TNF receptor type I (sTNFRI), type II (sTNFRII), IL-1 receptor antagonist (IL-1ra), and soluble IL-1 receptor type II (sIL-1RII) were measured for 123 patients with tuberculosis (TB) in various s
Chest radiographic findings in patients with tuberculosis with recent or remote infection [letter]: Am J Respir Crit Care Med. 1998 Apr;157(4 Pt 1):1348-9. Unique Identifier : AIDSLINE MED/98223249; Collazos J
The effect of drug lipophilicity on P-glycoprotein-mediated colchicine efflux at the blood-brain barrier.: Int J Clin Pharmacol Ther. 1998 Feb;36(2):84-6. Unique Identifier : AIDSLINE MED/98178974; Khan EU; Reichel A; Begley DJ; Roffey SJ; Jezequel SG; Abbott NJ; King's College, London, UK.
Synthesis of key sandramycin analogs: systematic examination of the intercalation chromophore.: Bioorg Med Chem. 1998 Jan;6(1):85-102. Unique Identifier : AIDSLINE MED/98161211; Boger DL; Chen JH; Saionz KW; Jin Q; Department of Chemistry and The Skaggs Institute of Chemical Biology,; The Scripps Research Institute, La Jolla, California 92037, USA.; The preparation and examination of 2-22 constituting a systematic study of the chromophore of sandramycin (1) are detailed. Fluorescence quenching studies were used to establish binding constants for 1-24 within calf thymus DNA, within a single high affinity bis-intercalation binding site 5 -d(GCATGC)2, and to establi
AIDS-associated secondary lymphoma of bone: a case report with review of the literature.: Am J Orthop. 1998 Feb;27(2):128-34. Unique Identifier : AIDSLINE MED/98167098; Aboulafia AJ; Khan F; Pankowsky D; Aboulafia DM; Department of Orthopaedic Surgery, Emory University School of; Medicine, Atlanta, Georgia, USA.; Although musculoskeletal lesions are not reported as commonly as pulmonary or central nervous system abnormalities in human immunodeficiency virus (HIV)-positive individuals, a wide variety of osseous and soft-tissue changes are seen in these patients. We describe the case of a 35-year-old injection drug user with acq
Ethnic differences in response to fluoxetine in a controlled trial with depressed HIV-positive patients.: Psychiatr Serv. 1998 Feb;49(2):239-40. Unique Identifier : AIDSLINE MED/98139257; Wagner GJ; Maguen S; Rabkin JG; New York State Psychiatric Institute, New York 10032, USA.; This study examined ethnic differences in response to antidepressant treatment. One hundred eighteen depressed HIV-positive patients entered an eight-week controlled trial of fluoxetine. Nineteen percent were black and 14 percent were Latino; the remaining two-thirds were white. Attrition was greater among Latinos tha
Differences in cellular infiltrates in the adenoid of allergic children compared with age- and gender-matched controls.: Clin Exp Allergy. 1998 Feb;28(2):187-95. Unique Identifier : AIDSLINE MED/98175343; Fokkens WJ; Vinke JG; De Jong SS; Bogaert DP; Kleinjan A; Eichhorn E; Department of Otorhinolaryngology, Erasmus University Medical Centre; Rotterdam, The Netherlands.; BACKGROUND: Allergic sensitization of the airways occurs in the mucosa of the shock organ, or in the lymphatic stations draining these structures. The lymphatic structure closest to the nasal mucosa is the adenoid. OBJECTIVES: The objective of this study was to find evidence for our hypothesis that allergic sensitizat
Hepatitis G virus infection in hepatitis C virus-positive patients co-infected or not with hepatitis B virus and/or human immunodeficiency virus.: J Viral Hepat. 1998 Mar;5(2):123-30. Unique Identifier : AIDSLINE MED/98233564; Thiers V; Pol S; Persico T; Carnot F; Zylberberg H; Berthelot P; Brechot C; Nalpas B; Centre de Biologie Moleculaire Specialisee, Institut Pasteur, Paris,; France.; This was a retrospective study to evaluate the prevalence and impact of hepatitis G virus (HGV) infection in hepatitis C virus HCV)-positive drug addicts, according to the serological status of hepatitis B virus (HBV) and human immunodeficiency virus (HIV) coinfection. Two hundred and thirty-five randomly selected int
Diagnosis and clinical management of neurological disorders caused by cytomegalovirus in AIDS patients. European Union Concerted Action on Virus Meningitis and Encephalitis.: J Neurovirol. 1998 Feb;4(1):120-32. Unique Identifier : AIDSLINE MED/98189504; Cinque P; Cleator GM; Weber T; Monteyne P; Sindic C; Gerna G; van Loon AM; Klapper PE; Ospedale San Raffaele, Milan, Italy.; Cytomegalovirus ( CMV ) infections are common and severe complications of HIV infection. The virus involves the nervous system, causing encephalitis, polyradiculomyelitis and peripheral neuropathies. Due to their limited sensitivity, traditional virological approa
Progressive multifocal leukoencephalopathy in patients with HIV infection.: J Neurovirol. 1998 Feb;4(1):59-68. Unique Identifier : AIDSLINE MED/98189496; Berger JR; Pall L; Lanska D; Whiteman M; Department of Neurology, University of Kentucky College of Medicine,; Lexington, USA.; Progressive multifocal leukoencephalopathy (PML), a formerly rare disease, is estimated to occur in up to 5% of all patients with AIDS. The high prevalence of PML in AIDS patients currently enables a comprehensive evaluation of this disorder. We evaluated the clinical and radiographic features of PML in a large cohort
HIV decreases glutamate transport in SK-N-MC neuroblastoma cells.: J Neurovirol. 1998 Feb;4(1):69-79. Unique Identifier : AIDSLINE MED/98189497; Pappas TC; Alagarsamy S; Pollard RB; Nokta M; Department of Internal Medicine, University of Texas Medical Branch,; Galveston 77555-0835, USA.; Autopsy studies of patients with AIDS dementia have shown neuronal loss consistent with a neurotoxic component of this disease. In vitro studies suggest that viral products or cytokines from HIV-infected macrophages (Mphi) may modulate or directly mediate excitotoxic cell death of
HIV-1 strain-associated variability in infection of primary neuroglia.: J Neurovirol. 1998 Feb;4(1):80-9. Unique Identifier : AIDSLINE MED/98189498; McCarthy M; He J; Wood C; Department of Neurology, Miami Veterans Administration Medical Center; and University of Miami School of Medicine, Florida 33125, USA.; Qualitative differences among strains of Human Immunodeficiency Virus type 1 (HIV-1) may influence viral infectivity for cells of the central nervous system (CNS) and determine or at least significantly influence the neuropathogenesis of brain infection. In this study, we compared infectivity for these cells in vitro
CSF, plasma viral load and HIV associated dementia.: J Neurovirol. 1998 Feb;4(1):90-4. Unique Identifier : AIDSLINE MED/98189499; Robertson K; Fiscus S; Kapoor C; Robertson W; Schneider G; Shepard R; Howe L; Silva S; Hall C; Department of Neurology, University of North Carolina at Chapel Hill,; 27599-7025, USA.; Plasma viral burden has proven valuable in predicting the future course of systemic HIV related disease and the response to treatment. It is not known whether plasma or cerebrospinal fluid CSF) viral burden can be used to predict onset of or response to treatment of nervous system disease. We propose a model of viral
Sustained cognitive decline in HIV infection: relationship to CD4+ cell count, plasma viremia and p24 antigenemia.: J Neurovirol. 1998 Feb;4(1):95-9. Unique Identifier : AIDSLINE MED/98189500; Dal Pan GJ; Farzadegan H; Selnes O; Hoover DR; Miller EN; Skolasky RL; Nance-Sproson TE; McArthur JC; Department of Neurology, Johns Hopkins University, Baltimore,; Maryland, USA.; To determine the clinical and virological correlates of neuropsychological test performance decline in HIV infection, we measured viral burden in blood in 272 HIV-seropositive men without dementia in the Baltimore arm of the Multicenter AIDS Cohort Study (MACS). These measures were
Tumor antigen presentation: changing the rules.: Cancer Immunol Immunother. 1998 Apr;46(2):70-4. Unique Identifier : AIDSLINE MED/98217083; Armstrong TD; Pulaski BA; Ostrand-Rosenberg S; Department of Biological Sciences, University of Maryland, Baltimore; 21250, USA.; Cell-based tumor vaccines have been developed on the basis of the hypothesis that tumor cells can be genetically modified to present antigen to T lymphocytes directly. Contrary to expectations, cross-priming is the predominant pathway for activation of tumor-specific CD8+ T cells, while direct presentation of antigen
Rape among African American women: sexual, psychological, and social correlates predisposing survivors to risk of STD/HIV.: J Womens Health. 1998 Feb;7(1):77-84. Unique Identifier : AIDSLINE MED/98172125; Wingood GM; DiClemente RJ; Department of Health Behavior, School of Public Health, University of; Alabama at Birmingham, USA.; The aim of this study was to examine the association of rape of adult African American women and sexual, psychologic, and social factors that predispose them to risks of sexually transmitted diseases, including human immunodeficiency virus (HIV). This cross-sectional study, conducted between February and December 1993
Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1.: Cell. 1998 Apr 3;93(1):81-91. Unique Identifier : AIDSLINE MED/98206470; Jin DY; Spencer F; Jeang KT; Laboratory of Molecular Microbiology, National Institute of Allergy; and Infectious Diseases, Bethesda, Maryland 20892-0460, USA.; In searching for cellular targets of the HTLV-I oncoprotein Tax, we identified TXBP181, which we characterized as the human homolog of yeast mitotic checkpoint MAD1 protein. Evidence supporting TXBP181 as HsMAD1 includes sequence conservation with yeast MAD1, hyperphosphorylation during S/G2/M phases and upon treatmen
Ceramic drug-delivery devices.: Crit Rev Ther Drug Carrier Syst. 1998;15(1):1-56. Unique Identifier : AIDSLINE MED/98183686; Lasserre A; Bajpai PK; Department of Biology, University of Dayton, OH 45469, USA.; A variety of ceramics and delivery systems have been used to deliver chemicals, biologicals, and drugs at various rates for desired periods of time from different sites of implantation. In vitro and in vivo studies have shown that ceramics can successfully be used as drug-delivery devices. Matrices, inserts, reservoir
The TH1/TH2 paradigm in allergy.: Immunotechnology. 1998 Jan;3(4):233-44. Unique Identifier : AIDSLINE MED/98191635; Maggi E; Clinical Immunology Dept., University of Firenze, Italy.; Recent evidence has been accumulated to suggest that allergen-reactive type 2 helper T cells (Th2) play a triggering role in the activation and/or recruitment of IgE antibody-producing B cells, mast cells and eosinophils, i.e. the cellular triad involved in the allergic inflammation. Interleukin IL)-4 production by a
Design, synthesis and CD4 binding studies of a fluorescent analogue of a peptide that enhances HIV-1 infectivity.: J Pept Res. 1998 Feb;51(2):110-5. Unique Identifier : AIDSLINE MED/98175800; Dettin M; Scarinci C; Zanotto C; Cabrelle A; De Rossi A; Di Bello C; Department of Chemical Process Engineering, University of Padua,; Italy.; We previously demonstrated that a 23-amino-acid peptide derived from the V3 loop of the surface glycoprotein of human immunodeficiency virus (HIV-1) strain MN was able to bind soluble CD4 and to enhance HIV-1 infection. Further studies suggested that the peptide/CD4 interaction induces an increase in both CD4 expressi
Snyder v. American Association of Blood Banks: a re-examination of liability for medical practice guideline promulgators.: J Eval Clin Pract. 1998 Feb;4(1):49-62. Unique Identifier : AIDSLINE MED/98185600; Noble A; Brennan TA; Hyams AL; Department of Health Policy & Management, Harvard School of Public; Health, Boston, MA 02115, USA.; Medical practice guidelines are playing an increasingly important role in both the medical and the legal context. As tools for the health practitioner, it is thought that medical practice guidelines may contribute to an increase in the quality of patient care and cost-effectiveness. In the legal setting, guidelines ma
Design and racemic synthesis of conformationally restricted carbocyclic pyrimidine nucleoside analogs based on the structure of the L-nucleoside residue in heterochiral DNA.: Chem Pharm Bull (Tokyo). 1998 Mar;46(3):458-61. Unique Identifier : AIDSLINE MED/98211057; Urata H; Miyagoshi H; Kakuya H; Tokumoto H; Kawahata T; Otake T; Akagi M; Osaka University of Pharmaceutical Sciences, Takatsuki, Japan.; Carbocyclic pyrimidine nucleoside analogs which have restricted glycosidic conformation at chi approximately 180 degrees were designed, based on the conformational features of the L-nucleotide residue in heterochiral DNA, and synthesized. The synthesis of (+/-)-carbocyclic 6,6 -O-cyclo-2 -deoxyuridine was achieved via
Early intervention to block HIV.: Health News. 1998 Apr 20;4(5):3. Unique Identifier : AIDSLINE MED/98224399; Boswell SL; Fenway Community Health Center, Harvard Medical School, Boston, USA.
Sensitivity of two enzyme-linked immunosorbent assay tests in relation to western blot in detecting human T-cell lymphotropic virus types I and II infection among HIV-1 infected patients from Sao Paulo, Brazil.: Diagn Microbiol Infect Dis. 1998 Mar;30(3):173-82. Unique Identifier : AIDSLINE MED/98233550; Caterino-de-Araujo A; de los Santos-Fortuna E; Meleiro MC; Suleiman J; Calabro ML; Favero A; De Rossi A; Chieco-Bianchi L; Instituto Adolfo Lutz, Sao Paulo, Brazil.; We investigated the presence of human T-cell lymphotropic virus types I and II (HTLV-I and HTLV-II) infections, first searching for specific antibodies in 553 serum samples obtained from HIV-1-infected patients from Sao Paulo, Brazil . Sera were screened using two enzyme-linked immu
HIV-associated autoimmune hemolytic anemia complicated by pulmonary embolism following a red blood cell transfusion: case report and review of the literature.: Conn Med. 1998 Feb;62(2):67-70. Unique Identifier : AIDSLINE MED/98203407; Saif MW; Morse EE; Greenberg BR; University of Connecticut School of Medicine, USA.; BACKGROUND: Though positive direct antiglobulin tests are common in AIDS patients, overt hemolysis is rare. A hypercoagulable state has recently been recognized in these patients and may contribute to the thromboembotic complications previously reported in three patients with HIV-associated autoimmune hemolytic anemia
Localized crusted scabies of the scalp and feet.: Cutis. 1998 Feb;61(2):87-8. Unique Identifier : AIDSLINE MED/98176188; Lewis EJ; Connolly SB; Crutchfield CE 3rd; Rest EB; Department of Dermatology, University of Minnesota, Minneapolis; 55455-0392, USA.; An atypical case of crusted scabies in a patient with acquired immunodeficiency syndrome is presented in which lesions at the time of evaluation were confined to the scalp and feet. Because of the unusual presentation, the scalp involvement (which clinically mimicked seborrheic dermatitis) was initially missed. Althou
Cytomegalovirus pneumonia in AIDS patients: value of cytomegalovirus culture from BAL fluid and correlation with lung disease.: Chest. 1998 Apr;113(4):919-23. Unique Identifier : AIDSLINE MED/98213347; Uberti-Foppa C; Lillo F; Terreni MR; Puglisi A; Guffanti M; Gianotti N; Lazzarin A; Department of Infectious Diseases, IRCCS San Raffaele Hospital and; University of Milan, Milano, Italy.; OBJECTIVES: To verify the value of cytomegalovirus ( CMV ) cultures of BAL fluid vs postmortem lung histopathology in detecting CMV pneumonia, and to correlate the BAL viral dose with the number of CMV inclusion bodies (CMV-IB)
Healing after anal fistulotomy: comparative study between HIV+ and HIV- patients.: Dis Colon Rectum. 1998 Feb;41(2):177-9. Unique Identifier : AIDSLINE MED/98215528; Nadal SR; Manzione CR; Galvao VM; Salim VR; Speranzini MB; Department of Proctology of the Emilio Ribas Infectious Diseases; Institute, Sao Paulo, Brazil.; PURPOSE: The aim of this work was to compare wound-healing after anal fistulotomy in human immunodeficiency virus (HIV)+ and HIV- patients and to recognize healing parameters in HIV+ patients. METHODS: Sixty patients were treated with fistulotomy for intersphincteric anal fistula. For each patient, we evaluated white
Increasing popularity of injection as the route of administration of amphetamine in Edinburgh.: Drug Alcohol Depend. 1997 Dec 15;48(3):227-34. Unique Identifier : AIDSLINE MED/98110510; Peters A; Davies T; Richardson A; Centre for HIV/AIDS and Drug Studies, City Hospital, Edinburgh,; Scotland, UK.; Six hundred and thirty four interviews of injecting drug users were performed between 1992 and 1994 as part of a study of injecting drug use and HIV prevalence in Edinburgh, Scotland. Amphetamine was injected by more subjects (44%) than any other drug. Preference for injection as the route of administration of ampheta
Antiretroviral therapy for HIV infection. A knowledge-based approach to drug selection and use.: Drugs. 1998 Mar;55(3):383-404. Unique Identifier : AIDSLINE MED/98191622; Moyle GJ; Gazzard BG; Cooper DA; Gatell J; Kobler Centre, Chelsea and Westminster Hospital, London, England.; In the absence of evidence that eradication of HIV from an infected individual is feasible, the established goal of antiretroviral therapy is to reduce viral load to as low as possible for as long as possible. Achieving this with the currently available antiretroviral agents involves appropriate selection of component
Saquinavir soft-gel capsule formulation. A review of its use in patients with HIV infection.: Drugs. 1998 Mar;55(3):461-86. Unique Identifier : AIDSLINE MED/98191627; Perry CM; Noble S; Adis International Limited, Auckland, New Zealand. demail@adis.co.nz; Saquinavir is an HIV protease inhibitor which, formulated as a hard-gel capsule (HGC), was the first drug of its class to become available for the treatment of patients with HIV infection. Despite the beneficial effects that saquinavir HGC-containing combination regimens have shown in the treatment of patients with HI
[AIDS and pregnancy]: Ginecol Obstet Mex. 1998 Jan;66:8-12. Unique Identifier : AIDSLINE MED/98188653; Arredondo Garcia JL; Hernandez Trejo M; Figueroa Damian R; Ortiz Ibarra FJ; Ahued Ahued JR; Near 70 per cent of Mexican women infected by the Human Immunodeficiency virus (HIV) are between 15 and 44 years old, in this women sexual transmission are the most frequent route of infection. The objective of this article was to describe the obstetric course and perinatal repercussion of the HIV-Positive pregnant wo
[Suppressive effects of a plant-origin polyol, dulcitol on collagen-induced arthritis in mice]: Nippon Yakurigaku Zasshi. 1997 Oct;110 Suppl 1:132P-137P. Unique Identifier : AIDSLINE MED/98164161; Kobayashi Y; Shen J; Li SH; Kakizoe E; Okunishi H; Chen JF; Department of Pharmacology, Shimane Medical University, Izumo, Japan.; Dulcitol was isolated chemically from Celastrus obiculatus Thumb and determined by HPLC. Effects of dulcitol were examined on collagen-induced arthritis (CIA) in DBA/1J mice. From 6 weeks after the first immunization with bovine type II collagen, dulcitol (100 mg/kg body weight/day) was administered orally to immunize
[Kinase inhibitors of microbial origins]: Nippon Yakurigaku Zasshi. 1997 Oct;110 Suppl 1:81P-86P. Unique Identifier : AIDSLINE MED/98164152; Nakanishi S; Matsuda Y; Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.; Microorganisms are beneficial as a source of natural products in the following sense, diversity of species, versatility and variety of substrates, and unique productivity. On top of them, advantage for industrial utilization of microorganisms is that mass production is feasible by culturing them in a fermentation tank
Splenic para-amyloid material: a possible vasculopathy of the acquired immunodeficiency syndrome.: Hum Pathol. 1998 Apr;29(4):371-6. Unique Identifier : AIDSLINE MED/98223276; Markowitz GS; Factor SM; Borczuk AC; Jacobi Medical Center and Albert Einstein College of Medicine, Bronx,; NY, USA.; We have observed perivascular para-amyloid in the spleens of acquired immune deficiency syndrome (AIDS) patients at autopsy. Whether this phenomenon is unique to AIDS patients or is a common degenerative phenomenon in the spleen has not been determined. Autopsy spleens from 355 patients (171 AIDS, 184 non-AIDS) were g
Mouse resident microglia: isolation and characterization of immunoregulatory properties with naive CD4+ and CD8+ T-cells.: Glia. 1998 Apr;22(4):348-59. Unique Identifier : AIDSLINE MED/98176744; Havenith CE; Askew D; Walker WS; Department of Immunology, St. Jude Children's Research Hospital,; Memphis, Tennessee 38105, USA.; We describe a non-enzymatic procedure designed to isolate in high purity resident microglia from the brains of normal mice. This procedure allowed for the characterization of the cells without concern that their surface features had been enzymatically altered during tissue processing. A cell population was obtained an
Sexual activity and knowledge of safe sex reported by HIV-infected persons receiving home care.: Home Healthc Nurse. 1998 Mar;16(3):183-92. Unique Identifier : AIDSLINE MED/98205527; Nickel JT; Salsberry PJ; O'Connell M; Long T; Ohio State University College of Nursing, Columbus, USA.; nickel.l@osu.edu; Sexual activity and knowledge of safe sex were assessed for 57 human immunodeficiency virus (HIV)-infected persons on admission to home care. More than one third of the individuals providing information were sexually active; 72% of the sexually active persons reported that they practiced safe sex. Definitions of safe
Specific interaction of HIV-1 and HIV-2 surface envelope glycoproteins with monolayers of galactosylceramide and ganglioside GM3.: J Biol Chem. 1998 Apr 3;273(14):7967-71. Unique Identifier : AIDSLINE MED/98192581; Hammache D; Pieroni G; Yahi N; Delezay O; Koch N; Lafont H; Tamalet C; Fantini J; Laboratoire de Biochimie et Biologie de la Nutrition, UPRESA-CNRS; 6033, Faculte des Sciences de St Jerome, 13397 Marseille Cedex 20,; France.; Cellular glycosphingolipids mediate the fusion between some viruses and the plasma membrane of target cells. In the present study, we have analyzed the interaction of human immunodeficiency virus (HIV)-1 and HIV-2 surface envelope glycoproteins from distinct viral isolates with monolayers of various glycosphingolipids
Diversity of HIV-1 Vpr interactions involves usage of the WXXF motif of host cell proteins.: J Biol Chem. 1998 Apr 3;273(14):8009-16. Unique Identifier : AIDSLINE MED/98192587; BouHamdan M; Xue Y; Baudat Y; Hu B; Sire J; Pomerantz RJ; Duan LX; The Dorrance H. Hamilton Laboratories, Center for Human Virology,; Division of Infectious Diseases, Department of Medicine, Jefferson; Medical College, Thomas Jefferson University, Philadelphia,; Pennsylvania 19107, USA.; Targeting protein or RNA moieties to specific cellular compartments may enhance their desired functions and specificities. Human immunodeficiency virus type I (HIV-1) encodes proteins in addition to Gag, Pol, and Env that are packaged into virus particles. One such retroviral-incorporated protein is Vpr, which is pres
HIV-1 Tat elongates the G1 phase and indirectly promotes HIV-1 gene expression in cells of glial origin.: J Biol Chem. 1998 Apr 3;273(14):8130-6. Unique Identifier : AIDSLINE MED/98192603; Kundu M; Sharma S; De Luca A; Giordano A; Rappaport J; Khalili K; Amini S; Center for NeuroVirology and NeuroOncology, Allegheny University of; the Health Sciences, Philadelphia, Pennsylvania 19102, USA.; Human immunodeficiency virus type-1 (HIV-1) infection of the central nervous system (CNS) gives rise to many of the neurological complications in patients with AIDS. Infection of microglial cells and astrocytes in the brain promotes the release of HIV-1 Tat and other candidate neurotoxins that may be associated with t
AIDS-associated Kaposi's sarcoma.: Hosp Pract (Off Ed). 1998 Apr 15;33(4):85-8, 95-6, 99-102. Unique Identifier : AIDSLINE MED/98223928; Kroll MH; Shandera WX; Baylor College of Medicine, Houston, USA.; In less than two decades, the disease mechanisms have been elucidated and hypotheses for innovative treatment have been developed. Our understanding of the sarcoma s pathogenesis has led directly to general knowledge of the physiology and pathology of angiogenesis. Hence, it can be expected that new treatments for all
Regression of Kaposi's sarcoma during therapy with HIV-1 protease inhibitors: a prospective pilot study.: J Am Acad Dermatol. 1998 Apr;38(4):594-8. Unique Identifier : AIDSLINE MED/98215084; Krischer J; Rutschmann O; Hirschel B; Vollenweider-Roten S; Saurat JH; Pechere M; Department of Dermatology, University Hospital Geneva, Switzerland.; BACKGROUND: Early studies using HIV protease inhibitors (PI) showed regression of Kaposi s sarcoma (KS) lesions in some patients. OBJECTIVE: Our purpose was to determine prospectively the influence of PI on HIV-related KS. METHODS: KS lesions of nine patients with p
Post-thymic maturation of migrating human thymic single-positive T cells: thymic CD1a- CD4+ T cells are more susceptible to anergy induction by toxic shock syndrome toxin-1 than cord blood CD4+ T cells.: J Immunol. 1998 Jan 1;160(1):112-9. Unique Identifier : AIDSLINE MED/98211689; Imanishi K; Seo K; Kato H; Miyoshi-Akiyama T; Zhang RH; Takanashi Y; Imai Y; Uchiyama T; Department of Microbiology and Immunology, The Heart Institute of; Japan, Tokyo Women's Medical College, Japan.; To determine whether human CD4+ T cells undergo post-thymic maturation, we compared the susceptibility to anergy induction in human thymic CD1a- CD4+ single-positive (CD4+), cord blood (CB) CD4+, and adult peripheral blood (APB) CD4+ T cells by stimulation with toxic shock syndrome toxin-1 (TSST-1). Most TSST-1-induce
Induction of granulomatous experimental autoimmune thyroiditis in IL-4 gene-disrupted mice.: J Immunol. 1998 Jan 1;160(1):155-62. Unique Identifier : AIDSLINE MED/98211693; Tang H; Sharp GC; Peterson KE; Braley-Mullen H; Department of Internal Medicine, University of Missouri-Columbia; School of Medicine, 65212, USA.; To study the role of IL-4 in development of granulomatous experimental autoimmune thyroiditis (EAT), IL-4 gene-disrupted mice expressing the EAT-susceptible H-2k haplotype were generated and used for EAT induction. Spleen cells from mouse thyroglobulin MTg) and LPS-primed IL-4(+/+) and IL-4(-/-) donors could induce se
Detection and delineation of CXCR-4 (fusin) as an entry and fusion cofactor for T cell-tropic HIV-1 by three different monoclonal antibodies.: J Immunol. 1998 Jan 1;160(1):180-8. Unique Identifier : AIDSLINE MED/98211696; Hori T; Sakaida H; Sato A; Nakajima T; Shida H; Yoshie O; Uchiyama T; Laboratory of AIDS Immunology, the Research Center for; Immunodeficiency Virus, Kyoto University, Japan.; thori@virus.kyoto-u.ac.jp; A chemokine receptor, CXCR-4, has been identified as an entry cofactor for T cell line-tropic (T-tropic) HIV-1. To detect expression of CXCR-4 at the single cell level and dissect postbinding events of HIV-1 infection, we generated three mAbs against human CXCR-4. These mAbs inhibited SDF-1-induced intracellular Ca2+
HIV-1 infection induces a selective reduction in STAT5 protein expression.: J Immunol. 1998 Jan 1;160(1):28-31. Unique Identifier : AIDSLINE MED/98211678; Pericle F; Pinto LA; Hicks S; Kirken RA; Sconocchia G; Rusnak J; Dolan MJ; Shearer GM; Segal DM; Experimental Immunology Branch, National Cancer Institute, National; Institutes of Health, Bethesda, MD, USA.; HIV-1 infection is accompanied by qualitative and quantitative defects in CD4+ T lymphocytes. Loss of immune function in HIV patients is usually associated with a profound dysregulation of cytokine production. To investigate whether cytokine signaling defects occur during HIV infection, PHA blasts from healthy human d
Legionella pneumophila infection in intratracheally inoculated T cell-depleted or -nondepleted A/J mice.: J Immunol. 1998 Jan 1;160(1):316-21. Unique Identifier : AIDSLINE MED/98211712; Susa M; Ticac B; Rukavina T; Doric M; Marre R; Department of Medical Microbiology and Hygiene, University of Ulm,; Germany. milorad.susa@medizin.uni-ulm.de; The inflammatory response and influence of T cell depletion on the pathogenesis of an experimental Legionella infection were studied. A/J mice were infected with 10(6) CFU of Legionella pneumophila intratracheally. With this dose all infected animals survived the infection and bacteria were cleared from lung, spleen,
Mechanism of protective immunity against influenza virus infection in mice without antibodies.: J Immunol. 1998 Jan 1;160(1):322-7. Unique Identifier : AIDSLINE MED/98211713; Epstein SL; Lo CY; Misplon JA; Bennink JR; Molecular Immunology Laboratory, Division of Cellular and Gene; Therapies, Center for Biologics Evaluation and Research, Food and Drug; Administration, Bethesda, MD 20892, USA. epsteins@A1.cber.fda.gov; There is considerable interest in developing viral vaccines intended to induce T cell immunity, especially cytotoxic CD8+ T lymphocytes, when Abs are not protective or are too narrow in viral strain specificity. We have studied protective immunity in doubly inactivated (DI) mice devoid of Abs and mature B cells. When
Successful adoptive cellular immunotherapy is dependent on induction of a host immune response triggered by cytokine IFN-gamma and granulocyte/macrophage colony-stimulating factor) producing donor tumor-infiltrating lymphocytes.: J Immunol. 1998 Jan 1;160(1):334-44. Unique Identifier : AIDSLINE MED/98211715; Nagoshi M; Goedegebuure PS; Burger UL; Sadanaga N; Chang MP; Eberlein TJ; Department of Surgery, Brigham and Women's Hospital, Harvard Medical; School, Boston, MA 02115, USA.; Adoptive immunotherapy with tumor-infiltrating lymphocytes (TIL) and systemic low dose rIL-2 effectively eradicates pulmonary metastases of the murine MCA-105 sarcoma. We described earlier that host CD8+ T cells are critical for tumor eradication and that successful treatment is associated with production of high leve
Chronic Listeria infection in SCID mice: requirements for the carrier state and the dual role of T cells in transferring protection or suppression.: J Immunol. 1998 Jan 1;160(1):376-84. Unique Identifier : AIDSLINE MED/98211720; Bhardwaj V; Kanagawa O; Swanson PE; Unanue ER; Center for Immunology and Department of Pathology, Washington; University School of Medicine, St. Louis, MO 63110, USA.; Listeriosis in mice with the SCID mutation results in a chronic infection. The chronic infection is characterized by abundant granulomas and neutrophil infiltrates. Both lesions were particularly noticeable in the liver. In the liver, about 95% are granulomas with 5% microabscesses involving intrahepatic infection. Th
An alternative translational reading frame encodes an immunodominant retroviral CTL determinant expressed by an immunodeficiency-causing retrovirus.: J Immunol. 1998 Jan 1;160(1):39-50. Unique Identifier : AIDSLINE MED/98211680; Mayrand SM; Schwarz DA; Green WR; Department of Microbiology and the Norris Cotton Cancer Center,; Dartmouth Medical School, Lebanon, NH 03756, USA.; Recognition of virus-infected or transformed cells by CD8+ CTL requires a trimolecular complex composed of MHC class I, beta2-microglobulin, and a specific foreign peptide composed of 8 to 10 linear amino acids. The generation of such CTL epitopes has traditionally been thought to be from the primary open reading fram
CD8+ myelin peptide-specific T cells can chemoattract CD4+ myelin peptide-specific T cells: importance of IFN-inducible protein 10.: J Immunol. 1998 Jan 1;160(1):444-8. Unique Identifier : AIDSLINE MED/98211728; Biddison WE; Cruikshank WW; Center DM; Pelfrey CM; Taub DD; Turner RV; Molecular Immunology Section, Neuroimmunology Branch, National; Institute of Neurological Disorders and Stroke, National Institutes of; Health, Bethesda, MD 20892, USA.; The demyelination process that occurs in the central nervous system (CNS) of patients with multiple sclerosis (MS) is due, in part, to an inflammatory response in which CD4+ and CD8+ T cells and macrophages infiltrate white matter. While it is thought that the inflammatory and demyelination process in MS is the produc
A new role for B cells in systemic autoimmunity: B cells promote spontaneous T cell activation in MRL-lpr/lpr mice.: J Immunol. 1998 Jan 1;160(1):51-9. Unique Identifier : AIDSLINE MED/98211681; Chan O; Shlomchik MJ; Section of Immunobiology, Yale University School of Medicine, New; Haven, CT 06520-8035, USA.; A conventional view of the pathogenesis of systemic lupus erythematosus has emerged. The role of B cells is to secrete pathogenic autoantibodies, while the role of T cells is to provide help for autoantibody-producing B cells. A problem with this view is that spontaneous T cell activation as well as T cell infiltratio
In SCID-hu mice, passive transfer of a humanized antibody prevents infection and atrophic change of medulla in human thymic implant due to intravenous inoculation of primary HIV-1 isolate.: J Immunol. 1998 Jan 1;160(1):69-76. Unique Identifier : AIDSLINE MED/98211683; Okamoto Y; Eda Y; Ogura A; Shibata S; Amagai T; Katsura Y; Asano T; Kimachi K; Makizumi K; Honda M; AIDS Research Center, National Institute of Infectious Diseases,; Tokyo, Japan.; Using SCID-hu mice, it was tested whether humanized mAb Rmu5.5 could prevent infection by HIV-1 i.v. inoculation. The Ab that recognizes the IHIGPGRAFYT motif in the principal neutralizing determinant (PND) of HIV(MN), as well as the original mouse mAb mu5.5, neutralized HIV(MN) with high activity. Seven primary field
Naturally occurring low affinity peptide/MHC class I ligands can mediate negative selection and T cell activation.: J Immunol. 1998 Jan 1;160(1):77-86. Unique Identifier : AIDSLINE MED/98211684; Motyka B; Teh HS; Department of Microbiology and Immunology, University of British; Columbia, Vancouver, Canada.; The affinity/avidity model for T cell development postulates that ligands with high affinity for the TCR are efficient in negative selection, whereas those with lower affinity/avidity favor positive selection. Using the 2C TCR transgenic model, we evaluated the efficacy of ligands with widely differing affinity for th
Normal responsiveness of CTLA-4-deficient anti-viral cytotoxic T cells.: J Immunol. 1998 Jan 1;160(1):95-100. Unique Identifier : AIDSLINE MED/98211686; Bachmann MF; Waterhouse P; Speiser DE; McKall-Faienza K; Mak TW; Ohashi PS; Department of Medical Biophysics, Ontario Cancer Institute, Toronto,; Canada.; CTLA-4 has been proposed to negatively regulate immune responses, and mice deficient for CTLA-4 expression succumb to a lymphoproliferative disorder within a few weeks after birth. This study assessed the responsiveness of CTLA-4-deficient T cells expressing a class I-restricted TCR specific for lymphocytic choriomeni
CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis.: J Immunol. 1998 Apr 15;160(8):3627-30. Unique Identifier : AIDSLINE MED/98217143; Zimmermann S; Egeter O; Hausmann S; Lipford GB; Rocken M; Wagner H; Heeg K; Institute of Medical Microbiology, Immunology and Hygiene, Technische; Universitat Munchen, Germany.; Synthetic oligodeoxynucleotides containing CpG dinucleotides CpG-ODN) mimic the immunostimulatory qualities of bacterial DNA. We asked whether immunostimulation by CpG-ODN predisposes for a commitment toward a Th1 vs a Th2 response in Leishmania major infection, a model for a lethal Th2-driven disease, in BALB/c mice.
Thymic lineage commitment rather than selection causes genetic variations in size of CD4 and CD8 compartments.: J Immunol. 1998 Apr 15;160(8):3649-54. Unique Identifier : AIDSLINE MED/98217147; van Meerwijk JP; Bianchi T; Marguerat S; MacDonald HR; Ludwig Institute for Cancer Research, Lausanne Branch, University of; Lausanne, Epalinges, Switzerland.; During their development, immature CD4+ CD8+ thymocytes become committed to either the CD4 or CD8 lineage. Subsequent complete maturation of CD4+ and CD8+ cells requires a molecular match of the expressed coreceptor and the MHC specificity of the TCR. The final size of the mature CD4+ and CD8+ thymic compartments is t
T:T antigen presentation by activated murine CD8+ T cells induces anergy and apoptosis.: J Immunol. 1998 Apr 15;160(8):3655-65. Unique Identifier : AIDSLINE MED/98217148; Chai JG; Bartok I; Scott D; Dyson J; Lechler R; Department of Immunology, Hammersmith Hospital, Imperial College of; Science, Technology, and Medicine, London, United Kingdom.; Using an IL-2-secreting, noncytolytic, H-Y-specific, CD8+ T cell clone, the functional consequences of Ag presentation by T cells to T cells were investigated. Incubation of the T cells with H-Y-soluble peptide led to nonresponsiveness to Ag rechallenge. This was due to the simultaneous induction of apoptosis, involvi
Identification of a developmentally regulated phase of postselection expansion driven by thymic epithelium.: J Immunol. 1998 Apr 15;160(8):3666-72. Unique Identifier : AIDSLINE MED/98217149; Hare KJ; Wilkinson RW; Jenkinson EJ; Anderson G; Department of Anatomy, Medical School, University of Birmingham,; Edgbaston, United Kingdom. K.J.Hare@bham.ac.uk; To investigate events following the initiation of positive selection, we have used reaggregate organ cultures to follow the maturation of purified CD4+8+69+ thymocytes; these thymocytes represent a subpopulation of thymocytes which have already received positive selection signals. Using a dilution analysis of an FITC-
CD8+ cells are not necessary for allograft rejection or the induction of apoptosis in an experimental model of small intestinal transplantation.: J Immunol. 1998 Apr 15;160(8):3673-80. Unique Identifier : AIDSLINE MED/98217150; Krams SM; Hayashi M; Fox CK; Villanueva JC; Whitmer KJ; Burns W; Esquivel CO; Martinez OM; Department of Surgery and Digestive Disease Center, Stanford; University School of Medicine, CA 94305-5487, USA.; Allospecific CTL can function as cellular effectors of solid organ graft rejection; however, the specific mechanisms of cell damage remain undetermined. In this study we examined the role of CD8+ T cells in apoptosis and rejection of small intestinal allografts. ACI rat intestinal grafts transplanted into Lewis rat re
MHC class I is required for peripheral accumulation of CD8+ thymic emigrants.: J Immunol. 1998 Apr 15;160(8):3705-12. Unique Identifier : AIDSLINE MED/98217154; Nesic D; Vukmanovic S; Department of Pathology and Kaplan Comprehensive Cancer Center, New; York University Medical Center, New York 10016, USA.; MHC molecules influence the fate of T lymphocytes at two important stages of their differentiation. Recognition of self peptide/MHC complexes in the thymus determines whether immature T cells should live and mature into immunocompetent T cells or whether they should die. In the periphery, recognition of Ags presented
Cross-reactivity in murine fluoroquinolone photoallergy: exclusive usage of TCR Vbeta13 by immune T cells that recognize fluoroquinolone-photomodified cells.: J Immunol. 1998 Apr 15;160(8):3719-28. Unique Identifier : AIDSLINE MED/98217156; Tokura Y; Seo N; Yagi H; Furukawa F; Takigawa M; Department of Dermatology, Hamamatsu University School of Medicine,; Japan. tokuray@hama-med.ac.jp; Fluoroquinolone antibacterial agents are well known to elicit photosensitivity as an adverse effect, and their cross-reactivity has been clinically documented. The photoallergenicity of fluoroquinolones is mainly derived from their photohaptenic moiety, and photomodification of skin epidermal cells with fluoroquinolon
Differential capacities of CD4+, CD8+, and CD4-CD8- T cell subsets to express IL-18 receptor and produce IFN-gamma in response to IL-18.: J Immunol. 1998 Apr 15;160(8):3759-65. Unique Identifier : AIDSLINE MED/98217161; Tomura M; Maruo S; Mu J; Zhou XY; Ahn HJ; Hamaoka T; Okamura H; Nakanishi K; Clark S; Kurimoto M; Fujiwara H; Biomedical Research Center, Osaka University Medical School, Suita,; Japan.; IL-12 and IL-18 have the capacity to stimulate IFN-gamma production by T cells. Using a T cell clone, we reported that IL-18 responsiveness is generated only after exposure to IL-12. Here, we investigated the induction of IL-18 responsiveness in resting CD8+, CD4+, and CD4-CD8- T cells. Resting T cells respond to neit
A cytokine cascade including prostaglandin E2, IL-4, and IL-10 is responsible for UV-induced systemic immune suppression.: J Immunol. 1998 Apr 15;160(8):3783-9. Unique Identifier : AIDSLINE MED/98217164; Shreedhar V; Giese T; Sung VW; Ullrich SE; Department of Immunology, The University of Texas, M. D. Anderson; Cancer Center, Houston 77030, USA.; Even though all of the energy contained with the UV wavelengths of solar radiation is absorbed within the epidermis and upper layers of the dermis, UV irradiation can suppress immune responses to Ag introduced at distant nonirradiated sites. In addition, data from a number of laboratories have suggested that one conse
Differential requirement for p56lck in fetal and adult thymopoiesis.: J Immunol. 1998 Apr 15;160(8):3828-34. Unique Identifier : AIDSLINE MED/98217170; Molina TJ; Perrot JY; Penninger J; Ramos A; Audouin J; Briand P; Mak TW; Diebold J; Department of Pathology, Hotel Dieu de Paris, AP-HR, France.; The protein tyrosine kinase p56lck is critical for the generation of mature thymocytes in adult mice. However its requirement during the maturation of thymocytes from the fetal to the adult stage has not been clearly defined. We analyzed prenatal and postnatal thymocyte maturation in mice deficient for p56lck lck[-/-]
Nuclear factor kappaB is required for peptide antigen-induced differentiation of a CD4+CD8+ thymocyte line.: J Immunol. 1998 Apr 15;160(8):3835-43. Unique Identifier : AIDSLINE MED/98217171; Ochoa-Garay J; Kaye J; Coligan JE; Laboratory of Molecular Structure, National Institute of Allergy and; Infectious Diseases, Rockville, MD 20852, USA.; NF-kappaB transcription factors are known to regulate the expression of a number of genes involved in T cell activation and function. Some evidence has suggested that they also play a role in T cell development. However, the role of NF-kappaB in Ag-induced thymocyte differentiation has not been directly addressed to d
Thymic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are strictly dependent on aryl hydrocarbon receptor activation in hemopoietic cells.: J Immunol. 1998 Apr 15;160(8):3844-54. Unique Identifier : AIDSLINE MED/98217172; Staples JE; Murante FG; Fiore NC; Gasiewicz TA; Silverstone AE; Department of Microbiology and Immunology, State University of New; York, Health Science Center, Syracuse 13210, USA.; 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related congeners affect the immune system, causing immunosuppression and thymic atrophy in a variety of animal species. TCDD is believed to exert its effects primarily through the ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR). Although the Ah
CTLA-4 regulates tolerance induction and T cell differentiation in vivo.: J Immunol. 1998 Apr 15;160(8):3855-60. Unique Identifier : AIDSLINE MED/98217173; Walunas TL; Bluestone JA; The Committee on Immunology and the Ben May Institute for Cancer; Research, The University of Chicago, IL 60637, USA.; Cytotoxic T lymphocyte Ag-4 (CTLA-4; CD152) is an important T cell regulatory molecule. In vitro experiments have shown that the blockade of signals through CTLA-4 augments T cell expansion, while CTLA-4 cross-linking results in decreased T cell proliferation due to decreased
Extracellular HIV-1 Tat protein induces the rapid Ser133 phosphorylation and activation of CREB transcription factor in both Jurkat lymphoblastoid T cells and primary peripheral blood mononuclear cells.: J Immunol. 1998 Apr 15;160(8):3891-8. Unique Identifier : AIDSLINE MED/98217178; Gibellini D; Bassini A; Pierpaoli S; Bertolaso L; Milani D; Capitani S; La Placa M; Zauli G; Institute of Microbiology, University of Bologna, Italy.; Extracellular HIV-1 Tat protein (0.1-100 ng/ml) induced a rapid peak at 30 min) increase in the Ser133 phosphorylation levels of the transcription factor CREB in serum-starved Jurkat cells, as revealed by Western blot and indirect immunofluorescence analyses. Nuclear cAMP-responsive element (CRE) binding activity in e
Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry.: J Immunol. 1998 Apr 15;160(8):3933-41. Unique Identifier : AIDSLINE MED/98217183; Rubbert A; Combadiere C; Ostrowski M; Arthos J; Dybul M; Machado E; Cohn MA; Hoxie JA; Murphy PM; Fauci AS; Weissman D; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892-1576, USA.; Cells of the dendritic lineage are thought to be among the first cells infected after mucosal exposure to HIV. In this study, we have identified the presence of multiple chemokine receptors on dendritic cells (DC) that may function as coreceptors for HIV entry. DC effectively used CCR5 for entry of macrophage M)-tropi
Induction of a Th1 immune response and simultaneous lack of activation of a Th2 response are required for generation of immunity to leishmaniasis.: J Immunol. 1998 Apr 15;160(8):3949-57. Unique Identifier : AIDSLINE MED/98217185; Sjolander A; Baldwin TM; Curtis JM; Handman E; The Walter and Eliza Hall Institute of Medical Research, Post Office; Royal Melbourne Hospital, Victoria, Australia.; Experimental systems based on immunization with plasmid DNA or immune-stimulating complexes were used to delineate the requirements for generation of protective immunity against murine leishmaniasis. Vaccination with plasmid DNA encoding the host-protective Leishmania major parasite surface Ag-2 primed for an essentia
Mice lacking IL-12 develop polarized Th1 cells during viral infection.: J Immunol. 1998 Apr 15;160(8):3958-64. Unique Identifier : AIDSLINE MED/98217186; Schijns VE; Haagmans BL; Wierda CM; Kruithof B; Heijnen IA; Alber G; Horzinek MC; Department of Infectious Diseases and Immunology, Faculty of; Veterinary Medicine, Utrecht University, The Netherlands.; virgil.schijns@intervet.akzonobel.nl; Studies in IL-12-deficient mice established the necessity for IL-12 to generate a Th1 cytokine response that is often required for elimination of intracellular pathogens. In this study, we demonstrate that mice with a targeted disruption of the IL-12p40 and/or p35 gene effectively control liver damage induced by mouse
Impaired macrophage function and enhanced T cell-dependent immune response in mice lacking CCR5, the mouse homologue of the major HIV-1 coreceptor.: J Immunol. 1998 Apr 15;160(8):4018-25. Unique Identifier : AIDSLINE MED/98217194; Zhou Y; Kurihara T; Ryseck RP; Yang Y; Ryan C; Loy J; Warr G; Bravo R; Department of Oncology, Bristol-Myers Squibb Pharmaceutical Research; Institute, Princeton, NJ 08543, USA.; The CC-chemokine receptor CCR5 has been shown to be the major coreceptor for HIV-1 entry into cells, and humans with homozygous mutation in the ccr5 gene are highly resistant to HIV-1 infection, despite the existence of many other HIV-1 coreceptors. To investigate the physiologic function of CCR5 and to understand the
Effects of [D-Ala1] peptide T-NH2 and HIV envelope glycoprotein gp120 on cyclic AMP dependent protein kinases in normal and psoriatic human fibroblasts.: J Invest Dermatol. 1998 Apr;110(4):332-7. Unique Identifier : AIDSLINE MED/98200039; Liapi C; Takahashi N; Raynaud F; Evain-Brion D; Anderson WB; Laboratory of Cellular Oncology, National Cancer Institute, NIH,; Bethesda, Maryland 20892, USA.; In addition to acquired immunodeficiency syndrome (AIDS), persons infected with human immunodeficiency virus often develop cutaneous manifestations, including severe psoriasis. In previous studies, we have established that psoriatic fibroblasts and erythrocytes obtained from psoriatic patients exhibit decreased levels
Backwards bifurcations and catastrophe in simple models of fatal diseases.: J Math Biol. 1998 Feb;36(3):227-48. Unique Identifier : AIDSLINE MED/98188552; Dushoff J; Huang W; Castillo-Chavez C; Department of Ecology and Evolutionary Biology, Princeton University,; NJ 08542, USA.
Three new diterpenes from the marine soft coral Lobophytum crassum.: J Nat Prod. 1998 Feb;61(2):237-40. Unique Identifier : AIDSLINE MED/98237012; Matthee GF; Konig GM; Wright AD; Institute for Pharmaceutical Biology, Technical University of; Braunschweig, Germany.; Three new terpenoid metabolites (1-3) were isolated from the CH2Cl2 extract of the soft coral Lobophytum crassum together with the eudesmane derivative 4 and the known cembrane 2S,7S,8S)-sarcophytoxide (5). Compound 1 is a new cembrane-based diterpene with an C7-C8-epoxide and a methyl ester functionality at C-16. (3E
HIV-inhibitory and cytotoxic oligostilbenes from the leaves of Hopea malibato.: J Nat Prod. 1998 Mar;61(3):351-3. Unique Identifier : AIDSLINE MED/98206209; Dai JR; Hallock YF; Cardellina JH 2nd; Boyd MR; Laboratory of Drug Discovery Research and Development, National Cancer; Institute, Frederick, Maryland 21702-1201, USA.; Three new oligostilbenes, malibatols A (1) and B (2) and dibalanocarpol (3), together with one known oligostilbene balanocarpol (4), were isolated from the organic extract of the leaves of Hopea malibato. The structure elucidation of these compounds was based on the interpretation of their chemical and spectral data.
Prognostic value of myocardial perfusion imaging with exercise and/or dipyridamole hyperemia in patients with preexisting left bundle branch block.: J Nucl Med. 1998 Apr;39(4):579-81. Unique Identifier : AIDSLINE MED/98204218; Nigam A; Humen DP; Division of Cardiology, University of Alberta Hospital, Edmonton,; Canada.; The detection of myocardial ischemia in patients with preexisting left bundle branch block (LBBB) remains problematic. Pharmacologic hyperemia with dipyridamole is now used routinely in such patients for detection of significant coronary artery disease. Little data exists on the prognostic value of cardiac nuclear sci
The toothbrush, Kaposi's sarcoma and AIDS: a case demonstrating interesting associations.: J Okla Dent Assoc. 1995 Fall;86(2):22-4. Unique Identifier : AIDSLINE MED/98186990; Glass RT; Min KW; Adler V; College of Dentistry, University of Oklahoma, Oklahoma City, USA.
Recent advances in vaccine adjuvants for systemic and mucosal administration.: J Pharm Pharmacol. 1998 Jan;50(1):1-10. Unique Identifier : AIDSLINE MED/98162955; O'Hagan DT; Chiron Corporation, Emeryville, CA, USA.; Although vaccines produced by recombinant DNA technology are safer than traditional vaccines, which are based on attenuated or inactivated bacteria or viruses, they are often poorly immunogenic. Therefore, adjuvants are often required to enhance the immunogenicity of these vaccines. A number of adjuvants which are par
Tuberculosis--an epidemic of injustice [letter]: J R Coll Physicians Lond. 1998 Jan-Feb;32(1):84. Unique Identifier : AIDSLINE MED/98168292; Darbyshire JH
Aseptic avascular osteonecrosis mimicking arthritis in HIV infection [letter]: J Rheumatol. 1998 Mar;25(3):604-5. Unique Identifier : AIDSLINE MED/98176971; Gerster JC; Rossetti G
Design, synthesis, and antiviral evaluations of 1-(substituted benzyl)-2-substituted-5,6-dichlorobenzimidazoles as nonnucleoside analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole.: J Med Chem. 1998 Apr 9;41(8):1252-62. Unique Identifier : AIDSLINE MED/98215787; Porcari AR; Devivar RV; Kucera LS; Drach JC; Townsend LB; Department of Medicinal Chemistry, College of Pharmacy, University of; Michigan, Ann Arbor, Michigan 48109-1065, USA.; We have recently reported that certain ribosylated polyhalogenated benzimidazoles are potent and selective inhibitors of HCMV replication at noncytotoxic concentrations. To extend the structure-activity relationship beyond these first-generation compounds, we alkylated 5,6-dichloro-2-substituted-benzimidazoles with ei
Synthesis and antiviral activity of novel acyclic nucleosides: discovery of a cyclopropyl nucleoside with potent inhibitory activity against herpesviruses.: J Med Chem. 1998 Apr 9;41(8):1284-98. Unique Identifier : AIDSLINE MED/98215790; Sekiyama T; Hatsuya S; Tanaka Y; Uchiyama M; Ono N; Iwayama S; Oikawa M; Suzuki K; Okunishi M; Tsuji T; Central Research Laboratories, Ajinomoto Company, Inc., 1-1; Suzuki-cho, Kawasaki 210, Japan.; A series of acyclic nucleosides with two hydroxymethyl groups mimicking the 3 - and 5 -hydroxyl groups of the 2 -deoxyribose moiety were prepared and evaluated for their antiherpetic activity. Among those, 9-[[cis-1 , 2 -bis(hydroxymethyl)cycloprop-1 -yl]methyl]guanine (3) showed extremely potent antiviral activity ag
Detection of Pneumocystis carinii among children with chronic respiratory disorders in the absence of HIV infection and immunodeficiency.: J Med Microbiol. 1998 Apr;47(4):329-33. Unique Identifier : AIDSLINE MED/98227954; Contini C; Villa MP; Romani R; Merolla R; Delia S; Ronchetti R; Institute of Infectious and Respiratory Diseases, University of; Ferrara, Italy.; A nested polymerase chain reaction (PCR) assay was investigated for detection of Pneumocystis carinii in 96 respiratory tract specimens from 82 children, of whom 28 were immunocompetent but with chronic lung disorders (CLD), eight had AIDS and P. carinii pneumonia (PCP), 16 had AIDS but no respiratory symptoms, and 30
Haemolysin from Mycobacterium avium complex isolates from AIDS patients.: J Med Microbiol. 1998 Apr;47(4):365-7. Unique Identifier : AIDSLINE MED/98227959; Deshpande RG; Khan MB; Bhat DA; Navalkar RG; Department of Microbiology and Immunology, Morehouse School of; Medicine, Atlanta, GA 30310, USA.; Cell-bound haemolytic activity was observed in isolates of Mycobacterium avium complex (MAC) from AIDS patients. M. avium type strains showed negligible activity. None of the culture supernates exhibited any haemolytic activity. Zwitterionic detergent 3-[(3-cholamidopropyl)-dimethyl-ammonio]-1-propanesulphonate CHAPS)
Ribozymes as therapeutic agents: are we getting closer? [editorial; comment]: J Natl Cancer Inst. 1998 Apr 15;90(8):558-9. Unique Identifier : AIDSLINE MED/98213095; Scanlon KJ; Kashani-Sabet M
Human leukocyte antigen class II alleles associated with human T-cell lymphotropic virus type I infection and adult T-cell leukemia/lymphoma in a Black population.: J Natl Cancer Inst. 1998 Apr 15;90(8):617-22. Unique Identifier : AIDSLINE MED/98213108; Manns A; Hanchard B; Morgan OS; Wilks R; Cranston B; Nam JM; Blank M; Kuwayama M; Yashiki S; Fujiyoshi T; Blattner W; Sonoda S; Division of Cancer Epidemiology and Genetics, National Cancer; Institute, Bethesda, MD 20892, USA.; BACKGROUND: Human T-cell lymphotropic virus type I (HTLV-I) is linked to adult T-cell leukemia/lymphoma (ATL) and HTLV-I-associated myelopathy (HAM; also known as tropical spastic paraparesis [TSP]), a chronic neurodegenerative disorder. Worldwide, several million HTLV-I carriers are at risk for disease, with an estim
Immunophenotypic characterization of simian immunodeficiency virus-infected dendritic cells in cervix, vagina, and draining lymph nodes of rhesus monkeys.: Lab Invest. 1998 Apr;78(4):435-51. Unique Identifier : AIDSLINE MED/98224559; Hu J; Pope M; Brown C; O'Doherty U; Miller CJ; California Regional Primate Research Center, School of Veterinary; Medicine, University of California, Davis 95616, USA.; Significant progress has been made in understanding the biology of heterosexual transmission of HIV by utilizing the simian immunodeficiency virus (SIV)/rhesus monkey animal model. Our previous studies have shown that SIV-infected cells within the stratified squamous epithelium of the vagina have a dendritic morpholog
Predictors of participation in aftercare sessions and self-help groups following completion of intensive outpatient treatment for substance abuse.: J Stud Alcohol. 1998 Mar;59(2):152-62. Unique Identifier : AIDSLINE MED/98159938; McKay JR; McLellan AT; Alterman AI; Cacciola JS; Rutherford MJ; O'Brien CP; Department of Psychiatry, University of Pennsylvania School of; Medicine, Treatment Research Center, Philadelphia 19104, USA.; OBJECTIVE: The goals of this study were to identify predictors of greater participation in aftercare treatment sessions and self-help groups during the first 3 months following completion of a 4-week intensive outpatient rehabilitation (IOP) program. METHOD: The subjects were 138 male veterans who met DSM-III-R criter
Phenotypical heterogeneity of CD4+CD8+ double-positive chronic T lymphoid leukemia.: Leukemia. 1998 Apr;12(4):499-504. Unique Identifier : AIDSLINE MED/98216685; Mizuki M; Tagawa S; Machii T; Shibano M; Tatsumi E; Tsubaki K; Tako H; Yokohama A; Satou S; Nojima J; Hirota T; Kitani T; Department of Hematology and Oncology, Osaka University Medical; School, Suita, Japan.; Chronic T lymphoid leukemias are defined as leukemias of post-thymic T cells. The CD4+CD8+ double-positive (DP) phenotype is seen in a few cases. Since DP generally occurs in thymic T cells, whether the DP T leukemia cells represent thymic or peripheral T cells has been a matter of controversy. To address this issue,
Cutaneous T cell lymphomas: mycosis fungoides, Sezary syndrome and HTLV-I-associated adult T cell leukemia (ATL) in Mali, West Africa: a clinical, pathological and immunovirological study of 14 cases and a review of the African ATL cases.: Leukemia. 1998 Apr;12(4):578-85. Unique Identifier : AIDSLINE MED/98216695; Fouchard N; Mahe A; Huerre M; Fraitag S; Valensi F; Macintyre E; Sanou F; de The G; Gessain A; Unite d'Epidemologie des Virus Oncogenes, Institut Pasteur, Paris,; France.; Cutaneous T cell lymphomas (CTCL) are rare lymphoproliferative diseases, which are frequently suspected to be of viral origin. As very few data were available concerning cutaneous T cell lymphomas in tropical Africa, we undertook a clinical, histopathological, immunological and viro-molecular study of patients with a
Profound abnormality of the B/T lymphocyte ratio during chemotherapy for pediatric acute lymphoblastic leukemia.: Leukemia. 1998 Apr;12(4):619-22. Unique Identifier : AIDSLINE MED/98216700; Caver TE; Slobod KS; Flynn PM; Behm FG; Hudson MM; Turner EV; Webster RG; Boyett JM; Tassie TL; Pui CH; Hurwitz JL; Department of Immunology, St Jude Children's Research Hospital,; Memphis, TN 38105, USA.; The fluorescence-activated cell sorter (FACS) was utilized to phenotype lymphocyte compartments in children receiving intensive chemotherapy for acute lymphoblastic leukemia (ALL). Sixteen patients (eight males and eight females) of diverse ages, risks of relapse, and within weeks 7-53 of maintenance/continuation chem
Clinician's guide to hepatitis C.: Mayo Clin Proc. 1998 Apr;73(4):355-60; quiz 361. Unique Identifier : AIDSLINE MED/98219794; Gross JB Jr; Division of Gastroenterology and Hepatology, Mayo Clinic Rochester, MN; 55905, USA.; Hepatitis C virus infection is common, often silent, and almost always chronic and can lead to cirrhosis and hepatocellular cancer. Deaths related to chronic hepatitis C are expected to increase dramatically in the future. Many cases of infection are asymptomatic and are undiagnosed because of a lack of recognition by
[Croatian terminology in AIDS]: Lijec Vjesn. 1997 Nov;119(10):296-7. Unique Identifier : AIDSLINE MED/98238933; Begovac J; Klinika za infektivne bolesti Dr. Fran Mihaljevic, Zagreb.
Infectivity and immunogenicity of SIVmac/HIV-1 chimeric viruses SHIVs) with deletions in two or three genes (vpr, nef and vpx).: Microbiol Immunol. 1998;42(1):71-4. Unique Identifier : AIDSLINE MED/98184698; Igarashi T; Kuwata T; Yamamoto H; Moriyama H; Ui M; Miyazaki Y; Hayami M; Laboratory of Pathogenic Virus, Institute for Virus Research, Kyoto; University, Japan.; Two SHIVs with two or three genes deleted (SHIV-drn and SHIV-dxrn) were constructed. The inoculation of monkeys with SHIV-drn resulted in short-term viremia, but inoculation with SHIV-dxrn did not. At 68 weeks post-inoculation, the monkeys were reinoculated with a 100-fold higher dose of each SHIV, but none showed vir
Elevated serum levels of the soluble form of gp130, the IL-6 signal transducer, in HTLV-1 infection and no involvement of alternative splicing for its generation.: Microbiol Immunol. 1998;42(2):109-16. Unique Identifier : AIDSLINE MED/98233569; Zhou Y; Horiuchi S; Yamamoto M; Yamamoto N; Department of Microbiology, Faculty of Medicine, Tokyo Medical and; Dental University, Japan.; By using an ELISA, increased levels of the soluble form (sgp130) of gp130, the IL-6 signal transducer, were detected in the sera of various HTLV-1-associated conditions (HC, ATL, HAM) as compared to normal healthy individuals. Sgp130 levels seemed to be correlated with disease severity. The 94 KD of sgp130 was specifi
Enhancement of human immunodeficiency virus type 1 (HIV-1) infection via increased membrane fluidity by a cationic polymer.: Microbiol Immunol. 1998;42(2):97-107. Unique Identifier : AIDSLINE MED/98233568; Owada T; Miyashita Y; Motomura T; Onishi M; Yamashita S; Yamamoto N; Department of Microbiology, Tokyo Medical and Dental University School; of Medicine, Japan.; Cationic polymers are known to have potent activity against bacteria, but their effects on viral activity have been little studied. We investigated the effect of one such polymer, polyethyleneimine (PEI), on HIV-1 infection. Although virus-cell binding was significantly inhibited by PEI, HIV-1 infection in human T-cel
[A case of vaccination-induced polio]: Med Klin. 1998 Jan 15;93(1):39-42. Unique Identifier : AIDSLINE MED/98165976; Mauel C; Merten C; Bewermeyer H; Medizinische Klinik, Landeskrankenhaus Bad Ischl.; CASE REPORT: We describe a 69 year-old female who became ill with polio after having changed the nappies of her grandchild who, six weeks earlier, had been vaccinated with oral live-vaccine against polio. Anamnesis and neurological status with limp paralysis in both legs oblige, with their implications, that the patie
Guidelines for the use of antiretroviral agents in pediatric HIV infection. Center for Disease Control and Prevention.: MMWR Morb Mortal Wkly Rep. 1998 Apr 17;47(RR-4):1-43. Unique Identifier : AIDSLINE MED/98232378; Although the pathogenesis of human immunodeficiency virus (HIV) infection and the general virologic and immunologic principles underlying the use of antiretroviral therapy are similar for all HIV-infected persons, there are unique considerations needed for HIV-infected infants, children, and adolescents, including a)
Report of the NIH Panel to Define Principles of Therapy of HIV Infection.: MMWR Morb Mortal Wkly Rep. 1998 Apr 24;47(RR-5):1-41. Unique Identifier : AIDSLINE MED/98231829; Recent research advances have afforded substantially improved understanding of the biology of human immunodeficiency virus HIV) infection and the pathogenesis of the acquired immunodeficiency syndrome (AIDS). With the advent of sensitive tools for monitoring HIV replication in infected persons, the risk of disease pro
Guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents. Department of Health and Human Services and Henry J. Kaiser Family Foundation.: MMWR Morb Mortal Wkly Rep. 1998 Apr 24;47(RR-5):43-82. Unique Identifier : AIDSLINE MED/98231830; With the development and FDA approval of an increasing number of antiretroviral agents, decisions regarding the treatment of HIV-infected persons have become complex; and the field continues to evolve rapidly. In 1996, the Department of Health and Human Services and the Henry J. Kaise
Failure of cytarabine in progressive multifocal leukoencephalopathy associated with human immunodeficiency virus infection. AIDS Clinical Trials Group 243 Team [see comments]: N Engl J Med. 1998 May 7;338(19):1345-51. Unique Identifier : AIDSLINE MED/98223107; Hall CD; Dafni U; Simpson D; Clifford D; Wetherill PE; Cohen B; McArthur J; Hollander H; Yainnoutsos C; Major E; Millar L; Timpone J; University of North Carolina at Chapel Hill School of Medicine,; 27599-7025, USA.; BACKGROUND: Progressive multifocal leukoencephalopathy affects about 4 percent of patients with the acquired immunodeficiency syndrome (AIDS), and survival after the diagnosis of leukoencephalopathy averages only about three months. There have been anecdotal reports of improvement but no controlled trials of therapy w
Progressive multifocal leukoencephalopathy--progress made and lessons relearned [editorial; comment]: N Engl J Med. 1998 May 7;338(19):1378-80. Unique Identifier : AIDSLINE MED/98223114; Greenlee JE
South African drugs agency to be replaced [news]: Nature. 1998 Apr 9;392(6676):527. Unique Identifier : AIDSLINE MED/98219061; Cherry M
Ex-UN AIDS chief is blasted for remarks on vaccine strategy [news]: Nature. 1998 Apr 9;392(6676):527-8. Unique Identifier : AIDSLINE MED/98219060; Wadman M
Neuropathy in diffuse infiltrative lymphocytosis syndrome: an HIV neuropathy, not a lymphoma [see comments]: Neurology. 1998 Apr;50(4):1041-4. Unique Identifier : AIDSLINE MED/98226043; Gherardi RK; Chretien F; Delfau-Larue MH; Authier FJ; Moulignier A; Roulland-Dussoix D; Belec L; Groupe d'Etude et de Recherche sour le Muscle et le Nerf, Creteil,; France.; OBJECTIVE: To determine whether CD8 lymphoid infiltrates in nerves of patients with HIV-associated diffuse infiltrative lymphocytosis syndrome (DILS) corresponds to a lymphomatous neoplastic process or to a proliferation of T cells reactional to HIV. BACKGROUND: DILS is characterized by persistent CD8 hyperlymphocytos
Response to corticosteroid therapy in a patient with HTLV-I-associated motor neuron disease.: Neurology. 1998 Apr;50(4):1188-9. Unique Identifier : AIDSLINE MED/98226080; Hanakawa T; Nakamura M; Suenaga T; Hashimoto S; Department of Neurology, Tenri Hospital, Nara, Japan.
The pathogenesis of diffuse infiltrative lymphocytosis syndrome: an AIDS-related peripheral neuropathy [editorial; comment]: Neurology. 1998 Apr;50(4):855-7. Unique Identifier : AIDSLINE MED/98226013; Berger JR; Simpson DM
Drug interactions and protease inhibitor therapy in the treatment of HIV/AIDS [news]: Nurse Pract. 1998 Feb;23(2):102-4, 106. Unique Identifier : AIDSLINE MED/98174406; Klaus BD; Grodesky MJ
Using unannounced standardized patients to assess the HIV preventive practices of family nurse practitioners and family physicians.: Nurse Pract. 1998 Feb;23(2):56-8, 63, 67-8 passim. Unique Identifier : AIDSLINE MED/98174404; Carney PA; Ward DH; Department of Community and Family Medicine, Dartmouth Medical School,; Hanover, New Hampshire, USA.; Measuring health risk assessment and counseling recommendations can be challenging. In this study, unannounced standardized patients (lay individuals trained to replicate a clinical encounter consistently) were used to evaluate HIV preventive performance of 22 family nurse practitioners (NPs) and family physicians. St
T cell receptor repertoire diversity and clonal expansion in human neonates.: Pediatr Res. 1998 Mar;43(3):396-402. Unique Identifier : AIDSLINE MED/98166179; Schelonka RL; Raaphorst FM; Infante D; Kraig E; Teale JM; Infante AJ; Department of Pediatrics, USAF Medical Center, Lackland AFB, Texas,; USA.; Newborn human infants, particularly those born prematurely, are susceptible to infection with a variety of microorganisms. We questioned whether limitations in the T cell repertoire contribute to the neonatal immunocompromised state. To describe developmental changes of the T cell repertoire, cDNA segments correspondi
Safety and immunogenicity of the Towne strain cytomegalovirus vaccine.: Pediatr Infect Dis J. 1998 Mar;17(3):200-6. Unique Identifier : AIDSLINE MED/98194894; Adler SP; Hempfling SH; Starr SE; Plotkin SA; Riddell S; Department of Pediatrics, Medical College of Virginia/Virginia; Commonwealth University, Richmond 23298-0163, USA. SADLER@GEMS.VCU.EDU; BACKGROUND: Women with naturally acquired serum antibodies to cytomegalovirus ( CMV ) are usually protected against both frequent secondary infection and giving birth to infants severely affected by intrauterine CMV infection.
Plasma glutathione concentrations in children infected with human immunodeficiency virus.: Pediatr Infect Dis J. 1998 Mar;17(3):236-41. Unique Identifier : AIDSLINE MED/98194900; Rodriguez JF; Cordero J; Chantry C; Gonzalez S; Rivera C; Febo I; Colon A; Diaz C; Department of Biochemistry, School of Medicine, Medical Sciences; Campus, University of Puerto Rico, San Juan 00936, USA.; J_RODRIGUEZ@RCMAXP.UPR.CLU.EDU; BACKGROUND: Glutathione (GSH) is the principal intracellular defense against oxidants, and HIV-infected individuals tend to have subnormal concentrations in plasma. This GSH deficiency may contribute to the pathogenesis of disease progression. In the pediatric population correlations between GSH concentrations with cl
HIV viral load.: Pediatr Infect Dis J. 1998 Mar;17(3):247-8. Unique Identifier : AIDSLINE MED/98194902; Yogev R; Northwestern University Medical School, Chicago, IL, USA.
["AIDS in Corsica" (news)]: Presse Med. 1997 Dec 6;26(38):1887. Unique Identifier : AIDSLINE MED/98231437; Solignac M
Electrostatic contributions to protein-protein binding affinities: application to Rap/Raf interaction.: Proteins. 1998 Mar 1;30(4):407-23. Unique Identifier : AIDSLINE MED/98192309; Muegge I; Schweins T; Warshel A; Department of Chemistry, University of Southern California, Los; Angeles 90089-1062, USA.; The challenge of evaluating absolute binding free energies of protein-protein complexes is addressed using the scaled Protein Dipoles Langevin Dipoles (PDLD/S) model in combination with the Linear Response Approximation (LRA). This is done by taking the complex between Rap1A (Rap) and the p21ras binding domain of c-Ra
HIV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle.: Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3419-24. Unique Identifier : AIDSLINE MED/98188218; Mahalingam S; Ayyavoo V; Patel M; Kieber-Emmons T; Kao GD; Muschel RJ; Weiner DB; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia, PA 19104, USA.; Several important and possibly interrelated functions have been identified for the HIV-1 accessory gene product Vpr. These include import of the HIV reverse transcription complex into the nucleus of nondividing cells, cellular differentiation including cell cycle arrest at the G2/M phase border, immune suppression, an
Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells.: Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3845-50. Unique Identifier : AIDSLINE MED/98188292; Migone TS; Cacalano NA; Taylor N; Yi T; Waldmann TA; Johnston JA; DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304,; USA. migone@dnax.org; Interleukin 2 ( IL-2 ) rapidly induces tyrosine phosphorylation of intracellular substrates, including the IL-2 receptor beta chain IL-2Rbeta), Janus kinase 1 (Jak1), Jak3, signal transducer/activator of transcription proteins, and Shc, but the mechanism underlying depho
Interferon alpha and Tat involvement in the immunosuppression of uninfected T cells and C-C chemokine decline in AIDS.: Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3851-6. Unique Identifier : AIDSLINE MED/98188293; Zagury D; Lachgar A; Chams V; Fall LS; Bernard J; Zagury JF; Bizzini B; Gringeri A; Santagostino E; Rappaport J; Feldman M; Burny A; Gallo RC; Universite Pierre et Marie Curie, Paris, France.; HIV type 1 (HIV-1) not only directly kills infected CD4(+) T cells but also induces immunosuppression of uninfected T cells. Two immunosuppressive proteins, interferon alpha (IFNalpha) and extracellular Tat, mediate this process because specific antibodies against these proteins prevent generation of suppressor cells
C-C chemokines, pivotal in protection against HIV type 1 infection.: Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3857-61. Unique Identifier : AIDSLINE MED/98188294; Zagury D; Lachgar A; Chams V; Fall LS; Bernard J; Zagury JF; Bizzini B; Gringeri A; Santagostino E; Rappaport J; Feldman M; O'Brien SJ; Burny A; Gallo RC; Universite Pierre et Marie Curie, Paris, France.; Exposure to HIV type 1 (HIV-1) does not usually lead to infection. Although this could be because of insufficient virus titer, there is now abundant evidence that some individuals resist infection even when directly exposed to a high titer of HIV. This protection recently has been correlated with homozygous mutations
Recombinant viruses expressing a human malaria antigen can elicit potentially protective immune CD8+ responses in mice.: Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3954-9. Unique Identifier : AIDSLINE MED/98188311; Miyahira Y; Garcia-Sastre A; Rodriguez D; Rodriguez JR; Murata K; Tsuji M; Palese P; Esteban M; Zavala F; Nussenzweig RS; Department of Medical and Molecular Parasitology, New York University; Medical Center, 341 E. 25th Street, New York, NY 10010, USA.; Extensive studies on protective immunity to rodent malaria provided the basis for the current experiments in which mice were immunized with recombinant (re) influenza and vaccinia viruses expressing selected sequences of the circumsporozoite (CS) protein of the human malaria parasite Plasmodium falciparum. Mice of dif
Assisted suicide and AIDS patients. A survey of physicians' attitudes.: Psychosomatics. 1998 Jan-Feb;39(1):18-23. Unique Identifier : AIDSLINE MED/98199497; Haghbin Z; Streltzer J; Danko GP; Department of Psychiatry, John A. Burns School of Medicine, University; of Hawaii, Honolulu, USA.; Physicians attitudes about assisted suicide were assessed by using a vignette of an acquired immune deficiency syndrome (AIDS) patients who requests a lethal injection. Of the 389 respondents, 34% received at least 1 request for assisted suicide; 9% had requests from an AIDS patient; and 41% had at least indirectly a
Psychiatric comorbidity in HIV and AIDS [letter]: Psychosomatics. 1998 Jan-Feb;39(1):80-2. Unique Identifier : AIDSLINE MED/98199507; Lynch S; Seth R
Depression in HIV-infected persons [letter]: Psychosomatics. 1998 Jan-Feb;39(1):82-3. Unique Identifier : AIDSLINE MED/98199508; Boland RJ
[HTLV-I/II infection in the state of Bahia]: Rev Soc Bras Med Trop. 1998 Jan-Feb;31(1):35-41. Unique Identifier : AIDSLINE MED/98138183; Britto AP; Galvao-Castro B; Straatmann A; Santos-Torres S; Tavares-Neto J; Faculdade de Medicina da Universidade Federal da Bahia, Salvador.; The city of Salvador, capital of Bahia, presents a population with the highest prevalence of HTLV-I infection in Brazil . Until now, only one study has investigated this infection in other cities of this state, even though by using a small sample. With objective to evaluate the prev
[Pneumocystis carinii pneumonia in HIV primary infection letter)]: Rev Clin Esp. 1998 Jan;198(1):50-1. Unique Identifier : AIDSLINE MED/98195846; Calderon-Osuna E; Otero Candelera R; del Castillo Otero D; Arenas Gordillo M
Suppressive BALF lymphocyte phenotype in a patient with prolonged stable alveolar proteinosis.: Respiration. 1998;65(1):79-82. Unique Identifier : AIDSLINE MED/98183973; Panagou P; Loukides S; Tsipra S; Kalogeropoulos N; Pulmonary Department, Army General Hospital, Athens, Greece.; The case history of a 25-year-old man suffering from idiopathic alveolar proteinosis is described. The patient showed a prolonged stable mild disease and a distinct suppressive phenotypic profile of BALF lymphocytes. Specifically, a low T4/T8 ratio and a high percentage of CD11b+ T8 lymphocytes was found. Correlations
Treatment of relapsed cytomegalovirus retinitis with the sustained-release ganciclovir implant.: Retina. 1998;18(1):50-5. Unique Identifier : AIDSLINE MED/98161386; Hatton MP; Duker JS; Reichel E; Morley MG; Puliafito CA; New England Eye Center, Boston, Massachusetts 02111, USA.; PURPOSE: Sustained-release ganciclovir implants are effective in delaying progression of newly diagnosed cytomegalovirus ( CMV ) retinitis. An uncontrolled case series was assembled to evaluate the efficacy of the intravitreal
Subretinal hemorrhage in cytomegalovirus.: Retina. 1998;18(1):73-5. Unique Identifier : AIDSLINE MED/98161392; Dornic D; Vann V; Wyszynski R; Case Western Reserve University, Cleveland, Ohio, USA.
[Prevalence of viral markers for hepatitis B, C and human immunodeficiency virus in volunteer blood donors in Northeast Mexico]: Rev Gastroenterol Mex. 1997 Oct-Dec;62(4):250-3. Unique Identifier : AIDSLINE MED/98188735; Ayala Gaytan JJ; Guerra Avalos FJ; Mora Brondo P; Casillas Romo A; Servicio de Infectologia, Hospital de Especialidades No. 25 del IMSS,; Monterrey.; OBJECTIVE: To ascertain the prevalence of Hepatitis-B, Hepatitis-C and Human-Immunodeficiency-Virus (HIV) markers among altruistic blood donors. PLACE: Blood bank of a third-level-hospital belonging to the Instituto Mexicano del Seguro Social (IMSS) system. SUBJECTS: Written records of the blood bank were reviewed, in
Patterns of HIV testing in Scotland: a general practitioner perspective.: Scott Med J. 1997 Aug;42(4):108-10. Unique Identifier : AIDSLINE MED/98168429; Ross JD; Goldberg DJ; Department of Genitourinary Medicine, Edinburgh Royal Infirmary,; Edinburgh.; General practitioners are one of the largest groups who offer HIV testing but little is known about the patient group who present for HIV counselling and testing in primary care. This study describes the risk factors, positivity rate, temporal trends and demographic profile of patients presenting to their general prac
Trends in survival of HIV infected patients attending the Department of Genito-Urinary Medicine, Royal Infirmary of Edinburgh.: Scott Med J. 1997 Aug;42(4):114-5. Unique Identifier : AIDSLINE MED/98168431; Brockington A; Scott GR; Department of Genito-Urinary Medicine, Royal Infirmary of Edinburgh.; In the early 1980s, median survival for patients with the acquired immunodeficiency syndrome (AIDS) was only 11 months. Survival improved in the mid-1980s, reaching a median of 20 months. We have looked at the trends in survival of patients attending the Genito-urinary Medicine Department of Edinburgh Royal Infirmary
Decrease in survival from AIDS after 1992 in Edinburgh [letter]: Scott Med J. 1997 Dec;42(6):165. Unique Identifier : AIDSLINE MED/98168436; Short LM; Nandwani R
Kaposi's sarcoma and protection from HIV dementia [letter]: Science. 1998 Apr 17;280(5362):361-2. Unique Identifier : AIDSLINE MED/98238942; Liestael K; Goplen AK; Dunlop O; Bruun JN; Maehlen J
Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection.: Science. 1998 Apr 17;280(5362):427-31. Unique Identifier : AIDSLINE MED/98212062; Veazey RS; DeMaria M; Chalifoux LV; Shvetz DE; Pauley DR; Knight HL; Rosenzweig M; Johnson RP; Desrosiers RC; Lackner AA; New England Regional Primate Research Center, Harvard Medical School,; 1 Pine Hill Drive, Post Office Box 9102, Southborough, MA 01772, USA.; Human and simian immunodeficiency virus (HIV and SIV) replicate optimally in activated memory CD4(+) T cells, a cell type that is abundant in the intestine. SIV infection of rhesus monkeys resulted in profound and selective depletion of CD4+ T cells in the intestine within days of infection, before any such changes in
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus.: Science. 1998 Apr 17;280(5362):450-3. Unique Identifier : AIDSLINE MED/98212069; Nakagawa T; Roth W; Wong P; Nelson A; Farr A; Deussing J; Villadangos JA; Ploegh H; Peters C; Rudensky AY; Howard Hughes Medical Institute and Department of Immunology,; University of Washington School of Medicine, Seattle, WA 98195, USA.; Degradation of invariant chain (Ii) is a critical step in major histocompatibility complex class II-restricted antigen presentation. Cathepsin L was found to be necessary for Ii degradation in cortical thymic epithelial cells (cTECs), but not in bone marrow (BM)-derived antigen-presenting cells (APCs). Consequently, p
Synthetic protease switch.: Science. 1998 Apr 17;280(5362):456. Unique Identifier : AIDSLINE MED/98238953; Sikorski R; Peters R
The risk of purified protein derivative positivity in homeless men with psychotic symptoms.: South Med J. 1998 Apr;91(4):345-8. Unique Identifier : AIDSLINE MED/98222889; Sakai J; Kim M; Shore J; Hepfer M; Tulane University School of Medicine, Department of Psychiatry, New; Orleans, LA, USA.; BACKGROUND: Homeless people with mental illness have relatively high rates of human immunodeficiency virus, comorbid antisocial personality disorder, and may be homeless more frequently and for greater lengths of time. All of these factors may increase the risk of tuberculosis. METHODS: Our study was done to ascertain
Nodular amyloidosis of the lung from intravenous drug abuse: an uncommon cause of multiple pulmonary nodules.: South Med J. 1998 Apr;91(4):402-4. Unique Identifier : AIDSLINE MED/98222903; Shah SP; Khine M; Anigbogu J; Miller A; Department of Medicine, Catholic Medical Center of Brooklyn and Queens; Inc, Jamaica, NY 11432, USA.; Bilateral pulmonary nodules in an immunocompromised host may offer a diagnostic dilemma. We present a case of a human immunodeficiency virus positive patient with history of intravenous drug abuse (IVDA) who was incidentally found to have bilateral multiple pulmonary nodules. She was diagnosed as having nodular pulmon
[The etiological structure and characteristics of liver involvement in patients with HIV infection]: Ter Arkh. 1997;69(11):32-5. Unique Identifier : AIDSLINE MED/98144736; Kravchenko AV; Roslyi IM; Serebrovskaia LV; Shakhgil'dian VI; Serova VV; Tishkevich OA; Ol'shanskii AIa; Gruzdev BM; Hepatic lesions were analyzed in 33 patients with HIV-infection. The patients were divided into two groups by the disease stage: early (stage IIB, IIIA, n = 12) and late (stage IIIB and IIIC, n = 21). Markers of hepatitis A, B and C were found in 42.4% of patients. Patients of group 1 had acute and chronic viral hepat
[The activation mechanisms in cytomegalovirus infection]: Ter Arkh. 1997;69(11):40-1. Unique Identifier : AIDSLINE MED/98144739; Zhiburt EB; Serebrianaia NB; Katkova IV; Shikhverdiev NN; Bel'skikh AN; D'iakova VV; Khubulava GG; Antibodies to cytomegalovirus class IgG and IgM and level of tumor necrosis factor (TNF) in the serum were measured in 81 patients with severe surgical infections. In patients with acute lung abscess TNF level was twice higher and activation of cytomegalovirus infection (specific I
[The first case of visceral leishmaniasis in a patient with HIV infection in Russia]: Ter Arkh. 1997;69(11):48-50. Unique Identifier : AIDSLINE MED/98144742; Ermak TN; Kravchenko AV; Gruzdev BM; Filippov PG; A case history of a 39-year-old male is reported. The patient was diagnosed to have visceral leishmaniasis and HIV infection in January 1997. HIV-infection manifested with advanced Kaposi s sarcoma, recurrent Candida and Herpes infection, a decrease of body mass by more than 10%. The diagnosis of visceral leishmaniasi
Risk factors for HIV seropositivity among first-time blood donors in Zimbabwe.: Transfusion. 1998 Mar;38(3):279-84. Unique Identifier : AIDSLINE MED/98222872; McFarland W; Mvere D; Shamu R; Katzenstein D; Center for AIDS Prevention Studies, University of California, San; Francisco, USA.; BACKGROUND: Factors associated with an increased likelihood of HIV infection among newly recruited blood donors in Zimbabwe are identified. Their feasibility as criteria for exclusion from donation is assessed. STUDY DESIGN AND METHODS: A self-administered survey including demogr
White cell reduction by filtration may significantly decrease human T-lymphotropic virus type 1 Tax sequences and Tax-encoded proteins in blood used for transfusion [letter]: Transfusion. 1998 Mar;38(3):317-8. Unique Identifier : AIDSLINE MED/98222880; Zucker-Franklin D; Pancake BA
Role of gp41 glycosylation sites in the biological activity of human immunodeficiency virus type 1 envelope glycoprotein.: Virology. 1998 Mar 15;242(2):338-45. Unique Identifier : AIDSLINE MED/98190353; Perrin C; Fenouillet E; Jones IM; NERC Institute of Virology, Oxford, United Kingdom.; The requirement for glycosylation in the transmembrane protein, gp41, of human immunodeficiency virus type 1 envelope protein for fusion activity has been studied. By using a mutant gene in which three conserved sites have been removed and which shows no fusion ability, genes were constructed which replace one, two, o
Arginine residues in the C-terminus of HIV-1 Vpr are important for nuclear localization and cell cycle arrest.: Virology. 1998 Mar 15;242(2):414-24. Unique Identifier : AIDSLINE MED/98190361; Zhou Y; Lu Y; Ratner L; Division of Molecular Oncology, Washington University School of; Medicine, St. Louis, Missouri 63110, USA.; HIV-1 viral protein R (Vpr) is predominantly localized to the nucleus and plays an important role for viral preintegration complex import into the nucleus. In this study, we investigated the influence on subcellular localization of Arg residues in the C-terminus of Vpr. Consistent with previous studies, about 90% of t
Molecular epidemiology of HTLV-II among United States blood donors and intravenous drug users: an age-cohort effect for HTLV-II RFLP type aO.: Virology. 1998 Mar 15;242(2):425-34. Unique Identifier : AIDSLINE MED/98190362; Murphy EL; Mahieux R; de The G; Tekaia F; Ameti D; Horton J; Gessain A; Department of Laboratory Medicine, University of California San; Francisco 94143, USA. murphy@labmed.ucsf.edu; Molecular subtyping was used to investigate the epidemiology of human T-lymphotropic virus type II (HTLV-II) in the United States . Nested polymerase chain reaction of the HTLV-II long terminal repeat region followed by restriction fragment length polymorphism (RFLP) analysis was perfor
The group B streptococcal capsular carbohydrate: immune response and molecular mimicry.: Adv Exp Med Biol. 1998;435:261-9. Unique Identifier : AIDSLINE MED/98159519; Feldman RG; Rijkers GT; Hamel ME; David S; Zegers BJ; Department of Infectious Diseases, Royal Postgraduate Medical School,; London, UK.
Periantral soft-tissue infiltration and its relevance to the early detection of invasive fungal sinusitis: CT and MR findings.: AJNR Am J Neuroradiol. 1998 Feb;19(2):321-5. Unique Identifier : AIDSLINE MED/98163014; Silverman CS; Mancuso AA; Department of Radiology, University of Florida College of Medicine,; Gainesville 32610, USA.; PURPOSE: Our goal was to illustrate the relevance of periantral soft-tissue infiltration to the early diagnosis of invasive fungal sinusitis and to describe variations in the appearance of normal periantral soft tissues. METHODS: We reviewed two cases of pathologically proved invasive maxillary fungal sinusitis in whi
Brain lactate and N-acetylaspartate in pediatric AIDS encephalopathy.: AJNR Am J Neuroradiol. 1998 Feb;19(2):383-5. Unique Identifier : AIDSLINE MED/98163027; Pavlakis SG; Lu D; Frank Y; Wiznia A; Eidelberg D; Barnett T; Hyman RA; Department of Neurology, New York University School of Medicine, North; Shore University Hospital, Manhasset 11030, USA.; Two children with acquired immunodeficiency syndrome (AIDS) and progressive encephalopathy underwent MR spectroscopy before and after antiretroviral therapy. Initial MR spectroscopy of the basal ganglia region showed decreased N-acetylaspartate NAA)/creatine (Cr) and a lactate peak. After therapy, there was improvemen
The prevention of perinatal HIV transmission in the less-developed world [editorial]: Am J Public Health. 1998 Apr;88(4):547-8. Unique Identifier : AIDSLINE MED/98212346; Susser M
HIV research, ethics, and the developing world [editorial]: Am J Public Health. 1998 Apr;88(4):548-50. Unique Identifier : AIDSLINE MED/98212347; Faden R; Kass N
Human rights and maternal-fetal HIV transmission prevention trials in Africa.: Am J Public Health. 1998 Apr;88(4):560-3. Unique Identifier : AIDSLINE MED/98212350; Annas GJ; Grodin MA; Health Law Department, Boston University School of Public Health,; Massachusetts 02118, USA.; The human rights issues raised by the conduct of maternal-fetal human immunodeficiency virus transmission trials in Africa are not unique to either acquired immunodeficiency syndrome or Africa, but public discussion of these trials presents an opportunity for the United States and othe
Placebo controls in HIV perinatal transmission trials: a South African's viewpoint.: Am J Public Health. 1998 Apr;88(4):564-6. Unique Identifier : AIDSLINE MED/98212351; Abdool Karim SS
The debate over maternal-fetal HIV transmission prevention trials in Africa, Asia, and the Caribbean: racist exploitation or exploitation of racism?: Am J Public Health. 1998 Apr;88(4):567-70. Unique Identifier : AIDSLINE MED/98212352; Bayer R; Columbia University School of Public Health, New York, NY 10032, USA.
Ethical challenges in efficacy trials of vaginal microbicides for HIV prevention.: Am J Public Health. 1998 Apr;88(4):571-5. Unique Identifier : AIDSLINE MED/98212353; de Zoysa I; Elias CJ; Bentley ME; Department of International Health, Johns Hopkins University School of; Public Hygiene, Baltimore, Md., USA.; This paper discusses some of the ethical challenges raised by advanced clinical trials designed to assess the safety and efficacy of vaginal microbicides in protecting women from HIV infection. The ethical principles that guide clinical research involving human subjects require that all participants in such trials be
The protective effect of condoms and nonoxynol-9 against HIV infection.: Am J Public Health. 1998 Apr;88(4):590-6. Unique Identifier : AIDSLINE MED/98212357; Wittkowski KM; Susser E; Dietz K; HIV Center, New York Psychiatric Institute, New York City, USA.; kmw@uni-tuebungen.de; OBJECTIVES: Whether or not spermicides can reduce the risk of human immunodeficiency virus (HIV) transmission remains an important question for the control of heterosexual HIV transmission. The authors provide estimates from a reanalysis of one of the few observational studies on the efficacy of condoms and spermicide
Informed consent for HIV testing in a South African hospital: is it truly informed and truly voluntary?: Am J Public Health. 1998 Apr;88(4):637-40. Unique Identifier : AIDSLINE MED/98212364; Abdool Karim Q; Abdool Karim SS; Coovadia HM; Susser M; Centre for Epidemiological Research in South Africa, South African; Medical Research Council, Durban, South Africa.; OBJECTIVE: The purpose of this study was to assess informed consent to human immunodeficiency virus (HIV) testing in a perinatal HIV transmission study in a major referral hospital serving a largely Black population in South Africa . METHODS: First-time antenatal clinic attenders w
Facilitating condom use with clients during commercial sex in Nevada's legal brothels.: Am J Public Health. 1998 Apr;88(4):643-6. Unique Identifier : AIDSLINE MED/98212366; Albert AE; Warner DL; Hatcher RA; Family Planning Program, Emory University School of Medicine, Atlanta,; GA 30303, USA.; OBJECTIVES: This study examined condom use in legal Nevada brothels. METHODS: Forty female prostitutes in two brothels were interviewed about client resistance to condoms and techniques for facilitating condom use. RESULTS: Of 3290 clients in the previous month, 2.7% (95% confidence interval [CI] = 2.2%,3.4%) were rel
Reporting sexual risk behavior for HIV: a practical risk index and a method for improving risk indices.: Am J Public Health. 1998 Apr;88(4):671-4. Unique Identifier : AIDSLINE MED/98212374; Susser E; Desvarieux M; Wittkowski KM; Department of Psychiatry, Columbia University, New York, NY 10032,; USA.; OBJECTIVES: As a means of enhancing public health efforts to control sexual transmission of human immunodeficiency virus HIV), methods were developed to report on risk behavior in a manner that is comparable and widely interpretable. METHODS: An elementary sexual behavior risk index (the vaginal episode equivalent ind
Anonymous HIV testing [letter]: Am J Public Health. 1998 Apr;88(4):683. Unique Identifier : AIDSLINE MED/98212379; Moser M
HIV testing [letter]: Am J Public Health. 1998 Apr;88(4):683-4. Unique Identifier : AIDSLINE MED/98212380; Dubois-Arber F
Not all behavior change is equivalent [letter]: Am J Public Health. 1998 Apr;88(4):684. Unique Identifier : AIDSLINE MED/98212381; Pinkerton SD; Abramson PR
Intestinal parasitic infections in human immunodeficiency virus HIV)-positive and HIV-negative individuals in San Pedro Sula, Honduras.: Am J Trop Med Hyg. 1998 Apr;58(4):431-5. Unique Identifier : AIDSLINE MED/98233974; Lindo JF; Dubon JM; Ager AL; de Gourville EM; Solo-Gabriele H; Klaskala WI; Baum MK; Palmer CJ; Center for Disease Prevention, and Department of Microbiology and; Immunology, University of Miami School of Medicine, Florida 33136,; USA.; Honduras has at least five-times more human immunodeficiency virus (HIV)-infected individuals than any other country in Central America. The relationship between HIV status and the presence of intestinal parasites in this part of th
Clinicoepidemiologic characteristics, prognostic factors, and survival analysis of patients coinfected with human immunodeficiency virus and Leishmania in an area of Madrid, Spain.: Am J Trop Med Hyg. 1998 Apr;58(4):436-43. Unique Identifier : AIDSLINE MED/98233975; Lopez-Velez R; Perez-Molina JA; Guerrero A; Baquero F; Villarrubia J; Escribano L; Bellas C; Perez-Corral F; Alvar J; Clinical Microbiology and Infectious Diseases Department, Hospital; Ramon y Cajal, Madrid, Spain.; From 1987 to 1995, a retrospective case study was conducted at the Ramon y Cajal Hospital in Madrid, Spain , a public teaching hospital with 1,100 beds, to determine the clinicoepidemiologic characteristics, survival, and prognostic factors of patients with visceral leishmaniasis (VL
Risk factors for trichomoniasis among women with human immunodeficiency virus (HIV) infection at a public clinic in Los Angeles County, California: implications for HIV prevention.: Am J Trop Med Hyg. 1998 Apr;58(4):495-500. Unique Identifier : AIDSLINE MED/98233985; Sorvillo F; Kovacs A; Kerndt P; Stek A; Muderspach L; Sanchez-Keeland L; HIV Epidemiology Program, Los Angeles County Department of Health; Services, California 90005, USA.; Persons with human immunodeficiency virus (HIV) infection who subsequently develop an acute sexually transmitted disease have an increased probability of transmitting HIV. Therefore, characterizing such persons can help direct prevention efforts to a group who are likely to be continuing sources of HIV transmission. W
[Vertical transmission of hepatitis C virus]: An Esp Pediatr. 1997 Dec;47(6):627-32. Unique Identifier : AIDSLINE MED/98112068; Casanovas Lax J; Silva Garcia G; Vargas Romero J; Nogales Perez MC; Aguayo Maldonado J; Cruz Guerrero G; Gonzalez Hachero J; Hospital Universitario de Valme, Sevilla.; OBJECTIVE: The objectives of this study were to know the prevalence of hepatitis C virus (HCV) in a population of pregnant women, to evaluate the vertical transmission rates of HCV in a prospective study and to determine the repercussions and consequences in children born to infected mothers. PATIENTS AND METHODS: A t
Notes on the pathogenesis of human immunodeficiency virus infection.: Ann Ist Super Sanita. 1997;33(2):219-23. Unique Identifier : AIDSLINE MED/98131020; Piconi S; Clerici M; Prima Divisione di Malattie Infettive, Universita degli Studi, Milan,; Italy.; The acquired immunodeficiency syndrome (AIDS) is a clinically multifaceted disease induced by infection with the human immunodeficiency virus (HIV). Infection with HIV is usually followed by a period of clinical latency which is followed by development of AIDS and death. The factors that influence the evolution of HIV
The demography, clinical manifestations and natural history of human immunodeficiency virus (HIV) infection in an older population in Singapore.: Ann Acad Med Singapore. 1997 Nov;26(6):731-5. Unique Identifier : AIDSLINE MED/98183570; Lee CC; Leo YS; Snodgrass I; Wong SY; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore.; In this retrospective study, we report 43 cases (41 males and 2 females) of human immunodeficiency virus (HIV) infection in the Singapore population aged 50 years and above at first presentation. We found an increasing proportion of these older individuals among our HIV-seroposi
Sexually-transmitted diseases in Singapore--trends in the last two decades.: Ann Acad Med Singapore. 1997 Nov;26(6):827-33. Unique Identifier : AIDSLINE MED/98183588; Ang P; Chan R; National Skin Centre, Singapore.; We review the epidemiology and trends of sexually transmitted diseases (STDs) in Singapore from 1977 to 1996. There has been a progressive decline in the incidence of bacterial STDs over the period of observation. However, viral STDs have not shown the same trends, remaining at
Aprotinin versus lysine analogues: the debate continues.: Ann Thorac Surg. 1998 Apr;65(4 Suppl):S9-19; discussion S27-8. Unique Identifier : AIDSLINE MED/98222861; Royston D; Department of Cardiothoracic Anesthesia, Harefield Hospital,; Middlesex, England.; The decision to use any pharmacologic intervention inevitably rests on balancing the efficacy and safety of the intervention. The advent of the acquired immunodeficiency syndrome epidemic greatly increased awareness of transfusion-related illnesses and focused attention on methods to prevent the need for blood and blo
[HIV infection and pericardial disease invasion in Africa]: Arch Mal Coeur Vaiss. 1997 Oct;90(10):1377-84. Unique Identifier : AIDSLINE MED/98200658; Longo-Mbenza B; Tonduangu K; Seghers KV; Mubagwa D; Centre de cardiologie du coeur de l'Afrique, Kinshasa-Limete, Zaire.; The number of cases with pericardial disease has been increasing in Africa and particularly in Zaire , after AIDS was defined. To investigate a possible link between HIV infection and risen incidence of pericardial effusions, 64 patients randomly selected 32 HIV carriers and 32 HIV
Loss of T cell receptor diminished tumorigenicity of thymocyte-derived lymphoma cells in the T cell receptor transgenic mice.: Arch Immunol Ther Exp (Warsz). 1997;45(4):307-13. Unique Identifier : AIDSLINE MED/98183607; Kobzdej M; Matuszyk J; Ziolo E; Strzadala L; Laboratory of Cellular Immunology, Polish Academy of Sciences,; Wroclaw, Poland.; Mice with transgenic T cell receptor (TCR) recognizing H-Y male antigen developed spontaneous lymphomas originated from immature thymocytes, with the surface expression of transgenic TCR and CD4/CD8 co-receptors. During in vitro long-term culture (3 months) some lymphoma cell lines lost the surface expression of TCR a
Structural studies of synthetic peptide fragments derived from the HIV-1 Vpr protein.: Biochem Biophys Res Commun. 1998 Mar 27;244(3):732-6. Unique Identifier : AIDSLINE MED/98205790; Luo Z; Butcher DJ; Murali R; Srinivasan A; Huang Z; Kimmel Cancer Institute, Jefferson Medical College, Thomas Jefferson; University, Philadelphia, Pennsylvania 19107, USA.; zhuang@nana.jci.tju.edu; Vpr, one of the accessory gene products of the human immunodeficiency virus-1 (HIV-1) genome, exhibits diverse biological characteristics. Vpr functions as a transcriptional activator of HIV and heterologous promoters. It is capable of arresting cells in cell cycle progression and plays a crucial role in the infection
HIV-1 gp120-induced apoptosis in the rat neocortex involves enhanced expression of cyclo-oxygenase type 2 (COX-2).: Biochem Biophys Res Commun. 1998 Mar 27;244(3):819-24. Unique Identifier : AIDSLINE MED/98205806; Bagetta G; Corasaniti MT; Paoletti AM; Berliocchi L; Nistico R; Giammarioli AM; Malorni W; Finazzi-Agro A; Department of Pharmaco-Biology, University of Calabria at Cosenza,; Italy. Bagetta@mail.csdim.unical.it; The effect of subchronic intracerebroventricular (i.c.v.) injection of the human immunodeficiency virus type 1 (HIV-1) recombinant protein gp120 (100 ng, given daily for up to 7 consecutive days) on cyclooxygenase type 2 (COX-2) expression was studied by immunohistochemistry in the brain of adult rats. In comparison t
Characteristics and treatment of hepatitis C virus infection in HIV-coinfected subjects.: Aids Patient Care STDS. 1998 Jan;12(1):11-9. Unique Identifier : AIDSLINE MED/98152821; Zylberberg H; Pol S; Service d'Hepatologie, Hopital Necker, Paris, France.; Hepatitis C virus (HCV) and HIV share the same parenteral routes of transmission. This common epidemiology explains the high frequency of combined infections by HCV and HIV. The aim of this review is to clarify some important issues dealing with the reciprocal impact of HIV and HCV-associated infections, including the
Antiribonucleoprotein antibodies in children with HIV infection: a comparative study with childhood-onset systemic lupus erythematosus.: Aids Patient Care STDS. 1998 Jan;12(1):21-8. Unique Identifier : AIDSLINE MED/98152822; Gonzalez CM; Lopez-Longo FJ; Samson J; Monteagudo I; Grau R; Rodriguez-Mahou M; St-Cyr C; Lapointe N; Carreno L; Experimental Medicine and Surgery Unit, Gregorio Maranon Hospital,; Universidad Complutense de Madrid, Spain.; A number of clinical and laboratory features of HIV infection are found in systemic lupus erythematosus (SLE). The objective of this study was to analyze the presence of circulating antibodies to small nuclear ribonucleoproteins (snRNP) in both diseases. Sera from 44 HIV-infected children, from 22 patients with childh
Using self-administered tampons to diagnose STDs.: Aids Patient Care STDS. 1998 Jan;12(1):29-32. Unique Identifier : AIDSLINE MED/98152823; Bowden FJ; Paterson BA; Tabrizi SN; Fairley CK; Garland SM; AIDS/STD Unit, Centre for Disease Control, Territory Health Services,; Darwin, Australia.; The new nucleic acid amplification techniques (e.g., LCR and PCR) have allowed the introduction of non- and minimally-invasive techniques for the detection of sexually transmitted diseases STDs). In this article, we describe one of these-the self-administrated tampon method-which we have used to detect the presence of
It isn't over [editorial; comment]: Aids Patient Care STDS. 1998 Jan;12(1):3-4. Unique Identifier : AIDSLINE MED/98152819; Laurence J
Restructuring life to face the future: the perspective of men after a positive response to protease inhibitor therapy [see comments]: Aids Patient Care STDS. 1998 Jan;12(1):33-42. Unique Identifier : AIDSLINE MED/98152824; Sowell RL; Phillips KD; Grier J; Department of Administrative and Clinical Nursing, University of South; Carolina, Columbia 29208, USA.; This article describes a qualitative study that explores the psychosocial changes and care delivery issues experienced by men with AIDS who were facing end-stage disease but then had dramatic physical improvement as a result of protease inhibitor therapy. In-depth interviews were conducted with 11 men with HIV/AIDS dr
Reproductive behavior in HIV-discordant heterosexual couples: implications for counseling.: Aids Patient Care STDS. 1998 Jan;12(1):43-9. Unique Identifier : AIDSLINE MED/98152825; Van Devanter N; Cleary PD; Moore J; Thacker AS; O'Brien TR; Division of Sociomedical Sciences, School of Public Health, Columbia; University, New York, NY 10032, USA.; The development of effective behavioral interventions is critical to controlling the HIV epidemic. Although heterosexual transmission accounts for a growing proportion of new infections in the United States , little is known about factors that influence sexual behavior in HIV-discordant
Primary esophageal lymphoma in AIDS.: Aids Patient Care STDS. 1998 Jan;12(1):5-9. Unique Identifier : AIDSLINE MED/98152820; Hamed KA; Hoffman MS; Department of Medicine, Department of Veterans Affairs Medical Center,; Bay Pines, FL 33744, USA.; Primary esophageal lymphomas are extremely rare. We report a primary esophageal T cell lymphoma of the diffuse large cell type in a patient with AIDS and review other published data. Although rare, the diagnosis should be considered in patients with dysphagia, weight loss (with or without hematemesis), and endoscopic
Low versus high prevalence of AIDS: effect on nursing students' attitudes and knowledge.: Aids Patient Care STDS. 1998 Jan;12(1):51-60. Unique Identifier : AIDSLINE MED/98152826; West AM; Davis-Lagrow P; Leasure R; Allen P; Kramer School of Nursing, Oklahoma City University, OK 73106, USA.; The purpose of this study was to compare AIDS knowledge and attitudes of baccalaureate nursing students living in a state with a high prevalence of AIDS and those who resided in a state with a low prevalence of AIDS. Students from the high-prevalence state had significantly higher AIDS knowledge scores than did studen
HIV/AIDS case histories: diagnostic problems. Varicella-zoster encephalitis.: Aids Patient Care STDS. 1998 Jan;12(1):61-2. Unique Identifier : AIDSLINE MED/98152827; Edgar M; Heier L; Department of Pathology, Cornell University Medical College, USA.
Ritonavir pediatric study results reported.: Aids Patient Care STDS. 1998 Jan;12(1):63. Unique Identifier : AIDSLINE MED/98152828
Head-to-head study of protease inhibitors.: Aids Patient Care STDS. 1998 Jan;12(1):63-4. Unique Identifier : AIDSLINE MED/98152829
Protease inhibitor trial started.: Aids Patient Care STDS. 1998 Jan;12(1):64. Unique Identifier : AIDSLINE MED/98152830
Efavirenz shows promising results.: Aids Patient Care STDS. 1998 Jan;12(1):64-5. Unique Identifier : AIDSLINE MED/98152831
Combination suppresses HIV RNA within the central nervous system.: Aids Patient Care STDS. 1998 Jan;12(1):65. Unique Identifier : AIDSLINE MED/98152832
Preliminary data on 141W94 reported.: Aids Patient Care STDS. 1998 Jan;12(1):65-6. Unique Identifier : AIDSLINE MED/98152833
Open clinical trials.: Aids Patient Care STDS. 1998 Jan;12(1):67. Unique Identifier : AIDSLINE MED/98152834
Novel vaccine undergoes testing.: Aids Patient Care STDS. 1998 Jan;12(1):67-8. Unique Identifier : AIDSLINE MED/98152835
Combination ganciclovir capsules and implant delays and reduces CMV disease.: Aids Patient Care STDS. 1998 Jan;12(1):68. Unique Identifier : AIDSLINE MED/98152837
NIH launches interleukin-2 study.: Aids Patient Care STDS. 1998 Jan;12(1):68. Unique Identifier : AIDSLINE MED/98152836
Liposomal amphotericin B found safe and effective.: Aids Patient Care STDS. 1998 Jan;12(1):69. Unique Identifier : AIDSLINE MED/98152838
Banjee Boys Are Down.: Aids Patient Care STDS. 1998 Jan;12(1):71. Unique Identifier : AIDSLINE MED/98152840
Black and Latino men who have sex with men share some common barriers to practicing safer sex.: Aids Patient Care STDS. 1998 Jan;12(1):71. Unique Identifier : AIDSLINE MED/98152839
Traditional Brooklyn neighborhoods keep young MSM closeted.: Aids Patient Care STDS. 1998 Jan;12(1):71-2. Unique Identifier : AIDSLINE MED/98152841
Latino MSM in Santa Clara might as well be in Kansas.: Aids Patient Care STDS. 1998 Jan;12(1):72. Unique Identifier : AIDSLINE MED/98152842
Latino machismo and social discrimination are barriers to safer sex.: Aids Patient Care STDS. 1998 Jan;12(1):72-3. Unique Identifier : AIDSLINE MED/98152843
Glycosidopyrroles. Part 2. Acyclic derivatives: 1-(1,3-dihydroxy-2-propoxy)methylpyrroles as potential antiviral agents.: Farmaco. 1997 Nov;52(11):667-72. Unique Identifier : AIDSLINE MED/98211262; Almerico AM; Diana P; Barraja P; Dattolo G; Mingoia F; Putzolu M; Perra G; Milia C; Musiu C; Marongiu ME; Istituto Farmacochimico, Universita degli Studi, Palermo, Italy.; The series of 1-(1,3-dihydroxy-2-propoxy)methylpyrroles 2a-o were prepared in good overall yields according to Scheme I. When evaluated for antiviral activity against HIV-1, only compounds of the triphenyl series (R3 = NH2, N3, Br) were found to inhibit the HIV-1 replication at concentrations that were very not cytoto
Anti-HIV agents. V. Synthesis, structure and in vitro anti-HIV activity of novel 1H,3H-naphtho[2',3':4,5]imidazo[1,2-c]thiazoles.: Farmaco. 1997 Nov;52(11):673-7. Unique Identifier : AIDSLINE MED/98211263; Chimirri A; Grasso S; Monforte AM; Monforte P; Rao A; Zappala M; Bruno G; Nicolo F; Scopelliti R; Dipartimento Farmaco-Chimico, Universita di Messina, Italy.; A series of 1H,3H-naphtho[2 ,3 :4,5]imidazo[1,2-c]thiazoles, TBZ analogues, was prepared in order to explore the influence on anti-HIV activity of the spatial requirements of the hydrophobic moiety fused to imidazothiazole system. In spite of a butterfly-like conformation evidenced by X-ray analysis of compound 4g, th
B-cell help by Tc2 cells [letter]: Immunol Today. 1998 Mar;19(3):142. Unique Identifier : AIDSLINE MED/98201097; Paganelli R; Scala E; Aiuti F; Fiorilli M
T-cell modulation in decidua [letter]: Immunol Today. 1998 Mar;19(3):142-3. Unique Identifier : AIDSLINE MED/98201098; Kelly RW; Critchley HO
Alternative approach to AIDS defense shows promise [news]: Dent Today. 1997 Jan;16(1):28, 31. Unique Identifier : AIDSLINE MED/98221394; Marino D
Possible HIV vaccine stirs hope [news]: Dent Today. 1997 Jan;16(1):35. Unique Identifier : AIDSLINE MED/98221395
Stroke, Alzheimer's patients may benefit from AIDS dementia drug [news]: Dent Today. 1997 Feb;16(2):29. Unique Identifier : AIDSLINE MED/98221370
A glance at gingiva.: Dent Today. 1997 Feb;16(2):58, 62-3. Unique Identifier : AIDSLINE MED/98221373; Rothstein JP
Features of the SIVmac transmembrane glycoprotein cytoplasmic domain that are important for Env functions.: AIDS Res Hum Retroviruses. 1998 Mar 20;14(5):373-83. Unique Identifier : AIDSLINE MED/98206873; Shacklett BL; Denesvre C; Boson B; Sonigo P; ICGM-CNRS UPR 0415, Genetique des Virus, Institut Cochin de Genetique; Moleculaire, Paris, France.; The cytoplasmic domain (CD) of the SIVmac transmembrane protein TM) can affect viral infectivity by modulating several Env functions, notably fusogenic capacity and incorporation into virions. In addition, envelopes with a truncated CD are counterselected in primary cells in culture and in vivo in rhesus macaques, sug
Efficacy of fusion peptide homologs in blocking cell lysis and HIV-induced fusion.: AIDS Res Hum Retroviruses. 1998 Mar 20;14(5):385-92. Unique Identifier : AIDSLINE MED/98206874; Silburn KA; McPhee DA; Maerz AL; Poumbourios P; Whittaker RG; Kirkpatrick A; Reilly WG; Manthey MK; Curtain CC; AIDS Cellular Biology Unit, Macfarlane Burnet Centre for Medical; Research, Fairfield, Victoria, Australia.; Contrary to earlier reports, we have found that tri- and hexapeptides analogous or homologous with segments of the 23-residue N-terminal fusion sequence (FS) of the viral transmembrane glycoprotein gp41 (residues 517-539) did not significantly inhibit HIV-1-induced syncytium formation, using an uninfected cell-infecte
Administration of recombinant human interleukin 12 to chronically SIVmac-infected rhesus monkeys.: AIDS Res Hum Retroviruses. 1998 Mar 20;14(5):393-9. Unique Identifier : AIDSLINE MED/98206875; Watanabe N; Sypek JP; Mittler S; Reimann KA; Flores-Villanueva P; Voss G; Lord CI; Letvin NL; Harvard Medical School, Beth Israel Deaconess Medical Center, Boston,; Massachusetts 02215, USA.; With the demonstration that interleukin 12 can enhance natural killer (NK) cell activity and drive CD4+ lymphocytes toward T helper type 1 (Thl) responses, there is a strong rationale for exploring the use of this cytokine as an immunomodulatory therapy in HIV-1-infected individuals. To assess its potential safety and
An experimental prime-boost regimen leading to HIV type 1-specific mucosal and systemic immunity in BALB/c mice.: AIDS Res Hum Retroviruses. 1998 Mar 20;14(5):401-7. Unique Identifier : AIDSLINE MED/98206876; Bruhl P; Kerschbaum A; Eibl MM; Mannhalter JW; Department of Immunological Research, Immuno AG, Vienna, Austria.; Induction of mucosal as well as systemic immunity to HIV-1 is considered to have high priority in current concepts of future AIDS vaccines. Here we show that the desired immune responses can be elicited by an experimental prime-boost regimen consisting of mucosal (intragastric) application of a recombinant vaccinia vi
Immunoliposomes containing antibodies to costimulatory molecules as adjuvants for HIV subunit vaccines.: AIDS Res Hum Retroviruses. 1998 Mar 20;14(5):409-17. Unique Identifier : AIDSLINE MED/98206877; Ozpolat B; Rao XM; Powell MF; Lachman LB; Department of Cell Biology, University of Texas M.D. Anderson Cancer; Center, Houston 77030, USA.; Immunoliposomes containing monoclonal antibodies (MAbs) to the costimulatory molecules CD28 and CTLA4 and their counterreceptors B7-1 (CD80) and B7-2 (CD86) were evaluated for the ability to increase the immune response to recombinant envelope protein rgp120 of the MN strain of human immunodeficiency virus type 1 HIV-
Immunologic cross-reaction between HIV type 1 p17 and Mycoplasma hyorhinis variable lipoprotein.: AIDS Res Hum Retroviruses. 1998 Mar 20;14(5):419-25. Unique Identifier : AIDSLINE MED/98206878; Pincus SH; Cole RL; Watson-McKown R; Pinter A; Honnen W; Cole B; Wise KS; Laboratory of Microbial Structure and Function, NIAID Rocky Mountain; Laboratories, Hamilton, Montana 59840, USA.; Monoclonal antibodies directed against the HIV-1 matrix protein p17 that react with a component present on the surface of HIV-1-infected cells have previously been described. In this study we show that one of these monoclonal antibodies binds to persistently HIV-1-infected cell lines that are coinfected with Mycoplasm
HIV type 1 infection of human macrophages induces an upregulation of manganese superoxide dismutase gene that may protect cells from death.: AIDS Res Hum Retroviruses. 1998 Mar 20;14(5):427-34. Unique Identifier : AIDSLINE MED/98206879; Raoul H; Le Naour R; Blond D; Dormont D; CEA, Service de Neurovirologie, DSV/DRM/SSA, Institut Paris Sud sur; les Cytokines, Fontenay aux Roses, France.; It has been previously demonstrated that HIV-1 infection induces a downregulation of MnSOD transcription in CD4+ lymphocytes. Using clinical isolates of macrophage-tropic HIV-1 strains we report here that conversely, purified normal human monocyte-derived macrophages (MDMs) overexpress the manganese superoxide dismuta
Macrophage protection against human immunodeficiency virus or herpes simplex virus by red blood cell-mediated delivery of a heterodinucleotide of azidothymidine and acyclovir.: AIDS Res Hum Retroviruses. 1998 Mar 20;14(5):435-44. Unique Identifier : AIDSLINE MED/98206880; Rossi L; Brandi G; Schiavano GF; Balestra E; Millo E; Scarfi S; Damonte G; Gasparini A; Magnani M; Perno CF; Benatti U; De Flora A; Institute of Biochemistry G. Fornaini, University of Urbino, Italy.; Human herpesvirus (HSVs) are distributed worldwide and are among the most frequent causes of viral infection in HIV-1-immunocompromised patients. Hence, therapeutic strategies able to inhibit HSV-1 and HIV-1 replication are sorely needed. Until now, the most common therapies against HSV-1 and HIV-1 infectivity have be
Phenotypic variability of lymphocyte populations in peripheral blood and lymph nodes from HIV-infected individuals and the impact of antiretroviral therapy. DATRI 003 Study Group. Division of AIDS Treatment Research Initiative.: AIDS Res Hum Retroviruses. 1998 Mar 20;14(5):445-51. Unique Identifier : AIDSLINE MED/98206881; Landay AL; Bethel J; Schnittman S; Department of Immunology/Microbiology, Rush-Presbyterian-St. Luke's; Medical Center, Chicago, Illinois 60612, USA.; This study presents immunophenotypic variation in lymphocyte populations obtained from peripheral blood and lymph nodes from individuals with early HIV disease who were enrolled in a prospective, open-label study. At baseline, there was a significantly greater percentage of B cells and significantly smaller percentage
Failure to quantify viral load with two of the three commercial methods in a pregnant woman harboring an HIV type 1 subtype G strain.: AIDS Res Hum Retroviruses. 1998 Mar 20;14(5):453-9. Unique Identifier : AIDSLINE MED/98206882; Debyser Z; Van Wijngaerden E; Van Laethem K; Beuselinck K; Reynders M; De Clercq E; Desmyter J; Vandamme AM; Department of Microbiology and Immunology, Rega Institute and; University Hospitals, Katholieke Universiteit Leuven, Belgium.; debyser@uz.kuleuven.ac.be; The level of HIV-1 RNA in plasma has become one of the most important markers in the follow-up of HIV-infected patients. Three techniques are commercially available: both the Amplicor HIV Monitor and the NASBA HIV-1 RNA QT are target amplification methods, whereas the Quantiplex HIV RNA assay is a branched DNA signal
Complete nef gene sequence of HIV type 1 subtype B' from professional plasma donors in the People's Republic of China.: AIDS Res Hum Retroviruses. 1998 Mar 20;14(5):461-4. Unique Identifier : AIDSLINE MED/98206883; Nerurkar VR; Wu Z; Dashwood WM; Woodward CL; Zhang M; Detels R; Yanagihara R; Retrovirology Research Laboratory, Pacific Biomedical Research Center,; University of Hawaii at Manoa, Honolulu 96816, USA.; nerurkar@hawaii.edu
HIV type 2 Vif proteins have specific conserved amino acid motifs.: AIDS Res Hum Retroviruses. 1998 Mar 20;14(5):465-9. Unique Identifier : AIDSLINE MED/98206884; Ribeiro AC; Moniz Pereira J; Barahona I; Departamento de Microbiologia, Faculdade de Farmacia de Lisboa,; Lisbon, Portugal.
Effect of selenium supplementation on mice infected with LP-BM5 MuLV, a murine AIDS model.: Biol Trace Elem Res. 1997 Winter;59(1-3):187-93. Unique Identifier : AIDSLINE MED/98182528; Chen C; Zhou J; Xu H; Jiang Y; Zhu G; Department of Chemistry, Huazhong University of Science and; Technology, Wuhan, PROC.; LP-BM5 Murine leukemia virus (MuLV) infection of C57BL/6 mice develop a disease that has many features in common with human acquired immunodeficiency syndrome (AIDS), in particular abnormal lymphoproliferation and severe immunodeficiency. Thus, this MAIDS model may be useful for evaluation of potent antirival agents i
High incidence of classical Kaposi's sarcoma in Iceland and the Faroe Islands.: Br J Cancer. 1998 Apr;77(7):1190-3. Unique Identifier : AIDSLINE MED/98228016; Hjalgrim H; Tulinius H; Dalberg J; Hardarson S; Frisch M; Melbye M; Department of Epidemiology Research, Danish Epidemiology Science; Centre, Statens Serum Institut, Copenhagen.; We have examined the incidence of non-AIDS-related Kaposi s sarcoma in Iceland (1955-79) and the Faroe Islands (1974-95). In Iceland, 19 cases, n
A new class of HIV-1 Tat antagonist acting through Tat-TAR inhibition.: Biochemistry. 1998 Apr 14;37(15):5086-95. Unique Identifier : AIDSLINE MED/98215633; Hamy F; Brondani V; Florsheimer A; Stark W; Blommers MJ; Klimkait T; Pharma Research, Novartis Pharma Inc., CH-4002 Basel, Switzerland.; The main transcriptional regulator of the human immunodeficiency virus, the Tat protein, recognizes and binds to a small structured RNA element at the 5 end of every viral mRNA, termed TAR. On the basis of published structural data of the molecular interactions between TAR and Tat-related peptides, we defined require
Binding of neomycin to the TAR element of HIV-1 RNA induces dissociation of Tat protein by an allosteric mechanism.: Biochemistry. 1998 Apr 21;37(16):5549-57. Unique Identifier : AIDSLINE MED/98217312; Wang S; Huber PW; Cui M; Czarnik AW; Mei HY; Department of Chemistry and Biochemistry, University of Notre Dame,; Indiana 46556, USA.; Neomycin inhibits the binding of Tat-derived peptides to the trans-activating region (TAR) of HIV-1 RNA. Kinetic studies reveal that neomycin acts as a noncompetitive inhibitor that can bind to the Tat-TAR complex and increase the rate constant (koff) for dissociation of the peptide from the RNA. Neomycin effects a co
Backbone cyclic peptide, which mimics the nuclear localization signal of human immunodeficiency virus type 1 matrix protein, inhibits nuclear import and virus production in nondividing cells.: Biochemistry. 1998 Apr 21;37(16):5616-22. Unique Identifier : AIDSLINE MED/98217320; Friedler A; Zakai N; Karni O; Broder YC; Baraz L; Kotler M; Loyter A; Gilon C; Department of Organic Chemistry, Institute of Chemistry, The Hebrew; University of Jerusalem, Israel.; Here, we describe an application of the backbone cyclic (BC) proteinomimetic approach to the design and the synthesis of a BC peptide which functionally mimics the nuclear localization signal NLS) region of the human immunodeficiency virus type 1 matrix protein (HIV-1 MA). On the basis of the NMR structure of HIV-1 MA
Granule associated DNase in T4 and T8 lymphocytes from patients with autoimmune diseases.: Biochim Biophys Acta. 1998 Feb 27;1406(1):51-61. Unique Identifier : AIDSLINE MED/98222590; Pio R; Gonzalez A; Lopez-Zabalza MJ; Prieto J; Santiago E; Lopez-Moratalla N; Department of Biochemistry, University of Navarra, Pamplona, Spain.; The presence of a DNase activity associated with secretion granules was detected in T4 and T8 lymphocytes from patients with autoimmune diseases. This activity was much higher in primary biliary cirrhosis (PBC) than in Graves disease (GD) and multiple sclerosis (MS) or in healthy subjects. This granule associated DNa
[Disseminated tuberculosis with cutaneous manifestations in AIDS patients. Presentation of 4 cases]: Enferm Infecc Microbiol Clin. 1998 Jan;16(1):31-4. Unique Identifier : AIDSLINE MED/98203428; Esquivel SP; Vigna L; Velazquez J; Cangelosi D; Figueiras O; Solari R; Corti M; Massini R; Hospital F.J. Muniz, Buenos Aires, Argentina.; BACKGROUND: Acute cutaneous miliary tuberculosis is a rare form of Mycobacterium tuberculosis infection which has been described in only 25 published cases in the last 15 years. The appearance of serious disseminated forms of tuberculosis is enhanced by the severe immunodeficiency which characterizes AIDS. METHODS: Fo
[Infection by Chromobacterium violaceum in a patient with acquired immunodeficiency virus infection (letter)]: Enferm Infecc Microbiol Clin. 1998 Jan;16(1):46-7. Unique Identifier : AIDSLINE MED/98203436; Fombuena M; Ballester JE; Pedro F; Chanza M; Garcia del Toro M; Herrera Ballester A
[Lymph node cryptococcosis as the initial manifestation of AIDS letter)]: Enferm Infecc Microbiol Clin. 1998 Jan;16(1):47-8. Unique Identifier : AIDSLINE MED/98203437; Garcia Diez F; Hermida I; Arazo P; Martinez R; Jimenez JM; Nerin C
[Effect of calcium channel antagonists in primary pulmonary hypertension in association with human immunodeficiency virus infection (letter)]: An Med Interna. 1998 Feb;15(2):114. Unique Identifier : AIDSLINE MED/98203326; Bragulat E; Garcia F; Fernandez F; Ballester E; Villalta J; Grau JM
[Multidrug resistant tuberculosis and AIDS (letter)]: An Med Interna. 1998 Feb;15(2):114-5. Unique Identifier : AIDSLINE MED/98203327; Martinez Lacasa JT; Casagran A; Coll N; Monso C; Martin N; Garau J
[Efficacy of ritonavir in HIV positive patients pretreated with nucleoside analogues]: An Med Interna. 1998 Feb;15(2):83-6. Unique Identifier : AIDSLINE MED/98203315; Gomez-Cano M; Soriano V; Polo R; Valencia E; Adrados M; Gonzalez-Lahoz J; Servicio de Enfermedades Infecciosas, Instituto de Salud Carlos III,; Madrid.; The virologic and immunologic efficacy of ritonavir , an HIV protease inhibitor, was examined in 14 HIV-infected patients with a mean CD4+ cell count of 183 x 10(6)/l at baseline. All had been exposed to nucleoside analogs for longer than 6 months; and
[Sjogren's syndrome: a new diagnostic approximation]: An Med Interna. 1998 Feb;15(2):87-90. Unique Identifier : AIDSLINE MED/98203316; Gabriel Botella F; Monteagudo Castro C; Labios Gomez M; Balaguer Martinez JV; Sempere Montes J; Guiral Olivan MV; Servicio de Medicina Interna, Hospital Clinico Universitario,; Valencia.; At presentation the history of a 51 years old woman with xerostomia and dry keratoconjunctivitis sicca (KCS) with a development of ten months. Investigations revealed the presence in serum of antibodies against cytoplasmic antigens SS-A (Ac anti-Ro/SS-A), antinuclear antibodies (ANAS), and rheumatoid factor (RF). The
Detection of cytomegalovirus (CMV) in HIV+ patients: comparison of cytomorphology, immunocytochemistry and in situ hybridization.: Cytopathology. 1998 Feb;9(1):29-37. Unique Identifier : AIDSLINE MED/98183727; Sheehan MM; Coker R; Coleman DV; Department of Cytopathology, St Mary's Hospital, London, UK.; CMV is regarded as an important pathogen in immunocompromised patients. This study compares three cytological methods of diagnosis of CMV in alcohol-fixed smears from bronchoalveolar lavage (BAL) specimens from 40 HIV+ patients, using cytomorphology (CM), immuno
Human immunodeficiency virus-1 infection interrupts thymopoiesis and multilineage hematopoiesis in vivo.: Blood. 1998 Apr 15;91(8):2672-8. Unique Identifier : AIDSLINE MED/98200571; Jenkins M; Hanley MB; Moreno MB; Wieder E; McCune JM; Gladstone Institute of Virology and Immunology, San Francisco, CA; 94141-9100, USA.; It is still uncertain whether multilineage hematopoietic progenitor cells are affected by human immunodeficiency virus-1 HIV-1) infection in vivo. The SCID-hu Thy/Liv model is permissive of long-term multilineage human hematopoiesis, including T lymphopoiesis. This model was used to investigate the effects of HIV-1 in
Macrophage inflammatory protein-1beta induces migration and activation of human thymocytes.: Blood. 1998 Apr 15;91(8):2905-13. Unique Identifier : AIDSLINE MED/98200597; Dairaghi DJ; Franz-Bacon K; Callas E; Cupp J; Schall TJ; Tamraz SA; Boehme SA; Taylor N; Bacon KB; Department of Immunology, DNAX Research Institute, Palo Alto, CA, USA.; The CC chemokine macrophage inflammatory protein 1beta MIP-1beta), has been shown to be a chemoattractant preferentially activating CD4(+) CD45RA+ T lymphocytes. Further analysis of chemokine action on lymphocytic cells has shown the potent migration-promoting capacity of MIP-1beta on human thymocytes. The responding
Hematopoietic remodeling in interferon-gamma-deficient mice infected with mycobacteria.: Blood. 1998 Apr 15;91(8):2914-24. Unique Identifier : AIDSLINE MED/98200598; Murray PJ; Young RA; Daley GQ; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Control of intracellular bacterial infections requires interferon-gamma (IFN-gamma) both for establishing a Th1 T-cell response and for activating macrophages to kill the bacteria. Exposure of mice deficient in IFN-gamma to mycobacterial infection produces an immune response characterized by a Th2 T-cell phenotype, fl
L-selectin expression affects T-cell circulation following isoproterenol infusion in humans.: Brain Behav Immun. 1997 Dec;11(4):333-42. Unique Identifier : AIDSLINE MED/98173997; Mills PJ; Karnik RS; Dillon E; University of California at San Diego, La Jolla 92093, USA.; pmills@ucsd.edu; beta-Adrenergic receptor agonists have been shown to affect leukocyte migration. This study examined the expression of cellular adhesion molecules on lymphocyte, monocyte, and granulocyte distribution following an infusion of isoproterenol 20 and 40 ng/kg/min for 15 min each) in 12 healthy subjects. Leukocyte populati
Glutathione in hypersensitivity to trimethoprim/sulfamethoxazole in patients with HIV infection.: Ann Pharmacother. 1998 Mar;32(3):381-3. Unique Identifier : AIDSLINE MED/98194263; Rose EW; McCloskey WW; Massachusetts College of Pharmacy and Allied Health Sciences, Boston,; USA.
Differential binding of lectins IL-2 and CSL to candida albicans and cancer cells.: Glycobiology. 1998 Mar;8(3):221-5. Unique Identifier : AIDSLINE MED/98119782; Zanetta JP; Bonaly R; Maschke S; Strecker G; Michalski JC; Laboratoire de Chimie Biologique, Cedex, France.; The demonstration that interleukin 2 ( IL-2 ) is a lectin specific for oligomannosides allows to understand a new function for this cytokine: as a bifunctional molecule when bound to its receptor ss, IL-2 associates the latter which the CD3/TCR complex, interacting with
Recombinant fusion proteins for the industrial production of disulfide bridge containing peptides: purification, oxidation without concatamer formation, and selective cleavage.: Protein Expr Purif. 1998 Apr;12(3):404-14. Unique Identifier : AIDSLINE MED/98205124; Dobeli H; Andres H; Breyer N; Draeger N; Sizmann D; Zuber MT; Weinert B; Wipf B; Preclinical Research, F. Hoffmann-La Roche, Basel, CH-4070,; Switzerland.; We report the biotechnical production of peptides of approximately 35-50 amino acids in length containing one intramolecular disulfide bridge, using a recombinant fusion tail approach. This method fills the technological gap when either (a) chemical synthesis fails due to known problematic peptide sequences or (b) if
Acoustic waves and the real-time study of biochemical macromolecules at the liquid/solid interface.: Faraday Discuss. 1997;(107):159-76. Unique Identifier : AIDSLINE MED/98231234; Cavic BA; Chu FL; Furtado LM; Ghafouri S; Hayward GL; Mack DP; McGovern ME; Su H; Thompson M; Department of Chemistry, University of Toronto, Ontario, Canada.; The adsorption of the proteins, bovine serum albumin, fibrinogen, avidin and neutravidin (non-glycosylated form of avidin) to a variety of surfaces imposed on thickness shear mode sensors in examined in a flow-injection analysis format. In all cases, adsorption of these moieties was essentially irreversible, although
Cannabis as medicine: time for the phoenix to rise? [editorial]: BMJ. 1998 Apr 4;316(7137):1034-5. Unique Identifier : AIDSLINE MED/98219716; Robson P
Rapid HIV testing urged in the US [news]: BMJ. 1998 Apr 4;316(7137):1039. Unique Identifier : AIDSLINE MED/98219722; Josefson D
Reducing the risk of nosocomial HIV infection in British health workers working overseas: role of post-exposure prophylaxis.: BMJ. 1998 Apr 11;316(7138):1158-60. Unique Identifier : AIDSLINE MED/98230861; Gilks CF; Wilkinson D; Division of Tropical Medicine, Liverpool School of Tropical Medicine.
Human herpesvirus 8 (HHV-8) in the pathogenesis of Kaposi's sarcoma and other diseases.: Leuk Lymphoma. 1998 Jan;28(3-4):255-64. Unique Identifier : AIDSLINE MED/98176674; Humphrey RW; Davis DA; Newcomb FM; Yarchoan R; HIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda,; MD 20892, USA.; The discovery of Kaposi s Sarcoma-associated herpesvirus/human herpesvirus-8 (KSHV/ HHV-8) and subsequent studies of this virus have provided a body of evidence that support the concept that this is an etiologic agent for Kaposi s sarcoma (KS). Several studies have indicated that this virus may also be a causal agent
Solvation studies of DMP323 and A76928 bound to HIV protease: analysis of water sites using grand canonical Monte Carlo simulations.: Protein Sci. 1998 Mar;7(3):573-9. Unique Identifier : AIDSLINE MED/98200461; Marrone TJ; Resat H; Hodge CN; Chang CH; McCammon JA; Department of Chemistry and Biochemistry, University of California at; San Diego, La Jolla 92093-0365, USA.; We examine the water solvation of the complex of the inhibitors DMP323 and A76928 bound to HIV-1 protease through grand canonical Monte Carlo simulations, and demonstrate the ability of this method to reproduce crystal waters and effectively predict water positions not seen in the DMP323 or A76928 structures. The simu
[Human microsporidiosis in the acquired immunodeficiency syndrome]: Rev Assoc Med Bras. 1997 Jul-Sep;43(3):254-64. Unique Identifier : AIDSLINE MED/98158982; Brasil P; de Lima DB; Moura H; Disciplina de Doencas Infecciosas, Faculdade de Ciencias Medicas,; Hospital Universitario Pedro Ernesto, Universidade Estadual do Rio de; Janeiro.
Emerging viruses.: Curr Opin Pediatr. 1998 Feb;10(1):34-40. Unique Identifier : AIDSLINE MED/98190472; Holland DJ; Centre for Virus Research, Westmead Institutes of Health Research,; Westmead Hospital, NSW, Australia.; An emerging virus is a term applied to a newly discovered virus, one that is increasing in incidence or with the potential to increase in incidence. Many viruses fit into this definition. HIV is the clearest example of a previously unknown virus that has now produced one of the largest pandemics in history. Recent adv
An update on transfusion-transmitted viruses.: Curr Opin Pediatr. 1998 Feb;10(1):53-9. Unique Identifier : AIDSLINE MED/98190476; Luban NL; Transfusion Medicine, Children's Hospital, Washington, DC 20010, USA.; Advances in blood donor screening have advanced the concept that a zero-risk blood supply may be possible in the future. Although the application of a large number of serologic tests and more stringent donor questioning has certainly aided our ability to screen out donors, risks still remain. In this article, the lite
AIDS and HIV infection.: Mol Cell Biol Hum Dis Ser. 1995;5:195-236. Unique Identifier : AIDSLINE MED/98193747; Smith C; Sullenger BA; Genzyme Corporation, Framingham, Massachusetts 01701-9322, USA.
Staining pattern of seven monoclonal anti-CD26 antibodies in leprosy: implications for the use of CD26 as a surrogate marker of a human Th1-like reaction.: Virchows Arch. 1998 Apr;432(4):343-7. Unique Identifier : AIDSLINE MED/98225017; Seitzer U; Scheel-Toellner D; Mattern T; Haas H; Flad HD; Gerdes J; Department of Immunology and Cell Biology, Forschungszentrum Borstel,; Germany.; In a previous study using the monoclonal anti-CD26 antibody MIB-DS2/7 in leprosy and other granulomatous diseases, it was shown that CD26 may be a candidate for use as an operational marker of a human Th1-like reaction. In this follow-up study, we compared seven different monoclonal anti-CD26 antibodies with respect t
AIDS in Norway: a post hoc evaluation of an AIDS home care project.: J Clin Nurs. 1998 Mar;7(2):183-7. Unique Identifier : AIDSLINE MED/98243575; Bunch EH; Institute of Nursing Science, University of Oslo, Norway.; Norway s National Health Care system guarantees all citizens a right to health care within a decentralized system based on values like solidarity and equality. Seventy-five per cent of people with HIV/AIDS live and are treated in Oslo, the capital. Local home care agencies have minimal, if any experience working with
Dissociation of the signalling and antiviral properties of SDF-1-derived small peptides.: Curr Biol. 1998 Mar 26;8(7):369-76. Unique Identifier : AIDSLINE MED/98212071; Heveker N; Montes M; Germeroth L; Amara A; Trautmann A; Alizon M; Schneider-Mergener J; Inserm U.332, Institut Cochin de Genetique Moleculaire, 22 rue; Mechain, 75014, Paris, France. heveker@cochin.inserm.fr; BACKGROUND: The chemokine receptor CXCR4 (a receptor for the Cys-X-Cys class of chemokines) is a CD4-associated coreceptor for T-cell-tropic strains of human immunodeficiency virus 1 (HIV-1) and represents a target for antiviral therapy. Infection by T-tropic HIV-1 can be blocked by stromal-cell-derived factor-1 SDF-1
Identification of a common docking topology with substantial variation among different TCR-peptide-MHC complexes.: Curr Biol. 1998 Mar 26;8(7):409-12. Unique Identifier : AIDSLINE MED/98212076; Teng MK; Smolyar A; Tse AG; Liu JH; Liu J; Hussey RE; Nathenson SG; Chang HC; Reinherz EL; Wang JH; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Department; of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.; Whether T-cell receptors (TCRs) recognize antigenic peptides bound to major histocompatability complex (MHC) molecules through common or distinct docking modes is currently uncertain. We report the crystal structure of a complex between the murine N15 TCR [1-4] and its peptide-MHC ligand, an octapeptide fragment repre
Direct isolation, phenotyping and cloning of low-frequency antigen-specific cytotoxic T lymphocytes from peripheral blood.: Curr Biol. 1998 Mar 26;8(7):413-6. Unique Identifier : AIDSLINE MED/98212077; Dunbar PR; Ogg GS; Chen J; Rust N; van der Bruggen P; Cerundolo V; Molecular Immunology Group, Institute of Molecular Medicine, Nuffield; Department of Clinical Medicine, University of Oxford, John Radcliffe; Hospital Oxford, OX3 9DS, UK. rdunbar@radius.jr2.ox.ac.uk; Cytotoxic T lymphocytes (CTLs) play an important role in controlling viral infections and certain tumours, but characterising specific CTL responses has always been technically limited. Fluorogenic tetramers of major histocompatibility complex (MHC) class I complexes have been exploited recently to quantify the mass
Frozen shoulder: a new delayed complication of protease inhibitor therapy?: Rev Rhum Engl Ed. 1998 Jan;65(1):72-4. Unique Identifier : AIDSLINE MED/98183992; Zabraniecki L; Doub A; Mularczyk M; Andrieu V; Marc V; Ginesty E; Dromer C; Massip P; Fournie B; Rheumatology Department, Purpan Teaching Hospital, Toulouse, France.; We report three cases of frozen shoulder (including one with bilateral involvement) in human immunodeficiency virus HIV)-positive patients under triple antiretroviral therapy. In each case, the diagnosis was confirmed by arthrography, and the classic causes of frozen shoulder were ruled out. We suggest that protease i
Antigenic homology of HIV-1 GP41 and human platelet glycoprotein GPIIIa (integrin beta3).: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 15;17(5):385-90. Unique Identifier : AIDSLINE MED/98220506; Dominguez V; Gevorkian G; Govezensky T; Rodriguez H; Viveros M; Cocho G; Macotela Y; Masso F; Pacheco M; Estrada JL; Lavalle C; Larralde C; Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma; de Mexico, DF, Mexico.; Fifty-eight of 89 serum samples (65.17%) from HIV-1-infected individuals at various disease stages contain antibodies that react with a platelet peptide located in the cytoplasmic domain of integrin beta3, glycoprotein GPIIIa (aa749-761; sequence DRKEFAKFEEERA). Rabbit polyclonal antibodies raised against the syntheti
HTLV-I and HTLV-II virus expression increase with HIV-1 coinfection.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 15;17(5):391-7. Unique Identifier : AIDSLINE MED/98220507; Beilke MA; Japa S; Vinson DG; Tulane University School of Medicine, Department of Medicine, and; Tulane/Louisiana State University/Charity General Clinical Research; Center, New Orleans 70118, USA. mabeilke@mailhost.tcs.tulane.edu; Coinfections with HIV-1 and HTLV-I or HTLV-II have been associated with unique immunophenotypes and an increased risk for development of neurodegenerative conditions. These findings may result from an increased HTLV-I or II viral burden in dually infected individuals. To investigate this possibility, HTLV-I/II tax/rex
Potential SECIS elements in HIV-1 strain HXB2.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 15;17(5):398-403. Unique Identifier : AIDSLINE MED/98220508; Grate L; Department of Computer Engineering, Jack Baskin School of Engineering,; University of California, Santa Cruz, USA. leslie@cse.ucsc.edu; It has been proposed on the basis of sequence analysis that HIV-1 encodes a protein containing the amino acid selenocysteine (Sec). Selenocysteine is known to be incorporated into protein in response to a specific RNA secondary structure motif within the mRNA that is being translated. This RNA motif, the selenocystein
Does pregnancy influence the course of HIV infection? Evidence from two large Swiss cohort studies.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 15;17(5):404-10. Unique Identifier : AIDSLINE MED/98220509; Weisser M; Rudin C; Battegay M; Pfluger D; Kully C; Egger M; University Children's Hospital, Basel, Switzerland.; The question whether the natural history of HIV infection in women is affected by pregnancy has not so far been convincingly answered. We used prospective cohort data to compare pregnant and nonpregnant HIV-infected women during follow-up within the Swiss HIV Cohort Study (SHCS) and the Swiss Collaborative HIV and Pre
Levels of HIV RNA are quantitatively related to prior weight loss in HIV-associated wasting.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 15;17(5):411-8. Unique Identifier : AIDSLINE MED/98220510; Rivera S; Briggs W; Qian D; Sattler FR; Department of Medicine, University of Southern California School of; Medicine, Los Angeles, USA.; Thirty-three patients referred to a wasting clinic were evaluated to assess whether levels of HIV RNA were related to the magnitude of prior weight loss. Their median RNA level was 46,887 gene copies/ml (range,
Susceptibility of peripheral blood mononuclear cells to apoptosis is correlated to plasma HIV load.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 15;17(5):419-23. Unique Identifier : AIDSLINE MED/98220511; Karmochkine M; Parizot C; Calvez V; Coutellier A; Herson S; Debre P; Gorochov G; Service de Medecine Interne, Hopital de la Pitie-Salpetriere, Paris,; France.; OBJECTIVES: To quantify spontaneous and activation-induced apoptosis in peripheral blood mononuclear cells (PBMC) of HIV-infected patients and to look for correlations between PBMC apoptosis levels, stages of HIV disease, CD4 count, and plasma viral load. STUDY POPULATIONS: 75 consecutive inpatients and outpatients in
Costs and outcomes of AIDS care: comparing a health maintenance organization with fee-for-service systems in the Boston Health Study.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 15;17(5):424-32. Unique Identifier : AIDSLINE MED/98220512; Wilson IB; Sullivan LM; Weissman JS; Primary Care Outcomes Research Institute and Department of Medicine,; New England Medical Center, Boston University School of Medicine, MA; 02111, USA. ira.wilson@es.nemc.org; OBJECTIVE: A 4-month observational cohort study was performed to compare the performance of one health maintenance organization HMO) with two fee-for-service (FFS) systems in Boston, Massachusetts in treating 255 patients with AIDS. MAIN OUTCOME MEASURES: Total 4-month costs; cost subcomponents, including inpatient, o
Toward a better understanding of health-related quality of life: a comparison of the Medical Outcomes Study HIV Health Survey MOS-HIV) and the HIV Overview of Problems-Evaluation System HOPES).: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 15;17(5):433-41. Unique Identifier : AIDSLINE MED/98220513; O'Leary JF; Ganz PA; Wu AW; Coscarelli A; Petersen L; University of California Los Angeles Jonsson Comprehensive Cancer; Center, University of California Los Angeles, 90024, USA.; Although enthusiasm for measuring health-related quality of life HRQL) in clinical trials exists, information is limited on the meaning of scores. We examined the relation between scores from the 34-item Medical Outcomes Study HIV Health Survey (MOS-HIV) and the more detailed HIV Overview of Problems-Evaluation System
Transforming laboratory test results to improve clinical outcome predictions in HIV patients. Swiss HIV Cohort Study.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 15;17(5):442-9. Unique Identifier : AIDSLINE MED/98220514; Perneger TV; Yerly S; Perrin L; Institute of Social and Preventive Medicine, University of Geneva; Medical School, Switzerland. thomas.perneger@medecine.unige.ch; Transforming natural units of laboratory markers of HIV disease may improve their ability to predict clinical outcomes. The authors examined this issue within a prospective study of 394 patients enrolled in the Swiss HIV Cohort Study (SHCS) between 1991 and 1993. Baseline predictors included CD4+ and CD8+ cell counts,
Conservation of total T-cell counts during HIV infection: alternative hypotheses and implications.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 15;17(5):450-7. Unique Identifier : AIDSLINE MED/98220515; Grossman Z; Herberman RB; Vatnik N; Intrator N; Department of Physiology and Pharmacology, Sackler Faculty of; Medicine, Tel Aviv, Israel.; While CD4+ T-cell counts in the blood of HIV-infected individuals gradually decrease, there is a parallel increase in the number of blood CD8+ T cells such that the total number of T cells remains essentially constant for several years (1). The basis and significance of this phenomenon are not known. Based on a statis
Endemic infection with HTLV-IIB in Venezuelan Indians: molecular characterization.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 15;17(5):458-64. Unique Identifier : AIDSLINE MED/98220516; Leon-Ponte M; Echeverria de Perez G; Bianco N; Hengst J; Dube S; Love J; Poiesz BJ; Institute of Immunology, Faculty of Medicine, Central University of; Venezuela, Caracas.; The peripheral blood of 41 Yaruro and Guahibo Indians from Venezuela was examined for HTLV antibodies and DNA. Twenty-five samples (61%) were found to be infected with HTLV-IIB. The sensitivities of the serologic and DNA polymerase chain reaction PCR) analyses were 80% and 96%,
HIV incidence in Ethiopian immigrants to Israel.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 15;17(5):465-9. Unique Identifier : AIDSLINE MED/98220517; Kaplan EH; Kedem E; Pollack S; Yale School of Management, New Haven, Connecticut 05620-8200, USA.; The HIV incidence in recent adult Ethiopian immigrants to Israel is estimated through the use of snapshot estimators based on percentage of CD4 progression with time since infection, whereas the preimmigration incidence experienced by this population is estimated using an epidemic
HIV counseling and testing: behavior and practices of women of childbearing age in Abidjan, Cote d'Ivoire. DYSCER-CI Group.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 15;17(5):470-6. Unique Identifier : AIDSLINE MED/98220518; Ramon R; La Ruche G; Sylla-Koko F; Boka-Yao A; Bonard D; Coulibaly IM; Welffens-Ekra C; Dabis F; National AIDS Program, Abidjan, Cote d'Ivoire, France.; We assessed factors associated with women s attitudes toward HIV test results in gynecology clinics in Abidjan, Cote d Ivoire . HIV testing was systematically offered to nonpregnant women attending two gynecology clinics in Abidjan. Individual pretest counseling was performed b
Risk behaviors, HIV seropositivity, and tuberculosis infection in injecting drug users who operate shooting galleries in Puerto Rico.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 15;17(5):477-83. Unique Identifier : AIDSLINE MED/98220519; Robles RR; Marrero CA; Reyes JC; Colon HM; Matos TD; Finlinson HA; Munoz A; Melendez M; Sahai H; Research Institute, Mental Health and Anti-Addiction Services; Administration, San Juan, Puerto Rico, USA.; This study was designed to assess HIV risk behaviors, HIV seroprevalence, and tuberculosis (TB) infection in shooting gallery managers in Puerto Rico . The subjects were 464 injection drug users (IDUs), of whom 12.5% reported managing shooting galleries. The median frequency of
Complications of radiologically placed central venous ports and Hickman catheters in patients with AIDS.: Can Assoc Radiol J. 1998 Apr;49(2):84-9. Unique Identifier : AIDSLINE MED/98221781; Muscedere G; Bennett JD; Lee TY; Mackie I; Vanderburgh L; Department of Diagnostic Radiology, St. Joseph's Health Centre,; London, Ont.; OBJECTIVE: To determine any differences in the complications following radiologic placement of 2 devices--Hickman catheters and central venous ports--to permit long-term central venous access in patients with AIDS. PATIENTS AND METHODS: Thirty-eight patients with AIDS received 52 long-term central venous access cathet
The progressive outer retinal necrosis syndrome: successful treatment with combination antiviral therapy.: Ophthalmic Surg Lasers. 1998 Mar;29(3):198-206. Unique Identifier : AIDSLINE MED/98208993; Ciulla TA; Rutledge BK; Morley MG; Duker JS; Department of Ophthalmology, Indiana University School of Medicine,; Indianapolis, USA.; BACKGROUND AND OBJECTIVE: To assess a two-drug combination of antiviral therapy for the progressive outer retinal necrosis syndrome (PORN), given the current poor outcome with acyclovir alone. PATIENTS AND METHODS: A retrospective review was performed on six consecutive patients
The use of pneumatic retinopexy to delay surgical repair of a retinal detachment associated with the ganciclovir intraocular device.: Ophthalmic Surg Lasers. 1998 Mar;29(3):244-6. Unique Identifier : AIDSLINE MED/98209000; McAuliffe PF; Heinemann MH; Department of Ophthalmology, New York Hospital-Cornell Medical Center,; NY 10021, USA.; Rhegmatogenous retinal detachments are associated with cytomegalovirus ( CMV ) retinitis and the use of the ganciclovir intraocular device. Pars plana vitrectomy with silicone oil tamponade is the preferred technique to repair
[Esophageal ulcer hemorrhage in HIV patient: treatment with argon laser (letter)]: Gastroenterol Hepatol. 1998 Feb;21(2):114. Unique Identifier : AIDSLINE MED/98210357; Mundi Sanchez-Ramade JL; Carmona Soria I; Lavin Castejon I; Trapero Martinez A; Fernandez Perez R; Palacios Perez A
Utilization of a mammalian cell-based RNA binding assay to characterize the RNA binding properties of picornavirus 3C proteinases.: RNA. 1998 Feb;4(2):215-25. Unique Identifier : AIDSLINE MED/98230247; Blair WS; Parsley TB; Bogerd HP; Towner JS; Semler BL; Cullen BR; Department of Genetics, Duke University Medical Center, Durham, North; Carolina 27710, USA.; Using an assay capable of detecting sequence-specific RNA/protein interactions in mammalian cells, we demonstrate that the poliovirus and rhinovirus 3C proteinases are able to bind structured target RNA sequences derived from their respective 5 noncoding regions in vivo. Specific RNA binding by poliovirus 3C was foun
Pharmacokinetics and metabolism of an oligodeoxynucleotide phosphorothioate (GEM91) in cynomolgus monkeys following intravenous infusion.: Antisense Nucleic Acid Drug Dev. 1998 Feb;8(1):43-52. Unique Identifier : AIDSLINE MED/98171046; Grindel JM; Musick TJ; Jiang Z; Roskey A; Agrawal S; Hybridon, Inc., Cambridge, MA 02139, USA.; The pharmacokinetics and metabolism of an antisense oligonucleotide phosphorothioate (GEM91) were studied in cynomolgus monkeys following intravenous infusion. [35S]-Labeled GEM91 was administered to 12 monkeys by means of a 2-hour intravenous infusion at a dose of 4 mg/kg. Plasma pharmacokinetic analysis revealed tha
Motor pathway analysis in HAM/TSP using magnetic stimulation and F-waves.: Can J Neurol Sci. 1998 Feb;25(1):48-54. Unique Identifier : AIDSLINE MED/98193449; Young RE; Morgan OS; Forster A; Department of Basic Medical Sciences, Faculty of Medical Sciences,; University of the West Indies, Mona, Jamaica.; BACKGROUND: Tropical Spastic Paraparesis/HTLV-I Associated Myelopathy (HAM/TSP) is a chronic, progressive myelopathy endemic to the Caribbean. In HAM/TSP, peripheral motor pathways have been assessed using electromyography and nerve conduction studies; central motor pathways have been assessed to a limited extent usin
Lymphomas associated with HIV infection.: Cancer Surv. 1997;30:263-93. Unique Identifier : AIDSLINE MED/98209218; Diebold J; Raphael M; Prevot S; Audouin J; Department of Pathology, Hotel Dieu, Paris, France.; Lymphomagenesis in HIV positive patients is a complex phenomenon not yet completely understood (Karp and Broder, 1992). The great majority of NHL are of the B cell type. Burkitt lymphoma seems to develop early during the evolution of HIV infection in patients with a CD4 count above 200/microliter. MYC is rearranged in
Congress Report: XIX symposium of the International Association for Comparative Research on Leukemia and Related Diseases, Mannheim/Heidelberg, Germany, July 13 - 18, 1997.: Eur J Med Res. 1998 Apr 8;3(4):216-22. Unique Identifier : AIDSLINE MED/98202623; Hochhaus A; Berger U; Kramer A; Reiter A; Seifarth W; Willer A; Hehlmann R; III. Medizinische Klinik, Klinikum Mannheim der Universitat; Heidelberg, Wiesbadener Str. 7-11, Mannheim, D-68305, Germany.; The XIX Symposium of the International Association for Comparative Research on Leukemia and Related Diseases (IACRLRD, President: Prof. Dr. R. Hehlmann) was held in Mannheim and Heidelberg, Germany , July 13 18, 1997. Comparative research in cancer was systematically established in
HIV trial abandoned [news]: Nat Biotechnol. 1998 Mar;16(3):219. Unique Identifier : AIDSLINE MED/98188414
Immunological right of veto [news; comment]: Nat Biotechnol. 1998 Mar;16(3):237-8. Unique Identifier : AIDSLINE MED/98188421; Nagy Z
Specific inhibition of CD4+ T lymphocytes by a hybrid antibody.: Nat Biotechnol. 1998 Mar;16(3):271-5. Unique Identifier : AIDSLINE MED/98188429; Qi Y; Staerz UD; Department of Medicine, National Jewish Center for Immunology and; Respiratory Medicine, Denver, CO 80206, USA.; T lymphocytes are crucial in the defense against foreign intruders and cancerous growths. Yet, in circumstances such as transplantation or autoimmunity, T-cell-mediated responses can be detrimental. Inhibition of these deleterious responses is currently achieved by drugs that induce general immune suppression. These c
Biomagnetic isolation of antigen-specific CD8+ T cells usable in immunotherapy.: Nat Biotechnol. 1998 Mar;16(3):281-5. Unique Identifier : AIDSLINE MED/98188431; Luxembourg AT; Borrow P; Teyton L; Brunmark AB; Peterson PA; Jackson MR; R.W. Johnson Pharmaceutical Research Institute, San Diego, CA 92121,; USA. aluxembourg@liai.org; Isolating antigen-specific T lymphocytes is hampered by the low frequency of the cells and the low affinity between T-cell receptors (TCR) and antigen. We describe the isolation and purification of antigen-specific CD8+ T lymphocytes from mixed T-cell populations. Magnetic beads coated with major histocompatibility co
[Determination of the dispersion of microorganisms in the course of dental surgical activity]: Rev Panam Salud Publica. 1998 Feb;3(2):84-7. Unique Identifier : AIDSLINE MED/98203571; Discacciati JA; Sander HH; de Castilho LS; Resende VL; Departamento de Odontologia Restauradora, Faculdade de Odontologia da; Universidade de Minas Gerais, Belo Horizonte, Brasil.; The professionals and patients involved in dental examinations are at risk for infection by various disease-causing bacteria, viruses, and fungi, such as those responsible for hepatitis, tuberculosis, herpes, and AIDS. It is known that aerosols and spatter containing pathogenic microorganisms can spread during an exam
Sex on the wards: Conundra for clinicians.: J Am Acad Psychiatry Law. 1997;25(4):441-60. Unique Identifier : AIDSLINE MED/98121335; Mossman D; Perlin ML; Dorfman DA; Should psychiatric inpatients be allowed to engage in sexual activities? Do clinicians have a right to prevent them from doing so? If so, when may sexual interaction be restricted? What sorts of clinical issues and problems are posed for nursing staff, and how should psychiatrists and administrators respond to these?
Sensitive liquid chromatographic technique to measure isoniazid in alveolar cells, bronchoalveolar lavage and plasma in HIV-infected patients.: J Chromatogr B Biomed Sci Appl. 1998 Feb 13;705(2):323-9. Unique Identifier : AIDSLINE MED/98180869; Delahunty T; Lee B; Conte JE; Department of Clinical Pharmacology, University of California San; Francisco, 94110, USA.; The need to monitor the effectiveness of antimicrobial drugs in treating opportunistic infections such as tuberculosis in HIV-infected patients requires the development of sensitive assays. A suitable HPLC method was developed to measure the concentration of isoniazid (INH) in plasma 1 h after a standard 300 mg dose a
Cholestatic hepatitis after liver transplantation is associated with persistently high serum hepatitis C virus RNA levels.: Liver Transpl Surg. 1998 Jan;4(1):15-21. Unique Identifier : AIDSLINE MED/98117166; Doughty AL; Spencer JD; Cossart YE; McCaughan GW; A. W. Morrow Gastroenterology and Liver Centre, Royal Prince Alfred; Hospital, University of Sydney, New South Wales, Australia.; Viral recurrence is universal after transplantation for hepatitis C infection. This may lead to difficulties in differentiating allograft dysfunction caused by chronic rejection from hepatitis C virus (HCV) recurrence. Cases of severe cholestatic hepatitis have also been reported in conjunction with reinfection of the
Pediatric compliance in combination HIV therapy. Getting it right the first time.: Adv Nurse Pract. 1998 Mar;6(3):35-8. Unique Identifier : AIDSLINE MED/98243544; Moloney C; Damon B; Regan AM; Division of Infectious Diseases, Boston Medical Center, USA.
The battle against ignorance.: Nurs Spectr (N Engl Ed). 1998 Feb 9;2(3):6. Unique Identifier : AIDSLINE MED/98199570; Pauly-O'Neill S
HIV-1 Vpr: G2 cell cycle arrest, macrophages and nuclear transport.: Prog Cell Cycle Res. 1997;3:21-7. Unique Identifier : AIDSLINE MED/98177828; Re F; Luban J; Department of Microbiology, Columbia University, College of Physicians; and Surgeons, New York, NY 10032, USA.; HIV-1 possesses six open reading frames in addition to the gag, pol, and env shared by all retroviruses. One of these accessory genes, vpr, is required for maximal viral replication in macrophages. The molecular mechanism underlying this effect may be related to one of the unusual properties of the encoded protein: so
Left ventricular structure and function in children infected with human immunodeficiency virus: the prospective P2C2 HIV Multicenter Study. Pediatric Pulmonary and Cardiac Complications of Vertically Transmitted HIV Infection (P2C2 HIV) Study Group.: Circulation. 1998 Apr 7;97(13):1246-56. Unique Identifier : AIDSLINE MED/98230119; Lipshultz SE; Easley KA; Orav EJ; Kaplan S; Starc TJ; Bricker JT; Lai WW; Moodie DS; McIntosh K; Schluchter MD; Colan SD; Department of Cardiology, Children's Hospital, Harvard Medical School,; Boston, Mass, USA. slipshultz@cc.urmc.rochester.edu; BACKGROUND: The frequency of, course of, and factors associated with cardiovascular abnormalities in pediatric HIV are incompletely understood. METHODS AND RESULTS: A baseline echocardiogram (median age, 2.1 years) and 2 years of follow-up every 4 months were obtained as part of a prospective study on 196 vertically H
Selective CD8+ T cells accumulate in the lungs of patients with allergic asthma after allergen bronchoprovocation.: Clin Exp Immunol. 1998 Apr;112(1):1-9. Unique Identifier : AIDSLINE MED/98226434; Wahlstrom J; Dahlen B; Ihre E; Wigzell H; Grunewald J; Eklund A; Microbiology and Tumour Biology Centre, Karolinska Institute,; Stockholm, Sweden.; Our objective was to study whether CD4+ or CD8+ T cells expressing particular T cell receptors (TCR) would accumulate in the lungs of patients with allergic asthma following allergen exposure. We thus analysed the TCR Valpha and Vbeta gene usage of CD4+ and CD8+ lung and peripheral blood lymphocytes (PBL) of eight pat
Changes to the cytokine microenvironment in the genital tract mucosa of HIV+ women.: Clin Exp Immunol. 1998 Apr;112(1):100-4. Unique Identifier : AIDSLINE MED/98226448; Olaitan A; Johnson MA; Reid WM; Poulter LW; Department of Obstetrics and Gynaecology, The Royal Free Hospital and; School of Medicine, London, UK.; As previous studies have indicated that genital tract mucosal T cell function may be impaired in HIV infection, we investigated the T cell cytokine mRNA in the genital tract mucosa of HIV-infected women to determine if there are alterations in the cytokine profile which may explain the T cell impairment. The in situ h
HIV-1 does not alter in vitro and in vivo IL-10 production by human monocytes and macrophages.: Clin Exp Immunol. 1998 Apr;112(1):105-11. Unique Identifier : AIDSLINE MED/98226449; Bergamini A; Bolacchi F; Faggioli E; Placido R; Vendetti S; Cappannoli L; Ventura L; Cerasari G; Uccella I; Andreoni M; Rocchi G; Department of Public Health and Cellular Biology, University of Rome; Tor Vergata, Italy.; The present study analyses the ability of HIV-1 to modulate IL-10 production in cells of monocyte-macrophage lineage cultured in the presence of macrophage colony-stimulating factor (M-CSF). Both monocytes and macrophages spontaneously produced low amount of IL-10. Lipopolysaccharide (LPS) induced a strong IL-10 respo
Recombinant human IL-16 inhibits HIV-1 replication and protects against activation-induced cell death (AICD).: Clin Exp Immunol. 1998 Apr;112(1):84-91. Unique Identifier : AIDSLINE MED/98226446; Idziorek T; Khalife J; Billaut-Mulot O; Hermann E; Aumercier M; Mouton Y; Capron A; Bahr GM; Institut Pasteur de Lille, INSERM U167, France.; The chemoattractant cytokine IL- 16 has been reported to suppress lymphocyte activation and to inhibit HIV-1 replication in acutely infected T cells. We have cloned and expressed human IL-16 in Escherichia coli and investigated whether the recombinant protein could regulate the level of lymphocyte apoptosis from HIV-1
Expression of macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES genes in lymph nodes from HIV+ individuals: correlation with a Th1-type cytokine response.: Clin Exp Immunol. 1998 Apr;112(1):92-9. Unique Identifier : AIDSLINE MED/98226447; Trumpfheller C; Tenner-Racz K; Racz P; Fleischer B; Frosch S; Department of Immunology, Bernhard Nocht-Institute for Tropical; Medicine, Hamburg, Germany.; The in vivo response of the immune system after HIV infection in regard to cytokine production and C-C chemokine synthesis is not well known. Here we have analysed cytokine and chemokine mRNA production in lymph nodes with follicular hyperplasia (FHLN) of HIV-infected patients by in situ hybridization using anti-sense
A reduced CD8+ lymphocyte subset distinguishes patients with polymyalgia rheumatica and temporal arteritis from patients with other diseases.: Clin Exp Rheumatol. 1998 Mar-Apr;16(2):155-60. Unique Identifier : AIDSLINE MED/98197454; Elling P; Olsson AT; Elling H; Department of Medicine, Randers Central Hospital, Randers, Denmark.; OBJECTIVE: To determine the diagnostic and screening test qualities of concentrations of the CD8+ lymphocyte subset in peripheral blood to discriminate patients with giant cell arteritis (GCA) from patients with other diseases. METHODS: A CD8+ lymphocyte test was performed in 454 patients from the Department of Medici
HIV infection and SLE: their pathogenic relationship.: Clin Exp Rheumatol. 1998 Mar-Apr;16(2):175-80. Unique Identifier : AIDSLINE MED/98197459; Sekigawa I; Kaneko H; Hishikawa T; Hashimoto H; Hirose S; Kaneko Y; Maruyama N; Department of Medicine, Juntendo University, Izu-Nagaoka Hospital,; Shizuoka, Japan.; Retroviruses have repeatedly been suggested as a possible trigger mechanism for systemic lupus erythematosus (SLE). We review the role of human immunodeficiency virus (HIV)-1 envelope glycoprotein (gp120) in the induction of immune dysregulation including autoimmunity in HIV-1 infection, and discuss the possible relat
Saquinavir. Clinical pharmacology and efficacy.: Clin Pharmacokinet. 1998 Mar;34(3):189-201. Unique Identifier : AIDSLINE MED/98195465; Vella S; Floridia M; Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy.; Saquinavir is an HIV protease inhibitor with no, or limited, effect on the activity of other structurally related human aspartic proteinases. As with other HIV protease inhibitors , saquinavir inhibits the cleavage of the gag-pol protein substrate leading to the rele
Pneumocystis pneumonia in the intensive care unit: location, location, location? [editorial; comment]: Crit Care Med. 1998 Apr;26(4):640-1. Unique Identifier : AIDSLINE MED/98218499; Walker R; Kaner RJ
Variations in intensive care unit utilization for patients with human immunodeficiency virus-related Pneumocystis carinii pneumonia: importance of hospital characteristics and geographic location [see comments]: Crit Care Med. 1998 Apr;26(4):668-75. Unique Identifier : AIDSLINE MED/98218505; Curtis JR; Bennett CL; Horner RD; Rubenfeld GD; DeHovitz JA; Weinstein RA; Department of Medicine, University of Washington, Seattle, USA.; OBJECTIVE: To determine whether intensive care unit (ICU) use and outcomes for patients with human immunodeficiency virus HIV)-related Pneumocystis carinii pneumonia vary by hospital characteristics and geographic location. DESIGN: Retrospective review of the medical records of 2,174 patients with HIV-related P. carin
Dentists, malpractice and not knowing enough: legal liability for failing to keep up with the profession.: Dent Pract Manage. 1992 Fall;:30-1. Unique Identifier : AIDSLINE MED/98185907; Maxston BE; Health Law Practice Group, Emery Jamieson, Edmonton, Alberta.; The law imposes an obligation on you to keep current with the developments of your profession, particularly those developments which directly affect the health of your patients. From a legal perspective, you risk liability when your professional inquisitiveness and awareness falls below that of the reasonable speciali
Haematological changes in human immunodeficiency virus infection. Part I: Review article.: East Afr Med J. 1997 Nov;74(11):732-6. Unique Identifier : AIDSLINE MED/98218208; Mwanda OW; Department of Haematology and Blood Transfusion, College of Health; Sciences, University of Nairobi.; This review attempts to put together the changes in the blood and bone marrow observed in those who are infected with human immunodeficiency virus (HIV). These are contribution of many published and unpublished data and experience on; blood counts, blood film and bone marrow films prepared and stained by MayGrunwald-G
Haematological changes in human immunodeficiency virus infection. Part II.: East Afr Med J. 1997 Nov;74(11):737-9. Unique Identifier : AIDSLINE MED/98218209; Mwanda OW; Department of Haematology and Blood Transfusion, College of Health; Sciences, University of Nairobi.; This second part of the review looks at change seen in the bone marrow haemostasis and malignancies found in HIV infection. Examination of bone marrow is requested in the presence of cytopaenias, splenomegaly, lymphomas and myelodysplasia. The findings include marrow hypocellularity, myelodysplasia and poor marrow rec
Sexually transmitted disease risk assessment used among low-risk populations in east central Africa: a review.: East Afr Med J. 1997 Dec;74(12):764-71. Unique Identifier : AIDSLINE MED/98218178; Welsh M; Feldblum P; Chen S; Family Health International, Nairobi, Kenya.; In sub-Saharan Africa where sexually transmitted diseases (STDs) are prevalent but health resources are scarce, algorithms that act as STD/HIV risk assessment (RA) tools for family planning FP) and maternal/child health (MCH) clinic attenders may be useful. These RA algorithms generally comprise questions about a pers
Socio-cultural and economic aspects of AIDS in Uganda: a review.: East Afr Med J. 1997 Dec;74(12):772-6. Unique Identifier : AIDSLINE MED/98218179; Monk F; Ineichen B; Imperial College of Science Technology and Medicine, London.; AIDS is long-established in Uganda ; prevalence rates are high. Most transmission is by heterosexual intercourse, and has been associated with population movements, especially of traders. Treatment resources are very limited and expensive. Some sexual practices inhibit contraceptive
T-lymphocytopaenia, opportunistic infections and pathological findings in Ghanaian AIDS patients and their sexual partners.: East Afr Med J. 1997 Dec;74(12):784-91. Unique Identifier : AIDSLINE MED/98218182; Ayisi NK; Wiredu EK; Sata T; Nyadedzor C; Tsiagbe VK; Newman M; Cofie CN; Taneguchi K; Virology Unit, Noguchi Memorial Institute for Medical Research,; University of Ghana, Legon, Ghana.; Ninety-nine patients at Center for Disease Control (CDC) clinical stage IV were studied. Twelve (12.12%) of these patients turned out to be HIV seronegative. Ten out of the 12 HIV negative patients were immunocompetent whereas the other two had proportional decreases in both CD4+ and CD8+ T-lymphocytes. HIV-1, HIV-2,
Perforation of terminal ileum and appendix in typhoid enteritis: report of two cases.: East Afr Med J. 1997 Dec;74(12):796-9. Unique Identifier : AIDSLINE MED/98218184; Golakai VK; Makunike R; Department of Surgery, University of Zimbabwe, Medical School,; Avondale, Harare, Zimbabwe.; Two cases of simultaneous typhoid perforation of terminal ileum and appendix are reported from Harare Central Hospital. These findings have not been reported before. Perforations were associated with schistosomiasis and HIV/AIDS. Definitive diagnosis was made only after laparotomy, serology and histopathology. With ea
Micronutrients and HIV infection: a review.: Eur J Clin Nutr. 1998 Mar;52(3):157-63. Unique Identifier : AIDSLINE MED/98196645; Friis H; Michaelsen KF; Research Department of Human Nutrition, The Royal Veterinary and; Agricultural University, Frederiksberg, Denmark. hfr@kvl.dk
AIDS related knowledge and behaviours among college students, Gondar, Ethiopia: a comparative study.: Ethiop Med J. 1997 Jul;35(3):185-90. Unique Identifier : AIDSLINE MED/98219468; Teka T; Clinical Sciences Division, International Centre for Diarrheaal,; Disease Research, Dhaka, Bangladesh.; AIDS-related knowledge and behaviours among students at the Gondar College of Medical Sciences, Gondar, Ethiopia were evaluated based on identical surveys conducted in 1990 and 1992. One hundred three second year students provided information in 1992. Analysis indicated that 49%
The V3 loop of human immunodeficiency virus type-1 envelope protein is a high-affinity ligand for immunophilins present in human blood.: Eur J Biochem. 1998 Mar 15;252(3):441-6. Unique Identifier : AIDSLINE MED/98206736; Endrich MM; Gehring H; Biochemisches Institut, Universitat Zurich, Switzerland.; Human immunodeficiency virus type-1 (HIV-1) infection requires binding of the envelope protein gp120 to host CD4 receptors and the action of the chemokine receptors CXCR4 or CCR5, which define cell tropism. The proline-containing V3 loop of gp120 determines the selection of the chemokine receptor and participates in c
Evidence for the persistence of monoclonal expansions of CD8+ T cells following primary simian immunodeficiency virus infection.: Eur J Immunol. 1998 Apr;28(4):1172-80. Unique Identifier : AIDSLINE MED/98225029; Wilson JD; Cranage M; Cook N; Leech S; McMichael AJ; Callan MF; Molecular Immunology Group, Institute of Molecular Medicine, John; Radcliffe Hospital, Oxford, GB.; A longitudinal study of the CD8+ TCR variable (Vbeta) chain repertoire was performed in rhesus macaques experimentally infected with simian immunodeficiency virus (SIV) using both TCR Vbeta chain-specific monoclonal antibodies and TCR beta chain CDR3 length analysis. Expansions of subpopulations of CD8+ T cells were d
Selective immunomodulation by the autoimmunity-inducing xenobiotics streptozotocin and HgCl2.: Eur J Immunol. 1998 Apr;28(4):1233-42. Unique Identifier : AIDSLINE MED/98225036; Albers R; de Heer C; Bol M; Bleumink R; Seinen W; Pieters R; Research Institute for Toxicology, Utrecht University, The; Netherlands.; Exposure to certain drugs and environmental chemicals can provoke the onset of autoimmune disease in susceptible individuals by releasing (self) epitopes for which tolerance has not been established, while simultaneously providing the necessary adjuvant activity. The resulting response type is influenced by the genoty
Natural truncation of RANTES abolishes signaling through the CC chemokine receptors CCR1 and CCR3, impairs its chemotactic potency and generates a CC chemokine inhibitor.: Eur J Immunol. 1998 Apr;28(4):1262-71. Unique Identifier : AIDSLINE MED/98225039; Struyf S; De Meester I; Scharpe S; Lenaerts JP; Menten P; Wang JM; Proost P; Van Damme J; Rega Institute for Medical Research, Laboratory of Molecular; Immunology, University of Leuven, Belgium.; Selective leukocyte trafficking towards sites of inflammation is mediated by chemokines. RANTES is a CC chemokine that attracts lymphocytes, monocytes, dendritic cells, eosinophils, basophils and NK cells. A natural form of human RANTES lacking two N-terminal residues was isolated from stimulated sarcoma cells, fibrob
A recombinant virus-like particle system derived from parvovirus as an efficient antigen carrier to elicit a polarized Th1 immune response without adjuvant.: Eur J Immunol. 1998 Apr;28(4):1401-7. Unique Identifier : AIDSLINE MED/98225053; Lo-Man R; Rueda P; Sedlik C; Deriaud E; Casal I; Leclerc C; Unite de Biologie des Regulations Immunitaires, Institut Pasteur,; Paris, France. rloman@pasteur.fr; Hybrid virus-like particles (VLP) were prepared by self-assembly of the modified porcine parvovirus (PPV) VP2 capsid protein carrying a CD8+ or CD4+ T cell epitope. Immunization of mice with a single dose of these hybrid pseudo-particles, without adjuvant, induced strong cytotoxic T lymphocyte and T helper (Th) respon
Type 1 and type 2 cytokine-producing mouse CD4+ and CD8+ T cells in acute Schistosoma mansoni infection.: Eur J Immunol. 1998 Apr;28(4):1408-16. Unique Identifier : AIDSLINE MED/98225054; Fallon PG; Smith P; Dunne DW; Department of Pathology, University of Cambridge, GB.; pgf@mole.bio.cam.ac.uk; CD4+ and CD8+ T cells can be divided based on the cytokines that they secrete into type 1 (Th1, Tc1) and type 2 (Th2, Tc2) subsets. Schistosoma mansoni infection in mice is characterized by a type 2-dominated response. We have used intracellular cytokine staining to demonstrate dramatic changes in the relative numbers
IL-12 prevents neonatal induction of transplantation tolerance in mice.: Eur J Immunol. 1998 Apr;28(4):1426-30. Unique Identifier : AIDSLINE MED/98225056; Donckier V; Flamand V; Desalle F; Vanderhaeghen ML; de Veerman M; Thielemans K; Abramowicz D; Goldman M; Laboratory of Experimental Immunology, Universite Libre des Bruxelles,; Brussels, Belgium.; We investigated the effect of IL-12 on the induction of transplantation tolerance by neonatal injection of allogenic cells. We first observed that injection of newborn BALB/c mice with IL-12 and (A/J x BALB/c)F1 spleen cells prevented the Th2 alloimmune response induced by neonatal inoculation of F1 cells alone and al
A semiautomated fluorescence-based cell-to-cell fusion assay for gp120-gp41 and CD4 expressing cells.: Exp Cell Res. 1998 Apr 10;240(1):49-57. Unique Identifier : AIDSLINE MED/98233456; Pine PS; Weaver JL; Oravecz T; Pall M; Ussery M; Aszalos A; Division of Applied Pharmacology Research, CDER, Food and Drug; Administration, Laurel, Maryland 20708, USA. PINE@CDER.FDA.GOV; A novel fluorescence-based method was developed to measure HIV envelope glycoprotein (env)-CD4-mediated cell fusion. This method measures the spread of a fluorescent dye as the cytosolic compartments of adjacent cells become contiguous upon cell-to-cell fusion. Calcein-labeled CD4+ Sup-T1 cells were seeded onto a mono
The fate of thymocytes labeled in vivo with CFSE.: Exp Cell Res. 1998 Apr 10;240(1):75-85. Unique Identifier : AIDSLINE MED/98233459; Graziano M; St-Pierre Y; Beauchemin C; Desrosiers M; Potworowski EF; Centre de Recherche en Immunologie, Institut Armand-Frappier, Laval,; Quebec, Canada.; The fate of thymic emigrants had so far been studied using a variety of markers, each of which had inherent limitations as to stability, toxicity, or selectivity. We describe a new technique which relies on the in vivo injection of CFSE, an esterified vital dye hitherto used at 80 times lower concentrations for in vit
Frequency and determinants of use of antiretroviral and prophylactic therapies against Pneumocystis carinii Pneumonia PCP) before AIDS diagnosis in Italy.: Eur J Epidemiol. 1998 Jan;14(1):41-7. Unique Identifier : AIDSLINE MED/98177051; Napoli PA; Dorrucci M; Serraino D; Pezzotti P; Franceschi S; Vella S; Rezza G; Centro Operativo AIDS, Laboratory of Epidemiology and Biostatistics,; Istituto Superiore di Sanita, Rome, Italy. erncosta@net.iss.it; To determine the frequency and the determinants of use of antiretroviral drugs and prophylaxis for Pneumocystis carinii Pneumonia (PCP) among HIV-infected individuals before AIDS diagnosis, a questionnaire was sent to all physicians reporting at least one AIDS case during the first six months of 1994 to the Italian Na
Increased immunoglobulin G production by short term cultured duodenal biopsy samples from HIV infected patients.: Gut. 1998 Mar;42(3):357-61. Unique Identifier : AIDSLINE MED/98238202; Schneider T; Zippel T; Schmidt W; Pauli G; Wahnschaffe U; Chakravarti S; Heise W; Riecken EO; Zeitz M; Ullrich R; Department of Gastroenterology, Free University of Berlin, Germany.; BACKGROUND: Secretory immunity is a major defence mechanism against infections at mucosal surfaces which are common in HIV infected patients. AIMS: To analyse intestinal immunoglobulin production in HIV infection in comparison with that in saliva and serum. PATIENTS AND METHODS: Immunoglobulin G (IgG), A (IgA), and M
Intracellular expression of P-170 glycoprotein in peripheral blood mononuclear cell subsets from healthy donors and HIV-infected patients.: Haematologica. 1998 Jan;83(1):13-20. Unique Identifier : AIDSLINE MED/98203441; Malorni W; Lucia MB; Rainaldi G; Cauda R; Cianfriglia M; Donelli G; Ortona L; Department of Ultrastructures, Istituto Superiore di Sanita, Rome,; Italy. malorni@mclink.it; BACKGROUND AND OBJECTIVE: P-glycoprotein (P-gp) is a transmembrane efflux pump that actively extrude a variety of unrelated drugs from cancer cells, leading to the so-called multidrug resistance (MDR) phenomenon. However, P-gp has also been found in normal bone marrow and peripheral blood mononuclear cells (PBMC). Rec
Primary effusion lymphoma containing human herpesvirus 8 DNA in two AIDS patients with Kaposi's sarcoma.: Haematologica. 1998 Jan;83(1):8-12. Unique Identifier : AIDSLINE MED/98203440; Ascoli V; Mastroianni CM; Galati V; Sirianni MC; Fruscalzo A; Pistilli A; Lo Coco F; Dipartimento di Medicina Sperimentale e Patologia, Universita La; Sapienza, Rome, Italy.; BACKGROUND AND OBJECTIVE: Primary effusion lymphomas (PELs) containing Kaposi s sarcoma-associated herpesvirus (human herpesvirus 8/HHV-8) DNA sequences represent a distinct but heterogeneous group of rare non-Hodgkin s lymphomas of null-cell phenotype/B-cell origin. We aimed to describe the clinicopathologic features
[Tuberculosis during pregnancy]: Harefuah. 1998 Jan 15;134(2):140-3. Unique Identifier : AIDSLINE MED/98178371; Barger H; Lessing JB; Gull I
Random expression of human immunodeficiency virus-1 (HIV-1) p17 epitopes) on the surface of the HIV-1-infected cell.: Hybridoma. 1998 Feb;17(1):73-5. Unique Identifier : AIDSLINE MED/98183842; Ota A; Liu X; Fujio H; Sakato N; Ueda S; Department of Neurovirology, Osaka University, Suita, Japan.; Twenty monoclonal antibodies (MAbs) were obtained by immunizing Balb/c mice with recombinant p17 (rp17) of HIV-1. Epitope specificity of each MAb was determined using six peptides that cover the entire region of p17. We found that each MAb reacts with only one of the peptides, residues 12-29, 30-52, 53-87, and 87-115
Monoclonal antibodies define a cellular antigen involved in HTLV-I infection.: Hybridoma. 1998 Feb;17(1):9-19. Unique Identifier : AIDSLINE MED/98183834; Agadjanyan MG; Chattergoon MA; Petrushina I; Bennett M; Kim J; Ugen KE; Kieber-Emmons T; Weiner DB; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia 19104, USA.; The exact mechanism by which the human T cell leukemia viruses HTLV) infects target cells remains unclear; although some molecules have been identified to be important in viral infection and entry. To investigate these phenomena, we generated a panel of monoclonal antibodies (MAb) against a B cell line (BJAB-WH) which
Genetic control of immune response to recombinant antigens carried by an attenuated Salmonella typhimurium vaccine strain: Nramp1 influences T-helper subset responses and protection against leishmanial challenge.: Infect Immun. 1998 May;66(5):1910-7. Unique Identifier : AIDSLINE MED/98234013; Soo SS; Villarreal-Ramos B; Anjam Khan CM; Hormaeche CE; Blackwell JM; Department of Pathology, University of Cambridge, United Kingdom.; Attenuated strains of Salmonella typhimurium have been widely used as vehicles for delivery and expression of vaccine antigens in murine models of infectious disease. In mice, early bacterial replication following infection with S. typhimurium is controlled by the gene (Nramp1, formerly Ity/Lsh/Bcg) encoding the natur
Involvement of T cells in enhanced resistance to Klebsiella pneumoniae septicemia in mice treated with liposome-encapsulated muramyl tripeptide phosphatidylethanolamine or gamma interferon.: Infect Immun. 1998 May;66(5):1962-7. Unique Identifier : AIDSLINE MED/98234020; ten Hagen TL; van Vianen W; Savelkoul HF; Heremans H; Buurman WA; Bakker-Woudenberg IA; Department of Clinical Microbiology and Antimicrobial Therapy, Erasmus; University Rotterdam, The Netherlands. tenhagen@heel.fgg.eur.nl; We have previously shown that prophylactic administration of the liposome-encapsulated immunomodulating agents muramyl tripeptide phosphatidylethanolamine (MTPPE) and gamma interferon (IFN-gamma) results in strongly increased survival of mice from a normally lethal septicemia with Klebsiella pneumoniae. It was anticip
Ambiguous role of interleukin-12 in Yersinia enterocolitica infection in susceptible and resistant mouse strains.: Infect Immun. 1998 May;66(5):2213-20. Unique Identifier : AIDSLINE MED/98234054; Bohn E; Schmitt E; Bielfeldt C; Noll A; Schulte R; Autenrieth IB; Max-von-Pettenkofer-Institut, Ludwig-Maximilians-University, Munich,; Germany.; Endogenous interleukin-12 (IL-12) mediates protection against Yersinia enterocolitica in C57BL/6 mice by triggering gamma interferon (IFN-gamma) production in NK and CD4+ T cells. Administration of exogenous IL-12 confers protection against yersiniae in Yersinia-susceptible BALB/c mice but exacerbates yersiniosis in r
Increased frequencies of interleukin-2- and interferon-gamma-producing T cells in patients with active Behcet's disease.: Invest Ophthalmol Vis Sci. 1998 May;39(6):996-1004. Unique Identifier : AIDSLINE MED/98239082; Sugi-Ikai N; Nakazawa M; Nakamura S; Ohno S; Minami M; Department of Ophthalmology, Yokohama City University School of; Medicine, Yokohama, Japan.; PURPOSE: To elucidate the profile of cytokine-producing T cells in patients with active or inactive Behcet s disease (BD), the frequencies of type 1 (Interleukin- [IL] 2, interferon-gamma [IFN-gamma]) and type 2 (IL-4) cytokine-producing CD4+ and CD8+ cells in peripheral blood were investigated, and the effect of immu
Infection with the human immunodeficiency virus (HIV) may have occurred as early as the late 1940s [editorial]: J Am Osteopath Assoc. 1998 Mar;98(3):139. Unique Identifier : AIDSLINE MED/98219540
Characterization of cysteamine as a potential contraceptive anti-HIV agent.: J Androl. 1998 Jan-Feb;19(1):37-49. Unique Identifier : AIDSLINE MED/98196580; Anderson RA Jr; Feathergill K; Kirkpatrick R; Zaneveld LJ; Coleman KT; Spear PG; Cooper MD; Waller DP; Thoene JG; Rush Presbyterian-St. Luke's Medical Center, Ob/Gyn Research, Chicago,; Illinois 60612-3864, USA.; Cysteamine (beta-mercaptoethylamine, or MEA) is a thiol-reducing agent and has anti-HIV activity. Because of these properties, cysteamine was evaluated as a vaginal contraceptive and tested for its effects on sperm function and on other sexually transmitted microbes. Cysteamine was contraceptive in the rabbit. Concept
The Gag domain of the Gag-Pol fusion protein directs incorporation into the L-A double-stranded RNA viral particles in Saccharomyces cerevisiae.: J Biol Chem. 1998 Apr 10;273(15):9306-11. Unique Identifier : AIDSLINE MED/98204933; Ribas JC; Wickner RB; Laboratory of Biochemistry and Genetics, NIDDK, National Institutes of; Health, Bethesda, Maryland 20892-0830, USA.; The L-A double-stranded RNA virus of yeast encodes its major coat protein, Gag, and a Gag-Pol fusion protein made by a -1 ribosomal frameshift, a coding strategy used by many retroviruses. We find that cells expressing only Gag from one plasmid and only Gag-Pol in frame) from a separate plasmid can support the propaga
Setaria digitata adult 14- to 20-kDa antigens induce differential Th1/Th2 cytokine responses in the lymphocytes of endemic normals and asymptomatic microfilariae carriers in bancroftian filariasis.: J Clin Immunol. 1998 Mar;18(2):114-23. Unique Identifier : AIDSLINE MED/98192339; Dalai SK; Das D; Kar SK; Centre for Biotechnology, Jawaharlal Nehru University, New Delhi,; India.; High titers of parasite antigen-specific IgG4 antibodies have been found to be circulating in the peripheral blood of chronic patients, asymptomatic microfilariae carriers, and endemic normals in bancroftian filariasis. But in contrast to this, the titers of antigen-specific IgG1, IgG2, and IgG3 isotype antibodies are
Induction of HIV-1 replication by type 1-like cytokines, interleukin (IL)-12 and IL-15: effect on viral transcriptional activation, cellular proliferation, and endogenous cytokine production.: J Clin Immunol. 1998 Mar;18(2):124-31. Unique Identifier : AIDSLINE MED/98192340; Al-Harthi L; Roebuck KA; Landay A; Department of Immunology/Microbiology, Rush-Presbyterian-St. Luke's; Medical Center, Chicago, Illinois 60612, USA.; Cytokine dysregulation is evident in HIV-1 infection and it may play an important role in HIV-1 pathogenesis. Administration of T helper cytokines potentially may restore the functional abnormalities to the HIV-1 immune response. Type 1-like cytokines, IL-2 , IL-12, and
Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout mice.: J Clin Invest. 1998 Apr 15;101(8):1717-25. Unique Identifier : AIDSLINE MED/98210110; Zhou X; Paulsson G; Stemme S; Hansson GK; Centre for Molecular Medicine, Karolinska Institute, S-17176; Stockholm, Sweden.; Atherosclerosis is an inflammatory-fibrotic response to accumulation of cholesterol in the artery wall. In hypercholesterolemia, low density lipoproteins (LDL) accumulate and are oxidized to proinflammatory compounds in the arterial intima, leading to activation of endothelial cells, macrophages, and T lymphocytes. We
Expression of the human histocompatibility leukocyte antigen DR3 transgene reduces the severity of demyelination in a murine model of multiple sclerosis.: J Clin Invest. 1998 Apr 15;101(8):1765-74. Unique Identifier : AIDSLINE MED/98210115; Drescher KM; Nguyen LT; Taneja V; Coenen MJ; Leibowitz JL; Strauss G; Hammerling GJ; David CS; Rodriguez M; Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905,; USA.; The role of various MHC genes in determining the progression of multiple sclerosis (MS) remains controversial. The HLA-DR3 gene has been associated with benign relapsing MS in some genetic epidemiologic studies, but with disease progression in others. We induced demyelination in highly susceptible B10.M and B10.Q mice
The effectiveness of different root debridement modalities in open flap surgery.: J Clin Periodontol. 1998 Mar;25(3):202-8. Unique Identifier : AIDSLINE MED/98202190; Huerzeler MB; Einsele FT; Leupolz M; Kerkhecker U; Strub JR; Department of Prosthodontics, Albert-Ludwigs University, Freiburg,; Germany.; It is unclear what degree of roughness or smoothness result from use of hand instruments alone in comparison to the use of hand instruments in combination with other aids and how it may effect the grade of cleanliness. The aim of this study was to determine in vivo whether the combination of hand instruments with othe
Gingival ulceration in HIV infection. A case series and case control study.: J Clin Periodontol. 1998 Mar;25(3):260-7. Unique Identifier : AIDSLINE MED/98202198; Robinson PG; Sheiham A; Challacombe SJ; Wren MW; Zakrzewska JM; Dept. Epidemiology and Public Health, University College, London, UK.; All cases of HIV-associated gingival ulceration seen at a dedicated dental clinic in a 5-year period were reviewed and compared against other patients attending the clinic. 94 (7.1%) of 1308 patients had 146 episodes of gingival ulceration. 89 patients had 140 episodes similar to acute necrotising ulcerative gingiviti
Protease inhibitors as inhibitors of human cytochromes P450: high risk associated with ritonavir.: J Clin Pharmacol. 1998 Feb;38(2):106-11. Unique Identifier : AIDSLINE MED/98210809; von Moltke LL; Greenblatt DJ; Grassi JM; Granda BW; Duan SX; Fogelman SM; Daily JP; Harmatz JS; Shader RI; Department of Pharmacology and Experimental Therapeutics, Tufts; University School of Medicine, Boston, MA 02111, USA.; Four protease inhibitor antiviral agents (ritonavir, indinavir, nelfinavir, saquinavir) were evaluated as in vitro inhibitors of the activity of six human cytochromes using an in vitro model based on human liver microsomes. Ritonavir was a highly pote
Educational intervention with international nurses and changes in knowledge, attitudes and willingness to provide care to patients with HIV/AIDS.: J Adv Nurs. 1998 Feb;27(2):267-73. Unique Identifier : AIDSLINE MED/98175386; McCann TV; Sharkey RJ; Faculty of Nursing, University of Newcastle, Callaghan, New South; Wales, Australia. vntm@cc.newcastle.edu.au; This paper reports the findings of a study which examines the relationship between the use of an educational intervention with nurses from several Asian countries and changes in knowledge, attitudes and willingness to care for patients with human immunodeficiency virus/acquired immunodeficiency syndrome HIV/AIDS). A p
HIV and AIDS awareness in midwives [letter]: J Adv Nurs. 1998 Feb;27(2):444. Unique Identifier : AIDSLINE MED/98175411; Robertson J; Lenton S
Favorable response to lymphoblastoid interferon-alpha in children with chronic hepatitis C.: J Hepatol. 1998 Feb;28(2):184-8. Unique Identifier : AIDSLINE MED/98173464; Sawada A; Tajiri H; Kozaiwa K; Guo W; Tada K; Etani Y; Okada S; Sako M; Department of Pediatrics, Osaka University, Faculty of Medicine,; Japan.; BACKGROUND/AIMS: We investigated the efficacy of interferon therapy for the treatment of children with chronic hepatitis C virus infection. METHODS: Twenty-four out of 26 children completed the 6-month treatment with lymphoblastoid interferon-alpha and were followed for 12 months or longer. Response to interferon ther
Frequency of parenteral exposure and seroprevalence of HBV, HCV, and HIV among operation room personnel.: J Hosp Infect. 1998 Feb;38(2):133-7. Unique Identifier : AIDSLINE MED/98182760; Mujeeb SA; Khatri Y; Khanani R; Blood Transfusion Services, Jinnah Postgraduate Medical Centre,; Karachi, Pakistan.; A study was designed to determine the frequency of needle-stick injuries, immunization status for hepatitis B virus (HBV) and sero-prevalence of HBV, hepatitis C virus (HCV), and human immunodeficiency virus (HIV) infections among operation room personnel. Self-assessment questionnaires were completed and blood tested
Growth and enterotoxin production by diarrhoeagenic Bacillus cereus in dietary supplements prepared for hospitalized HIV patients.: J Hosp Infect. 1998 Feb;38(2):139-46. Unique Identifier : AIDSLINE MED/98182761; Rowan NJ; Anderson JG; Department of Bioscience and Biotechnology, University of Strathclyde,; Glasgow, Scotland.; This study was initiated because of an increase in diarrhoeal episodes in a ward caring for patients infected with the human immunodeficiency virus (HIV). An examination of hospital-prepared dietary supplements (build-up food) found Bacillus cereus to be a potential problem. Due in part to inadequate refrigeration con
Natural killer cell depletion fails to influence initial CD4 T cell commitment in vivo in exogenous antigen-stimulated cytokine and antibody responses.: J Immunol. 1998 Feb 1;160(3):1098-105. Unique Identifier : AIDSLINE MED/98230449; Wang M; Ellison CA; Gartner JG; HayGlass KT; Department of Immunology, University of Manitoba, Winnipeg, Canada.; The role played by NK- and NK1.1-expressing T cells in CD4 T cell activation and induction of immune responses in vivo is controversial. These effector cells of the innate immune response are hypothesized to play a pivotal role in shaping initial T cell activation, with some groups reporting that classical NK cells ar
Alloantigen-reactive Th1 development in IL-12-deficient mice.: J Immunol. 1998 Feb 1;160(3):1132-8. Unique Identifier : AIDSLINE MED/98230453; Piccotti JR; Li K; Chan SY; Ferrante J; Magram J; Eichwald EJ; Bishop DK; Department of Surgery, University of Michigan School of Medicine, Ann; Arbor 48109, USA.; IL-12p70, a 70- to 75-kDa heterodimer consisting of disulfide-bonded 35-kDa (p35) and 40-kDa (p40) subunits, enhances Th1 development primarily by its ability to induce IFN-gamma production by NK and Th1 cells. Although homodimers of the p40 subunit of IL-12 are potent IL-12 receptor antagonists in some systems, we ha
Autologous human monocyte-derived dendritic cells genetically modified to express melanoma antigens elicit primary cytotoxic T cell responses in vitro: enhancement by cotransfection of genes encoding the Th1-biasing cytokines IL-12 and IFN-alpha.: J Immunol. 1998 Feb 1;160(3):1139-47. Unique Identifier : AIDSLINE MED/98230454; Tuting T; Wilson CC; Martin DM; Kasamon YL; Rowles J; Ma DI; Slingluff CL Jr; Wagner SN; van der Bruggen P; Baar J; Lotze MT; Storkus WJ; Department of Surgery, University of Pittsburgh School of Medicine,; University of Pittsburgh Cancer Institute, PA 15261, USA.; DNA-based immunization strategies designed to elicit cellular antitumor immunity offer an attractive alternative to protein- or peptide-based approaches. In the present study we have evaluated the feasibility of DNA vaccination for the induction of CTL reactivity to five different melanoma Ags in vitro. Cultured, mono
Polymorphism within a TCRAV family influences the repertoire through class I/II restriction.: J Immunol. 1998 Feb 1;160(3):1204-11. Unique Identifier : AIDSLINE MED/98230462; Sim BC; Wung JL; Gascoigne NR; Department of Immunology, The Scripps Research Institute, La Jolla, CA; 92037, USA.; Antibody-staining experiments have shown that closely related members of the TCRAV3 family are reciprocally selected into the CD4 or CD8 peripheral T cell subsets. This has been attributed to the individual AV3 members interacting preferentially with either MHC class I or MHC class II molecules. Single amino acid resi
Development of Th1 and Th2 populations and the nature of immune responses to hepatitis B virus DNA vaccines can be modulated by codelivery of various cytokine genes.: J Immunol. 1998 Feb 1;160(3):1320-9. Unique Identifier : AIDSLINE MED/98230477; Chow YH; Chiang BL; Lee YL; Chi WK; Lin WC; Chen YT; Tao MH; Division of Cancer Research, Institute of Biomedical Sciences,; Academia Sinica, Taipei, Taiwan.; In this study, we provide direct evidence that the magnitude and nature of the immune response to a DNA vaccine can be differentially regulated by codelivery of various mouse cytokine genes. Mice immunized with a hepatitis B virus (HBV) DNA vaccine and the IL-12 or IFN-gamma gene exhibited a significant enhancement of
Decreased resistance of TNF receptor p55- and p75-deficient mice to chronic toxoplasmosis despite normal activation of inducible nitric oxide synthase in vivo.: J Immunol. 1998 Feb 1;160(3):1340-5. Unique Identifier : AIDSLINE MED/98230479; Yap GS; Scharton-Kersten T; Charest H; Sher A; Immunobiology Section, Laboratory of Parasitic Diseases, National; Institutes of Allergy and Infectious Diseases, Bethesda, MD 20892,; USA.; The importance of TNF-alpha in host defense to the intracellular parasite, Toxoplasma gondii, was investigated in mice lacking both the p55 and p75 receptors for this cytokine. Upon i.p. infection with the avirulent ME49 strain, knockout mice were capable of limiting acute i.p. infection, but succumbed within 3 to 4 w
Factors involved in regulating primary and secondary immunity to infection with Histoplasma capsulatum: TNF-alpha plays a critical role in maintaining secondary immunity in the absence of IFN-gamma.: J Immunol. 1998 Feb 1;160(3):1359-68. Unique Identifier : AIDSLINE MED/98230482; Zhou P; Miller G; Seder RA; Laboratory of Clinical Investigation, National Institute of Allergy; and Infectious Diseases, Bethesda, MD 20892, USA.; Primary infection to Histoplasma capsulatum often results in a self-limited upper respiratory infection in humans; however, in immunocompromised hosts, disseminated infection can occur through reactivation of a previous infection. Since disseminated histoplasmosis has emerged as a difficult clinical entity to treat in
Induction of pulmonary allergic responses by antigen-specific Th2 cells.: J Immunol. 1998 Feb 1;160(3):1378-84. Unique Identifier : AIDSLINE MED/98230484; Li XM; Schofield BH; Wang QF; Kim KH; Huang SK; Johns Hopkins Asthma and Allergy Center, School of Medicine, The Johns; Hopkins University, Baltimore, MD 21224, USA.; The development of pulmonary allergic responses was examined in mice following pulmonary transfer of Ag (conalbumin)-specific Th2 cells. The levels of serum-specific IgE, cellular infiltrates, airway mucus goblet cells, and airway responsiveness were analyzed and compared with those in Ag-sensitized and -challenged mi
CC chemokine receptors 1 and 3 are differentially regulated by IL-5 during maturation of eosinophilic HL-60 cells.: J Immunol. 1998 Feb 1;160(3):1385-92. Unique Identifier : AIDSLINE MED/98230485; Tiffany HL; Alkhatib G; Combadiere C; Berger EA; Murphy PM; Laboratory of Host Defenses, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892, USA.; CC chemokine receptors 1 and 3 (CCR1 and CCR3) are expressed by eosinophils; however, factors regulating their expression and function have not previously been defined. Here we analyze chemokine receptor expression and function during eosinophil differentiation, using the eosinophilic cell line HL-60 clone 15 as a mod
Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern.: J Immunol. 1998 Feb 1;160(3):1411-8. Unique Identifier : AIDSLINE MED/98230488; Kodelja V; Muller C; Politz O; Hakij N; Orfanos CE; Goerdt S; Klinik und Poliklinik fur Dermatologie, Universitatsklinikum Benjamin; Franklin, Freie Universitat Berlin, Germany.; We have cloned a novel human CC-chemokine, alternative macrophage activation-associated CC-chemokine (AMAC)-1. The isolated cDNA clone (803 bp) shows a single open reading frame of 267-bp coding for 89 amino acid residues; mature AMAC-1 protein is predicted to consist of 69 amino acids with a m.w. of 7855. Sequence al
Cytokine induction of MIP-1 alpha and MIP-1 beta in human fetal microglia.: J Immunol. 1998 Feb 1;160(3):1449-55. Unique Identifier : AIDSLINE MED/98230493; McManus CM; Brosnan CF; Berman JW; Department of Pathology, Albert Einstein College of Medicine, Bronx,; NY 10461, USA.; Leukocyte infiltration into the central nervous system (CNS) is a key event in the inflammatory processes of neuroimmunologic diseases. Microglia, resident macrophages of the CNS, may contribute to this process by elaborating chemoattractants that are capable of recruiting leukocytes across the blood-brain barrier. Su
Cells transfected with a non-neutralizing antibody gene are resistant to HIV infection: targeting the endoplasmic reticulum and trans-Golgi network.: J Immunol. 1998 Feb 1;160(3):1489-96. Unique Identifier : AIDSLINE MED/98230498; Zhou P; Goldstein S; Devadas K; Tewari D; Notkins AL; Oral Infection and Immunity Branch, National Institute of Dental; Research, Bethesda, MD 20892, USA.; Plasmids containing single chain Fv (scFv) non-neutralizing human anti-HIV-1 gp41 Ab cDNA, with or without endoplasmic reticulum ER) or trans-Golgi network (TGN) retention signals, were constructed. Stable transfectants expressing these scFvs then were generated from COS-7 cells and HIV-1-susceptible CD4+ human T cell
Mechanisms of acquired thymic tolerance in vivo: intrathymic injection of antigen induces apoptosis of thymocytes and peripheral T cell anergy.: J Immunol. 1998 Feb 1;160(3):1504-8. Unique Identifier : AIDSLINE MED/98230500; Chen W; Sayegh MH; Khoury SJ; Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard; Medical School, Boston, MA 02115, USA.; Intrathymic injection of Ag induces Ag-specific tolerance in several clinically relevant experimental autoimmune and transplantation models. However, the exact mechanisms of acquired thymic tolerance in vivo remain unclear. We investigated the mechanisms of acquired thymic tolerance in mice that are transgenic for the
Cytokine production and surface marker expression in acute and stable multiple sclerosis: altered IL-12 production and augmented signaling lymphocytic activation molecule (SLAM)-expressing lymphocytes in acute multiple sclerosis.: J Immunol. 1998 Feb 1;160(3):1514-21. Unique Identifier : AIDSLINE MED/98230502; Ferrante P; Fusi ML; Saresella M; Caputo D; Biasin M; Trabattoni D; Salvaggio A; Clerici E; de Vries JE; Aversa G; Cazzullo CL; Clerici M; Cattedra di Virologia, Universita degli Studi di Milano, Italy.; Ag-stimulated IL-2 production and mitogen-stimulated type 1 and type 2 cytokine production by PBMC, as well as expression of Th1- and Th2-associated phenotypical markers, of B7-1, B7-2, and CD95 Fas) on the surface of immune cells, and the serum concentration of solubl
Intracellular and surface expression of the HIV-1 coreceptor CXCR4/fusin on various leukocyte subsets: rapid internalization and recycling upon activation.: J Immunol. 1998 Feb 1;160(3):1522-31. Unique Identifier : AIDSLINE MED/98230503; Forster R; Kremmer E; Schubel A; Breitfeld D; Kleinschmidt A; Nerl C; Bernhardt G; Lipp M; Max Delbruck Center for Molecular Medicine, Berlin-Buch, Germany.; rfoerst@mdc-berlin.de; We describe the expression and regulation of the HIV-1 coreceptor CXCR4/fusin. Using anti-CXCR4 mAb, we demonstrate that this chemokine receptor is highly expressed on neutrophils, monocytes, B cells, and naive T cells among peripheral blood cells. In secondary lymphoid organs CXCR4 was found to be expressed on B cell
alpha/beta-T cell receptor (TCR)+CD4-CD8- (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic NOD)/Lt mice by the influence of interleukin (IL)-4 and/or IL-10.: J Exp Med. 1998 Apr 6;187(7):1047-56. Unique Identifier : AIDSLINE MED/98197161; Hammond KJL; Poulton LD; Palmisano LJ; Silveira PA; Godfrey DI; Baxter AG; Autoimmunity Research Group, Centenary Institute of Cancer Medicine; and Cell Biology, Newtown, New South Wales 2042, Australia.; We have previously shown that nonobese diabetic (NOD) mice are selectively deficient in alpha/beta-T cell receptor TCR)+CD4-CD8- NKT cells, a defect that may contribute to their susceptibility to the spontaneous development of insulin-dependent diabetes mellitus (IDDM). The role of NKT cells in protection from IDDM in
Ca2+ signaling modulates cytolytic T lymphocyte effector functions.: J Exp Med. 1998 Apr 6;187(7):1057-67. Unique Identifier : AIDSLINE MED/98197162; Esser MT; Haverstick DM; Fuller CL; Gullo CA; Braciale VL; Department of Microbiology, University of Virginia, Health Sciences; Center, Charlottesville, Virginia 22908, USA.; Cytolytic T cells use two mechanisms to kill virally infected cells, tumor cells, or other potentially autoreactive T cells in short-term in vitro assays. The perforin/granule exocytosis mechanism uses preformed cytolytic granules that are delivered to the target cell to induce apoptosis and eventual lysis. FasL/Fas C
Human immunodeficiency virus type 1 Vpr is a positive regulator of viral transcription and infectivity in primary human macrophages.: J Exp Med. 1998 Apr 6;187(7):1103-11. Unique Identifier : AIDSLINE MED/98197166; Subbramanian RA; Kessous-Elbaz A; Lodge R; Forget J; Yao XJ; Bergeron D; Cohen EA; Laboratory of Human Retrovirology, Department of Microbiology and; Immunology, University of Montreal, Montreal, Quebec, Canada H3C3J7.; It is currently well established that HIV-1 Vpr augments viral replication in primary human macrophages. In its virion-associated form, Vpr has been suggested to aid efficient translocation of the proviral DNA into the cell nucleus. Although Vpr growth-arrests dividing T cells, the relevance of this biological activit
HIV-1 directly kills CD4+ T cells by a Fas-independent mechanism.: J Exp Med. 1998 Apr 6;187(7):1113-22. Unique Identifier : AIDSLINE MED/98197167; Gandhi RT; Chen BK; Straus SE; Dale JK; Lenardo MJ; Baltimore D; Department of Biology, Massachusetts Institute of Technology,; Cambridge, Massachusetts 02139, USA.; The mechanism by which HIV-1 induces CD4(+) T cell death is not known. A fundamental issue is whether HIV-1 primarily induces direct killing of infected cells or indirectly causes death of uninfected bystander cells. This question was studied using a reporter virus system in which infected cells are marked with the ce
Productive infection of neonatal CD8+ T lymphocytes by HIV-1.: J Exp Med. 1998 Apr 6;187(7):1139-44. Unique Identifier : AIDSLINE MED/98197170; Yang LP; Riley JL; Carroll RG; June CH; Hoxie J; Patterson BK; Ohshima Y; Hodes RJ; Delespesse G; University of Montreal, Centre de Recherche Louis-Charles Simard,; Hopital Notre-Dame, Montreal, Quebec H2L 4M1, Canada.; CD8+ T lymphocytes confer significant but ultimately insufficient protection against HIV infection. Here we report that activated neonatal CD8+ T cells can be productively infected in vitro by macrophage-tropic (M-tropic) HIV-1 isolates, which are responsible for disease transmission, whereas they are resistant to T c
DNA as an adjuvant: capacity of insect DNA and synthetic oligodeoxynucleotides to augment T cell responses to specific antigen.: J Exp Med. 1998 Apr 6;187(7):1145-50. Unique Identifier : AIDSLINE MED/98197171; Sun S; Kishimoto H; Sprent J; Department of Immunology, The Scripps Research Institute, La Jolla,; California 92037, USA.; How strong adjuvants such as complete Freund s adjuvant (CFA) promote T cell priming to protein antigens in vivo is still unclear. Since the unmethylated CpG motifs in DNA of bacteria and other nonvertebrates are stimulatory for B cells and antigen-presenting cells, the strong adjuvanticity of CFA could be attributed,
Antimicrobial peptides melittin and cecropin inhibit replication of human immunodeficiency virus 1 by suppressing viral gene expression.: J Gen Virol. 1998 Apr;79 ( Pt 4):731-40. Unique Identifier : AIDSLINE MED/98227923; Wachinger M; Kleinschmidt A; Winder D; von Pechmann N; Ludvigsen A; Neumann M; Holle R; Salmons B; Erfle V; Brack-Werner R; Institute of Molecular Virology, GSF-National Research Center for; Environment and Health, Neuherberg, Germany.; Antimicrobial peptides are effectors of innate immunity, providing their hosts with rapid non-specific defence against parasitic invaders. In this report, the effects are assessed of two well-characterized antimicrobial amphipathic peptides melittin and cecropin) on human immunodeficiency virus 1 (HIV-1) replication a
Replication of human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus strain mac (SIVmac) and chimeric HIV-1/SIVmac viruses having env genes derived from macrophage-tropic viruses: an indication of different mechanisms of macrophage-tropism in human and monkey cells.: J Gen Virol. 1998 Apr;79 ( Pt 4):741-5. Unique Identifier : AIDSLINE MED/98227924; Chen J; Ido E; Jin M; Kuwata T; Igarashi T; Mizuno A; Koyanagi Y; Hayami M; Laboratory of Pathogenic Virus, Institute for Virus Research, Kyoto; University, Japan.; To investigate the transferability of macrophage (Mphi)-tropism among primate lentiviruses, we constructed recombinants of human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus strain mac (SIVmac) and chimeric HIV-1/SIVmac (SHIV) having env region Mphi-tropic determinants. A recombinant HIV-1 havi
Antigenic variants of J subgroup avian leukosis virus: sequence analysis reveals multiple changes in the env gene.: J Gen Virol. 1998 Apr;79 ( Pt 4):757-66. Unique Identifier : AIDSLINE MED/98227926; Venugopal K; Smith LM; Howes K; Payne LN; Institute for Animal Health, Compton, Newbury, Berkshire, UK.; HPRS-103, the prototype of avian leukosis virus (ALV) subgroup J, was isolated in 1989 from meat-type chickens from commercial flocks where it induces myelocytic myeloid leukosis (ML). The HPRS-103 env gene differs considerably from other ALV subgroups but shows high identity (75-97%) to env-like sequences of the diff
Mice lacking inducible nitric-oxide synthase are more susceptible to herpes simplex virus infection despite enhanced Th1 cell responses.: J Gen Virol. 1998 Apr;79 ( Pt 4):825-30. Unique Identifier : AIDSLINE MED/98227933; MacLean A; Wei XQ; Huang FP; Al-Alem UA; Chan WL; Liew FY; Division of Virology, University of Glasgow, UK.; Mice deficient in the inducible nitric-oxide synthase (iNOS), constructed by gene-targeting, were significantly more susceptible to herpes simplex virus (HSV)-1 infection, displayed a delayed clearance of virus from the dorsal root ganglia (DRG) and exhibited an increase in the frequency of virus reactivation in DRG c
Evidence against a key role for transforming growth factor-beta1 in cytomegalovirus-induced bone marrow aplasia.: J Gen Virol. 1998 Apr;79 ( Pt 4):867-76. Unique Identifier : AIDSLINE MED/98227938; Dobonici M; Podlech J; Steffens HP; Maiberger S; Reddehase MJ; Institute for Virology, Johannes Gutenberg-University, Mainz, Germany.; During immunodeficiency after sublethal haematoablative treatment, cytomegalovirus ( CMV ) infection interferes with haematopoietic reconstitution and can cause lethal bone marrow BM) aplasia. The in vivo model of murine CMV in
Localised 1H-MR spectroscopy for metabolic characterisation of diffuse and focal brain lesions in patients infected with HIV.: J Neurol Neurosurg Psychiatry. 1998 Apr;64(4):516-23. Unique Identifier : AIDSLINE MED/98236083; Simone IL; Federico F; Tortorella C; Andreula CF; Zimatore GB; Giannini P; Angarano G; Lucivero V; Picciola P; Carrara D; Bellacosa A; Livrea P; Institute of Neurology, University of Bari, Italy.; Livera@.Cimedoc.Uniba.it; OBJECTIVES: To evaluate the role of proton MR spectroscopy 1H-MRS) in detecting metabolic changes in diffuse or focal lesions in the brain of patients infected with HIV. METHODS: Sixty HIV seropositive patients (25 with HIV related encephalopathies, 20 with toxoplasmosis, eight with progressive multifocal leukoencepha
Fumagillin analog in the treatment of Kaposi's sarcoma: a phase I AIDS Clinical Trial Group study. AIDS Clinical Trial Group No. 215 Team.: J Clin Oncol. 1998 Apr;16(4):1444-9. Unique Identifier : AIDSLINE MED/98211776; Dezube BJ; Von Roenn JH; Holden-Wiltse J; Cheung TW; Remick SC; Cooley TP; Moore J; Sommadossi JP; Shriver SL; Suckow CW; Gill PS; Beth Israel Deaconess Medical Center, Boston, MA, USA.; PURPOSE: Angiogenesis is a major component of Kaposi s sarcoma KS) and a critical process in tumor growth. The present study was designed primarily to test the toxicity and pharmacokinetics PK) of the angiogenesis inhibitor TNP-470 and secondarily to evaluate tumor response in patients with early AIDS-related KS. PATI
Neonatal hypoperistalsis associated with perinatal zidovudine administration.: J Perinatol. 1998 Jan-Feb;18(1):20-3. Unique Identifier : AIDSLINE MED/98188359; Neuman MI; Molle Z; Handelsman EL; Desai N; Orentlicher RJ; Rabinowitz SS; Department of Gastroenterology and Nutrition, Children's Medical; Center at Brooklyn, USA.; OBJECTIVE: This paper presents the cases of two infants exposed to perinatal zidovudine in whom hypoperistalsis and intestinal pseudoobstruction developed. STUDY DESIGN: Clinical case reports were prepared of two infants born to women infected with human immunodeficiency virus who were treated with perinatal zidovudin
Development of liposomal amphotericin B formulation.: J Microencapsul. 1998 Mar-Apr;15(2):137-51. Unique Identifier : AIDSLINE MED/98193699; Gulati M; Bajad S; Singh S; Ferdous AJ; Singh M; University Institute of Pharmaceutical Sciences, Panjab University,; Chandigarh, India.; A considerable effort has been spent in the past three decades to investigate various aspects of liposomes as novel drug delivery systems. In 1990, the first amphotericin B (AmB) liposomal preparation (L-AmB) under the brand name AmBisome was introduced into the market by Vestar. The successful marketing of the produc
Drug retention and stability of solid lipid nanoparticles containing azidothymidine palmitate after autoclaving, storage and lyophilization.: J Microencapsul. 1998 Mar-Apr;15(2):173-84. Unique Identifier : AIDSLINE MED/98193702; Heiati H; Tawashi R; Phillips NC; Faculte de Pharmacie, Universite de Montreal, Quebec, Canada.; Solid lipid nanoparticles (SLNs) were prepared using trilaurine TL) as the SLN core and phospholipid (PL) as coating. Neutral and negatively charged PLs were used to produce neutral and negatively charged SLNs. An ester prodrug of 3 -azido-3 -deoxythymidine (Zidovudine,
In vitro blood-brain barrier permeability of nevirapine compared to other HIV antiretroviral agents.: J Pharm Sci. 1998 Mar;87(3):306-10. Unique Identifier : AIDSLINE MED/98182157; Glynn SL; Yazdanian M; Department of Pharmaceutics, Boehringer Ingelheim Pharmaceuticals; Inc., Ridgefield, Connecticut 06877, USA.; To combat infection and inhibit viral replication of HIV in the brain, antiretroviral agents must cross the blood-brain barrier BBB). An in vitro BBB model consisting of bovine brain microvessel endothelial cells grown on porous filters was used to study and compare the transport of
In vivo maternal-fetal-amniotic fluid pharmacokinetics of zidovudine in the pigtailed macaque: comparison of steady-state and single-dose regimens.: J Pharmacol Exp Ther. 1998 Apr;285(1):54-62. Unique Identifier : AIDSLINE MED/98205002; Tuntland T; Odinecs A; Nosbisch C; Unadkat JD; Department of Pharmaceutics, School of Pharmacy, and the Regional; Primate Center, University of Washington, Seattle, Washington; 98195-7610, USA.; The purpose of this study was to characterize the disposition of zidovudine in the maternal-fetal-amniotic fluid unit in vivo. Zidovudine was administered as a constant-rate infusion or a bolus dose to the dam, fetus and amniotic cavity (bolus dose only) of the near-term pigtailed macaque model. A fetal-maternal plasm
A randomized controlled trial of double-versus single-gloving in vascular surgery.: J R Coll Surg Edinb. 1998 Feb;43(1):9-10. Unique Identifier : AIDSLINE MED/98221268; Berridge DC; Starky G; Jones NA; Chamberlain J; Department of Vascular Surgery, Freeman Hospital, Newcastle-upon-Tyne,; UK.; With the increasing incidence of hepatitis B and HIV, and the increasing awareness of the risk and prevalence of hepatitis C, it is becoming even more necessary to adopt stricter policies to safeguard personnel and to reduce the risk of transmission. Previous studies have shown a need for eye protection, protective cl
Nurses' evaluations of sources of information about HIV and AIDS.: J R Soc Health. 1997 Oct;117(5):298-303. Unique Identifier : AIDSLINE MED/98180191; Irving KL; Ferguson E; Cox T; Farnsworth WJ; Irving & Irving Associates, Sudborough, Northants.; Reviews of the literature indicate that nurses feel ill-informed about HIV/AIDS and that poor knowledge is associated with anxiety and negative attitudes towards infected patients and their care. Although some studies have sought to identify the sources of HIV/AIDS information available to nurses, few have attempted t
Interactions of primary amphipathic vector peptides with membranes. Conformational consequences and influence on cellular localization.: J Membr Biol. 1998 Apr 1;162(3):259-64. Unique Identifier : AIDSLINE MED/98210128; Vidal P; Chaloin L; Heitz A; Van Mau N; Mery J; Divita G; Heitz F; CRBM-CNRS (UPR 1086), 1919, Route de Mende, F. 34293 Montpellier Cedex; 5, France.; The conformations of two peptides produced by the combinations of a nuclear localization sequence and a sequence issued from the fusion protein gp41 of HIV 1 have been analyzed both in solution and in membranes or in membrane mimicking environments. Both are shown to be nonordered in water, alpha-helical when incorpor
Our obligation to treat AIDS patients [editorial]: J Mich Dent Assoc. 1995 Feb;77(2):8. Unique Identifier : AIDSLINE MED/98169638; Chase WR
Antiretroviral therapy for HIV infection: promises and problems.: JAMA. 1998 May 6;279(17):1343-4. Unique Identifier : AIDSLINE MED/98241189; Volberding PA; Deeks SG; University of California, San Francisco, and San Francisco General; Hospital, 94110, USA.
Effect of parenteral medium- and long-chain triglycerides on lymphocytes subpopulations and functions in patients with acquired immunodeficiency syndrome: a prospective study.: JPEN J Parenter Enteral Nutr. 1998 Mar-Apr;22(2):67-71. Unique Identifier : AIDSLINE MED/98188382; Gelas P; Cotte L; Poitevin-Later F; Pichard C; Leverve X; Barnoud D; Leclercq P; Touraine-Moulin F; Trepo C; Bouletreau P; Intensive Care Unit, Hotel Dieu, Lyon, France.; BACKGROUND: Total parenteral nutrition (TPN) may offer significant clinical benefit in malnourished patients with acquired immunodeficiency syndrome (AIDS). However, the immunologic effect of parenteral lipids remains unknown in these severely immunodepressed patients. METHODS: We undertook a prospective randomized do
Cyclophosphamide given after active specific immunization augments antitumor immunity by modulation of Th1 commitment of CD4+ T cells.: J Surg Oncol. 1998 Apr;67(4):221-7. Unique Identifier : AIDSLINE MED/98238971; Li L; Okino T; Sugie T; Yamasaki S; Ichinose Y; Kanaoka S; Kan N; Imamura M; Department of Surgery and Surgical Basic Science, Graduate School of; Medicine, Kyoto University, Japan.; BACKGROUND AND OBJECTIVES: In order to evaluate the regulatory effect of cyclophosphamide (CPA) on active specific immunization ASI)-induced antitumor immunity, we examined the timing of CPA 100 mg/kg) with ASI, and focused on whether CPA given after ASI augments antitumor immunity by modulation of Th1 commitment of C
Target cell limited and immune control models of HIV infection: a comparison.: J Theor Biol. 1998 Feb 7;190(3):201-14. Unique Identifier : AIDSLINE MED/98181041; De Boer RJ; Perelson AS; Theoretical Biology, Utrecht University, Padualaan 8, CH Utrecht,; 3584, The Netherlands. rdb@alive.biol.ruu.nl; We develop various mathematical models of the clinical latency stage of HIV-1 infection assuming that HIV-1 infection is limited either by the availability of cells that HIV can infect or by a specific anti-HIV cellular immune response. The former models we call target-cell-limited . Comparing the models by phase pla
LEA-1/ICAM-1 interaction is essentially involved in the pathogenesis of delayed-type hypersensitivity-induced liver injury to picryl chloride.: Life Sci. 1998;62(15):1281-92. Unique Identifier : AIDSLINE MED/98226422; Xu Q; Jiang J; Cao J; Wu F; Fujii H; Saiki I; Department of Pharmacology for Chinese Materia Medica, China; Pharmaceutical University, Nanjing, The People's Republic of China.; The kinetics of lymphocyte function associated antigen 1 (LFA-1) expression on spleen cells (SPC) and liver non-parenchymal cells NPC), and intercellular adhesion molecule 1 (ICAM-1) expression on hepatocytes (HC) was examined in acute liver injury mice induced by a DTH reaction to picryl chloride (PCl). The peak expr
Epidemiological study on knowledge, attitudes and behaviour of health care workers with respect to HIV infection.: Med Lav. 1997 Nov-Dec;88(6):495-506. Unique Identifier : AIDSLINE MED/98203499; Brusaferro S; Martina P; Puzzolante L; Gasparini V; Chair of Hygiene, Faculty of Medicine, University of Udine.; To analyse knowledge, perception of risk, attitudes and behaviour towards HIV infection among health workers in two hospitals in the North-East of Italy , we sent all health care workers who were working in direct contact with patients an anonymous self-administered questionnaire cov
[New HIV treatment guidelines (news)]: Med Monatsschr Pharm. 1998 Feb;21(2):64. Unique Identifier : AIDSLINE MED/98192943
Diagnosis and reporting of HIV and AIDS in states with integrated HIV and AIDS surveillance--United States, January 1994-June 1997.: MMWR Morb Mortal Wkly Rep. 1998 Apr 24;47(15):309-14. Unique Identifier : AIDSLINE MED/98239571; Recent reports based on acquired immunodeficiency syndrome (AIDS) surveillance data have highlighted substantial declines in AIDS incidence and deaths. As a result of improvements in treatment and care of persons infected with human immunodeficiency virus HIV), surveillance of AIDS alone no longer accurately reflects
Linear and cyclic peptides mimicking the disulfide loops in HIV-2 envelope glycoprotein induced antibodies with different specificity.: Mol Immunol. 1997 Nov-Dec;34(16-17):1177-89. Unique Identifier : AIDSLINE MED/98226417; Jrad BB; Bahraoui E; Laboratoire d'Immuno-Virologie, Universite Paul Sabatier, Toulouse,; France.; The aim of this study was to compare the immunogenicity and antigenicity of cyclic and linear peptides that mimic the disulfide loops in HIV-2ROD gp125. Based on the hypothetical assignment of intrachain disulfide bonds in HIV-2 envelope glycoprotein, peptides expected to mimic all 11 disulfide-bonded domains were syn
Ritonavir-associated myasthenia gravis [letter]: Muscle Nerve. 1998 May;21(5):680-1. Unique Identifier : AIDSLINE MED/98231969; Saadat K; Kaminski HJ
Epstein-Barr virus and a cellular signaling pathway in lymphomas from immunosuppressed patients [see comments]: N Engl J Med. 1998 May 14;338(20):1413-21. Unique Identifier : AIDSLINE MED/98234128; Liebowitz D; Marjorie B. Kovler Viral Oncology Laboratories, Department of; Medicine, University of Chicago, IL 60637, USA.; BACKGROUND: Epstein-Barr virus (EBV) is associated with various malignant and benign lymphoproliferative disorders. It also efficiently transforms human B lymphocytes in vitro. The latent membrane protein 1 (LMP1) of EBV-infected cells plays a central part in this process by mimicking members of the family of tumor ne
Epstein-Barr virus in action in vivo [editorial; comment]: N Engl J Med. 1998 May 14;338(20):1461-3. Unique Identifier : AIDSLINE MED/98234136; Rickinson AB
[Immunologic foundations of new vaccination strategies]: Naturwissenschaften. 1998 Feb;85(2):62-72. Unique Identifier : AIDSLINE MED/98191745; Kaufmann SH; Abteilung fur Immunologie, Universitat Ulm, Germany.; kaufmann@mpiib-berlin.mpg.de; Vaccines provide cost-efficient means for control of infectious diseases. Yet, several infectious diseases exist, for which efficacious vaccines are not available, as yet. Recent progress in immunology has led to the identification of the parameters which promote the development of the most appropriate immune response
How do North Carolina prenatal care providers counsel and test pregnant women for HIV? Survey measures knowledge of HIV testing benefits.: N C Med J. 1998 Mar-Apr;59(2):105-9. Unique Identifier : AIDSLINE MED/98219609; Walter EB; Lampe MA; Livingston E; Royce RA; Dept. of Pediatrics, Duke University Medical Center, Durham, USA.
[Immunologic aspects of allergic and non-allergic asthma]: Minerva Med. 1998 Mar;89(3):49-56. Unique Identifier : AIDSLINE MED/98236242; Anania A; Fassio S; Cascio G; Dipartimento di Medicina Interna, Universita degli Studi, Torino.; METHODS: The peripheral blood lymphocytes and lung function have been studied in 25 patients: 12 affected by atopic asthma and 13 affected by non atopic asthma. RESULTS: The results obtained indicate that peripheral blood CD3 and CD4 cell as well as HLA-DR marker are higher in the extrinsic asthma group. CONCLUSIONS:
Rapid progression to invasive cervix cancer in a woman infected with the human immunodeficiency virus.: Obstet Gynecol. 1998 May;91(5 Pt 2):848-50. Unique Identifier : AIDSLINE MED/98231898; Holcomb K; Maiman M; Dimaio T; Gates J; Department of Obstetrics and Gynecology, State University of New; York-Health Science Center at Brooklyn, USA. kholc@msn.com; BACKGROUND: Previous studies have shown an increased risk of cervical dysplasia in women infected with human immunodeficiency virus (HIV), as well as an increased risk of progression to higher-grade lesions. It is not known whether the rate of progression is accelerated over that in immunocompetent women. CASE: During
The handpiece issue.: N M Dent J. 1992 Summer;43(3):19. Unique Identifier : AIDSLINE MED/98205412; Neiburger EJ; Center for Dental AIDS Research, Waukegan, IL 60085, USA.
Identification of a nucleotide binding site in HIV-1 integrase.: Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4170-5. Unique Identifier : AIDSLINE MED/98208511; Drake RR; Neamati N; Hong H; Pilon AA; Sunthankar P; Hume SD; Milne GW; Pommier Y; Department of Biochemistry and Molecular Biology, University of; Arkansas for Medical Sciences, Little Rock, AR 72205, USA.; drakerichardr@exchange.uams.edu; HIV-1 integrase is essential for viral replication and can be inhibited by antiviral nucleotides. Photoaffinity labeling with the 3 -azido-3 -deoxythymidine ( AZT ) analog 3 ,5-diazido-2 , 3 -dideoxyuridine 5 -monophosphate (5N3-AZTMP) and proteolytic m
A novel glutamine-RNA interaction identified by screening libraries in mammalian cells.: Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4247-52. Unique Identifier : AIDSLINE MED/98208525; Tan R; Frankel AD; Department of Biochemistry and Biophysics, University of California,; 513 Parnassus Avenue, San Francisco, CA 94143-0448, USA.; The arginine-rich motif provides a versatile framework for RNA recognition in which few amino acids other than arginine are needed to mediate specific binding. Using a mammalian screening system based on transcriptional activation by HIV Tat, we identified novel arginine-rich peptides from combinatorial libraries that
Disruption of the CD4-major histocompatibility complex class II interaction blocks the development of CD4(+) T cells in vivo.: Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4493-8. Unique Identifier : AIDSLINE MED/98208568; Riberdy JM; Mostaghel E; Doyle C; Department of Immunology, Box 3010, Duke University Medical Center,; Durham, NC 27710, USA.; The experiments presented in this report were designed to specifically examine the role of CD4-major histocompatibility complex (MHC) class II interactions during T cell development in vivo. We have generated transgenic mice expressing class II molecules that cannot interact with CD4 but that are otherwise competent t
Copresentation of natural HIV-1 agonist and antagonist ligands fails to induce the T cell receptor signaling cascade.: Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4527-32. Unique Identifier : AIDSLINE MED/98208574; Purbhoo MA; Sewell AK; Klenerman P; Goulder PJ; Hilyard KL; Bell JI; Jakobsen BK; Phillips RE; University of Oxford, Nuffield Department of Medicine and Institute of; Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3; 9DU, United Kingdom.; It is not known how human immunodeficiency virus type 1 HIV-1)-derived antagonist peptides interfere with intracellular activation of cytotoxic T lymphocytes (CTL). We identified Gag epitope variants in HIV-1-infected patients that act as antagonists of CTL responses to unmutated epitopes. We then investigated the eff
T cell vaccination induces T cell receptor Vbeta-specific Qa-1-restricted regulatory CD8(+) T cells.: Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4533-7. Unique Identifier : AIDSLINE MED/98208575; Jiang H; Kashleva H; Xu LX; Forman J; Flaherty L; Pernis B; Braunstein NS; Chess L; Department of Medicine, College of Physicians and Surgeons, Columbia; University, New York, NY 10032, USA.; Vaccination of mice with activated autoantigen-reactive CD4(+) T cells (T cell vaccination, TCV) has been shown to induce protection from the subsequent induction of a variety of experimental autoimmune diseases, including experimental allergic encephalomyelitis (EAE). Although the mechanisms involved in TCV-mediated
Extracellular HIV-1 virus protein R causes a large inward current and cell death in cultured hippocampal neurons: implications for AIDS pathology.: Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4595-600. Unique Identifier : AIDSLINE MED/98208586; Piller SC; Jans P; Gage PW; Jans DA; Membrane Biology Program, John Curtin School of Medical Research,; Australian National University, Canberra, Australia.; The small HIV-1 accessory protein Vpr (virus protein R) is a multifunctional protein that is present in the serum and cerebrospinal fluid of AIDS patients. We previously showed that Vpr can form cation-selective ion channels across planar lipid bilayers, introducing the possibility that, if incorporated into the membr
Latent varicella-zoster virus is located predominantly in neurons in human trigeminal ganglia.: Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4658-62. Unique Identifier : AIDSLINE MED/98208597; Kennedy PG; Grinfeld E; Gow JW; Glasgow University Department of Neurology, Institute of Neurological; Sciences, Southern General Hospital National Health Service Trust,; Glasgow G51 4TF, United Kingdom.P.G.Kennedy@clinmed.gla.ac.uk; Varicella-zoster virus (VZV) is a human herpesvirus that causes varicella (chicken pox) as a primary infection and, after a variable period of latency in trigeminal and dorsal root ganglia, reactivates to cause herpes zoster (shingles). Both of these conditions may be followed by a variety of neurological complication
Social stress results in altered glucocorticoid regulation and shorter survival in simian acquired immune deficiency syndrome.: Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4714-9. Unique Identifier : AIDSLINE MED/98208607; Capitanio JP; Mendoza SP; Lerche NW; Mason WA; California Regional Primate Research Center, University of California,; One Shields Avenue, Davis, CA 95616, USA. jpcapitanio@ucdavis.edu; From early in the AIDS epidemic, psychosocial stressors have been proposed as contributors to the variation in disease course. To test this hypothesis, rhesus macaques were assigned to stable or unstable social conditions and were inoculated with the simian immunodeficiency virus. Animals in the unstable condition dis
Modulation of cytokine production by dehydroepiandrosterone DHEA) plus melatonin (MLT) supplementation of old mice.: Proc Soc Exp Biol Med. 1998 May;218(1):76-82. Unique Identifier : AIDSLINE MED/98231865; Inserra P; Zhang Z; Ardestani SK; Araghi-Niknam M; Liang B; Jiang S; Shaw D; Molitor M; Elliott K; Watson RR; Arizona Prevention Center, University of Arizona, Tucson 87524, USA.; Tissue levels of the antioxidants melatonin (MLT) and dehydroepiandrosterone (DHEA) decline with age, and this decline is correlated with immune dysfunction. The aim of the current study is to determine whether hormone supplementation with MLT and DHEA together would synergize to reverse immune senescence. Old (16.5 m
Effects of dexamethasone on the profile of cytokine secretion in human whole blood cell cultures.: Regul Pept. 1998 Jan 2;73(1):59-65. Unique Identifier : AIDSLINE MED/98197024; Franchimont D; Louis E; Dewe W; Martens H; Vrindts-Gevaert Y; De Groote D; Belaiche J; Geenen V; Institute of Pathology, University of Liege, Belgium.; EXPERIMENTAL OBJECTIVES: The interaction between the endocrine and immune systems is a very intriguing area. Endogenous glucocorticoids, as end-effectors of the hypothalamo-pituitary-adrenal axis, inhibit the immune and inflammatory responses and are used as immunosuppressive drugs in many inflammatory, autoimmune and
[Bacteremia: a Spanish multicenter study with 5000 cases. The Hospital Infection Study Group (GEIH)]: Rev Clin Esp. 1997 Dec;197 Suppl 5:3-9. Unique Identifier : AIDSLINE MED/98219292; Sota Busselo M; Ezpeleta Baquedano C; Cisterna Cancer R; INTRODUCTION: Bacteremia is one of the most common nosocomial infections and is still a severe condition that frequently represents a life-threatening problem for the patient. MATERIAL AND METHODS: SEPSIS DATA is a software programme developed by the SEIMC (Spanish Society of Infectious Diseases and Clinical Microbiol
[Bacteremia in HIV-infected and IVDA patients]: Rev Clin Esp. 1997 Dec;197 Suppl 5:62-5. Unique Identifier : AIDSLINE MED/98219306; Romanik Cabrera J; Servicio de Microbiologia, Hospital Principe de Asturias, Alcala de; Henares.
[Prevalence of viral antibodies and syphilis serology in blood donors from a hospital]: Rev Invest Clin. 1997 Nov-Dec;49(6):475-80. Unique Identifier : AIDSLINE MED/98188754; Pita-Ramirez L; Torres-Ortiz GE; Servicio de Hematologia y Hemoterapia, Hospital General Vasco de; Quiroga, ISSSTE, Morelia, Mich.; OBJECTIVE: To establish the prevalence of viral antibodies and luetic reagins in blood donors in a Mexican hospital. SETTING: A third level general hospital for government employees located in the city of Morelia, State of Michoacan, Mexico . MATERIAL AND METHODS: Blood samples were
[The isolation and subtyping of the human immunodeficiency virus HIV) from children in Moldova. The evidence for subtype F]: Rev Med Chir Soc Med Nat Iasi. 1995 Jan-Jun;99(1-2):124-8. Unique Identifier : AIDSLINE MED/98185356; Apetrei C; Collin G; Diculencu D; Ajaka IL; Farfara I; Panzaru C; Coman G; Duca M; Brun-Vezinet F; Simon F; Laboratorul de Virologie, Universitatea de Medicina si Farmacie Gr. T.; Popa, Iasi.; HIV epidemic related to nosocomial transmission in Romanian nursed children represents up to now more than 50% of paediatric AIDS cases in Europe. Although the sources of this epidemic are obscure, HIV-1 subtype F, a minor form in Brasil and Africa, realised a founder effect in this risk group, thus becoming the major
[HIV cladistics: or about the branches of the olive tree of helplessness in knowledge (editorial)]: Rev Med Chir Soc Med Nat Iasi. 1995 Jan-Jun;99(1-2):14-20. Unique Identifier : AIDSLINE MED/98185339; Apetrei C; Duca MC
The effect of treatment with alpha-interferon on hepatitis G/GBV-C viraemia. The CONSTRUCT Group.: Scand J Gastroenterol. 1998 Feb;33(2):195-200. Unique Identifier : AIDSLINE MED/98176709; Jarvis LM; Bell H; Simmonds P; Hawkins A; Hellum K; Harthug S; Maeland A; Ritland S; Myrvang B; von der Lippe B; Raknerud N; Skaug K; Dept. of Medical Microbiology, University of Edinburgh, UK.; BACKGROUND: Hepatitis G virus (HGV) or GBV-C is frequently detected in patients co-infected with hepatitis C virus (HCV). This study investigated host and virologic factors influencing the response to HGV/GBV-C to alpha-interferon treatment. METHODS: HGV/GBV-C was detected and quantified by nested polymerase chain rea
Human immunodeficiency virus-related abdominal pain in South Africa. Aetiology, diagnosis and survival.: Scand J Gastroenterol. 1998 Feb;33(2):212-7. Unique Identifier : AIDSLINE MED/98176712; O'Keefe EA; Wood R; Van Zyl A; Cariem AK; Dept. of Medicine, University of Cape Town, Somerset Hospital,; Greenpoint, South Africa.; BACKGROUND: Abdominal pain in acquired immunodeficiency syndrome AIDS) patients is often a marker of an underlying opportunistic pathologic condition. There are no data on HIV-related abdominal pain in Africa. METHODS: Forty-four consecutive Cape Town patients with advanced human immunodeficiency virus (HIV) infection
Mannan-binding lectin in the sub-Saharan HIV and tuberculosis epidemics.: Scand J Immunol. 1997 Aug;46(2):204-8. Unique Identifier : AIDSLINE MED/98246519; Garred P; Richter C; Andersen AB; Madsen HO; Mtoni I; Svejgaard A; Shao J; Tissue Typing Laboratory of the Department of Clinical Immunology, The; National University Hospital (Rigshospitalet), Copenhagen, Denmark.; Inherited deficiency of mannan-binding lectin (MBL) has been shown to predispose to infections. Conversely, it has also been suggested that MBL might facilitate the uptake of certain intracellular microbes. The aim of this study was to investigate whether MBL plays a role in the HIV and tuberculosis epidemics in Afric
T cell subsets and T cell function in cartilage-hair hypoplasia.: Scand J Immunol. 1997 Aug;46(2):209-15. Unique Identifier : AIDSLINE MED/98246520; Kooijman R; van der Burgt CJ; Weemaes CM; Haraldsson A; Scholtens EJ; Zegers BJ; Department of Immunology, University Hospital for Children and Youth,; Utrecht, The Netherlands.; Cartilage hair hypoplasia is a rare autosomal recessive form of short-limbed dwarfism associated with a cellular immunodeficiency. In eight patients, the authors studied the presence of T cell subsets and in vitro T cell function in order to address the basis for the immunological disorder. Both the proliferative resp
Double-negative (CD4-CD8-) TCRalphabeta+ cells in patients with systemic lupus erythematosus.: Scand J Rheumatol. 1998;27(2):130-4. Unique Identifier : AIDSLINE MED/98232352; Liu MF; Li JS; Weng TH; Lei HY; Department of Medicine, Medical College, National Cheng Kung; University, Tainan, Taiwan, ROC.; Massive accumulation of CD4-CD8-TCRalphabeta+ cells in secondary lymphoid organs is characteristic of lupus-prone MRL/lpr mice. However, the role of these double negative T cells (DNT) in human lupus patients receive only limited attention. Herein, we investigate the frequency of DNT in the peripheral blood mononuclea
Clinical experience with anti-D in the treatment of idiopathic thrombocytopenic purpura.: Semin Hematol. 1998 Jan;35(1 Suppl 1):52-7. Unique Identifier : AIDSLINE MED/98181923; Scaradavou A; Bussel JB; Department of Pediatrics, Hematology and Oncology, New York; Hospital-Cornell Medical Center, New York 10021, USA.; Idiopathic thrombocytopenic purpura (ITP), an autoimmune disease of children and adults, is characterized by low platelet counts and bleeding through mucous membranes. While not uncommon among otherwise healthy adults and children, ITP is a frequent complication of human immunodeficiency virus (HIV) infection. Anti-D
Idiopathic thrombocytopenia purpura: Treatment patterns and an analysis of cost associated with intravenous immunoglobulin and anti-D therapy.: Semin Hematol. 1998 Jan;35(1 Suppl 1):58-64. Unique Identifier : AIDSLINE MED/98181924; Simpson KN; Coughlin CM; Eron J; Bussel JB; University of North Carolina School of Public Health, Chapel Hill; 27599, USA.; A retrospective study was conducted to determine treatment patterns for idiopathic thrombocytopenia purpura (ITP) across the US and to determine the cost of its treatment with high-dose intravenous immunoglobulin (IVIg) and anti-D therapy. Information on the incidence, treatment patterns, hospital care, and costs for
Clinics in diagnostic imaging (32). Opportunistic pneumonia in acquired immunodeficiency syndrome (AIDS).: Singapore Med J. 1997 Dec;38(12):535-9. Unique Identifier : AIDSLINE MED/98212278; Peh WC; Simarak SC; Muttarak M; Department of Diagnostic Radiology, University of Hong Kong Queen Mary; Hospital Hong Kong.; A 24-year old HIV-positive patient presented with fever and productive cough. Chest radiograph showed a cavitating pulmonary infiltrate. Diagnosis of Nocardosis was made from modified acid-fast stain of his sputum specimen. He responded well to antibiotics. The radiographic patterns of opportunistic infection in patie
Cultural constraints on the delivery of HIV/AIDS prevention in Ireland.: Soc Sci Med. 1998 Mar;46(6):661-72. Unique Identifier : AIDSLINE MED/98182897; Smyth F; Department of Geography, University of Manchester, U.K.; HIV appeared in Ireland following an opiate epidemic in the early 1980s. Initially, however, the gay community mounted the only response to the spread of the virus while the implementation of early actions by the government was hamp
Biological behavior and cell properties of new AKR lymphoma malignancy variants.: Tissue Cell. 1998 Feb;30(1):95-103. Unique Identifier : AIDSLINE MED/98231141; Klein O; Staroselsky A; Huszar M; Hiss J; Kay S; Donin N; Zeidel L; Michowitz M; Leibovici J; Department of Pathology, Sackler Faculty of Medicine, Tel-Aviv; University, Israel.; The AKR lymphoma-leukemia is a T lymphocyte neoplasm, most suitable as a model for human T cell malignancies. We have been interested in the process of tumor progression in the AKR lymphoma system. In the present study, two newly isolated variants, the TAU-42 and TAU-44, were characterized with respect to their biolog
Mercury-induced autoimmunity in Brown Norway rats: kinetics of changes in RT6+ T lymphocytes correlated with IgG isotypes of circulating autoantibodies to laminin 1.: Toxicology. 1998 Feb 6;125(2-3):215-31. Unique Identifier : AIDSLINE MED/98230260; Kosuda LL; Whalen B; Greiner DL; Bigazzi PE; Department of Pathology, University of Connecticut Health Center,; Farmington 06030, USA.; Repeated exposure to mercury causes various autoimmune effects in rats of the Brown Norway (BN) strain. Previous studies from our laboratory have shown that on day 15 of HgCl2 treatment BN rats exhibit a relative decrease in RT6.2+ T cells. At the same time, they produce high level
Peloisis hepatis due to Bartonella henselae in transplantation: a hemato-hepato-renal syndrome.: Transplantation. 1998 Apr 15;65(7):1000-3. Unique Identifier : AIDSLINE MED/98224781; Ahsan N; Holman MJ; Riley TR; Abendroth CS; Langhoff EG; Yang HC; Department of Medicine, The Milton S. Hershey Medical Center,; Pennsylvania State University, College of Medicine, Hershey 17033,; USA.; BACKGROUND: Bacillary peliosis hepatis is an uncommon but well recognized disease due to disseminated Bartonella infections occurring predominantly in immunocompromised individuals infected with human immunodeficiency virus, type 1. A similar condition in the absence of Bartonella infection when described in organ tra
Possible induction of graft-versus-leukemia effect against a leukemia refractory to antileukemia response in ordinary MHC-compatible, allogeneic bone marrow transplantation.: Transplantation. 1998 Apr 15;65(7):893-8. Unique Identifier : AIDSLINE MED/98224763; Aizawa S; Kamisaku H; Sado T; Division of Biology and Oncology, National Institute of Radiological; Sciences, Chiba, Japan.; We previously indicated that intensity of the graft-versus-leukemia (GVL) effect varied among different leukemias in MHC-compatible, allogeneic bone marrow transplantation (BMT). Cellular factors responsible for differences in intensity of the GVL effect were examined by using two types of leukemias, i.e., a resistant
[Neurologic manifestations of HIV infections and AIDS]: Wiad Lek. 1997;50(10-12):304-11. Unique Identifier : AIDSLINE MED/98217865; Bander D; Kliniki Chorob Zakaznych Pomorskiej Akademii Medycznej w Szczecinie.; The paper presents the review of neurological manifestations of HIV infection. The pathogenesis of changes caused by HIV within central nervous system is discussed. The most common neurological syndromes occurring in AIDS patients as well as the division of these changes concerning peripheral and central nervous syste
AIDS-related primary lymphoma of the pleural cavity. A case report.: Acta Cytol. 1998 Mar-Apr;42(2):371-3. Unique Identifier : AIDSLINE MED/98229558; Mansour G; Charlotte F; Calvez V; Davi F; Merle-Beral H; Department of Pathology, Pitie-Salpetriere Hospital, Paris, France.; BACKGROUND: Pleural effusions are common in patients with the acquired immunodeficiency syndrome (AIDS). Their most frequent causes are Kaposi s sarcoma and mycobacterial infections. We report cytologic, immunophenotypic and molecular features of a primary pleural non-Hodgkin s lymphom
Cytodiagnosis of a primary effusion lymphoma. A case report.: Acta Cytol. 1998 Mar-Apr;42(2):374-6. Unique Identifier : AIDSLINE MED/98229559; Vadmal MS; Smilari TF; Brody JP; Koduru P; Hajdu SI; Department of Pathology, North Shore University Hospital, Manhasset,; New York 11030, USA.; BACKGROUND: Primary effusion lymphoma (PEL), commonly described in AIDS patients, is a unique subset of lymphoma in which the neoplastic lymphocytes proliferate exclusively in serous cavities. CASE: A 27-year-old male, HIV positive for five years and with multiple opportunistic infections in the past, was admitted for
Head and neck manifestations of AIDS in adults.: Am Fam Physician. 1998 Apr 15;57(8):1813-22. Unique Identifier : AIDSLINE MED/98236233; Moazzez AH; Alvi A; Mount Sinai Hospital Medical Center, Chicago, Illinois, USA.; Head and neck manifestations of acquired immunodeficiency syndrome (AIDS) are among the most common complications of this disease. Some of these manifestations are the initial signs of human immunodeficiency virus (HIV) infection, and others are associated with full-blown AIDS. Otologic manifestations include otitis e
CDC releases the 1998 Guidelines for the Treatment of Sexually Transmitted Diseases.: Am Fam Physician. 1998 Apr 15;57(8):2003-4, 2007-8. Unique Identifier : AIDSLINE MED/98236241; Rose VL
Detection of oligoclonal bands in cerebrospinal fluid by immunofixation electrophoresis.: Am J Clin Pathol. 1998 May;109(5):585-8. Unique Identifier : AIDSLINE MED/98236114; Cavuoti D; Baskin L; Jialal I; Parkland Memorial Hospital and Department of Pathology, The University; of Texas Southwestern Medical Center at Dallas, 75235-9072, USA.; Multiple sclerosis is a severe demyelinating disease, the diagnosis of which is aided by biochemical tests, such as detection of oligoclonal immunoglobulin bands in the cerebrospinal fluid (CSF). Because interpretation of agarose gel electrophoresis (AGE) of CSF for oligoclonal bands is often equivocal, we compared im
T-cell subset analysis of peripheral T-cell lymphomas by paraffin section immunohistology and correlation of CD4/CD8 results with flow cytometry.: Am J Clin Pathol. 1998 May;109(5):610-7. Unique Identifier : AIDSLINE MED/98236118; Macon WR; Salhany KE; Department of Pathology, Vanderbilt University Medical Center,; Nashville, Tennessee 37232-2561, USA.; Peripheral T-cell lymphomas (PTCLs) are often diagnosed after demonstration of T-lineage-related antigen expression on neoplastic lymphocytes by paraffin immunoperoxidase (PIP). However, complete T-cell subset analysis for helper, suppressor/cytotoxic, alphabeta, and gammadelta phenotypes has not been examined by PIP.
Community reinforcement approach in the treatment of opiate addicts.: Am J Drug Alcohol Abuse. 1998 Feb;24(1):17-30. Unique Identifier : AIDSLINE MED/98174813; Abbott PJ; Weller SB; Delaney HD; Moore BA; Department of Psychiatry, University of New Mexico, Albuquerque, USA.; The authors studied the efficacy of the community reinforcement approach (CRA) as compared to standard counseling in opiate-dependent patients on methadone maintenance. One hundred eighty subjects were randomized to three treatment conditions: standard, CRA, and CRA with relapse prevention (CRA/RP). Of these, 151 subj
A preliminary investigation of lamotrigine for cocaine abuse in HIV-seropositive patients.: Am J Drug Alcohol Abuse. 1998 Feb;24(1):85-101. Unique Identifier : AIDSLINE MED/98174817; Margolin A; Avants SK; DePhilippis D; Kosten TR; Department of Psychiatry, Yale University School of Medicine, New; Haven, Connecticut 06519, USA.; Theoretical considerations as well as pre-clinical data suggest a potential role for glutamate-inhibiting agents in the treatment of cocaine addiction. At present, however, there is little clinical data to inform the use of these agents for this application. In this preliminary study eighteen HIV-seropositive cocaine
Gabapentin for lancinating neuropathic pain.: Am J Nurs. 1998 Apr;98(4):12. Unique Identifier : AIDSLINE MED/98217421; McCaffery M; College of Nursing, Rush University, Chicago, IL., USA.
Thalidomide pros and cons.: Am J Nurs. 1998 Apr;98(4):63. Unique Identifier : AIDSLINE MED/98217434
HIV seroprevalence among street-recruited injection drug and crack cocaine users in 16 US municipalities.: Am J Public Health. 1998 Jan;88(1):108-13. Unique Identifier : AIDSLINE MED/98247742; Kral AH; Bluthenthal RN; Booth RE; Watters JK; Institute for Health Policy Studies, School of Medicine, University of; California, San Francisco, USA.; OBJECTIVES: This study deter- mined human immunodeficiency virus HIV) seroprevalence and factors associated with HIV infection among street-recruited injection drug users and crack cocaine smokers. METHODS: An analysis was performed on HIV serologies and risk behaviors of 6402 injection drug users and 3383 crack smoke
Histories of substance use and risk behavior: precursors to HIV seroconversion in homosexual men.: Am J Public Health. 1998 Jan;88(1):113-6. Unique Identifier : AIDSLINE MED/98247743; Chesney MA; Barrett DC; Stall R; Center for AIDS Prevention Studies, School of Medicine, Unviersity of; California, San Francisco, USA.; OBJECTIVES: This study compared history of substance use and episodic use in terms of HIV seroconversion. METHODS: A sample of 337 baseline HIV-negative gay men was followed for 6 years. Bivariate and survival analyses were used to compare 39 converters with nonconverters on substance use behaviors. RESULTS: Seroconve
Retention, HIV risk, and illicit drug use during treatment: methadone dose and visit frequency.: Am J Public Health. 1998 Jan;88(1):34-9. Unique Identifier : AIDSLINE MED/98247727; Rhoades HM; Creson D; Elk R; Schmitz J; Grabowski J; Substance Abuse-Medications Development Research Center, Department of; Psychiatry and Behavioral Sciences, School of Medicine, University of; Texas-Houston, 77030, USA.; OBJECTIVES: This study examined two major methadone treatment factors, visit frequency and methadone dose, posited to be important in reducing intravenous drug use and human immunodeficiency virus (HIV) transmission. METHODS: One hundred fifty opiate-dependent subjects randomly assigned to four groups received 50 or 8
Surface-enhanced Raman gene probe for HIV detection.: Anal Chem. 1998 Apr 1;70(7):1352-6. Unique Identifier : AIDSLINE MED/98214108; Isola NR; Stokes DL; Vo-Dinh T; Life Sciences Division, Oak Ridge National Laboratory, Tennessee; 37831-6101, USA.; We report, for the first time, the use of surface-enhanced Raman SERS)-active labels for primers used in polymerase chain reaction amplification of specific target DNA sequences. This method has the potential for combining the spectral selectivity and high sensitivity of the SERS technique with the inherent molecular
Quantifying HIV-1 RNA without amplification [news]: Anal Chem. 1998 Apr 1;70(7):244A-245A. Unique Identifier : AIDSLINE MED/98214101
Antitumor effect of human pancreatic cancer cells transduced with cytokine genes which activate Th1 helper T cells.: Anticancer Res. 1998 Jan-Feb;18(1A):333-5. Unique Identifier : AIDSLINE MED/98229519; Yoshida Y; Tasaki K; Kimurai M; Takenaga K; Yamamoto H; Yamaguchi T; Saisho H; Sakiyama S; Tagawa M; Division of Pathology, Chiba Cancer Center Research Institute, Japan.; We have examined antitumor effect of human pancreatic carcinoma cells (AsPC-1) retrovirally transduced with interleukin-12 IL-12), IL-15 or IL-18 gene in nude mice. The tumor growth of IL-12-expressing AsPC-1 cells was significantly retarded and that of IL-15-expressing cells was also impeded compared with that of wil
Effect of trichosanthin an anti-leukemia protein on normal mouse spleen cells.: Anticancer Res. 1998 Jan-Feb;18(1A):357-61. Unique Identifier : AIDSLINE MED/98229523; Takemoto DJ; Department of Biochemistry, Kansas State University Manhattan 66506,; USA. dtak@ksu.edu; Trichosanthin, from Trichosanthes kirilowii is a member of the Cucurbitaceae family. It has been reported to have anti-cancer activity. The effects of Trichosanthin peptides (15 amino acids in length) on ConA stimulated incorporation of 3[H] thymidine into cultured, primary mouse spleen cells and L1210 cells were dete
Inhibition of acute-, latent-, and chronic-phase human immunodeficiency virus type 1 (HIV-1) replication by a bistriazoloacridone analog that selectively inhibits HIV-1 transcription.: Antimicrob Agents Chemother. 1998 Mar;42(3):487-94. Unique Identifier : AIDSLINE MED/98177100; Turpin JA; Buckheit RW Jr; Derse D; Hollingshead M; Williamson K; Palamone C; Osterling MC; Hill SA; Graham L; Schaeffer CA; Bu M; Huang M; Cholody WM; Michejda CJ; Rice WG; Laboratory of Antiviral Drug Mechanisms, Developmental Therapeutics; Program, SAIC Frederick, Maryland 21702-1201, USA.; Nanomolar concentrations of temacrazine 1,4-bis[3-(6-oxo-6H-v-triazolo[4,5,1-de]acridin-5-yl)amino-propy- l ]piperazine) were discovered to inhibit acute human immunodeficiency virus type 1 (HIV-1) infections and suppress the production of virus from chronically and latently infected cells containing integrated provir
Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA.: Antimicrob Agents Chemother. 1998 Mar;42(3):612-7. Unique Identifier : AIDSLINE MED/98177120; Robbins BL; Srinivas RV; Kim C; Bischofberger N; Fridland A; Department of Infectious Diseases, St. Jude Children's Research; Hospital, Memphis, Tennessee 38105, USA.; Bis(isopropyloxymethylcarbonyl) 9-R-(2-phosphonomethoxypropyl)adenine [bis(POC)PMPA] has been identified as a novel prodrug of PMPA. The anti-human immunodeficiency virus activity of bis(POC)PMPA was >100-fold greater than that of PMPA in both an established T-cell line and primary peripheral blood lymphocytes. This i
1,1,3-Trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (TTD) derivatives: a new class of nonnucleoside human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitors with anti-HIV-1 activity.: Antimicrob Agents Chemother. 1998 Mar;42(3):618-23. Unique Identifier : AIDSLINE MED/98177121; Witvrouw M; Arranz ME; Pannecouque C; Declercq R; Jonckheere H; Schmit JC; Vandamme AM; Diaz JA; Ingate ST; Desmyter J; Esnouf R; Van Meervelt L; Vega S; Balzarini J; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit Leuven,; Belgium. myriam.witvrouw@uz.kuleuven.ac.be; We report the development of a new group of nonnucleoside reverse transcriptase inhibitors (NNRTIs). One of the most active congeners of this series of 1,1,3-trioxo-2H,4H-thieno[3,4-e] [1,2,4]thiadiazine (TTD) derivatives, i.e., 2-(3-fluorobenzyl)-4-cyanomethylen-l,1,3-trioxo-2H,4H- thieno [3,4-e] [1,2,4] thiadiazine)
Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.: Antimicrob Agents Chemother. 1998 Mar;42(3):631-9. Unique Identifier : AIDSLINE MED/98177123; Hafner R; Bethel J; Power M; Landry B; Banach M; Mole L; Standiford HC; Follansbee S; Kumar P; Raasch R; Cohn D; Mushatt D; Drusano G; Division of AIDS, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Rockville, Maryland; 20852-7620, USA. rh23v@nih.gov; This study evaluated the tolerance and potential pharmacokinetic interactions between clarithromycin (500 mg every 12 h) and rifabutin (300 mg daily) in clinically stable human immunodeficiency virus-infected volunteers with CD4 counts of
Pharmacokinetics and bioavailability of the anti-human immunodeficiency virus nucleotide analog 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in dogs.: Antimicrob Agents Chemother. 1998 Mar;42(3):687-90. Unique Identifier : AIDSLINE MED/98177131; Cundy KC; Sueoka C; Lynch GR; Griffin L; Lee WA; Shaw JP; Gilead Sciences, Inc., Foster City, California 94404, USA.; Ken_cundy@gilead.com; The pharmacokinetics, bioavailability, and metabolism of the anti-human immunodeficiency virus nucleotide analog 9[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) were determined in beagle dogs following intravenous, intraperitoneal, and oral administration. Fasted male beagle dogs (n = 5) were pretreated with pentagast
Clinical, pathologic, and immunologic features of human T-lymphotrophic virus type I-associated infective dermatitis in children [see comments]: Arch Dermatol. 1998 Apr;134(4):439-44. Unique Identifier : AIDSLINE MED/98212956; La Grenade L; Manns A; Fletcher V; Derm D; Carberry C; Hanchard B; Maloney EM; Cranston B; Williams NP; Wilks R; Kang EC; Blattner WA; Department of Medicine, University of the West Indies, Kingston,; Jamaica.; OBJECTIVES: To define the clinical and laboratory features associated with infective dermatitis (ID) and confirm its association with human T-lymphotrophic virus type I (HTLV-I). DESIGN: A case series of patients with ID were compared with patients with atopic dermatitis (AD), which is an important disease in the diff
Infective dermatitis: a pabulum for human T-lymphotrophic virus type I leukemogenesis? [editorial; comment]: Arch Dermatol. 1998 Apr;134(4):487-8. Unique Identifier : AIDSLINE MED/98212963; Tschachler E; Franchini G
Study of human neurovegetative and hematologic effects of environmental low-frequency (50-Hz) electromagnetic fields produced by transformers.: Arch Environ Health. 1998 Mar-Apr;53(2):87-92. Unique Identifier : AIDSLINE MED/98237040; Bonhomme-Faivre L; Marion S; Bezie Y; Auclair H; Fredj G; Hommeau C; Service de Pharmacie, Hopital Paul Brousse, Villejuif, France.; A survey of neurovegetative and hematologic disorders was conducted in a population (n = 13) exposed occupationally to environmental electromagnetic fields; the population was matched with 13 control subjects. The exposed subjects worked at least 8 h/d for 1-5 y in premises located above transformers and high-tension
Remission of relapsing Pseudomonas aeruginosa bronchopulmonary infection following antiretroviral therapy [letter]: Arch Intern Med. 1998 Apr 27;158(8):929-30. Unique Identifier : AIDSLINE MED/98230110; Domingo P; Ferre A; Baraldes MA; Ris J; Sanchez F
Refolding of denatured trichosanthin in the presence of GroEL.: Biochem Biophys Res Commun. 1998 Apr 7;245(1):149-54. Unique Identifier : AIDSLINE MED/98204774; Lau CK; Wong RN; Lo SC; Kwok F; Department of Biochemistry, The University of Tennessee, Knoxville,; Tennessee, 37996-0840, USA.; The stability of trichosanthin (TCS), a 27-kDa ribosome-inactivating protein, was investigated in the presence of guanidinium chloride (GdnHCl). The process of unfolding was monitored by CD and fluorescence spectroscopy. Both methods show the presence of partially folded intermediates. Unfolding of TCS is attained in
Inhibition of HIV-1 replication by an anti-tat hammerhead ribozyme.: Biochem Biophys Res Commun. 1998 Apr 7;245(1):81-4. Unique Identifier : AIDSLINE MED/98204762; Jackson WH Jr; Moscoso H; Nechtman JF; Galileo DS; Garver FA; Lanclos KD; Department of Biology and Geology, University of South Carolina,; Aiken, South Carolina, 29801, USA.; Tat is a virally expressed regulatory protein involved in the replication of HIV-1, the etiological agent of AIDS. To investigate the effect of tat inhibition on HIV replication, we constructed a retroviral vector to express an anti-tat hammerhead ribozyme as part of the 3 untranslated region of beta-galactosidase tr
Identical cis-acting elements and related trans-acting factors control activity of nonviral promoter in Schizosaccharomyces pombe and mammalian cells.: DNA Cell Biol. 1998 Apr;17(4):349-58. Unique Identifier : AIDSLINE MED/98230077; Brys R; Nelles L; van der Schueren E; Silvestre N; Huylebroeck D; Remacle JE; Laboratory of Molecular Biology (CELGEN), University of Leuven,; Belgium.; We have analyzed the transcriptional activity of the human plasminogen activator inhibitor-1 promoter in the fission yeast Schizosaccharomyces pombe. This promoter is active in S. pombe, and the initiation site of transcription corresponds to the site identified previously in mammalian cells. Mutations in the AP-1-bin
Pathologic characteristics of primary cutaneous T-cell lymphoma in Korea.: J Korean Med Sci. 1998 Feb;13(1):31-8. Unique Identifier : AIDSLINE MED/98198722; Kim JE; Huh J; Cho K; Kim CW; Department of Pathology, Seoul National University College of; Medicine, Korea.; Cutaneous T-cell lymphomas (CTCL) represent a heterogeneous group of peripheral T-cell lymphomas arising in the skin and show considerable variations in clinicopathological features. This study was designed to examine viral genomes and cellular proliferation markers in CTCLs arising in Korea. On the basis of their mor
Human herpesvirus 8 in Kaposi's sarcoma and Kaposi's sarcoma-mimicking vascular tumors.: J Korean Med Sci. 1998 Feb;13(1):54-9. Unique Identifier : AIDSLINE MED/98198726; Kang GH; Kwon GY; Kim CW; Asan Medical Center, Ulsan University College of Medicine, Department; of Pathology, Seoul, Korea.; Kaposi s sarcoma (KS) had been a rare and unusual vascular tumor until a recent epidemic of a disseminated and fulminant form of KS in AIDS patients. Infectious agents have been suspected of causing KS, and recently partial genomic DNA sequences of human herpesvirus 8 (HHV8) have been identified in AIDS-associated KS
Update on infection control: an exclusive interview with Dr. John A. Molinari [interview by Phillip Bonner]: Dent Today. 1994 Aug;13(8):28, 30-1. Unique Identifier : AIDSLINE MED/98201347; Molinari JA
HIV inhibitor identified in saliva [news]: Dent Today. 1995 Mar;14(3):22, 26-7. Unique Identifier : AIDSLINE MED/98201359; Marino D
More frequent dental visits prescribed for children with AIDS [news]: Dent Today. 1995 Jun;14(6):25. Unique Identifier : AIDSLINE MED/98201294
Genetic defect wards off AIDS infection, say researchers [news]: Dent Today. 1997 Jul;16(7):35. Unique Identifier : AIDSLINE MED/98221466
Thalidomide heals AIDS-related mouth ulcers [news]: Dent Today. 1997 Jul;16(7):38. Unique Identifier : AIDSLINE MED/98221467
Relative amplification efficiency of differently sized templates by long-distance PCR.: Biotechniques. 1998 Mar;24(3):400-2. Unique Identifier : AIDSLINE MED/98187396; Sanchez G; Gautheret D; Xu X; Chenine AL; Hirsch I; INSERM U. 372, CNRS EP 91, Marseille, France.
AIDS-related malignancies.: Cancer Chemother Biol Response Modif. 1997;17:408-27. Unique Identifier : AIDSLINE MED/98212580; Saville MW; San Diego Cancer Center, University of California San Diego 92103,; USA.
Management of AIDS-associated Kaposi's sarcoma: a multidisciplinary perspective.: Oncology (Huntingt). 1998 Feb;12(2 Suppl 3):1-24. Unique Identifier : AIDSLINE MED/98185653; Von Roenn JH; Krown SE; Northwestern University, Chicago, Illinois, USA.
Human herpesvirus 8 is not detectable by polymerase chain reaction in angiosarcoma [letter]: Br J Dermatol. 1998 Mar;138(3):546-7. Unique Identifier : AIDSLINE MED/98241921; Martinez-Escribano JA; del Pino Gil-Mateo M; Miquel J; Ledesma E; Aliaga A
Molecular basis of resistance to HIV-1 protease inhibition: a plausible hypothesis.: Biochemistry. 1998 Apr 28;37(17):5791-7. Unique Identifier : AIDSLINE MED/98226614; Luque I; Todd MJ; Gomez J; Semo N; Freire E; Department of Biology and Biocalorimetry Center, The Johns Hopkins; University, Baltimore, Maryland 21218, USA.; The binding thermodynamics of the HIV-1 protease inhibitor acetyl pepstatin and the substrate Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln, corresponding to one of the cleavage sites in the gag, gag-pol polyproteins, have been measured by direct microcalorimetric analysis. The results indicate that the binding of the peptide s
Fidelity of mutant HIV-1 reverse transcriptases: interaction with the single-stranded template influences the accuracy of DNA synthesis.: Biochemistry. 1998 Apr 28;37(17):5831-9. Unique Identifier : AIDSLINE MED/98226618; Kim B; Hathaway TR; Loeb LA; The Joseph Gottstein Memorial Cancer Research Laboratory, Department; of Pathology, University of Washington, Seattle 98195-3577, USA.; bkim@u.washington.edu; We have used random sequence mutagenesis and complementation in a bacterial selection system to establish a large library of immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) mutants with amino acid substitutions in the beta3-beta4 region of the fingers subdomain [Kim, B., Hathaway, T. R., and Loeb, L.
The p51 subunit of human immunodeficiency virus type 1 reverse transcriptase is essential in loading the p66 subunit on the template primer.: Biochemistry. 1998 Apr 28;37(17):5903-8. Unique Identifier : AIDSLINE MED/98226625; Harris D; Lee R; Misra HS; Pandey PK; Pandey VN; Department of Biochemistry and Molecular Biology, University of; Medicine and Dentistry at New Jersey Medical School, Newark 07103,; USA.; Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase RT) is a dimeric enzyme consisting of p66 and p51 subunits. The functional role of the p51 subunit remains elusive since all the catalytic functions appear to be executed through the p66 subunit. We report here that the p51 subunit, in addition to provi
Joint molecular modeling and spectroscopic studies of DNA complexes of a bis(arginyl) conjugate of a tricationic porphyrin designed to target the major groove.: Biochemistry. 1998 Apr 28;37(17):6165-78. Unique Identifier : AIDSLINE MED/98226658; Mohammadi S; Perree-Fauvet M; Gresh N; Hillairet K; Taillandier E; Laboratoire de Chimie Structurale et Spectroscopie Biomoleculaire; (CNRS-URA 1430), Universite Paris 13, Bobigny, France.; To target selectively the major groove of double-stranded B DNA, we have designed and synthesized a bis(arginyl) conjugate of a tricationic porphyrin (BAP). Its binding energies with a series of double-stranded dodecanucleotides, having in common a central d(CpG)2 intercalation site were compared. The theoretical resu
Direct structural evidence for formation of a stem-loop structure involved in ribosomal frameshifting in human immunodeficiency virus type 1.: Biochim Biophys Acta. 1998 Apr 1;1397(1):73-8. Unique Identifier : AIDSLINE MED/98222607; Kang H; Kumho Life and Environmental Science Laboratory, Korea Kumho; Petrochemical Co. Ltd., Kwangju, South Korea. hskang@ksc.kumho.co.kr; Programmed ribosomal frameshifting in viral messenger RNA occurs in response to neighboring sequence elements consisting of: a frameshift site, a spacer, and a downstream enhancer sequence. In human immunodeficiency virus type 1 (HIV-1) mRNA, this sequence element has a potential to form either a stem-loop or a pseudo
Refractory mucosal candidiasis in patients with human immunodeficiency virus infection.: Clin Infect Dis. 1998 Mar;26(3):556-65. Unique Identifier : AIDSLINE MED/98185510; Fichtenbaum CJ; Powderly WG; Department of Medicine, Washington University School of Medicine, St.; Louis, Missouri 63108, USA.; Difficult-to-manage mucosal candidal infection has been a hallmark of individuals with advanced infection due to human immunodeficiency virus type 1. In this AIDS Commentary, Drs. Fichtenbaum and Powderly comprehensively review the literature and their experience with refractory candidiasis in such patients. Of intere
Invasive pneumococcal disease in Dallas County, Texas: results from population-based surveillance in 1995.: Clin Infect Dis. 1998 Mar;26(3):590-5. Unique Identifier : AIDSLINE MED/98185516; Pastor P; Medley F; Murphy TV; Department of Pediatrics, University of Texas Southwestern Medical; Center at Dallas, USA.; We studied the epidemiology of invasive disease caused by Streptococcus pneumoniae in 1995 among 1.9 million residents of Dallas County, Texas. The sociodemographic characteristics and chronic medical conditions of 432 patients were identified through active, population-based surveillance and review of medical records
Successful medical management of isolated renal zygomycosis: case report and review.: Clin Infect Dis. 1998 Mar;26(3):601-5. Unique Identifier : AIDSLINE MED/98185518; Weng DE; Wilson WH; Little R; Walsh TJ; Medicine Branch, National Cancer Institute, National Institute of; Health, Bethesda, Maryland 20892, USA.; We describe the medical management of isolated renal zygomycosis in an adult patient with AIDS during chemotherapy for AIDS-related lymphoma. After initial presentation during the first cycle of chemotherapy, the infection was contained within the kidney following recovery of the neutrophil count without medical or su
Once weekly azithromycin therapy for prevention of Mycobacterium avium complex infection in patients with AIDS: a randomized, double-blind, placebo-controlled multicenter trial.: Clin Infect Dis. 1998 Mar;26(3):611-9. Unique Identifier : AIDSLINE MED/98185520; Oldfield EC 3rd; Fessel WJ; Dunne MW; Dickinson G; Wallace MR; Byrne W; Chung R; Wagner KF; Paparello SF; Craig DB; Melcher G; Zajdowicz M; Williams RF; Kelly JW; Zelasky M; Heifets LB; Berman JD; Naval Hospital, San Diego, California, USA.; We conducted a randomized, double-blind, placebo-controlled multicenter trial of azithromycin (1,200 mg once weekly) for the prevention of Mycobacterium avium complex (MAC) infection in patients with AIDS and a CD4 cell count of
Clinical and microbiological assessment of Mycobacterium simiae isolates from a single laboratory in southern Arizona.: Clin Infect Dis. 1998 Mar;26(3):625-30. Unique Identifier : AIDSLINE MED/98185522; Rynkiewicz DL; Cage GD; Butler WR; Ampel NM; Infectious Diseases Section, University of Arizona College of; Medicine, Tucson, USA.; Mycobacterium simiae was the third most common mycobacterium identified over a 2-year period from a single clinical laboratory in southern Arizona. Thirty-three isolates from 25 patients were identified over 1 year. The isolation of M. simiae was considered clinically significant for only two of 23 evaluable patients.
Adjunctive corticosteroid therapy for patients whose treatment for disseminated Mycobacterium avium complex infection has failed [see comments]: Clin Infect Dis. 1998 Mar;26(3):682-6. Unique Identifier : AIDSLINE MED/98185532; Dorman SE; Heller HM; Basgoz NO; Sax PE; Infectious Disease Division, Brigham and Women's Hospital, Boston,; Massachusetts 02115, USA.; Patients with AIDS and disseminated Mycobacterium avium complex MAC) infection can have progressive disease despite combination antimycobacterial therapy. Our goal was to determine the utility of corticosteroids as adjunctive therapy for AIDS patients with disseminated MAC infection and refractory symptoms despite com
Are corticosteroids useful adjunctive agents in the treatment of disseminated Mycobacterium avium complex infection associated with human immunodeficiency virus infection? [editorial; comment]: Clin Infect Dis. 1998 Mar;26(3):687-8. Unique Identifier : AIDSLINE MED/98185533; Goetz MB
The significance of vitamin A and carotenoid status in persons infected by the human immunodeficiency virus.: Clin Infect Dis. 1998 Mar;26(3):711-8. Unique Identifier : AIDSLINE MED/98185538; Nimmagadda A; O'Brien WA; Goetz MB; Department of Medicine, Veterans Affairs Medical Center, West Los; Angeles, California 90073, USA.; Hyporetinemia is associated with increased childhood morbidity and mortality that is reversible with vitamin A supplementation. Although vitamin A deficiency is otherwise rare in developed countries, the prevalence of hyporetinemia in human immunodeficiency virus (HIV)-infected persons is up to 29%. Hyporetinemic HIV-
Resolution of Mycobacterium avium complex bacteremia following highly active antiretroviral therapy.: Clin Infect Dis. 1998 Mar;26(3):758-9. Unique Identifier : AIDSLINE MED/98185544; Hadad DJ; Lewi DS; Pignatari AC; Martins MC; Vitti Junior W; Arbeit RD; Division of Infectious and Parasitic Diseases, Sao Paulo Federal; University, Brazil.
Fungemia due to Hormonema dematioides following intense avian exposure.: Clin Infect Dis. 1998 Mar;26(3):759-60. Unique Identifier : AIDSLINE MED/98185545; Kent D; Wong T; Osgood R; Kosinski K; Coste G; Bor D; Department of Medicine, Cambridge Hospital/Harvard, Medical School,; Cambridge, Massachusetts, USA.
Possible transmission of human immunodeficiency virus type 1 from body piercing.: Clin Infect Dis. 1998 Mar;26(3):767-8. Unique Identifier : AIDSLINE MED/98185553; Pugatch D; Mileno M; Rich JD; Miriam Hospital/Brown University, Providence, Rhode Island, USA.
Infective endocarditis associated with fiberoptic bronchoscopy in a patient with mitral-valve prolapse.: Clin Infect Dis. 1998 Mar;26(3):768-9. Unique Identifier : AIDSLINE MED/98185554; Jurado RL; Klein S; Medical Service, Atlanta Veterans Affairs Medical Center, Decatur,; Georgia 30033, USA.
Unraveling the mystery of HLA-B27 association with human spondyloarthropathies using transgenic and knock out mice.: Semin Immunol. 1998 Feb;10(1):15-23. Unique Identifier : AIDSLINE MED/98190543; Khare SD; Luthra HS; David CS; Department of Immunology, Mayo Clinic and Medical School, Rochester,; MN 55905, USA.; Human spondyloarthropathies have a strong association with the presence of MHC class I allele, HLA-B27. Spondyloarthropathies occur predominantly in males and are usually triggered by an infection with an enterobacteria. Similar to human disease, experimental animals with HLA-B27 transgene also develop spontaneous inf
Detection of infectious simian immunodeficiency virus in B- and T-cell lymphomas of experimentally infected macaques.: Blood. 1998 May 1;91(9):3103-11. Unique Identifier : AIDSLINE MED/98226665; Maggiorella MT; Monardo F; Koanga-Mogtomo ML; Cioe L; Sernicola L; Corrias F; Baroni CD; Verani P; Titti F; Laboratory of Virology, Istituto Superiore Sanita, Rome, Italy.; An increasing frequency of malignant lymphomas occurs among patients infected by human immunodeficiency virus. Because of the close similarities to human malignancies, we used a nonhuman primate model to study the pathogenesis of simian immunodeficiency virus (SIV)-associated malignancies. Specifically, we investigate
Ineffective platelet production in thrombocytopenic human immunodeficiency virus-infected patients.: Blood. 1998 May 1;91(9):3239-46. Unique Identifier : AIDSLINE MED/98226681; Cole JL; Marzec UM; Gunthel CJ; Karpatkin S; Worford L; Sundell IB; Lennox JL; Nichol JL; Harker LA; Department of Medicine, Emory University School of Medicine, Ponce de; Leon Center, Atlanta, GA, USA.; Thrombocytopenia has been characterized in six patients infected with human immunodeficiency virus (HIV) with respect to the delivery of viable platelets into the peripheral circulation peripheral platelet mass turnover), marrow megakaryocyte mass product of megakaryocyte number and volume), megakaryocyte progenitor c
gp130, the cytokine common signal-transducer of interleukin-6 cytokine family, is downregulated in T cells in vivo by interleukin-6.: Blood. 1998 May 1;91(9):3308-14. Unique Identifier : AIDSLINE MED/98226689; Wang XJ; Taga T; Yoshida K; Saito M; Kishimoto T; Kikutani H; Department of Molecular Immunology, Research Institute for Microbial; Diseases, Osaka University, Osaka, Japan.; gp130 is a common signal-transducing receptor component for the interleukin-6 (IL-6) family of cytokines. To investigate the expression of gp130 in T-cell subsets and its regulation, anti-murine gp130 monoclonal antibody (MoAb) was used for flow cytometric analysis. In normal mice, gp130 was differentially expressed i
Efficient retroviral-mediated gene transfer to human cord blood stem cells with in vivo repopulating potential.: Blood. 1998 May 1;91(9):3487-93. Unique Identifier : AIDSLINE MED/98226711; Conneally E; Eaves CJ; Humphries RK; Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada.; Recent studies have shown efficient gene transfer to primitive progenitors in human cord blood (CB) when the cells are incubated in retrovirus-containing supernatants on fibronectin-coated dishes. We have now used this approach to achieve efficient gene transfer to human CB cells with the capacity to regenerate lympho
High frequency of T-cell lines responsive to immunodominant epitopes of thyrotropin receptor in healthy subjects.: Thyroid. 1998 Mar;8(3):241-7. Unique Identifier : AIDSLINE MED/98204672; Molteni M; Zulian C; Scrofani S; Della Bella S; Bonara P; Kohn LD; Scorza R; Istituto di Medicina Interna, Malattie Infettive e Immunopatologia,; Universita degli Studi di Milano, IRCCS Ospedale Maggiore di Milano,; Italy.; In this study we analyzed the proliferative response to the extracellular domain of thyrotropin receptor (TSHR-ECD) of T-cell lines raised from healthy subjects. We found high frequencies of cell lines reactive to TSHR-ECD, ranging from 12% to 37%. The response of the cell lines to a set of overlapping peptides of TSH
[Cancer in Madagascar. Experience of the Institut Pasteur de Madagascar from September 1992 to June 1996]: Bull Soc Pathol Exot. 1998;91(1):17-21. Unique Identifier : AIDSLINE MED/98219904; Raharisolo Vololonantenaina C; Pecarrere JL; Roux JF; Institut Pasteur de Madagascar.; The Unit of the anatomo-pathology in the Institut Pasteur de Madagascar (IPM) examined in the period from September 1992 to June 1996 tissue specimens from 10,275 patients. Tumorous pathology presented 40% of the tissues and half of which were of malign etiology. 64% of the c
[AIDS in Madagascar. I. Epidemiology, projections, socioeconomic impact, interventions]: Bull Soc Pathol Exot. 1998;91(1):68-70. Unique Identifier : AIDSLINE MED/98219922; Andriamahenina R; Ravelojaona B; Rarivoharilala E; Ravaoarimalala C; Andriamiadana J; Andriamahefazafy B; May JF; Behets F; Rasamindrakotroka A; Laboratoire national de reference MST/sida, Antananarivo, Madagascar.; Madagascar is still among the rare states of low prevalence of HIV. The seroprevalence rate is nevertheless rising. The aim of this study is to show the current view of the epidemic, its future tendency, its economical and social impact on people and what measures to be taken a
[Aids in Madagascar. II. Intervention policy for maintaining low HIV infection prevalence]: Bull Soc Pathol Exot. 1998;91(1):71-3. Unique Identifier : AIDSLINE MED/98219923; Ravaoarimalala C; Andriamahenina R; Ravelojaona B; Rabeson D; Andriamiadana J; May JF; Behets F; Rasamindrakotroka A; Ministere de la sante.; The HIV seroprevalence per 100,000 adults Malagasy rose from 20 in 1989, to 30 in 1992, and to 70 in 1995. In that year, the total number of HIV infected people in the Big Island was estimated at 5,000, the number of people sick with AIDS at 130, and the people at risk at more than 1,000,000. The latter are the person
Focal splenic lesions in patients with AIDS: sonographic findings.: Abdom Imaging. 1998 Mar-Apr;23(2):196-200. Unique Identifier : AIDSLINE MED/98194991; Porcel-Martin A; Rendon-Unceta P; Bascunana-Quirell A; Amaya-Vidal A; Rodriguez-Ramos C; Soria de la Cruz MJ; Martin-Herrera L; Servicio de Gastroenterologia, Hospital Universitario Puerta del Mar,; Cadiz, Spain.; BACKGROUND: The purpose of this study was to describe the sonographic features of the focal splenic lesions in patients with AIDS and to know the frequency and etiology of these features. METHODS: Sonographic exams of 278 AIDS patients were reviewed retrospectively. We recorded the clinical indications for sonograms a
Is Africa near to collapse? [news]: Natl Med J India. 1998 Jan-Feb;11(1):38-9. Unique Identifier : AIDSLINE MED/98249997; Walker AR
Active-site mobility in human immunodeficiency virus, type 1, protease as demonstrated by crystal structure of A28S mutant.: Protein Sci. 1998 Feb;7(2):300-5. Unique Identifier : AIDSLINE MED/98180400; Hong L; Hartsuck JA; Foundling S; Ermolieff J; Tang J; Protein Studies, Oklahoma Medical Research Foundation, University of; Oklahoma Health Sciences Center, Oklahoma City 73104, USA.; The mutation Ala28 to serine in human immunodeficiency virus, type 1, (HIV-1) protease introduces putative hydrogen bonds to each active-site carboxyl group. These hydrogen bonds are ubiquitous in pepsin-like eukaryotic aspartic proteases. In order to understand the significance of this difference between HIV-1 protea
Public health. AIDS research [news]: Hosp Health Netw. 1998 Apr 5;72(7):16. Unique Identifier : AIDSLINE MED/98243722
Pharmaceuticals. AZT price cut [news]: Hosp Health Netw. 1998 Apr 20;72(8):18, 20. Unique Identifier : AIDSLINE MED/98243734
AIDS Education and Training Centers fact sheet. U.S. Department of Health and Human Services Health Resources and Services Administration.: Dent Assist. 1995 1st Quarter;64(1):14-5. Unique Identifier : AIDSLINE MED/98185827
[Comparison of virulence by Acanthamoeba strains in a murine model of acquired immunodeficiency syndrome]: Korean J Parasitol. 1998 Mar;36(1):23-31. Unique Identifier : AIDSLINE MED/98190765; Kong HH; Yee ST; Chung DI; Department of Parasitology, Kyungpook National University School of; Medicine, Taegu, Korea.; The pathogenic potential of Acanthamoeba strains was evaluated by experimental infection of murine AIDS (MAIDS) model. C57BL/6 mice were induced to immunocompromized state by intraperitoneal injection of LP-BM5 MuLV and revealed the typical splenomegaly and lymphatic enlargement of axillar and inguinal regions on necr
Maximizing the utility of HIV patient observational databases. Proceedings of a symposium. Amsterdam, The Netherlands, August 24, 1996.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998;17 Suppl 1:S1-53. Unique Identifier : AIDSLINE MED/98258356
Determinants of progression to AIDS in HIV-infected individuals: an update from the Italian Seroconversion Study.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998;17 Suppl 1:S13-6. Unique Identifier : AIDSLINE MED/98246057; Rezza G; National AIDS Unit, Centro Operativo AIDS, Istituto Superiore di; Sanita, Rome, Italy.; The Italian Seroconversion Study (ISS) involves 16 major HIV-treatment centers across Italy and about 1,200 individuals. These individuals were HIV-negative less than 2 years before the first positive test and seroconverted between 1980 and 1994. The majority were infected through i
The HIV Epidemiology Research Study, HIV Out-Patient Study, and the Spectrum of Disease Studies.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998;17 Suppl 1:S17-9. Unique Identifier : AIDSLINE MED/98246058; Smith D; Centers for Disease Control, Atlanta, Georgia 30330, USA.; The Division of HIV/AIDS Prevention at the United States Centers for Disease Control (CDC) has several observational databases through which it collects individual level data that can be used to evaluate the spectrum of HIV-related diseases and the utilization of HIV-related health car
The AIDS Research Consortium of Atlanta database.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998;17 Suppl 1:S20-2. Unique Identifier : AIDSLINE MED/98246059; Thompson MA; AIDS Research Consortium of Atlanta, Inc., Georgia 30308, USA.; The AIDS Research Consortium of Atlanta (ARCA) is a nonprofit-making community-based clinical and epidemiologic research unit serving a population of more than 15,000 patients with HIV infection. This database derives from a core based on the Centers for Disease Control Adult Spectrum of Disease Study ADS), of which A
The Western Australian HIV Cohort Study, Perth, Australia.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998;17 Suppl 1:S23-7. Unique Identifier : AIDSLINE MED/98246060; Mallal SA; Royal Perth Hospital, Australia.; The efficacy of primary prophylactic treatment for opportunistic infections can be estimated in an observational cohort study by adjusting for clinical and laboratory markers of the immunodeficiency (e.g., oral candidiasis, CD4%, lymphocyte cell counts) as time-dependent co-variates (providing that the treatment does
Research potentials and pitfalls in the use of an HIV clinical database: Chelsea and Westminster Hospital.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998;17 Suppl 1:S28-33. Unique Identifier : AIDSLINE MED/98246061; Easterbrook PJ; Chelsea and Westminster Hospital, London, England.; This article summarizes the various problems and pitfalls in using clinical databases for epidemiologic research, with particular reference to an HIV clinical database. The combined population of HIV-infected individuals attending the Chelsea and Westminster Hospital, the Charing Cross Hospital, and the Victoria Clini
The Albion Street Centre database, Sydney, Australia.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998;17 Suppl 1:S34-7. Unique Identifier : AIDSLINE MED/98246062; Gold J; Albion Street Centre, Sydney, New South Wales, Australia.; The Albion Street Centre was established in 1985 as an HIV testing and early management center. More than 22,000 people have been screened for HIV and other blood-borne infections at the Centre, and approximately 3,600 people with HIV/AIDS have been managed there. Approximately 1,600 patients with various stages of HI
Understanding the clinical and economic outcomes of HIV therapy: the Johns Hopkins HIV clinical practice cohort.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998;17 Suppl 1:S38-41. Unique Identifier : AIDSLINE MED/98246063; Moore RD; Johns Hopkins University School of Medicine, Baltimore, Maryland; 21205, USA.; The Johns Hopkins AIDS Service is the principal provider of medical care for HIV-infected patients in Maryland, a state in which the majority of HIV-infected patients live in an urban environment. A component of the HIV service at Johns Hopkins Medical Center is an information system that is used to track longitudinal
The Amsterdam Cohort Studies on HIV infection and AIDS.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998;17 Suppl 1:S4-8. Unique Identifier : AIDSLINE MED/98246055; Coutinho RA; Municipal Health Service, Amsterdam, The Netherlands.; The Amsterdam Cohort Studies (ACS) on HIV infection and AIDS are a collaborative effort between the Academic Medical Centre departments of Retrovirology and Internal Medicine), the Central Laboratory of Netherlands Red Cross Blood Transfusion Service, and the Amsterdam Municip
Session A: Natural history of HIV disease and predictors of clinical outcome.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998;17 Suppl 1:S43-5. Unique Identifier : AIDSLINE MED/98246064; Lange J; Academic Medical Centre, Amsterdam, The Netherlands.
Session B: The role of patient databases in assessing antiretroviral treatment.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998;17 Suppl 1:S46-7. Unique Identifier : AIDSLINE MED/98246065; Graham N; Johns Hopkins School of Hygiene and Public Health, Baltimore,; Maryland, USA.
Session C: The role of patient databases in assessing treatment safety.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998;17 Suppl 1:S48-52. Unique Identifier : AIDSLINE MED/98246066; Tilson H; Glaxo Wellcome, Research Triangle Park, North Carolina, USA.
Studies of antiretroviral therapy in the Multicenter AIDS Cohort Study.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998;17 Suppl 1:S9-12. Unique Identifier : AIDSLINE MED/98246056; Graham NM; John Hopkins School of Hygiene and Public Health, Baltimore, Maryland,; USA.; The Food and Drug Administration has been increasingly reliant on surrogate end points to fast-track the licensing of antiretroviral agents. As a result, critical information, such as long-term adverse events, clinical progression rates, survival, and development of resistance, are not available before licensure. Ther
New vaccines are aimed at the rich says UNICEF. United Nations Children's Fund [news]: Nat Med. 1998 May;4(5 Suppl):477. Unique Identifier : AIDSLINE MED/98244585; Birmingham K
Panel recommends White House coordinates AIDS vaccine development [news]: Nat Med. 1998 May;4(5 Suppl):477-8. Unique Identifier : AIDSLINE MED/98244586; Birmingham K; Watanabe ME
Why do we not have an HIV vaccine and how can we make one?: Nat Med. 1998 May;4(5 Suppl):495-8. Unique Identifier : AIDSLINE MED/98244593; Burton DR; Moore JP; Department of Immunology, The Scripps Research Institute, La Jolla,; California 92037, USA. burton@scripps.edu
Recruiting HLA to fight HIV [news]: Nat Med. 1998 May;4(5 Suppl):505. Unique Identifier : AIDSLINE MED/98244598; Laumbacher B; Wank R
Vaccine developments.: Nat Med. 1998 May;4(5 Suppl):515-9. Unique Identifier : AIDSLINE MED/98244601; Liu MA; Chiron Vaccines Research, Meryville, California 94608, USA.
HIV vaccines--where are we going?: Nat Med. 1998 May;4(5 Suppl):532-4. Unique Identifier : AIDSLINE MED/98244604; Heilman CA; Baltimore D; Division of AIDS, National Institutes of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Vertical transmission of hepatitis C virus: risk factors and infantile prognosis.: J Obstet Gynaecol Res. 1998 Feb;24(1):57-61. Unique Identifier : AIDSLINE MED/98225267; Xiong SK; Okajima Y; Ishikawa K; Watanabe H; Inaba N; Department of Obstetrics and Gynecology, Dokkyo University School of; Medicine, Tochigi, Japan.; OBJECTIVES: To clarify the incidence and risk factors of the vertical transmission of hepatitis C virus (HCV) and to determine the prognosis of the carrier infants. METHODS: At our hospital, 1,941 non-pathological (non-HIV carriers) Japanese pregnant women were screened for anti-HCV antibodies. Sera of the antibody-po
Lymphatic endothelium and Kaposi's sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor-3.: Cancer Res. 1998 Apr 15;58(8):1599-604. Unique Identifier : AIDSLINE MED/98222931; Jussila L; Valtola R; Partanen TA; Salven P; Heikkila P; Matikainen MT; Renkonen R; Kaipainen A; Detmar M; Tschachler E; Alitalo R; Alitalo K; Department of Pathology, Haartman Institute, University of Helsinki,; Finland.; Lymphatic vessels have been difficult to study in detail in normal and tumor tissues because of the lack of molecular markers. Here, monoclonal antibodies against the extracellular domain of the vascular endothelial growth factor-C receptor that we have named VEGFR-3 were found to specifically stain endothelial cells
The density of the class II MHC T cell receptor ligand influences IFN-gamma/IL-4 ratios in immune responses in vivo.: Cell Immunol. 1998 Jan 10;183(1):70-9. Unique Identifier : AIDSLINE MED/98239869; DiMolfetto L; Neal HA; Wu A; Reilly C; Lo D; Department of Immunology, Scripps Research Institute, La Jolla,; California 92037, USA.; Activation of CD4+ T cells depends on T cell receptor recognition of MHC class II/peptide and on costimulation provided by CD28/B7. It has been shown that different levels of costimulation can influence T helper cell differentiation into Th1 versus Th2 phenotypes. Similar arguments have been made for different levels
Oesophageal tuberculosis mimicking secondary oesophageal involvement of mediastinal neoplasm.: Ital J Gastroenterol Hepatol. 1997 Dec;29(6):564-8. Unique Identifier : AIDSLINE MED/98175021; Di Febo G; Calabrese C; Areni A; Savastio G; Grazia M; Miglioli M; Department of Internal Medicine and Gastroenterology, University of; Bologna, Italy.; During the last decade the number of cases of abdominal tuberculosis diagnosed in Western countries has dramatically increased. There are many reasons, including the appearance of AIDS and the increased morbidity of people across the world due to the westward migration of many people coming from areas with a high inci
AIDS-related chronic diarrhoea in a developing country. A retrospective study [letter]: Ital J Gastroenterol Hepatol. 1997 Dec;29(6):577-8. Unique Identifier : AIDSLINE MED/98175025; Elia C; Fogaca HS; de Souza HS; Belo MT; Elia PP; Fang HL; Pimentel ML
Use of IS901 and IS1245 in RFLP typing of Mycobacterium avium complex: relatedness among serovar reference strains, human and animal isolates.: Int J Tuberc Lung Dis. 1998 Mar;2(3):242-51. Unique Identifier : AIDSLINE MED/98186946; Ritacco V; Kremer K; van der Laan T; Pijnenburg JE; de Haas PE; van Soolingen D; Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos; Aires, Argentina.; SETTING: Mycobacterium avium complex (MAC) includes major acquired immune deficiency syndrome (AIDS)-associated pathogens. Formerly, MAC serotyping was used for epidemiological purposes. Recently, restriction fragment length polymorphism (RFLP) typing has become available. OBJECTIVE: Examination of the usefulness of i
CD4+ T-lymphocytopenia in pulmonary tuberculosis [letter]: Int J Tuberc Lung Dis. 1998 Mar;2(3):261-2. Unique Identifier : AIDSLINE MED/98186950; Grange JM
Activation-inactivation of HIV-1 in the lung.: J Biomed Sci. 1998;5(1):1-10. Unique Identifier : AIDSLINE MED/98230435; Rich EA; Department of Medicine, Case Western Reserve University, Cleveland,; Ohio 44106-4984, USA. ear7@po.cwru.edu; The lung is prominently afflicted during the course of HIV-1 disease by both infectious and noninfectious complications. Direct or indirect effects of HIV-1 are likely central to the pathogenesis of these complications. Thus, any changes in viral load locally would negatively impact on the lung. This review focuses on
Regulation of equine infectious anemia virus expression.: J Biomed Sci. 1998;5(1):11-23. Unique Identifier : AIDSLINE MED/98230436; Maury W; Department of Microbiology, University of South Dakota School of; Medicine, Vermillion 57069, USA. wmaury@sundance.usd.edu; Equine infectious anemia virus (EIAV) is an ungulate lentivirus that is related to human immunodeficiency virus (HIV). Much of the understanding of lentiviral gene regulation comes from studies using HIV. HIV studies have provided insights into molecular regulation of EIAV expression; however, much of the regulation o
Tat, Tat-associated kinase, and transcription.: J Biomed Sci. 1998;5(1):24-7. Unique Identifier : AIDSLINE MED/98230437; Jeang KT; Molecular Virology Section, Laboratory of Molecular Microbiology,; NIAID, NIH, Bethesda, MD 20892-0460, USA. kj7e@nih.gov; The HIV-1 Tat protein is an RNA-binding transcriptional transactivator. Recent findings suggest that Tat associates with a cellular kinase that phosphorylates the carboxyl-terminal domain of the largest subunit of RNA polymerase II. Here we review, in brief, the role of Tat-associated kinase in Tat-activated transcrip
Human immunodeficiency virus type 1 long terminal repeat quasispecies differ in basal transcription and nuclear factor recruitment in human glial cells and lymphocytes.: J Biomed Sci. 1998;5(1):31-44. Unique Identifier : AIDSLINE MED/98230439; Krebs FC; Mehrens D; Pomeroy S; Goodenow MM; Wigdahl B; Department of Microbiology and Immunology, The Pennsylvania State; University College of Medicine, Hershey 17033, USA.; The generation of genomic diversity during the course of infection has the potential to affect all aspects of HIV-1 replication, including expression of the proviral genome. To gain a better understanding of the impact of long terminal repeat LTR) sequence diversity on LTR-directed gene expression in cells of the cent
Clinical applications of N-acetylcysteine.: Altern Med Rev. 1998 Apr;3(2):114-27. Unique Identifier : AIDSLINE MED/98238108; Kelly GS; Alternative Medicine Review, Greenwich, CT.; N-acetylcysteine (NAC), the acetylated variant of the amino acid L-cysteine, is an excellent source of sulfhydryl (SH) groups, and is converted in the body into metabolites capable of stimulating glutathione (GSH) synthesis, promoting detoxification, and acting directly as free radical scavengers. Administration of NA
National tuberculosis programme review: experience over the period 1990-95.: Bull World Health Organ. 1997;75(6):569-81. Unique Identifier : AIDSLINE MED/98170370; Pio A; Luelmo F; Kumaresan J; Spinaci S; National Programme Support, Global Tuberculosis Programme, World; Health Organization, Geneva, Switzerland.; Since 1990 the WHO Global Tuberculosis Programme (GTB) has promoted the revision of national tuberculosis programmes to strengthen the focus on directly observed treatment, short-course DOTS) and close monitoring of treatment outcomes. GTB has encouraged in-depth evaluation of activities through a comprehensive progra
Suppression of viral replication in a long-term nonprogressing rhesus macaque experimentally infected with pathogenic simian immunodeficiency virus (SIV).: Clin Immunol Immunopathol. 1998 Apr;87(1):101-5. Unique Identifier : AIDSLINE MED/98236930; Spring M; Stahl-Hennig C; Nisslein T; Locher C; Fuchs D; Bodemer W; Hunsmann G; Dittmer U; Department of Virology and Immunology, German Primate Centre,; Gottingen, Germany.
CD95 expression and apoptosis during pediatric HIV infection: early upregulation of CD95 expression.: Clin Immunol Immunopathol. 1998 Apr;87(1):33-41. Unique Identifier : AIDSLINE MED/98236922; McCloskey TW; Oyaizu N; Bakshi S; Kowalski R; Kohn N; Pahwa S; Department of Pediatrics, North Shore University Hospital-New York; University School of Medicine, Manhasset 11030, USA.; Pediatric HIV infection is characterized by a progressive decline in CD4 T lymphocytes and faster disease progression than is typically seen in adults. Apoptosis, possibly mediated through the CD95 antigen, has been proposed as a mechanism for cell loss which eventually leads to immune dysfunction. In this study of pe
Oral administration of schistosome egg antigens and insulin B-chain generates and enhances Th2-type responses in NOD mice.: Clin Immunol Immunopathol. 1998 Apr;87(1):85-92. Unique Identifier : AIDSLINE MED/98236928; Maron R; Palanivel V; Weiner HL; Harn DA; Center for Neurologic Diseases, Brigham and Women's Hospital, Boston,; Massachusetts, USA.; In murine Schistosoma mansoni, parenteral administration of parasite eggs or saline-soluble egg antigens (SEA), generates Th2 T-cell responses to both schistosome-specific and unrelated third-party antigens. Oral administration of insulin to NOD mice suppresses or delays the onset of diabetes by skewing the response t
Membranoproliferative glomerulonephritis in the aged and its possible causal relationship with CD8+CD57+ lymphocytes.: Clin Nephrol. 1998 Mar;49(3):138-44. Unique Identifier : AIDSLINE MED/98205176; Hotta O; Yusa N; Furuta T; Onodera S; Kitamura H; Taguma Y; Department of Nephrology, Sendai Shakaihoken Hospital, Japan.; Membranoproliferative glomerulonephritis (MPGN) is a chronic progressive glomerulonephritis that occurs primarily in patients under the age of 30, and is rare in the elderly. We report eight aged patients with MPGN associated with CD8+CD57+ lymphocytosis. All eight patients showed a significant increase in CD8+CD57+ l
Toxoplasma encephalitis in a HIV patient: unusual involvement of the corpus callosum.: Clin Neurol Neurosurg. 1997 Dec;99(4):287-90. Unique Identifier : AIDSLINE MED/98152008; Supiot F; Guillaume MP; Hermanus N; Telerman-Toppet N; Karmali R; Department of Neurology, Brugmann Hospital, Free University of; Brussels (ULB), Belgium.; In patients with acquired immuno-deficiency syndrome, the differential diagnosis between primary brain lymphoma and toxoplasma encephalitis is not radiologically always straightforward, especially in the presence of a solitary cerebral lesion. In this context, involvement of the corpus callosum is almost exclusively a
Fas gene polymorphisms are not associated with systemic lupus erythematosus, multiple sclerosis and HIV infection.: Dis Markers. 1998 Feb;13(4):221-5. Unique Identifier : AIDSLINE MED/98214352; Cascino I; Ballerini C; Audino S; Rombola G; Massacesi L; Colombo G; Scorza Smeraldi R; d'Alfonso S; Momigliano Richiardi P; Tosi R; Ruberti G; Department of Immunobiology, National Research Council, Roma, Italy.
The trading of sex for money or drugs, sexually transmitted diseases (STDs), and HIV-related risk behaviors among multisubstance using alcoholic inpatients.: Drug Alcohol Depend. 1997 Dec;49(1):33-8. Unique Identifier : AIDSLINE MED/98135564; Windle M; Research Institute on Addictions, Buffalo, NY 14203, USA.; Data from 802 multisubstance using alcoholic inpatients (481 men and 321 women) were analyzed to determine whether trading sex for money or drugs was associated with self-reported STDs, self-reported HIV infection, and perceptions of current and future probable infection. Logistic and ordinal polychotomous regression
[Cyclospora cayetanensis--an intestinal protozoan pathogenic for humans which is of increasing clinical significance]: Dtsch Med Wochenschr. 1998 Apr 17;123(16):504-9. Unique Identifier : AIDSLINE MED/98250912; Lindhorst E; Long EG; Universitatsklinik fur Chirurgie, Johann Wolfgang Goethe-Universitat,; Frankfurt/Main.
Helical and coiled-coil-forming properties of peptides derived from and inhibiting human immunodeficiency virus type 1 integrase assessed by 1H-NMR--use of NH temperature coefficients to probe coiled-coil structures.: Eur J Biochem. 1998 Apr 1;253(1):236-44. Unique Identifier : AIDSLINE MED/98237594; Krebs D; Maroun RG; Sourgen F; Troalen F; Davoust D; Fermandjian S; Laboratoire de RMN, UPRES-A CNRS 6014, IRCOF, IFRMP n~ 23, Mont; Saint-Aignan, France.; Human immunodeficiency virus type 1 integrase (HIV-1 IN) which catalyzes viral DNA integration into the host genome of infected cells represents an attractive target for AIDS therapy. We have previously demonstrated the ability of the IN-(147-175)-peptide derived from the catalytic core domain of HIV-1 IN to inhibit t
Translationally repressive RNA structures monitored in vivo using temperate DNA bacteriophages.: Gene. 1998 Mar 27;210(1):135-42. Unique Identifier : AIDSLINE MED/98192549; Fouts DE; Celander DW; Department of Microbiology, University of Illinois at; Urbana-Champaign, Urbana, IL, USA.; The RNA challenge phage system enables genetic selection of proteins with RNA-binding activity in bacteria. These phages are modified versions of the temperate DNA bacteriophage P22 in which post-transcriptional regulatory events control the developmental fate of the phage. The system was originally developed to ident
The single-stranded DNA binding protein, Pur-alpha, binds HIV-1 TAR RNA and activates HIV-1 transcription.: Gene. 1998 Mar 27;210(1):37-44. Unique Identifier : AIDSLINE MED/98192538; Chepenik LG; Tretiakova AP; Krachmarov CP; Johnson EM; Khalili K; Center for NeuroVirology, NeuroOncology, Allegheny University of the; Health Sciences, Philadelphia, PA 19102, USA.; Previous studies indicate that the bulge and loop domains of TAR, the HIV-1 RNA regulatory element, bind viral and cellular factors that are critical for efficient transcription of the HIV-1 genome. In this report, we demonstrate that the cellular protein, Pur-alpha, a previously characterized sequence specific, singl
Prevalence, risk factors, and accuracy of cytologic screening for cervical intraepithelial neoplasia in women with the human immunodeficiency virus.: Gynecol Oncol. 1998 Mar;68(3):233-9. Unique Identifier : AIDSLINE MED/98233492; Maiman M; Fruchter RG; Sedlis A; Feldman J; Chen P; Burk RD; Minkoff H; Department of Obstetrics and Gynecology, State University of New; York-Health Science Center at Brooklyn 11203, USA.; OBJECTIVES: The objective was to evaluate the sensitivity and specificity of cervical cytology in women infected with the human immunodeficiency virus (HIV), risk factors for abnormal cytology in HIV-infected and uninfected women, and risk factors for histologic diagnosis of cervical intraepithelial neoplasia (CIN) in
An HIV-infected woman with choriocarcinoma presenting with a nasal mass.: Gynecol Oncol. 1998 Mar;68(3):304-6. Unique Identifier : AIDSLINE MED/98233506; Tangtrakul S; Linasmita V; Wilailak S; Srisupandit S; Bullangpoti S; Ayudhya NI; Department of Obstetrics and Gynecology, Faculty of Medicine,; Ramathibodi Hospital, Bangkok, Thailand.; Gestational choriocarcinoma metastasized to the nasal mucosa is extremely rare. An HIV-infected woman with choriocarcinoma presenting with a nasal mass is reported. The clinical findings are compared with a previous reported case. She responded to multiagent chemotherapy and has obtained complete remission. The role o
Assessment of hematological and immunological function during long-term follow-up after peripheral blood stem cell transplantation.: Haematologica. 1998 Feb;83(2):138-42. Unique Identifier : AIDSLINE MED/98211095; Laurenti L; Sica S; Salutari P; Rutella S; Serafini R; D'Onofrio G; Rumi C; Leone G; Istituto Semeiotica Medica, Universita Cattolica del Sacro Cuore,; Rome, Italy.; BACKGROUND AND OBJECTIVE: Long-term hemopoietic and immunological profile after autologous peripheral blood progenitor cells transplantation (PBPCT), in patients affected by hematological malignancies is largely unknown. The aim of this work was to detect the impact of high dose chemotherapy and PBPCT on hemopoietic a
Health status of homeless and marginally housed users of mental health self-help agencies.: Health Soc Work. 1998 Feb;23(1):45-52. Unique Identifier : AIDSLINE MED/98182671; Segal SP; Gomory T; Silverman CJ; Center for Self-Help Research, University of California, Berkeley; 94720, USA. spsegal@ucljnk2.berkeley.edu; The study discussed in this article investigated the health status of 310 homeless and marginally housed people to determine the usefulness of mental health self-help agencies (SHAs) in addressing their physical health needs. The study compared self-reported health problems among SHA users with similar reports and cli
Children with HIV/AIDS and their families: a successful social work intervention based on the culturally specific health care model.: Health Soc Work. 1998 Feb;23(1):61-9. Unique Identifier : AIDSLINE MED/98182673; Goicoechea-Balbona A; School of Social Work, University of Maryland, MD 21205-1777, USA.; agoicoec@ssw02.ab.umd.edu; Health care utilization and community support are of utmost importance in minimizing the sociomedical problems of people with HIV/AIDS. This article describes a health clinic in Belle Glade, Florida, that effectively uses the Culturally Specific Health Care Model defined by the author in a previous article. The curren
Syndromic management of sexually transmitted diseases in developing countries: what role in the control of the STD and HIV epidemics? [editorial; comment]: Genitourin Med. 1997 Dec;73(6):427-8. Unique Identifier : AIDSLINE MED/98255367; Wilkinson D
HIV therapy guidelines [editorial]: Genitourin Med. 1997 Dec;73(6):429-30. Unique Identifier : AIDSLINE MED/98243261; Williams IG
Randomised trials of STD treatment for HIV prevention: report of an international workshop. HIV/STD Trials Workshop Group [see comments]: Genitourin Med. 1997 Dec;73(6):432-43. Unique Identifier : AIDSLINE MED/98243262; Hayes R; Wawer M; Gray R; Whitworth J; Grosskurth H; Mabey D; London School of Hygiene and Tropical.; Three community trials of the impact of STD treatment interventions on HIV incidence in rural populations have been completed or are in progress in Uganda and Tanzania . Investigators from these trials met for a joint technical workshop in Balt
Voluntary confidential HIV testing of STD patients in Switzerland, 1990-5: HIV test refusers cause different biases on HIV prevalences in heterosexuals and homo/bisexuals. Swiss Network of Dermatovenereology Policlinics.: Genitourin Med. 1997 Dec;73(6):444-7. Unique Identifier : AIDSLINE MED/98243263; Paget WJ; Zwahlen M; Eichmann AR; Division of Epidemiology and Infectious Diseases, Swiss Federal Office; of Public Health, Bern, Switzerland.; OBJECTIVES: To monitor the prevalence of HIV infection among heterosexual and male homo/bisexual STD patients and assess the effect of HIV test refusers on the HIV prevalences. METHODS: A voluntary confidential HIV test was offered to all people diagnosed with an STD at the Swiss Network of Dermatovenerology Policlini
Sexual behaviour of adolescents before and after the advent of AIDS.: Genitourin Med. 1997 Dec;73(6):448-52. Unique Identifier : AIDSLINE MED/98243264; Ostergaard L; Department of Infectious Diseases, Aarhus University Hospital,; Denmark.; OBJECTIVES: To asses changes in sexual behaviour and use of contraceptive methods in Danish adolescents from the period before the advent of AIDS up to the present. DESIGN: Comparative study comparing data obtained from two identical cross sectional surveys SETTING: Grenaa Gymnasium,
Behavioural and demographic characteristics of attenders at two genitourinary medicine clinics in England.: Genitourin Med. 1997 Dec;73(6):457-61. Unique Identifier : AIDSLINE MED/98243266; Catchpole M; Connor N; Brady A; Kinghorn G; Mercey D; Band B; Thin N; PHLS Communicable Disease Surveillance Centre, London.; OBJECTIVES: To investigate how attenders with sexually transmitted disease (STD) differ from the general population with respect to sexual behaviour, and to identify which attenders at genitourinary medicine (GUM) clinics are at particular behavioural risk for acquiring STD. DESIGN: Multicentre cross sectional survey.
Necrotising herpetic retinopathy in patients with advance HIV disease.: Genitourin Med. 1997 Dec;73(6):462-6. Unique Identifier : AIDSLINE MED/98243267; Miller RF; Brink NS; Cartledge J; Sharvell Y; Frith P; Department of Sexually Transmitted Diseases, UCL Medical School,; London.; OBJECTIVES: To describe the presenting features, clinical and laboratory diagnosis, response to treatment, and outcome of necrotising herpetic retinopathy (NHR) in HIV infected patients. METHODS: Retrospective case records/laboratory data review of five HIV infected patients presenting to the specialist HIV/AIDS unit
Herpes zoster and the stage and prognosis of HIV-1 infection.: Genitourin Med. 1997 Dec;73(6):467-70. Unique Identifier : AIDSLINE MED/98243268; McNulty A; Li Y; Radtke U; Kaldor J; Rohrsheim R; Cooper DA; Donovan B; Taylor Square Private Clinic, Australia.; OBJECTIVES: To examine the incidence of herpes zoster in HIV-1 infection. To assess the prognostic significance of the occurrence of herpes zoster and progression to AIDS or death DESIGN AND METHODS: 146 homosexually active men with known times of HIV-1 seroconversion were identified through the Sydney AIDS Prospectiv
Prior fluconazole exposure as an independent risk factor for fluconazole resistant candidosis in HIV positive patients: a case-control study.: Genitourin Med. 1997 Dec;73(6):471-4. Unique Identifier : AIDSLINE MED/98243269; Cartledge JD; Midgley J; Gazzard BG; Department of HIV and GU Medicine, Chelsea and Westminster Health Care; Trust, London.; OBJECTIVES: To determine if prior fluconazole exposure was an independent risk factor for fluconazole resistant candidosis in HIV positive patients. METHODS: Twenty five HIV positive cases with fluconazole resistant oral candidosis were matched by CD4 lymphocyte count and time since first episode of candidosis to 25 H
Women with recurrent vaginal candidosis have normal peripheral blood B and T lymphocyte subset levels.: Genitourin Med. 1997 Dec;73(6):475-6. Unique Identifier : AIDSLINE MED/98243270; White DJ; Stevenson M; Shahmanesh M; Gentle T; Department of Genitourinary Medicine, General Hospital Birmingham.; OBJECTIVE: To compare the B and T lymphocyte subset levels of otherwise healthy women suffering from frequently recurrent vaginal candidosis with a healthy control group. SUBJECTS: 26 unselected otherwise healthy women of reproductive age with at least four attacks of vaginal candidosis in the past year and more than
Nasopharyngeal flora in HIV seropositive men who have sex with men.: Genitourin Med. 1997 Dec;73(6):477-80. Unique Identifier : AIDSLINE MED/98243271; Carlin EM; Hannan M; Walsh J; Talboys C; Shah D; Flynn R; Azadian BS; Boag FC; Kobler Centre, Chelsea and Westminster Hospital, London.; OBJECTIVES: To assess, in men who were infected with the human immunodeficiency virus (HIV) and who identified themselves as having had sex with men; the nasopharyngeal prevalence of Neisseria gonorrhoeae, N meningitidis, Corynebacterium diphtheriae, and candida species; oral sexual behaviour; the relation between ora
Serological markers for treponemal infection in children in rural Kilimanjaro, Tanzania: evidence of syphilis or non-venereal treponematoses?: Genitourin Med. 1997 Dec;73(6):522-7. Unique Identifier : AIDSLINE MED/98243280; Klouman E; Masenga EJ; Sam NE; Institute of General Practice and Community Medicine, University of; Oslo, Norway.; OBJECTIVE: To determine the seroprevalence of treponemal infection and possible risk factors among children aged 0-14 in the general population of a rural Tanzanian village. METHODS: The survey was conducted as a part of a cross section study of a total village population on HIV and sexually transmitted disease. Among
Sexually transmissible diseases--knowledge and practices of general practitioners in Victoria, Australia.: Genitourin Med. 1997 Dec;73(6):533-7. Unique Identifier : AIDSLINE MED/98243282; Mulvey G; Temple-Smith MJ; Keogh LA; Centre for the Study of Sexually Transmissible Diseases, LaTrobe; University, Australia.; OBJECTIVE: To examine knowledge and practices in relation to sexually transmissible diseases (STDs) of general practitioners GPs) in Victoria, Australia . METHOD: A questionnaire was distributed to 520 Victorian GPs randomly selected from the Australian Medical Publishing Company
Vulvodynia and HIV: causal or casual association?: Genitourin Med. 1997 Dec;73(6):545-7. Unique Identifier : AIDSLINE MED/98243285; Raiteri R; Sinicco A; Pippione M; Tomasini C; Solaroli C; Vitale L; Morticelli L; Gioannini P; Department of Medical and Surgical Sciences, University of Turin,; Italy.; BACKGROUND: No study exists on HIV and vulvodynia. OBJECTIVE: To evaluate vulvodynia in HIV infected women and its possible association with HIV. DESIGN: Cross sectional study. SETTING: Department of Medical and Surgical Sciences, Section of Infectious Diseases, University of Turin. METHODS: 235 HIV positive and 272 H
Necropsies in HIV medicines.: Genitourin Med. 1997 Dec;73(6):548-50. Unique Identifier : AIDSLINE MED/98243286; Kellock DJ; Rogstad KE; Department of Genitourinary Medicine, Royal Hallamshire Hospital,; Glossop.; OBJECTIVE: The objective of this study was to determine the availability of necropsy services to departments dealing with HIV positive patients, and to assess their satisfaction with, and utilisation of, these services. METHOD: Confidential questionnaires were sent to 187 consultants in genitourinary medicine and infe
Knowledge of HIV infected individuals about prevention of cryptosporidiosis.: Genitourin Med. 1997 Dec;73(6):551. Unique Identifier : AIDSLINE MED/98243287; Slade PM; Kepple JS; Churchill DR; Department of Genitourinary Medicine and Communicable Diseases,; Imperial College School of Medicine at St Mary's, London.
Sexual risk behaviour among subgroups of heterosexual HIV infected patients in an urban setting.: Genitourin Med. 1997 Dec;73(6):552-4. Unique Identifier : AIDSLINE MED/98243288; DeHovitz JA; Feldman J; Brown LS; Minkoff H; SUNY Health Science Center at Brooklyn, Brooklyn 11201, USA.; OBJECTIVE: To determine the frequency of characteristics associated with unprotected heterosexual intercourse in HIV infected adults in an urban area. DESIGN: Retrospective comparison of sexual risk transmission behaviour between HIV infected men and women from a drug treatment site and between women from the drug sit
Sexually transmitted disease among married Zambian women: the role of male and female sexual behaviour in prevention and management.: Genitourin Med. 1997 Dec;73(6):555-7. Unique Identifier : AIDSLINE MED/98243289; Morrison CS; Sunkutu MR; Musaba E; Glover LH; Family Health International, Research Triangle Park, NC 27709, USA.; OBJECTIVES: Few studies have evaluated the relation between male and female sexual behaviour and STD among married African women. The objectives of this study were to identify male and female sexual behaviour associated with female STD, and to explore whether incorporating male and female sexual behaviour and male sym
What is the role of the HIV liaison psychiatrist?: Genitourin Med. 1997 Dec;73(6):568-70. Unique Identifier : AIDSLINE MED/98243294; Clark BR; Everall IP; Maudsley Hospital, Denmark Hill, London.; In this article we review the field of HIV liaison psychiatry and illustrate the manner in which psychiatric care can contribute to the health and quality of life of this group of patients. To illustrate our discussion we review experience and findings in relation to affective illness, cognitive impairments, and perso
IL-4, IL-5 and IL-10 are not required for the control of M. bovis-BCG infection in mice.: Immunol Cell Biol. 1998 Feb;76(1):41-6. Unique Identifier : AIDSLINE MED/98214391; Erb KJ; Kirman J; Delahunt B; Chen W; Le Gros G; Malaghan Institute of Medical Research, Wellington, New Zealand.; Mycobacterial infections in mice are normally characterized by a profound Th1 cell-mediated immune response, in which T cells secrete large amounts of IFN-gamma. Recent evidence suggests that this response also includes a Th2 component. In order to investigate whether production of IL-4, IL-5, or IL-10 influenced the
Effects of vaccination with T cell receptor peptides: epitope switching to a possible disease-protective determinant of myelin basic protein that is cross-reactive with a TCR BV peptide.: Immunol Cell Biol. 1998 Feb;76(1):83-90. Unique Identifier : AIDSLINE MED/98214396; Vandenbark AA; Chou YK; Whitham R; Bourdette DN; Offner H; Research Service, Veterans Affairs Medical Center, Portland, OR 97201,; USA. vandenbark.arthur_a@portland.va.gov; Immunization of Lewis rats with guinea-pig myelin basic protein Gp-MBP) induced T cell responses to primary and secondary encephalitogenic determinants, as well as to a third non-encephalitogenic epitope, residues 55-69. This sequence is of interest due to its protective activity against experimental autoimmune enceph
Synthesis of some new pyrimidine derivatives as potential anticancer and anti-HIV agent.: Indian J Exp Biol. 1997 Nov;35(11):1208-13. Unique Identifier : AIDSLINE MED/98229170; Debi M; Department of Chemical Technology, Calcutta University, India.; Several 2,4-diaminopyrimidines have been synthesized and tested for their anticancer and anti-HIV activities. Out of these, eight compounds displayed significant activity against leukemia, melanoma, non-small cell and CNS cancer. Two compounds were active against leukemia P388. One compound has been found to be modera
Blepharitis and lid ulcer as initial ocular manifestation in acquired immunodeficiency syndrome patients.: Indian J Ophthalmol. 1997 Dec;45(4):233-4. Unique Identifier : AIDSLINE MED/98228401; Biswas J; Madhavan HN; Kumarasamy N; Solomon S; Vision Research Foundation, Chennai, India.
Lid abscess with extensive molluscum contagiosum in a patient with acquired immunodeficiency syndrome.: Indian J Ophthalmol. 1997 Dec;45(4):234-6. Unique Identifier : AIDSLINE MED/98228402; Biswas J; Therese L; Kumarasamy N; Solomon S; Yesudian P; Vision Research Foundation, Chennai, India.
HTLV-1 infection in a population-based cohort of older persons in Guinea-Bissau, West Africa: risk factors and impact on survival.: Int J Cancer. 1998 May 4;76(3):293-8. Unique Identifier : AIDSLINE MED/98239164; Melbye M; Poulsen AG; Gallo D; Pedersen JB; Biggar RJ; Larsen O; Dias F; Aaby P; Projecto de Saude de Bandim, Bissau, Guinea-Bissau. mme@ssi.dk; In 1989, a population-based cohort of persons aged > or = 50 years was established in an urban area of Guinea-Bissau , West Africa. Overall, 346 persons were interviewed in detail about risk behaviors and had capillary blood drawn. Among women, 12.4% were HTLV-1 seropositive, compa
Tumor-specific peptides in cutaneous T-cell lymphoma: association with class I major histocompatibility complex and possible derivation from the clonotypic T-cell receptor.: Int J Cancer. 1998 May 4;76(3):304-11. Unique Identifier : AIDSLINE MED/98239166; Berger CL; Longley BJ; Imaeda S; Christensen I; Heald P; Edelson RL; Department of Dermatology, Yale University School of Medicine, New; Haven, CT 06519-8059, USA. BergerCL@MASPO1.MAS.YALE.EDU; We wished to identify and characterize tumor-associated class I peptides which could potentially serve as immunogens for an immunoprotective CD8 response in cutaneous T-cell lymphoma CTCL). Candidate idiotypic peptides were identified from the third complementarity determining region (CDR3) of the clonotypic T-cell